PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Usp7 Anaphase-promoting complex subunit 2, LD21042p, Morula 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G CG4973 protein, CG4973-PA, LD35003p, Midlife crisis Usp7 22036573 biogrid exp G G G G G G G G G Pen Usp7 14605208 biogrid,i2d,mint,intact exp G G CG43896, isoform C, CG43896, isoform D Usp7 14605208 biogrid exp Usp7 Visual system homeobox 2 ortholog, isoform B 14605208 biogrid,i2d,mint,intact exp G alpha-catenin-related Usp7 14605208 biogrid,i2d,mint,intact exp G G G LD23102p, Zinc finger protein 30C Usp7 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G dsx Usp7 14605208 biogrid,i2d,mint,intact exp G G G G G G HHEX ortholog Usp7 14605208 biogrid,i2d,mint,intact exp GMP synthetase Usp7 i2d exp Usp7 Usp7 14605208 intact exp, ortho G G G G G G G G G G Burgundy, isoform B, Burgundy, isoform C, LD42771p Usp7 22036573 biogrid exp, ortho G G G G G G G G G G Dhc64C Usp7 ortho G G G G G G G G G G Etl1 Usp7 ortho G G G G G G G N Usp7 ortho G G G G Tip60 Usp7 ortho G G G G G G G G G LD20667p, Zizimin-related Usp7 ortho G G G G G G G G G r Usp7 ortho G G n-syb Usp7 ortho G G G SmD1 Usp7 ortho G G G G G G G G G G Ubiquitin-conjugating enzyme E2 S Usp7 ortho G G G G ALG-2 interacting protein X, LD25543p Usp7 ortho G G G G G G G G G G rad23 Usp7 ortho G G G G G G G G G G Bub3-RA Usp7 ortho G G G G G G G G G G Prosalpha2 Usp7 ortho G G G G G G G G G G Vha55 Usp7 ortho G G G G G G G G G G Usp7 CSN5 ortho G G G G G G G G G G Srp68 Usp7 ortho G G G G G G G G G G Sirt7 Usp7 ortho G G G G G Pka-C1 Usp7 ortho G G G G G G G G G Tubulin-binding cofactor B Usp7 ortho G G G G G G G G G G betaTub56D Usp7 ortho G G G G G G G G G G Usp7 CG5808 ortho G Mcm5 Usp7 ortho G Usp7 l.2.35Df ortho G G G G G G G G G G Sce Usp7 ortho G G G G G G G CSN6 Usp7 ortho G G G G G G G G G G Vacuolar protein sorting-associated protein 29 Usp7 ortho G G G G G G G G G G Nipped-A Usp7 ortho G G G G G G G G G G Usp7 CG3000-PA, isoform A, GH07620p, RE20929p, Retina aberrant in pattern, isoform B ortho G G G G G G G G G G Usp7 LD20987p, TNF-receptor-associated factor 1, TNF-receptor-associated factor 4, isoform A ortho G G G Probable protein phosphatase CG10417 Usp7 ortho G G G G G G G G G G Cullin 4, isoform A, Cullin 4, isoform B, FI05474p, LP02965p Usp7 ortho G G G G G G G G G G slim Usp7 ortho G G G G G G G G G G Dilute class unconventional myosin, isoform C Usp7 ortho G G G G G G G G G CG6287-PA, GH03305p Usp7 ortho G G G G G G G G G G Vha36-1 Usp7 ortho G G G G G G G G G G Iap2 Usp7 ortho G G G G G G G G G G IP16020p, Phosphatase PTEN, Pten, isoform B, Pten, isoform D, Pten, isoform G, Pten, isoform H Usp7 ortho G G G G G G G G G CG9293-RB Usp7 ortho G G G G G G G G G G RpS27A Usp7 ortho G G G G G G G G G G hoip Usp7 ortho Usp7 GH01161p, TNF-receptor-associated factor 6 ortho G G G G G G G G G tws Usp7 ortho G G G G G G G G G G Usp7 Prosbeta2R1 ortho G G G G G G G G G G ninaC Usp7 ortho G G flr Usp7 ortho G G G G G G G G G CG9273 protein, CG9273-PA, GM04951p, Replication protein A2, isoform A, Replication protein A2, isoform B Usp7 ortho G G G Usp7 PICK1 ortholog, isoform E ortho G G G G isopeptidase-T-3 Usp7 ortho G G G G G G G G G E(z) Usp7 ortho G G G G G G G Klc Usp7 ortho G G G G G G G G G G vas Usp7 ortho CG3338-RA Usp7 ortho G G G G G G G G G Arginine methyltransferase 1, CG6554 protein, CG6554-PA, LD28808p Usp7 ortho G G G G G G G G G G CG4195-PA, Lethal (3) 73Ah, isoform B, RE11339p Usp7 ortho G G G G G G G G G G RuvB-like helicase 2 Usp7 ortho G G G G G G G G G G CG7289, LD12115p Usp7 ortho G G G G G G G G G G Ubi-p63E Usp7 ortho G G G G G G G G G G Prosalpha5 Usp7 ortho G G G G G G G G G G LD47396p, Tcp-1eta Usp7 ortho G G G G G G G G G G SMC3 Usp7 ortho G G cdc2c Usp7 ortho G G G Hsc70-5 Usp7 ortho G G G G G G G G G G Aspartyl-tRNA synthetase, isoform A, Aspartyl-tRNA synthetase, isoform B, Aspartyl-tRNA synthetase, isoform C, GM14334p Usp7 ortho G G G G G G G G G G RpA-70 Usp7 ortho G G G G G G G G G G Prosalpha7 Usp7 ortho G G G G G G G G G G Cdk5 Usp7 ortho