PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Trailer hitch, isoform H Amp 25294943 intact exp G G G G G G G G G G CG43347, isoform C Amp 15710747 biogrid,intact exp G G G Amp Nup54 14605208 biogrid,intact exp G G G G G G G CG15071 Amp 14605208 biogrid,intact exp G Amp CG34133, isoform C, RE64336p 15710747 biogrid exp G G G G G G G G Amp CG11652, isoform A, CG11652, isoform B, CG11652, isoform C, LD10878p 25294943 intact exp G G G G G G G G G G Amp Huntingtin, isoform A, Huntingtin, isoform B, Huntington disease protein homolog 15710747 biogrid exp G G G G G G G G G Amp CG32352 15710747,14605208 biogrid,intact exp G G G G G G G G Amp CG15764-RA 14605208 biogrid,intact exp G CG8026-RB Amp 25294943 intact exp G G G G G G G G G G Amp Slow as molasses, isoform B, Slow as molasses, isoform C 15710747 biogrid,intact exp G Pkc53E Amp 25294943 intact exp G G G G G Amp CG11289 25294943 intact exp Amp Amp 15710747 biogrid,intact exp G G G G G G G G G G Amp Hrs 15710747 biogrid,intact exp G G G G G G G G G G tub Amp 14605208 biogrid,intact exp G G G G G G G G G Amp CG18476-RA 25294943 intact exp G G Amp Hsp70Ba 25294943 intact exp Amp DCP1 14605208 biogrid,intact exp G G G G G G G G G G GH19431p Amp 15710747 intact exp Amp CG14411-RA 14605208 biogrid,intact exp G G G G G G G G G G Amp EG:22E5.6 25294943 intact exp Amp BTB-VII protein domain 15710747 intact exp Amp Nedd4 15710747 biogrid,intact exp G G G G G G G G G Amp CG5214, GM01350p, LP03989p 25294943 intact exp G G G G G G G G G G Amp htt 15710747 intact exp Amp Hsp70Bb 25294943 intact exp Amp RpL24 14605208 biogrid,intact exp G G G G G G G G G G Amp Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p 14605208 biogrid,intact exp G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9W0R0 Q7KLE5 - 14605208 - X 2 Q7KLE5 E8NH30 - 14605208 - X 2 Q7KLE5 Q9VSM2 - 14605208 - X 2 Q7KLE5 Q7KLE5 - 15710747 - X 2 Q7KLE5 Q9VSM2 - 15710747 - X 2 Q7KLE5 - 15710747 - X 2 B7FNJ7 Q7KLE5 - 15710747 - X 2 Q9VY15 Q7KLE5 - 14605208 - X 2 Q9W465 Q7KLE5 - 14605208 - X 2 Q9W1H5 Q7KLE5 - 14605208 - X 2 Q7KLE5 Q9V3N4 - 15710747 - X 2 Q7KLE5 Q9VJY6 - 14605208 - X 2 Q9VVI3 Q7KLE5 - 15710747 - X 2 A1ZBC3 Q7KLE5 - 14605208 - X 2 A8WHJ2 Q7KLE5 - 15710747 - X 2 Q7K501 Q7KLE5 - 15710747 - X 2 Q9V6B9 Q7KLE5 - 14605208 - X 2 Q960S0 Q7KLE5 - 15710747 - X 2 Q9W0R0 Q7KLE5 two hybrid 14605208 direct interaction X 2 Q7KLE5 E8NH30 two hybrid 14605208 direct interaction X 2 Q7KLE5 Q7KLE5 two hybrid 15710747 direct interaction X 2 Q7KLE5 Q9VME5 two hybrid 15710747 direct interaction X 2 B7FNJ7 Q7KLE5 two hybrid 15710747 direct interaction X 2 Q9VY15 Q7KLE5 two hybrid 14605208 direct interaction X 2 Q0KHZ4 Q7KLE5 two hybrid 15710747 direct interaction X 2 Q9W465 Q7KLE5 two hybrid 14605208 direct interaction X 2 B7Z141 Q7KLE5 two hybrid 15710747 direct interaction X 2 Q9W1H5 Q7KLE5 two hybrid 14605208 direct interaction X 2 Q7KLE5 Q9VJY6 two hybrid 14605208 direct interaction X 2 Q7KLE5 Q9V3N4 two hybrid 15710747 direct interaction X 2 Q7KLE5 M9PFK2 two hybrid 15710747 direct interaction X 2 Q7KLE5 M9NFP8 two hybrid 15710747 direct interaction X 2 Q7KLE5 M9NFP8 two hybrid 14605208 direct interaction X 2 A1ZBC3 Q7KLE5 two hybrid 14605208 direct interaction X 2 Q9V6B9 