PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Rac1 15710747 biogrid,i2d,intact exp G G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Stardust protein MAGUK1 isoform 15475968 mint,intact exp LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B D 14605208 intact exp G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B numb 18854163 intact exp G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Bazooka, isoform B 20434988 i2d,intact exp G G G G G G baz LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B unassigned4,18854163 intact exp LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B GCC88 ortholog, LD02947p 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B CDase 14605208 biogrid,i2d,mint,intact exp G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B gro 14605208 biogrid,i2d,mint,intact,dip exp G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Protein PTOV1 homolog 14605208 biogrid,i2d,mint,intact exp LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Patj i2d exp G G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B CG34382, isoform C, CG34382, isoform E, LP17019p 14605208 biogrid exp pon LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B 18854163 intact exp LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B LD33695p, Pins protein, RE22964p, Rapsynoid 14605208 biogrid,i2d,mint,intact,dip exp G G G G G G G G G CG8709-RH LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B 14605208 biogrid,intact exp G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Miranda, isoform A 18854163 intact exp G Sosondowah, isoform G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B 14605208 biogrid,i2d exp G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B vret 14605208 biogrid,i2d,mint,intact exp G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Cdc42 15475968,22078569 i2d,mint,intact,dip exp, ortho G G G G G G G G G G Atypical protein kinase C LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B 12629552,14605208,18854163 biogrid,intact exp, ortho G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B l(2)gl 12629552,22036573,18854163 biogrid,i2d,intact exp, ortho G G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Protein fem-1 homolog CG6966 ortho G G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B ortho G G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B BG:DS02740.2 ortho G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B 14-3-3zeta ortho G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Dmn ortho G G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B Pkc53E ortho G G G G G Hsc70Cb, isoform G, Hsc70Cb, isoform H LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B ortho G G G G G G G G G G LD29223p, PAR-6, Par-6, isoform A, Par-6, isoform B 14-3-3epsilon ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O97111 A1Z9X0 - 15907474 - X 2 O97111 A1Z9X0 - 12629552 - X 2 O97111 Q9VCB1 - 14605208 - X 2 O97111 A1Z9X0 - 14605208 - X 2 O97111 - 14605208 - X 2 O97111 M9NFF8 - 15177032 - X 2 O97111 A1Z9X0 - 15177032 - X 2 O97111 Q9VX75 - 15177032 - X 2 O97111 P16371-2 - 14605208 - X 2 O97111 - 15475968 - X 2 A4V3N7 O97111 - 14605208 - X 2 O97111 - 14605208 - X 2 O97111 Q7JX82 - 14605208 - X 2 O97111 Q9VCU7 - 14605208 - X 2 O97111 Q9VGR1 - 14605208 - X 2 O97111 M9PBH7 - 15710747 - X 2 O97111 - 15023337 - X 2 O97111 M9NCX1 - 12629552 - X 2 O97111 Q9VB22 - 14605208 - X 2 O97111 A4V1B2 - 15177032 - X 2 O97111 M9NCX1 - 12629552 - X 2 O97111 A1Z9X0 affinity chromatography technology 12629552 physical association X 2 O97111 Q9VCB1 two hybrid 14605208 direct interaction X 2 O97111 A1Z9X0 two hybrid 14605208 direct interaction X 2 O97111 Q960W9 two hybrid 14605208 direct interaction X 2 O97111 P16371-2 two hybrid 14605208 direct interaction X 2 A4V3N7 O97111 two hybrid 14605208 direct interaction X 2 O97111 Q9VGR1 two hybrid 14605208 direct interaction X 2 O97111 Q7JX82 two hybrid 14605208 direct interaction X 2 O97111 M9NCX1 affinity chromatography technology 12629552 physical association X 2 O97111 Q9VB22 two hybrid 14605208 direct interaction X 2 O97111 M9PBH7 two hybrid 15710747 direct interaction X 2 O97111 Q9VCU7 two hybrid 14605208 direct interaction X 2 O97111 M9NCX1 affinity chromatography technology 22036573 physical association X 2 Q29R15 O97111 two hybrid 14605208 direct interaction X 2 O97111 M9NFF8 nuclear magnetic resonance 22078569 direct interaction X 2 O97111 A1Z9X0 two hybrid 14605208 physical association X 2 O97111 Q9VCB1 two hybrid 14605208 physical association X 2 O97111 P16371-2 two hybrid 14605208 physical association X 2 A4V3N7 O97111 two hybrid 14605208 physical association X 2 O97111 two hybrid 14605208 physical association X 2 O97111 Q9VGR1 two hybrid 14605208 physical association X 2 O97111 Q7JX82 two hybrid 14605208 physical association X 2 O97111 Q9VCU7 two hybrid 14605208 physical association X 2 O97111 Q9VB22 two hybrid 14605208 physical association X 2 Q29R15 O97111 two hybrid 14605208 physical association X 2 O97111 pull down 20434988 physical association C 3 O97111 pull down 18854163 association C 5 O97111 anti bait coimmunoprecipitation 18854163 association C 4 O97111 anti bait coimmunoprecipitation 18854163 association C 4 O97111 pull down 18854163 association C 4 O97111 A1Z9X0 two hybrid 14605208 physical association X 2 O97111 A1Z9X0 two hybrid 14605208 physical association X 2 O97111 Q9VCB1 two hybrid 14605208 physical association X 2 O97111 P16371 two hybrid 14605208 physical association X 2 O97111 