PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus EG:BACR37P7.5 Atg5 14605208 biogrid,i2d,mint,intact exp CG14191-PA Atg5 14605208 biogrid,i2d,mint,intact exp CG17337, isoform A, RE11562p Atg5 14605208 biogrid,intact exp G G G G G G G G G Cnot 4 homologue, isoform K Atg5 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G mAc Atg5 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Dorsal interacting protein 2, SD09045p Atg5 i2d exp RpS3 Atg5 14605208 biogrid,i2d,mint,intact,dip exp BcDNA.LD34343 Atg5 22036573 biogrid exp G G G G G G G G G Atg5 CG4325-RA 22036573 biogrid exp G G CG3557, isoform A, GH20409p Atg5 14605208 biogrid,i2d,mint,intact exp Pkc98E Atg5 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G ATP-dependent Clp protease proteolytic subunit Atg5 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Aspartyl-tRNA synthetase, isoform A, Aspartyl-tRNA synthetase, isoform B, Aspartyl-tRNA synthetase, isoform C, GM14334p Atg5 14605208 biogrid,intact exp G G G G G G G G G ND42 Atg5 14605208 biogrid,i2d,mint,intact,dip exp G G G G G G G G G Dorsal interacting protein 2 Atg5 14605208 biogrid,i2d,mint,intact exp G G G G G G G G Fem-1 Atg5 14605208 biogrid exp G G G G G G G G G Act5C Atg5 22036573 biogrid exp G G G G G G G G G Cam Atg5 22036573 biogrid exp G G G G G G G Cytochrome c heme lyase, isoform A, Cytochrome c heme lyase, isoform B, HL08191p Atg5 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Autophagy-specific gene 16, isoform C, IP15590p Atg5 14605208,22036573 biogrid,i2d,mint,intact exp, ortho G G G G G G G G G Blue cheese Atg5 ortho G G G G G Pcmt Atg5 ortho G G G G G G G G G CG15525-RA Atg5 ortho G G G G G G G G Pros-alpha-6T Atg5 ortho TER94 Atg5 ortho G G G G G G G G G Autophagy-related protein 3 Atg5 ortho G G G G G G G G G FI11917p, KEAP1, Keap1, isoform B Atg5 ortho G G G G G G G G Ef1beta Atg5 ortho G G G G G G G G G emb Atg5 ortho G G G G G G G G G ATPsyndelta Atg5 ortho G G G G G G G G G Transgelin Atg5 ortho G G G G G G G G G RnrL Atg5 ortho G G CG10749-RA Atg5 ortho G G G G G G G G G CG10576, isoform A, CG10576, isoform C, CG10576, isoform D Atg5 ortho G G G G G G G G G Nedd8 Atg5 ortho G G G G G G G G G Atg5 LD12055p, Rhophilin, Rhophilin, isoform A, Rhophilin, isoform B ortho G G G G G endoB Atg5 ortho G G G G Pex23 Atg5 ortho G G G G G G G G G Caf1 Atg5 ortho G G G G G G G G G Atg101 Atg5 ortho G G G G G G G G G CG32672-PA, LD05816p Atg5 ortho G G G G G G G G G Got2-RB Atg5 ortho G G G G G G G G G CG9149 Atg5 ortho G G G G G G G G G Rpt2 Atg5 ortho G G G G G G G G G CG6543, isoform A, CG6543, isoform B, LD24265p Atg5 ortho G G G G G G G G G 14-3-3epsilon Atg5 ortho G G G G G G G G G Prosalpha7 Atg5 ortho G G G G G G G G G Atg5 Atg5 ortho G G G G G G G G G Prosalpha2 Atg5 ortho G G G G G G G G G Nap1-RA Atg5 ortho G G G G G G G G G Nuclear migration protein NudC, NudC, isoform A, NudC, isoform B, RE55422p Atg5 ortho G G G G G G G G G RpL3 Atg5 ortho G G G G G G G G G Atg12 Atg5 ortho G G G G G G G G G cpa Atg5 ortho G G G G G G G G G Atg18 Atg5 ortho G G G G G G G G G Probable oligoribonuclease Atg5 ortho G G G G G G G G G LD45860p, Proteasome regulator dREG, REG, isoform A, REG, isoform B Atg5 ortho G G G G G G G G G dak1 Atg5 ortho G G G G G G G G G Probable 6-phosphogluconolactonase, 6PGL Atg5 ortho G G G G G G G G G CG2970, isoform A, CG2970, isoform B, IP15825p Atg5 ortho G G G G G G G G G LD12946p, Membrane steroid binding protein, isoform A, Membrane steroid binding protein, isoform B, Membrane steroid binding protein, isoform C, Steroid membrane binding protein Atg5 ortho G G G G G G G G G Vha26 Atg5 ortho G G G G G G G G G CG9135 protein, CG9135, isoform A, CG9135, isoform B, CG9135, isoform C, CG9135, isoform D, CG9135-PA, LD39815p Atg5 ortho G G G G G Non-specific serine/threonine protein kinase Atg5 ortho G G G G G G G G G translin Atg5 ortho G G G G G G G G G Atg6 Atg5 ortho G G G G G G G G G Pdi Atg5 ortho G G G G G G G G G sec8 Atg5 ortho G G G G G G G G G RpS16 Atg5 ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VAF9 Q9W3R7 - 14605208 - X 2 Q9W3R7 - 14605208 - X 2 Q9VWM4 Q9W3R7 - 14605208 - X 2 Q8IPB9 Q9W3R7 - 14605208 - X 2 Q9W3R7 Q9VD55 - 14605208 - X 2 Q9W3R7 A4V383 - 14605208 - X 2 Q9W3R7 Q7K0E6 - 14605208 - X 2 Q9W3R7 Q9VKY3 - 14605208 - X 2 Q9W3R7 Q9VQB9 - 14605208 - X 2 Q9W3R7 Q9VN42 - 14605208 - X 2 Q9W3R7 - 14605208 - X 2 Q9W3R7 Q9V3G9 - 14605208 - X 2 Q9W3R7 Q06559 - 14605208 - X 2 Q9W3R7 Q8MT58 - 14605208 - X 2 Q9VWM4 Q9W3R7 two hybrid 14605208 direct interaction X 2 Q9W3R7 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q9VQB9 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q7K0E6 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q9VKY3 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q9VD55 two hybrid 14605208 direct interaction X 2 Q9W3R7 A4V383 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q9VIE8 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q9VN42 two hybrid 14605208 direct interaction X 2 Q9W3R7 A1ZBY1 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q9VB23 affinity chromatography technology 22036573 physical association X 2 Q9W3R7 P62152 affinity chromatography technology 22036573 physical association X 2 Q9W3R7 P10987 affinity chromatography technology 22036573 physical association X 2 Q9W3R7 Q9V3G9 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q8MT58 two hybrid 14605208 direct interaction X 2 Q9W3R7 M9PFI0 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q06559 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q95TJ1 two hybrid 14605208 direct interaction X 2 Q9W3R7 Q95TJ1 affinity chromatography technology 22036573 physical association X 2 Q9W3R7 Q9XZS4 affinity chromatography technology 22036573 physical association X 2 A1ZBY1-3 Q9W3R7 two hybrid 14605208 physical association X 2 Q9VWM4 Q9W3R7 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VKX1 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VQB9 two hybrid 14605208 physical association X 2 Q9W3R7 Q7K0E6 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VKY3 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VD55 two hybrid 14605208 physical association X 2 Q9W3R7 A4V383 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VIE8 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VN42 two hybrid 14605208 physical association X 2 Q9W3R7 two hybrid 14605208 physical association X 2 Q9W3R7 Q9V3G9 two hybrid 14605208 physical association X 2 Q9W3R7 Q8MT58 two hybrid 14605208 physical association X 2 Q9W3R7 Q86BR6 two hybrid 14605208 physical association X 2 Q9W3R7 Q06559 two hybrid 14605208 physical association X 2 Q9VWM4 Q9W3R7 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VKX1 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VQB9 two hybrid 14605208 physical association X 2 Q9W3R7 Q7K0E6 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VKY3 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VD55 two hybrid 14605208 physical association X 2 Q9W3R7 A4V383 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VIE8 two hybrid 14605208 physical association X 2 Q9W3R7 Q9VN42 two hybrid 14605208 physical association X 2 P13678 Q9W3R7 two hybrid 14605208 physical association X 2 Q9W3R7 Q9V3G9 two hybrid 14605208 physical association X 2 Q9W3R7 Q8MT58 two hybrid 14605208 physical association X 2 Q9W3R7 Q86BR6 two hybrid 14605208 physical association X 2 Q9W3R7 Q06559 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Q8MMF5 Atg5 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|(intact) MINT_9199|MINT_9198|UniProt_60872|UniProt_60873 prey|bait|prey|bait bait|prey|bait|prey ttm3 Atg5 MI:0004(affinity chromatography technology) 16554755 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_385057 bait prey SK Atg5 MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_433383 bait prey Dip2 Atg5 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_60875|MINT_9201|BIOGRID_41522 prey|prey|prey bait|bait|bait Atg5 CG3149 