PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rpn13 Rpn11 22036573 biogrid exp G G G G G G G G G G Trxr-1 Rpn11 19079254 intact exp G G G G G G G G G G Prosalpha4 Rpn11 22036573 biogrid exp G G G G G G G G G G Rpn11 Spindly 22036573 biogrid exp G l(2)03709 Rpn11 19079254 intact exp G G G G G G G G G G Prosalpha6 Rpn11 22036573 biogrid exp G G G G G G G G G G Vha16-1 Rpn11 25294943 intact exp G G G G G G G G G G Rpt6 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G CG17337, isoform A, RE11562p Rpn11 14605208 biogrid,intact exp, ortho G G G G G G G G G G Rpn11 26S proteasome regulatory complex subunit p97, Regulatory particle non-ATPase 1 22036573 biogrid exp, ortho G G G G G G G G G G Rpn6 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G Rpn3 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G 26S proteasome regulatory complex subunit p48B, Regulatory particle triple-A ATPase 1, SD07148p Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G 26S proteasome regulatory complex subunit p39A, LD17530p, Regulatory particle non-ATPase 9, isoform A, Regulatory particle non-ATPase 9, isoform B Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G Prosalpha2 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G Prosalpha3 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 Prosbeta3 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 LD38919p, Ubiquilin, isoform A, Ubiquilin, isoform B 22215586 biogrid exp, ortho G G G G G G G G G G Rpn11 LD13601p, UGP, isoform A 19079254 intact exp, ortho G Rpn8 Rpn11 19079254,14605208,22036573 biogrid,i2d,mint,intact exp, ortho G G G G G G G G G G Prosalpha5 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G Rpt2 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 26S proteasome regulatory complex subunit p50, GH12068p, Regulatory particle triple-A ATPase 5 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 Prosbeta7 19079254,22036573 biogrid,intact exp, ortho G G G G G G G G G G Prosbeta6 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 Prosalpha7 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 Rpt3-RA 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 Prosbeta2R1 19079254,22036573 biogrid,intact exp, ortho G G G G G G G G G G Rpn11 Regulatory particle triple-A ATPase 4 22036573 biogrid exp, ortho G G G G G G G G G G Rpn7 Rpn11 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 Rpn2 22036573 biogrid exp, ortho G G G G G G G G G G Rpn11 GH11341p, Hypothetical 55kDa protein, Regulatory particle non-ATPase 5 22036573 biogrid exp, ortho G G G G G G G G G G CG10092, isoform A, CG10092, isoform B, RE18459p Rpn11 ortho G G G G G G Hsc70-3 Rpn11 ortho G G G G G G G G G G RpI135 Rpn11 ortho G G G G Gs1 Rpn11 ortho G G G G G G G G G G Rpn11 RuvB-like helicase 2 ortho G G G G G G G G G G Fdh Rpn11 ortho G G G G G G G G G G Sod Rpn11 ortho G G G G G G G G G G Rpn11 Probable deoxyhypusine synthase, DHS ortho G G G G G G G Rpn11 Gclc ortho G G G G G G G G G G Rpn11 Drp1-RA ortho G G G G G G G G G G Rpn11 CG15923, isoform B, RE49535p ortho Rpn11 CG10932, isoform A, CG10932, isoform B, LD24105p ortho G G G G G G G G G Rpn11 AdSS ortho G G G G G G G G G G Rpn11 Aldehyde dehydrogenase, Aldehyde dehydrogenase, isoform A, Aldehyde dehydrogenase, isoform B ortho G G G G G G G G G G RpS2 Rpn11 ortho G G G G G G