Q7KLE5 two hybrid 14605208 direct interaction X 2 Q9W0R0 Q7KLE5 two hybrid 14605208 physical association X 2 Q7KLE5 E8NH30 two hybrid 14605208 physical association X 2 Q7KLE5 Q9VME5 two hybrid 15710747 physical association X 2 Q7KLE5 Q9VME5 two hybrid 15710747 physical association X 2 Q7KLE5 Q7KLE5 two hybrid 15710747 physical association Y 1 B7FNJ7 Q7KLE5 two hybrid 15710747 physical association X 2 Q9VY15 Q7KLE5 two hybrid 14605208 physical association X 2 Q9W465 Q7KLE5 two hybrid 14605208 physical association X 2 Q9W1H5 Q7KLE5 two hybrid 14605208 physical association X 2 Q7KLE5 Q9VJY6 two hybrid 14605208 physical association X 2 A1ZBC3 Q7KLE5 two hybrid 14605208 physical association X 2 Q9V6B9 Q7KLE5 two hybrid 14605208 physical association X 2 Q9VSM0 Q7KLE5 two hybrid 15710747 physical association X 2 Q9VSM0 Q7KLE5 two hybrid 15710747 physical association X 2 Q9VSM0 Q7KLE5 two hybrid 14605208 physical association X 2 Q960S0 Q7KLE5 two hybrid 15710747 physical association X 2 Q9W0R0 Q7KLE5 two hybrid 14605208 physical association X 2 Q7KLE5 E8NH30 two hybrid 14605208 physical association X 2 Q7KLE5 Q9VME5 two hybrid fragment pooling approach 15710747 physical association X 2 Q7KLE5 Q9VME5 two hybrid fragment pooling approach 15710747 physical association X 2 Q7KLE5 Q7KLE5 two hybrid fragment pooling approach 15710747 physical association X 2 B7FNJ7 Q7KLE5 two hybrid fragment pooling approach 15710747 physical association X 2 Q9VY15 Q7KLE5 two hybrid 14605208 physical association X 2 Q9W465 Q7KLE5 two hybrid 14605208 physical association X 2 Q9W2T1 Q7KLE5 two hybrid fragment pooling approach 15710747 physical association X 2 Q9W1H5 Q7KLE5 two hybrid 14605208 physical association X 2 Q9VSM1 Q7KLE5 two hybrid fragment pooling approach 15710747 physical association X 2 Q7KLE5 anti tag coimmunoprecipitation 25294943 association C 4 Q7KLE5 pull down 25294943 association C 8 Q7KLE5 Q9VJY6 two hybrid 14605208 physical association X 2 Q7KLE5 P10636-7 pull down 23399914 physical association X 2 Q9VVI3 Q7KLE5 two hybrid fragment pooling approach 15710747 physical association X 2 A1ZBC3 Q7KLE5 two hybrid 14605208 physical association X 2 A1ZBC3 Q7KLE5 two hybrid 14605208 physical association X 2 Q9VZU6 Q7KLE5 two hybrid fragment pooling approach 15710747 physical association X 2 Q7K501 Q7KLE5 two hybrid fragment pooling approach 15710747 physical association X 2 Q8T069 Q7KLE5 two hybrid fragment pooling approach 15710747 physical association X 2 Q9V6B9 Q7KLE5 two hybrid 14605208 physical association X 2 Q9VSM0 Q7KLE5 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Amph CG15071 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(biogrid)|MI:0465(dip) UniProt_59638|UniProt_59639|BIOGRID_31818|DIP_15668 prey|bait|prey|- bait|prey|bait|- Amph CG32352 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208,15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_32945|BIOGRID_62883 prey|bait bait|prey Amph htt MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_62078 bait prey Amph Nup54 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|(biogrid) UniProt_53227|DIP_25971|BIOGRID_47725 prey|-|bait bait|-|prey Amph htt MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_42773 