G G G G G G G G G Prosbeta7 Usp7 ortho G G G G G G G G G G EcR Usp7 ortho G G G G G Su(H) Usp7 ortho G G G G G G G Medea Usp7 ortho G G G G G G G G G vib Usp7 ortho G G G G G G G G G G CG1440-RC Usp7 ortho G G G G G G G G G G CG32850-PA, RE41137p Usp7 ortho G G G G G G G G G Dipeptidase C, isoform A, Dipeptidase C, isoform B, LD07362p Usp7 ortho G G G G G G G G G G Tho2, isoform B Usp7 ortho G G G G G G G G G G endoB Usp7 ortho G G G G Nop56-RA Usp7 ortho G G G G G G G G G G GH17639p, TRAPP subunit 31 ortholog Usp7 ortho G G G G G G G G G grp Usp7 ortho G G G G G G G G G G Nup98-RA Usp7 ortho G G G G G G G G l(2)tid Usp7 ortho G G G G G G G G G G BG:DS01068.6 Usp7 ortho G G G G G G Dcr-1 Usp7 ortho G G Rpd3 Usp7 ortho G G G G G G G G G Sirt6 Usp7 ortho G Usp7 Rae1 ortho G G G G G G G G G G RFeSP-RB Usp7 ortho G G G G G G G G G G Isocitrate dehydrogenase [NADP] Usp7 ortho G G G G G G G G G G Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Usp7 ortho Su(z)12 Usp7 ortho G G G G G G G G G G Cdc37 Usp7 ortho G G G G G G G G G G Nop60B Usp7 ortho G G G G G G G G G G Usp7 CG13900-RA ortho G G G G G G G G G G DNA replication licensing factor Mcm6, DmMCM6 Usp7 ortho G GH07711p, GM06266p, Sds22 Usp7 ortho G G G G G G G G G G dpa Usp7 ortho G G Usp7 CG8184, isoform H ortho G G G G G G G G G G PpV Usp7 ortho G G G G G G G G G Bifunctional phosphopantetheine adenylyltransferase-Dephospho-CoA kinase Usp7 ortho G G G G G G G G G G RpL40 Usp7 ortho G G G G G G G G G G Cullin 3, isoform F, FI19425p1 Usp7 ortho G G G G G G G G G G CG3542, LD24714p Usp7 ortho G G G G G G Trap1-RA Usp7 ortho G G G G G G G G G G Fs(2)Ket Usp7 ortho G G G G G G G G G G mle Usp7 ortho G G G G G G G HtrA2 Usp7 ortho G G G G Uch Usp7 ortho G G G G G G G G G G CG4813, LD46938p, RE63826p Usp7 ortho G G G G w Usp7 ortho G Pixie, isoform A, Pixie, isoform B, RE71924p Usp7 ortho G G G G G G G G G G 14-3-3epsilon Usp7 ortho G G G G G G G G G G HDAC6, isoform G Usp7 ortho G G G G G G G G G G Mini-chromosome maintenance complex-binding protein, MCM-BP, MCM-binding protein Usp7 ortho G Klp54D-RA Usp7 ortho G G G G G CG5290-RA Usp7 ortho G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VYQ8 - 14605208 - X 2 Q9VYQ8 - 15749019 - X 2 Q9VYQ8 - 14605208 - X 2 Q9VYQ8 - 14605208 - X 2 Q9W1E5 Q9VYQ8 - 14605208 - X 2 Q9VL91 Q9VYQ8 - 14605208 - X 2 P23023-2 Q9VYQ8 - 14605208 - X 2 Q9VYQ8 two hybrid 14605208 direct interaction X 2 Q9W1F1 Q9VYQ8 two hybrid 14605208 direct interaction X 2 Q9VYQ8 two hybrid 14605208 direct interaction X 2 Q9W1E5 Q9VYQ8 two hybrid 14605208 direct interaction X 2 Q9VL91 Q9VYQ8 two hybrid 14605208 direct interaction X 2 Q9VIE7 Q9VYQ8 affinity chromatography technology 22036573 physical association X 2 Q9VYQ8 two hybrid 14605208 direct interaction X 2 Q9W4B3 Q9VYQ8 two hybrid 14605208 direct interaction X 2 Q9VDP8 Q9VYQ8 affinity chromatography technology 22036573 physical association X 2 P52295 Q9VYQ8 two hybrid 14605208 direct interaction X 2 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9W1E5 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9VL91 Q9VYQ8 two hybrid 14605208 physical association X 2 P23023 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9VYQ8 two hybrid 14605208 physical association X 2 P52295 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9W1F1 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9W1E5 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9VL91 Q9VYQ8 two hybrid 14605208 physical association X 2 P23023 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9VDF0 Q9VYQ8 two hybrid 14605208 physical association X 2 Q9W4B3 Q9VYQ8 two hybrid 14605208 physical association X 2 P52295 Q9VYQ8 two hybrid 14605208 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VYQ8 Q9VDF0 USP7 HHEX 0.21 14605208 Q9VYQ8 P19538 USP7 CI 0.702 26120032 Q9VYQ8 P23023 USP7 DSX 0.354 14605208 Q9VYQ8 Q9VL91 USP7 ZF30C 0.183 14605208 Q9W1E5 Q9VYQ8 MR USP7 0.183 14605208 Q9W1F1 Q9VYQ8 ALPHA-CATENIN-RELATED USP7 0.183 14605208 Q9W4B3 Q9VYQ8 VSX2 USP7 0.183 14605208 Q9VYQ8 P52295 USP7 PEN 0.354 14605208