G G G G Rpn11 Nedd8 ortho G G G G G G G G G G Rpn11 Elp1 ortho G G G G G G G G Rpn11 Cyt-c1 ortho G G G G G G G G G G Rpn11 HERC2 ortho G G G G G G G G G G Rpn11 mAc ortho G G G G G G G G G G Nuclear GTP binding protein, Nucleostemin ortholog 2, SD10213p Rpn11 ortho G G Rpn11 BcDNA.GH06451 ortho G G G G G G G G G G Vha68-1 Rpn11 ortho G G G G G G G G G Rpn11 CSN6 ortho G G G G G G G G G G Rpn11 Cystathionine beta-synthase ortho G G G G G G G G G Rpn11 FI07923p, Karyopherin beta 3, isoform A, Karyopherin beta 3, isoform B ortho G G G G G G G G G G Rpn11 Pros-alpha-6T ortho G CG10077, isoform D, CG10077-PA, isoform A, GH10652p Rpn11 ortho G G G G G G G G G G Hsc70-5 Rpn11 ortho G G G G G G G G G G Rpn11 CG5290-RA ortho G G G G rab8 Rpn11 ortho G G G G G G G G G G Cpr Rpn11 ortho G G G G G G G G G G Pngl Rpn11 ortho G G G G G G G G G G Rpn11 CG5313-PA, Replication factor C subunit 3, SD11293p ortho G G Dredd Rpn11 ortho G G G G G G G G G G CkIIalpha Rpn11 ortho G G G G G G G G G G Rpn11 CG9330-RA ortho G G G G G G G G G G Rpn11 l(1)G0022 ortho G G G G G G G G G G Rpn11 Probable phosphomannomutase, PMM ortho G G G G G G G G G CG11980, isoform C, RE51612p Rpn11 ortho G G G G G G G G G G CG10924, isoform A, RE12569p Rpn11 ortho G G G Rpn11 26S proteasome non-ATPase regulatory subunit 9 ortho G G G G G G G G G G Rpn11 CG7033, SD02216p ortho G G G G G G G G G G Rpn11 CG5919 protein, CG5919, isoform A, CG5919, isoform B, CG5919-PA, GM08271p ortho G G G G G G G G G G Vha26 Rpn11 ortho G G G G G G G G G G RE34924p, Rpb5, isoform A, Rpb5, isoform B Rpn11 ortho G G G G G G G G G G Nop60B Rpn11 ortho G G G G G G G G G G Rpn11 Methionine aminopeptidase 1, MAP 1, MetAP 1 ortho G G G G G G G G G G Rpn11 CG10565, isoform A, CG10565, isoform B, LD23875p ortho G G G G G G G G G G dod Rpn11 ortho G G G G Hel25E Rpn11 ortho G G G G G G G G G G Rpn11 eIF3-S10 ortho G G G G G G G G G G TfIIB Rpn11 ortho G G G G G G G G G G Histidyl-tRNA synthetase, isoform D Rpn11 ortho G G G G G G G G G G Act5C Rpn11 ortho G G G G G G G G G G Rpn11 Coatomer subunit alpha ortho G G G G G G G G G G Rpn11 Protein HGH1 homolog ortho G G G G G Rpn11 Nap1-RA ortho G G G G G G G G G G Rpn11 Jafrac1 ortho G G G G G G G G G G Rpn11 Upf1 ortho G G G G G G G G G G Rpn11 Adenylyltransferase and sulfurtransferase MOCS3 ortho G G G G G G G G G G Rpn11 BcDNA:LD24639 ortho G G G G G G G G G G blw Rpn11 ortho G G G G G G G G G G Psa-RC Rpn11 ortho G G G G G G G G G G Actin related complex p41 subunit, Actin-related protein 2/3 complex, subunit 1, isoform A, Actin-related protein 2/3 complex, subunit 1, isoform B, SD06579p Rpn11 ortho G G G G G G G G G G Rpn11 Branched-chain-amino-acid aminotransferase ortho G G G G G G Rpn11 Ptp61F ortho G G G G G G G G G G Elongation factor Tu Rpn11 ortho G G G G G G G G G G RpS5a Rpn11 ortho G G G G G G G G G G Rpn11 RpS7 ortho G G G G G G G G G G CG5946-RB Rpn11 ortho G G G G G G G G G G Rpn11 CG10652-PA, isoform A, RE25263p, Ribosomal protein L30, isoform B, Ribosomal protein L30, isoform E ortho G G G G G G G G G G Pacman, isoform B Rpn11 ortho G G G G G G G G G G prp8 Rpn11 ortho G G G G G G G G G G 14-3-3epsilon Rpn11 ortho G G G G G G G G G G EG:152A3.1 Rpn11 ortho G G G G G G G G G Rpn11 Probable 6-phosphogluconolactonase, 6PGL ortho G G G G G G G G G G RpS13 Rpn11 ortho G G G G G G