bait prey CG34133 Amph MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_62028 prey bait tub Amph MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip) UniProt_58979|BIOGRID_29973|DIP_6902 prey|bait|- bait|prey|- CG34133 Amph MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_42769 prey bait Amph BtbVII MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_42648 bait prey Amph CG14411-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|(biogrid) UniProt_47821|DIP_14506|BIOGRID_39989 bait|-|prey prey|-|bait Amph Nedd4 MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_42768 bait prey Amph CG15764 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact) BIOGRID_32015|DIP_16692|UniProt_60647 prey|-|prey bait|-|bait Amph CG32352 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_27331 bait prey Amph CG32352 MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_21614 - - Amph CG43078-RA MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_42772 bait prey Amph CG43347 MI:0018(two hybrid)|MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_62298|UniProt_42777 bait|bait prey|prey Amph Dcp1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|(biogrid) UniProt_54651|DIP_8568|BIOGRID_36151 bait|-|prey prey|-|bait Amph CG6905 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip) UniProt_63163|BIOGRID_47192|DIP_25256 prey|prey|- bait|bait|- Amph slam MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0399(two hybrid fragment pooling approach)|MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact)|(intact) DIP_27811|BIOGRID_62041|UniProt_42775|UniProt_42774 -|bait|bait|bait -|prey|prey|prey Amph RpL24 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_53228|BIOGRID_47726 bait|bait prey|prey Amph Hrs MI:0399(two hybrid fragment pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip) UniProt_42483|BIOGRID_62176|DIP_27506 prey|prey|- bait|bait|- Amph BtbVII MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_27671 - -

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7KLE5 P22812 AMPH TUB 0.183 14605208 Q8T069 Q7KLE5 HTT AMPH 0.126 15710747 Q7KLE5 Q7K501 AMPH Q7K501 0.126 15710747 Q7KLE5 A1Z7S4 AMPH A1Z7S4 0.126 25294943 Q7KLE5 C7LA76 AMPH HSP70BA-RA 0.126 25294943 Q7KLE5 P05130 AMPH PKC53E 0.126 25294943 Q7KLE5 P10636 AMPH MAPT 0.21 23399914 Q7KLE5 Q7KLE5 AMPH AMPH 0.155 15710747 Q960X8 Q7KLE5 HRS AMPH 0.126 15710747 Q9BIS2 Q7KLE5 HSP70BB AMPH 0.126 25294943 Q9VGK1 Q7KLE5 CG18476-RA AMPH 0.126 25294943 Q9VGQ1 Q7KLE5 Q9VGQ1 AMPH 0.126 25294943 Q9VM44 Q7KLE5 Q9VM44 AMPH 0.126 25294943 Q9VTM2 Q7KLE5 Q9VTM2 AMPH 0.126 25294943 Q9VTZ0 Q7KLE5 TRAL AMPH 0.126 25294943 Q9W0R0 Q7KLE5 CDC5 AMPH 0.183 14605208 Q9W465 Q7KLE5 CG15764-RA AMPH 0.183 14605208 Q9W528 Q7KLE5 EG:22E5.6 AMPH 0.126 25294943 Q9V6B9 Q7KLE5 NUP54 AMPH 0.21 14605208 Q9VJY6 Q7KLE5 RPL24 AMPH 0.183 14605208 Q9VME5 Q7KLE5 SLAM AMPH 0.126 15710747 Q9VSM0 Q7KLE5 Q9VSM0 AMPH 0.183 14605208 Q9VSM1 Q7KLE5 CG43078-RA AMPH 0.126 15710747 Q9VVI3 Q7KLE5 NEDD4 AMPH 0.126 15710747 Q9VY15 Q7KLE5 CG14411-RA AMPH 0.183 14605208 Q9VZU6 Q7KLE5 BTBVII AMPH 0.126 15710747 Q9W1H5 Q7KLE5 DCP1 AMPH 0.183 14605208 Q9W2T1 Q7KLE5 Q9W2T1 AMPH 0.126 15710747 Q7KLE5 A1ZBC3 AMPH A1ZBC3 0.332 14605208