PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Spn28D CG16947-RA 14605208 biogrid,i2d,mint,intact exp G G G pwn CG16947-RA 14605208 biogrid,intact exp HEXIM ortholog, isoform B CG16947-RA 14605208 biogrid,i2d,mint,intact exp G G G G G CG13159, RE25177p CG16947-RA 14605208 biogrid,intact exp G sol CG16947-RA 14605208 biogrid,i2d,mint,intact exp G G G G G CG10263 CG16947-RA i2d exp Hakai, isoform F CG16947-RA 14605208 biogrid,i2d,mint,intact exp G G G G G eIF3-S8 CG16947-RA 14605208 biogrid,i2d,intact exp G G G G G CG2201-RB CG16947-RA 14605208 biogrid,i2d,mint,intact exp G G G G G CG16947-RA CG7197, LD31204p 14605208 biogrid,i2d,mint,intact exp G G G G G nub CG16947-RA 14605208 biogrid exp G RpL3 CG16947-RA 14605208 biogrid,i2d,mint,intact exp G G G G G Cyp6a23 CG16947-RA 14605208 biogrid,i2d,mint,intact exp G G G CG16947-RA frtz 14605208 biogrid,i2d,mint,intact exp G G l(2)not CG16947-RA 14605208 biogrid,i2d,mint,intact exp G G G G G CG16947-RA l(1)G0156 14605208 biogrid,i2d,mint,intact exp G G G G G CG16947-RA Brinker, Brk, Putative transcription factor, RE18244p 14605208 biogrid,i2d,mint,intact exp CG16947-RA CG16947-RA 14605208 intact exp, ortho G G G G G Protein UBASH3A homolog CG16947-RA ortho G G G CG16947-RA epsilonCOP ortho G G G G G 14-3-3epsilon CG16947-RA ortho G G G G G CG16947-RA Probable 6-phosphogluconolactonase, 6PGL ortho G G G G G Ubi-p63E CG16947-RA ortho G G G G G Cyclin-dependent kinase 9, GH21935p, Positive transcription elongation factor b small subunit CG16947-RA ortho G G G G G Arf102F CG16947-RA ortho G G G G G eff CG16947-RA ortho G G G G G Sce CG16947-RA ortho G G G G G LD18774p, Oligosaccharide transferase delta subunit, isoform A CG16947-RA ortho G G G G G CG1274-PA, isoform A, GH25379p, Secretable thioredoxin peroxidase, Thioredoxin peroxidase 2, Thioredoxin peroxidase 2, isoform B, Thioredoxin peroxidase 2, isoform C CG16947-RA ortho G G G G G CG16947-RA SrpR-beta ortho G G G G G Drab11 CG16947-RA ortho G G G G G RpL40 CG16947-RA ortho G G G G G Tip60 CG16947-RA ortho G G G G G CG16947-RA CG17441 ortho G G G G G Cyclin-dependent kinase 4, isoform A, Cyclin-dependent kinase 4, isoform B, Cyclin-dependent kinase 4, isoform C, Cyclin-dependent kinase 4, isoform D, Cyclin-dependent kinase 4, isoform E, LD31205p CG16947-RA ortho G lok CG16947-RA ortho G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O16797-3 Q9VMD4 - 14605208 - X 2 Q8INF6 Q9VMD4 - 14605208 - X 2 Q9VWH4 Q9VMD4 - 14605208 - X 2 C4IXX8 Q9VMD4 - 14605208 - X 2 Q9VMD4 - 14605208 - X 2 Q9VMD4 A1Z6W9 - 14605208 - X 2 Q9VMD4 Q7JWN2 - 14605208 - X 2 Q9VMD4 - 14605208 - X 2 Q9VMD4 Q9VQ36 - 14605208 - X 2 Q9VMD4 Q9VSG8 - 14605208 - X 2 Q9V771 Q9VMD4 - 14605208 - X 2 Q9VMD4 P27398-2 - 14605208 - X 2 Q9VMD4 Q9VLU4 - 14605208 - X 2 Q9VMD4 Q8IMF3 - 14605208 - X 2 Q9VMD4 A1ZAX1 - 14605208 - X 2 Q9VWH4 Q9VMD4 two hybrid 14605208 direct interaction X 2 C4IXX8 Q9VMD4 two hybrid 14605208 direct interaction X 2 Q9XTN4 Q9VMD4 two hybrid 14605208 direct interaction X 2 Q9VMD4 M9PBE2 two hybrid 14605208 direct interaction X 2 Q9VMD4 Q7JWN2 two hybrid 14605208 direct interaction X 2 Q9VMD4 Q9VQ36 two hybrid 14605208 direct interaction X 2 Q9VMD4 two hybrid 14605208 direct interaction X 2 Q9VMD4 Q9VSG8 two hybrid 14605208 direct interaction X 2 Q9VMD4 A1Z6W9 two hybrid 14605208 direct interaction X 2 Q9VMD4 A8DYZ8 two hybrid 14605208 direct interaction X 2 Q9VMD4 P27398 two hybrid 14605208 direct interaction X 2 Q9VMD4 Q9VFH2 two hybrid 14605208 direct interaction X 2 Q9V771 Q9VMD4 two hybrid 14605208 direct interaction X 2 Q9VMD4 A1ZAX1 two hybrid 14605208 direct interaction X 2 Q9VMD4 Q8IMF3 two hybrid 14605208 direct interaction X 2 Q9VMD4 Q9VLU4 two hybrid 14605208 direct interaction X 2 Q8INF6 Q9VMD4 two hybrid 14605208 physical association X 2 Q9VWH4 Q9VMD4 two hybrid 14605208 physical association X 2 C4IXX8 Q9VMD4 two hybrid 14605208 physical association X 2 Q9XTN4 Q9VMD4 two hybrid 14605208 physical association X 2 Q9VMD4 two hybrid 14605208 physical association X 2 Q9VMD4 A1Z6W9 two hybrid 14605208 