G G G G Rpn11 CG1444, RH59310p ortho G G G G G G G G G Succinyl-CoA ligase subunit beta Rpn11 ortho G G G G G G G G G G Rpn11 LD45860p, Proteasome regulator dREG, REG, isoform A, REG, isoform B ortho G G G G G G G G G G Rpn11 Tal ortho G G G G G G G G G G Rpn11 sgll ortho G G G G G G G G G G CG32850-PA, RE41137p Rpn11 ortho G G G G G G G G G Argininosuccinate synthase Rpn11 ortho G G G G G Rpn11 CG9281, isoform B, CG9281, isoform C, CG9281, isoform D, LD02975p ortho G G G G G G G G G dre4 Rpn11 ortho G G G G G G G G G G Rpn11 CG15261-PA, GM01181p, UK114, isoform B ortho G G G G G G G G G G Rpn11 CG2656, LD11854p ortho G G G G G G G G G G RpI1 Rpn11 ortho G G G G G G G G G G Rpn11 CG8630, RE43130p ortho G Rpn11 As ortho G G G G G G G G G G EG:152A3.5 protein (Fbgn0003116, GH15456p, PRUNE protein, Prune Rpn11 ortho G G G G G G G G G Aats-val Rpn11 ortho G G G G G G G G G betaTub56D Rpn11 ortho G G G G G G G G G G r Rpn11 ortho G G Rpn11 MCTS1 ortho G G G G G G G G CG6950-RC Rpn11 ortho G G G G G G G G G G Rpn11 26S proteasome regulatory complex subunit p30, CG4157-PA, RE36854p ortho G G G G G G G G G G Rpn11 CG5567-RA ortho G G G G G G G G G G Pgi Rpn11 ortho G G G G G G G G G G Actn Rpn11 ortho G G G G G G G G G G FK506-bp2 Rpn11 ortho G G G G G G G G G G PyK Rpn11 ortho G G G G G G G G G G Rpn11 LD24721p, MIP20650p, Small glutamine-rich tetratricopeptide containing protein, isoform A, Small glutamine-rich tetratricopeptide containing protein, isoform B ortho G G G G G G G G G G Rpn11 Nsun2 ortho G G G RnrS Rpn11 ortho G G G G G G G Cctgamma Rpn11 ortho G G G G G G G G G G Ntmt Rpn11 ortho G G G G G G G G G G Aats-cys Rpn11 ortho G G G G G G G G G G Rpn11 rad23 ortho G G G G G G G G G G Sec23 Rpn11 ortho G G G G G G G G G G BG:DS00797.2 Rpn11 ortho G G G G G G G G G G eff Rpn11 ortho G G G G G G G G G G Rpn11 CG3756, LP03982p ortho G G G G G G G G G G Rpn11 CG8184, isoform H ortho G G G G G G G G G G Rpn11 Tyrosine--tRNA ligase ortho G G G G G G G G G G Rab1-RA Rpn11 ortho G G G G G G G G G G Rpn11 l(1)G0156 ortho G G G G G G G G G G Arl1 Rpn11 ortho G G G G G G G G G G Rpn11 Aats-gly-RB ortho G G G G G G G G G G RpLP0 Rpn11 ortho G G G G G G G G G G Aprt Rpn11 ortho G G G G G G G G G Rpn11 Probable nucleolar GTP-binding protein 1 ortho G G G G G G G G G G CG1440-RC Rpn11 ortho G G G G G G G G G G Rpn11 Tctp ortho G G G G G G G G G G CG9674, isoform F, CG9674, isoform G Rpn11 ortho G G G G G G G G G G AT18092p, CG6084, isoform B Rpn11 ortho G G G G G G G G G G Rpn11 60S ribosome subunit biogenesis protein NIP7 homolog ortho G G G G G G G G G G Cdc42 Rpn11 ortho G G G G G G G G G G Rpn11 Mtap ortho G G G G G G G G G G TER94 Rpn11 ortho G G G G G G G G G G Rpn11 CG3999, isoform A, CG3999, isoform B, RH34107p ortho G G Arp3 Rpn11 ortho G G G G G G G G G G Rpn11 Mannose-6-phosphate isomerase ortho G G G G G G G G G G Rpn11 nero ortho G G G G G G G G G G BcDNA.GM09489 Rpn11 ortho G G G G G G G G G G GM12270p, T-complex chaperonin 5, isoform A Rpn11 ortho G G G G G G G G G G Cyt-c-p Rpn11 ortho G G G G G G G G G G CanA1 Rpn11 ortho G G Nacalpha Rpn11 ortho G G G G G G G G G G GH01724p, p47 Rpn11 ortho G G G G G G G G G G hrg Rpn11 ortho G G G G G G G G G G Rpn11 CG7519-PA, RE39629p ortho G G G G G G G G G G Rpn11 Protein purity of essence ortho G G G G G G G G G G Pgk Rpn11 