M9NFF8 fluorescence technology 15475968 direct interaction X 2 O97111 A1Z9X0 pull down 18854163 physical association X 2 O97111 Q9VX75 pull down 20434988 physical association X 2 O97111 O96782 experimental interaction detection - physical association X 2 A4V3N7 O97111 two hybrid 14605208 physical association X 2 O97111 pull down 18854163 association C 4 O97111 pull down 18854163 association C 5 O97111 pull down 18854163 association C 5 O97111 pull down 18854163 association C 6 O97111 Q9VGR1 two hybrid 14605208 physical association X 2 O97111 Q7JX82 two hybrid 14605208 physical association X 2 O97111 Q9VCU7 two hybrid 14605208 physical association X 2 O97111 Q9VB22 two hybrid 14605208 physical association X 2 O97111 Q9JLB2 pull down 15475968 direct interaction X 2 O97111 Q9JLB2 pull down 15475968 direct interaction X 2 O97111 Q8WRS3 pull down 15475968 direct interaction X 2 O97111 Q9JLB2 x-ray crystallography 15475968 direct interaction X 2 O97111 M9PBH7 two hybrid fragment pooling approach 15710747 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B par-6 Q9V782 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_30553|MINT_30554 bait|prey prey|bait par-6 Q9V375 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_24844 prey bait par-6 aPKC MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18854163 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact) UniProt_43898|UniProt_43891|UniProt_43899|UniProt_43893 bait|bait|bait|bait prey|prey|prey|prey par-6 aPKC MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_58188|UniProt_58189 prey|bait bait|prey par-6 CDase MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(intact)|(biogrid)|MI:0471(mint) DIP_15074|UniProt_48368|BIOGRID_40312|MINT_7424 -|prey|prey|prey -|bait|bait|bait par-6 Rac1 MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_42077 prey bait par-6 Cdc42 MI:0096(pull down)|MI:0114(x-ray crystallography) 15475968 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(intact) MINT_19911|UniProt_39396 neutral component|neutral component neutral component|neutral component par-6 l(2)gl MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12629552,18854163,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_43898|UniProt_43899|UniProt_43893|BIOGRID_61161|BIOGRID_65443 bait|bait|bait|prey|prey prey|prey|prey|bait|bait par-6 kermit MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|(biogrid) DIP_9646|UniProt_63705|BIOGRID_36886 -|prey|prey -|bait|bait par-6 gro MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|MI:0471(mint)|(intact)|(biogrid) DIP_24704|MINT_16390|UniProt_62596|BIOGRID_46780 -|prey|prey|bait -|bait|bait|prey par-6 aPKC MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 12629552,14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0465(dip) BIOGRID_61160|BIOGRID_29812|DIP_6117 bait|prey|- prey|bait|- par-6 sowah MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_30029 prey bait par-6 Q8IQH1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_59238|MINT_22517 prey|prey bait|bait par-6 sdt MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0096(pull down) 15475968 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|MI:0471(mint) UniProt_39395|UniProt_165349|MINT_19910 prey|prey|prey bait|bait|bait par-6 Q9VT63 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_29108|UniProt_47486 prey|prey bait|bait par-6 CG34382 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_61481 prey bait par-6 virB11 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:176299() MI:0915(physical association) MI:0465(dip) DIP_14169 - - par-6 baz MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 20434988 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_43967|UniProt_43968 prey|prey bait|bait par-6 CG13609 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0465(dip)|(biogrid) UniProt_52660|MINT_28312|DIP_13340|BIOGRID_39232 prey|prey|-|prey bait|bait|-|bait par-6 raps MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|MI:0465(dip) BIOGRID_46691|MINT_16256|UniProt_62453|DIP_24564 prey|prey|prey|- bait|bait|bait|- baz par-6 MI:0045(experimental interaction detection)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18854163 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact) UniProt_45409|UniProt_43898|UniProt_43899|UniProt_43893 unspecified role|prey|prey|prey unspecified role|bait|bait|bait par-6 vret MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0465(dip)|(biogrid)|MI:0471(mint) UniProt_61542|DIP_23671|BIOGRID_33327|MINT_15434 prey|-|prey|prey bait|-|bait|bait par-6 CG10703 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0465(dip)|(intact) BIOGRID_35326|MINT_22798|DIP_7456|UniProt_53530 prey|prey|-|prey bait|bait|-|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O97111 O44224 PAR-6 MIRA 0.21 18854163 O97111 O96561 PAR-6 PON 0.21 18854163 Q9VCB1 O97111 Q9VCB1 PAR-6 0.183 14605208 P40793 O97111 CDC42 PAR-6 0.309 15475968 P40792 O97111 RAC1 PAR-6 0.126 15710747 Q7JX82 O97111 KERMIT PAR-6 0.183 14605208 Q9VGR1 O97111 GCC88 PAR-6 0.183 14605208 Q9VCU7 O97111 VRET PAR-6 0.183 14605208 Q9JLB2 O97111 MPP5 PAR-6 0.523 15475968 O97111 A1Z9X0 PAR-6 APKC 0.671 18854163,14605208 P08111 O97111 L(2)GL PAR-6 0.376 18854163 P16371 O97111 GRO PAR-6 0.21 14605208 O97111 O96782 PAR-6 BAZ 0.454 18854163,unassigned4 Q8WRS3 O97111 SDT PAR-6 0.309 15475968 Q9VA70 O97111 CDASE PAR-6 0.183 14605208 Q9VB22 O97111 RAPS PAR-6 0.21 14605208 Q9VX75 O97111 BAZ PAR-6 0.376 20434988 P16554 O97111 NUMB PAR-6 0.21 18854163