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12150911,14759368,16429126,16554755,17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_338188|BIOGRID_433426|BIOGRID_384416|BIOGRID_338187|BIOGRID_351937|BIOGRID_388571 prey|prey|prey|bait|bait|bait bait|bait|bait|prey|prey|prey RpS3 Atg5 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|MI:0465(dip) MINT_9197|UniProt_60871|BIOGRID_41520|DIP_16912 prey|prey|prey|- bait|bait|bait|- TfIIB Atg5 MI:0096(pull down) 15871019 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0794(synthetic genetic interaction defined by inequality) (biogrid) BIOGRID_377542 bait prey CG5045 Atg5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint)|MI:0465(dip) BIOGRID_41517|UniProt_60868|MINT_9194|DIP_16909 prey|prey|prey|- bait|bait|bait|- CG17337 Atg5 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_41512|UniProt_60862 prey|prey bait|bait Act5C Atg5 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_69816 bait prey Atg5 Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_32074|DIP_16913 bait|- prey|- Ptp10D Atg5 MI:0004(affinity chromatography technology) 23209026 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_650601 bait prey Acon Atg5 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_41521|MINT_9200|UniProt_60874 prey|prey|prey bait|bait|bait CG3557 Atg5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact)|MI:0471(mint) DIP_16907|BIOGRID_41515|UniProt_60866|MINT_9192 -|prey|prey|prey -|bait|bait|bait wdb Atg5 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67948 bait prey CG31033 Atg5 MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 14605208,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_32073|BIOGRID_64714 prey|prey bait|bait CG31033 Atg5 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact) DIP_16905|MINT_9190|UniProt_60864 -|bait|bait -|prey|prey Atg5 CG11103 MI:0004(affinity chromatography technology) 19061648 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_451785 prey bait Atg5 CG14191 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|MI:0471(mint)|(intact) BIOGRID_39787|DIP_14203|MINT_29125|UniProt_47521 prey|-|bait|bait bait|-|prey|prey Pkc98E Atg5 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0465(dip)|(intact) MINT_9189|BIOGRID_41513|DIP_16904|UniProt_60863 bait|prey|-|bait prey|bait|-|prey Cam Atg5 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68364 bait prey cact Atg5 MI:0004(affinity chromatography technology) 16762320 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_401297 bait prey Q9V9H1 Atg5 MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_9188 prey bait EG:BACR37P7.5 Atg5 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0465(dip)|(biogrid) MINT_26262|UniProt_65217|DIP_11199|BIOGRID_37828 prey|prey|-|bait bait|bait|-|prey Atg5 Acon MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_16914 - - Q9V6H8 Atg5 MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_9193 prey bait ND42 Atg5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0465(dip) UniProt_60870|BIOGRID_41519|MINT_9196|DIP_16911 prey|prey|prey|- bait|bait|bait|- Aats-asp Atg5 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_41516|UniProt_60867 prey|prey bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9W3R7 A0A0B4 ATG5 ND4L {ECO:0000313|EMBL:ABJ80715.1} 0.033 14605208 Q9W3R7 P62152 ATG5 CAM 0.126 22036573 Q9W3R7 P10987 ATG5 ACT5C 0.126 22036573 Q9W3R7 Q8MT58 ATG5 Q8MT58 0.21 14605208 Q9W3R7 Q9V3G9 ATG5 EG:BACR37P7.5 0.21 14605208 Q9W3R7 Q9VD55 ATG5 CCHL 0.21 14605208 Q9W3R7 Q9VIE8 ATG5 ACON 0.21 14605208 Q9W3R7 Q9VKY3 ATG5 Q9VKY3 0.21 14605208 Q9W3R7 Q9VKX1 ATG5 CNOT4 0.21 14605208 Q9W3R7 Q9VQB9 ATG5 Q9VQB9 0.21 14605208 Q9W3R7 Q9VWM4 ATG5 Q9VWM4 0.21 14605208 Q9W3R7 Q86BR6 ATG5 ATG16 0.21 14605208 Q9W3R7 P13678 ATG5 PKC98E 0.332 14605208 Q9W3R7 Q7K0E6 ATG5 AATS-ASP 0.21 14605208 Q9W3R7 Q06559 ATG5 RPS3 0.354 14605208 Q9W3R7 Q9VN42 ATG5 DIP2 0.21 14605208 Q9W3R7 A1ZBY1 ATG5 FEM-1 0.21 14605208 Q9W3R7 P91929 ATG5 ND42 0.354 14605208