ortho G G G G G G G G G G T-cp1 Rpn11 ortho G G G G G G G G G G Rpn11 Spt5 ortho G G G G G G G G G G Rpn11 LD02044p, Nesthocker ortho Rpn11 CG3356, LP03102p ortho G G G G G G G G G G CG11876, isoform A, CG11876, isoform D, GH08474p Rpn11 ortho G G G G G G G G G G Rpn11 eRF1 ortho G G G G G G G G G G Rpn11 Probable glutamine-dependent NAD(+) synthetase ortho G G G G G G G G NAA20 ortholog, isoform B Rpn11 ortho G G G G G G G G G G eIF3-S9 Rpn11 ortho G G G G G G G G G G Rpn11 Nedd4 ortho G G G G G G G G G Isoleucyl-tRNA synthetase, isoform A, Isoleucyl-tRNA synthetase, isoform C, Isoleucyl-tRNA synthetase, isoform D, LD27166p Rpn11 ortho G G G G G G G G G G Rpn11 Rpn11 ortho G G G G G G G G G G Rpn11 Vha44 ortho G G G G G G G G G G Rpn11 GDP dissociation inhibitor, isoform A, GDP dissociation inhibitor, isoform B, GDP dissociation inhibitor, isoform C, LD46767p, LP03430p ortho G G G G G G G G G G Adk2 Rpn11 ortho G G G G G G G G G G PAPS synthetase, isoform D Rpn11 ortho G G G G G G G G G Obg-like ATPase 1 Rpn11 ortho G G G G G G G G G G Ahcy13 Rpn11 ortho G G G G G G G G G G Rpn11 CG8336, isoform A, CG8336, isoform B, CG8336, isoform C, CG8336, isoform D, GH06403p ortho G G G G G G G G G G Rpn11 Ykt6 ortho G G G G G G G G G G Rpn11 CG1416, isoform A, CG1416, isoform B, CG1416, isoform C, LD43819p ortho G G G G G G G G G G Snap Rpn11 ortho G G G G G G G G Rpn11 CG11474, isoform A, CG11474, isoform C, LD03212p ortho G G G G G G G G G Rpn11 CG11811, GH06691p, RE11961p ortho G G G G G G G G G G Rpn11 CG9426-PA, GH03286p ortho G G G G G G G G G G RpL19 Rpn11 ortho G G G G G G G G G G CG8258, LD24495p Rpn11 ortho G G G G G G G G G G Mannose-1-phosphate guanyltransferase beta Rpn11 ortho G G G G G G G G G G Vha55 Rpn11 ortho G G G G G G G G G G Rpn11 Pixie, isoform A, Pixie, isoform B, RE71924p ortho G G G G G G G G G G CG15100 Rpn11 ortho G G G G G G G G G G eIF-2alpha Rpn11 ortho G G G G G G G G G G Rpn11 Probable phenylalanine--tRNA ligase beta subunit ortho G G G G G G G G G G Arp2 Rpn11 ortho G G G G G G G G G G Rpn11 DENR ortho G G G G G G G G G G Rpn11 LD37736p, Zpr1 ortho G G G G G G G G G G Rpn11 Serine hydroxymethyltransferase ortho G G G G G G G G G G Rpn11 CG33123, isoform A, CG33123, isoform B ortho G G G G G G G G G G Rpn11 Proteasome-associated protein ECM29 homolog ortho G G G G G G G G G G CG1645 Rpn11 ortho G G Rpn10 Rpn11 ortho G G G G G G G G G G FI06027p, Tryptophanyl-tRNA synthetase Rpn11 ortho G G G G Rpn11 cnir ortho G G G G Rpn11 Oat ortho G G G G G G G G G RpS20 Rpn11 ortho G G G G G G G G G G Rpn11 Aats-lys-RC ortho G G G G G G G G G G Rpn11 Adenylyl cyclase-associated protein ortho G G G G G G G G G G Rpn11 CG6230-RA ortho G G G G G G G G G G Rpn11 Spermidine synthase, isoform A, Spermidine synthase, isoform C ortho G G G G Rpn11 RuvB-like helicase 1 ortho G G G G G G G G G G Rpn11 Arp5 ortho G G G G G G G eIF3-S8 Rpn11 ortho G G G G G G G G G G Hsp60 Rpn11 ortho G G G G G G G G G G Uch Rpn11 ortho G G G G G G G G G G Rpn11 CG3590-RA ortho G G G G G G G Rpn11 CG8132, LD31229p ortho G G G G G G G G G Rpn11 CG5776, isoform A, CG5776, isoform B, LD25466p ortho G Tpi Rpn11 ortho G G G G G G G G G G Rpn11 Aats-ala ortho G G G G G G G G G G Rpn11 Ubiquitin-like domain-containing C-terminal domain phosphatase 1 ortho G G G G G G G G G G Gl Rpn11 ortho G G G G G G G G G G Rpn11 EG:BACR7A4.17 ortho G G G G G G G G G RpII140 Rpn11 ortho G G G G G G G G G G Rpn11 CG2720-PA, LD03220p ortho G G G G G G G G G G Rpn11 l(1)G0255-RA ortho G G G G G G G G G G Zw Rpn11 ortho G G G G G G G G Rpn11 CG7444 ortho G G G Rpn11 Arginine methyltransferase 1, CG6554 protein, CG6554-PA, LD28808p ortho G G G G G G G G G G Rpn11 Fib ortho G G G G G G G G G G Rpn11 Eukaryotic translation initiation factor 2A, eIF-2A ortho G G G G G G G G G G Rpn11 Probable phenylalanine--tRNA ligase alpha subunit ortho G G G G G G G G G G cdc2c Rpn11 ortho G G G ATPsyn-beta Rpn11 ortho G G G G G G G G G G Rpn11 26S proteasome non-ATPase regulatory subunit 5 ortho G G G G G G G G G G porin Rpn11 ortho G G G G G G G G G G Rpn11 CG8239, isoform A, CG8239, isoform B, LD10857p ortho G G emb Rpn11 ortho G G G G G G G G G G CG5482, isoform A, CG5482, isoform B, CG5482, isoform C, CG5482, isoform D, LD36412p Rpn11 ortho G G G G G G G G G G Rpn11 CG9302-RA ortho G G G G G G G G Rpn11 AT06125p, CG6195 ortho G G G G G G G G G G ade3 Rpn11 ortho G G G G G G Multiprotein bridging factor 1, isoform E Rpn11 ortho G G G G G G G G G G Nop56-RA Rpn11 ortho G G G G G G G G G G Ef1beta Rpn11 ortho G G G G G G G G G G E3 ubiquitin-protein ligase parkin Rpn11 ortho G G G G G G G G G Rpn11 flr ortho G G G G G G G G G Rack1 Rpn11 ortho G G G G G G G G G G Rpn11 LD47396p, Tcp-1eta ortho G G G G G G G G G G Rpn11 Trx-2 ortho G G G G G G G G G G Aspartyl-tRNA synthetase, isoform A, Aspartyl-tRNA synthetase, isoform B, Aspartyl-tRNA synthetase, isoform C, GM14334p Rpn11 ortho G G G G G G G G G G Drab11 Rpn11 ortho G G G G G G G G G G RpII215 Rpn11 ortho G G G G G G G G G G Pka-R2 Rpn11 ortho G G G G G G G G Hsc70Cb, isoform G, Hsc70Cb, isoform H Rpn11 ortho G G G G G G G G G G V-type proton ATPase subunit a Rpn11 ortho G G G G G G G G G G betaCop Rpn11 ortho G G G G G G G G G G HMG coenzyme A synthase, isoform A, HMG coenzyme A synthase, isoform B, HMG coenzyme A synthase, isoform C, HMG coenzyme A synthase, isoform D, HMG coenzyme A synthase, isoform E, HMG coenzyme A synthase, isoform F, HMG coenzyme asynthase, LD26976p Rpn11 ortho G G G G G G G G G G Rpn11 Aminopeptidase P, Aminopeptidase P, isoform A, Aminopeptidase P, isoform B, LD20901p ortho G G G G G G G G G G Rpn11 CG5537, isoform A, CG5537, isoform C, LD21741p ortho G G G G G G G G G G Rpn11 Pglym87 ortho G gho Rpn11 ortho G G G G G G G G G G Tip60 Rpn11 ortho G G G G G G G G G Rpn11 Ef1alpha-like factor, isoform A, Ef1alpha-like factor, isoform B, Ef1alpha-like factor, isoform D, RE07731p ortho G G G G G G G G G G Rpn11 sec13 ortho G G G G G G G G G G Rpn11 Aats-thr-RA ortho G G G G G G G G G G Rpn11 Phospholipase A2 activator protein, isoform A, Phospholipase A2 activator protein, isoform B, Phospholipase A2 activator protein, isoform C, SD05646p ortho G G G G G G G G G G Rpn11 eIF-2b(epsilon) ortho G G G G G G G G G G Rpn11 Probable phosphoserine aminotransferase, PSAT ortho G G G G G G G G G Rpn11 Tom70-RA ortho G G G G G G G G G G Rpn11 VhaAC39-1 ortho G G G G G G G G G G gammaCop Rpn11 ortho G G G G G G G G G G Cdk5 Rpn11 ortho G G G G G G G G G Isocitrate dehydrogenase [NADP] Rpn11 ortho G G G G G G G G G G Rpn11 RpL5 ortho G G G G G G G G G G Glutamate oxaloacetate transaminase 1, isoform B Rpn11 ortho G G G G G G G G G G pug Rpn11 ortho G G G G G G G G G G Rpn11 Cdc6 ortho G Ubi-p63E Rpn11 ortho G G G G G G G G G G Rpn11 Aats-gln ortho G G G G G G G G G G CG32409 Rpn11 ortho G G G G G G G G Rpn11 Delta-aminolevulinic acid dehydratase ortho G G G G G G G G G Rpn11 CG17259, isoform A, CG17259, isoform B, LP20978p ortho G G G G G G G G G G drk Rpn11 ortho G G G G G G G G G G Rpn11 Acetyltransferase component of pyruvate dehydrogenase complex ortho G G G G G G G G G G Rpn11 Protein YIPF ortho G G G G G G G G G G Pp2A-29B Rpn11 ortho G G G G G G G G G G Rpn11 RpL23a ortho G G G G G G G G G G SkpA Rpn11 ortho G G G G G G G G G G Rpn11 CG4752-RA ortho G G G G G G G G G Elp2 Rpn11 ortho G G G G G G G G Fim-RD Rpn11 ortho G G G G G G G G G G PCNA Rpn11 ortho G G G Chc Rpn11 ortho G G G G G G G G G G RpL10 Rpn11 ortho G G G G G G G G G G alc-RA Rpn11 ortho Rpn11 Sac1 ortho G G G G G G G G G G me31B Rpn11 ortho G G G G G G G G G G tRNA (guanine-N(7)-)-methyltransferase Rpn11 ortho G G G G G G G G G Rpn11 eIF5 ortho G G G G G G G G G G Rpn11 T-complex protein 1 subunit delta ortho G G G G G G G G G G CG17514, isoform A Rpn11 ortho G G G G G G G G G G Farnesyl pyrophosphate synthase, GM06581p, RE52884p Rpn11 ortho G G G G G G G G G G GH24511p, Ubiquitin activating enzyme 1, isoform A Rpn11 ortho G G G G G G G G G G beta'Cop Rpn11 ortho G G G G G G G G G G Rpn11 CG7265, LD09414p ortho G G G G G G G G G G Rpn11 PPP5 ortho G G G G G G G G G G Nurf-38 Rpn11 ortho G G G G G G G G G G Rpn11 GH01161p, TNF-receptor-associated factor 6 ortho G G G G G G G G G Rpn11 Bifunctional phosphopantetheine adenylyltransferase-Dephospho-CoA kinase ortho G G G G G G G G G G Rpn11 CG5203-PA, Carboxy terminus of Hsp70-interacting protein, RE01069p ortho G G G G G G G G G G RpS3 Rpn11 ortho Rpn11 Ns3 ortho G G G G G G G G G ATPase ASNA1 homolog Rpn11 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9V3H2 Q8MT58 - 14605208 - X 2 Q9V3H2 P26270 - 14605208 - X 2 Q9V3V6 Q9V3H2 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q8MT58 two hybrid 14605208 direct interaction X 2 Q9V3H2 P26270 two hybrid 14605208 direct interaction X 2 Q9V3H2 P26270 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9V3P6 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9V3G7 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9XYN7 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q95083 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 P48601 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q7KMP8 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 P22769 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q7K148 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9VJJ0 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9V5C6 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 P25161 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 affinity chromatography technology 22036573 physical association X 2 Q9VW54 Q9V3H2 affinity chromatography technology 22036573 physical association X 2 P12881 Q9V3H2 affinity chromatography technology 22036573 physical association X 2 Q7KMQ0 Q9V3H2 affinity chromatography technology 22036573 physical association X 2 P40301 Q9V3H2 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9VWD9 pull down 22215586 direct interaction X 2 Q9V3H2 Q9V405 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q7K2G1-2 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 A0AQH0 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q7KLV9 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 P18053 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 O18413 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9VNA5 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9W414 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 P40304 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9V3Z4 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q9VUJ1 affinity chromatography technology 22036573 physical association X 2 Q9V3H2 Q8MT58 two hybrid 14605208 physical association X 2 Q9V3H2 P26270 two hybrid 14605208 physical association X 2 Q9V3H2 pull down 25294943 association C 59 Q9V3H2 P26270 two hybrid 14605208 physical association X 2 Q9V3H2 Q8MT58 two hybrid 14605208 physical association X 2 Q9V3H2 P91938 two hybrid array 19079254 physical association X 2 Q9V3H2 Q7K148 two hybrid array 19079254 physical association X 2 Q9V3H2 P26270 two hybrid array 19079254 physical association X 2 Q9V3H2 Q0E924 two hybrid array 19079254 physical association X 2 Q9V3H2 A5XCL5 two hybrid array 19079254 physical association X 2 Q9V3H2 Q9VNA5 two hybrid array 19079254 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Rpn11 UGP MI:0397(two hybrid array) 19079254 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_43450 bait prey Pros26.4 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68058 bait prey Mlc-c Rpn11 MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476068 prey bait Rpn7 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66859 bait prey Rpn6 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67680 bait prey Rpn11 hgo MI:0004(affinity chromatography technology) 11743162 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_362897 bait prey Rpn11 CG9536 MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476094 bait prey Rpn11 CG12375 MI:0004(affinity chromatography technology) 16554755 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_383597 bait prey Pros25 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71399 prey bait Rpn11 Rpt4 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_69493 prey bait Rpn11 Or7a MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476092 bait prey Rpn11 Spindly MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74902 bait prey Ppi20 Rpn11 MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 11743162,19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_476064|BIOGRID_362895 prey|prey bait|bait CG13349 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66323 prey bait Pros45 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68655 bait prey Rpn11 elB MI:0004(affinity chromatography technology) 16554755 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_383541 prey bait Rpn11 CG17331 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_69295 bait prey Rpn11 Prosalpha7 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70075 prey bait Rpn11 Rpn1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67185 bait prey Rpn11 Rpn2 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66722 prey bait Rpn11 Rpt3 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65994 prey bait Rpn11 Tbp-1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68499 prey bait Rpn11 Prosbeta2 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74961 prey bait Prosalpha5 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67931 bait prey Rpn11 Q9V9H1 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_9937 prey bait Rpn11 CG5065 MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476075 bait prey pnut Rpn11 MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476091 prey bait Pros35 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67372 prey bait Pros26 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70230 bait prey Rpt1 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70493 bait prey nrv2 Rpn11 MI:0004(affinity chromatography technology) 21987634 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_620571 bait prey CG17337 Rpn11 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_32246|UniProt_55661 bait|bait prey|prey Rpn11 Prosbeta1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67203 prey bait Rpn11 CG11981 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67905 prey bait Pros29 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68057 prey bait l(2)03709 Rpn11 MI:0397(two hybrid array) 19079254 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_43421 bait prey Mov34 Rpn11 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 14605208,19079254,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0465(dip)|(biogrid)|(intact) UniProt_43447|BIOGRID_32419|MINT_10757|DIP_18604|BIOGRID_65196|UniProt_56530 bait|prey|bait|-|bait|bait prey|bait|prey|-|prey|prey Aats-phe Rpn11 MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476284 bait prey ebi Rpn11 MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476086 prey bait Prosbeta5 Rpn11 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 19079254,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_69097|UniProt_43446 prey|prey bait|bait Rpn9 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68954 bait prey Trxr-1 Rpn11 MI:0397(two hybrid array) 19079254 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_43401 bait prey Pros28.1 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_69007 bait prey Rpn3 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71336 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9V3H2 Q0E924 RPN11 PHB2 0.126 19079254 Q9V3H2 P22769 RPN11 PROSALPHA4 0.126 22036573 Q9V3H2 P23380 RPN11 VHA16-1 0.126 25294943 Q9V3H2 O18413 RPN11 RPT6 0.126 22036573 Q9XYN7 Q9V3H2 PROSBETA3 RPN11 0.126 22036573 Q9V3H2 Q7KLV9 RPN11 RPN6 0.126 22036573 Q9V3H2 P26270 RPN11 RPN8 0.507 19079254,14605208,22036573 Q9V3H2 Q95083 RPN11 PROSALPHA5 0.126 22036573 Q9V3H2 Q9V3G7 RPN11 RPN7 0.126 22036573 Q9V3H2 A5XCL5 RPN11 UGP 0.126 19079254 Q9V3H2 P12881 RPN11 PROSALPHA6 0.126 22036573 Q9V3H2 P18053 RPN11 PROSALPHA3 0.126 22036573 Q9V3H2 P25161 RPN11 RPN3 0.126 22036573 Q9V3H2 P40301 RPN11 PROSALPHA2 0.126 22036573 Q9V3H2 P91938 RPN11 TRXR-1 0.236 19079254 Q9V3H2 Q7K148 RPN11 PROSBETA5 0.236 19079254 Q9V3H2 Q7K2G1 RPN11 RPN13 0.126 22036573 Q9V3H2 Q8MT58 RPN11 Q8MT58 0.183 14605208 Q9V3P6 Q9V3H2 RPN2 RPN11 0.126 22036573 Q9V5C6 Q9V3H2 PROSALPHA7 RPN11 0.126 22036573 Q9V3H2 P40304 RPN11 PROSBETA6 0.126 22036573 Q9VNA5 Q9V3H2 PROSBETA7 RPN11 0.332 22036573,19079254 Q9V3H2 P48601 RPN11 RPT2 0.126 22036573