physical association X 2 Q9VMD4 Q7JWN2 two hybrid 14605208 physical association X 2 Q9VMD4 P27398 two hybrid 14605208 physical association X 2 Q9VMD4 Q9VQ36 two hybrid 14605208 physical association X 2 Q9VMD4 Q8IMF4 two hybrid 14605208 physical association X 2 Q9VMD4 Q9VSG8 two hybrid 14605208 physical association X 2 O16797 Q9VMD4 two hybrid 14605208 physical association X 2 Q9V771 Q9VMD4 two hybrid 14605208 physical association X 2 Q8INW0 Q9VMD4 two hybrid 14605208 physical association X 2 Q9VMD4 A1ZAX1 two hybrid 14605208 physical association X 2 Q9VMD4 Q9VLU4 two hybrid 14605208 physical association X 2 Q9VWH4 Q9VMD4 two hybrid 14605208 physical association X 2 Q9XTN4 Q9VMD4 two hybrid 14605208 physical association X 2 Q9VMD4 A1Z6W9 two hybrid 14605208 physical association X 2 Q9VMD4 Q7JWN2 two hybrid 14605208 physical association X 2 Q9VMD4 P27398 two hybrid 14605208 physical association X 2 Q9VMD4 Q9VQ36 two hybrid 14605208 physical association X 2 Q9VMD4 Q9VFH2 two hybrid 14605208 physical association X 2 Q9VMD4 Q9VSG8 two hybrid 14605208 physical association X 2 O16797 Q9VMD4 two hybrid 14605208 physical association X 2 Q9V771 Q9VMD4 two hybrid 14605208 physical association X 2 Q9VIT1 Q9VMD4 two hybrid 14605208 physical association X 2 Q9VMD4 Q9V9R4 two hybrid 14605208 physical association X 2 Q9VMD4 Q27333 two hybrid 14605208 physical association X 2 Q9VMD4 A1ZAX1 two hybrid 14605208 physical association X 2 Q9VMD4 Q9VLU4 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Hakai CG16947-RA MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_6152 - - CG2201 CG16947-RA MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_32146 prey bait RpL3 CG16947-RA MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_17221|MINT_18503|BIOGRID_41719|UniProt_61177 -|null|prey|null -|bait|bait|bait CG3508 CG16947-RA MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_17219 - - Hakai CG16947-RA MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_34404 bait prey Q9V4J6 CG16947-RA MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_23468 prey bait CG16947-RA l(1)G0156 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint)|MI:0465(dip) BIOGRID_37619|UniProt_64877|MINT_25936|DIP_10854 prey|bait|bait|- bait|prey|prey|- CG16947-RA frtz MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|MI:0465(dip) BIOGRID_41718|MINT_9485|UniProt_61173|DIP_17217 bait|bait|bait|- prey|prey|prey|- CG16947-RA CG7197 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid)|MI:0465(dip) UniProt_61179|MINT_9490|BIOGRID_41721|DIP_17223 bait|bait|bait|- prey|prey|prey|- Q9V6A3 CG16947-RA MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_27549 prey bait Cyp6a23 CG16947-RA MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0465(dip)|(intact)|(biogrid) MINT_30526|DIP_6089|UniProt_58160|BIOGRID_34351 prey|-|prey|bait bait|-|bait|prey CG3508 CG16947-RA MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_9487|BIOGRID_32147|UniProt_61175 prey|prey|prey bait|bait|bait CG13159 CG16947-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip) UniProt_51877|BIOGRID_38693|DIP_12551 prey|bait|- bait|prey|- Q9VK77 CG16947-RA MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_60224|MINT_8574 bait|bait prey|prey CG2201 CG16947-RA MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0465(dip) MINT_9486|UniProt_61174|DIP_17218 prey|prey|- bait|bait|- Hakai CG16947-RA MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_30589|UniProt_58224 prey|prey bait|bait CG16947-RA eIF3-S8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip) BIOGRID_41720|UniProt_61178|DIP_17222 bait|bait|- prey|prey|- l(2)not CG16947-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0471(mint)|(intact) DIP_17220|BIOGRID_32148|MINT_9488|UniProt_61176 -|prey|prey|prey -|bait|bait|bait sol CG16947-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip)|MI:0471(mint) BIOGRID_31377|UniProt_47059|DIP_13742|MINT_28698 bait|bait|-|bait prey|prey|-|prey CG16947-RA pwn MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_30241|UniProt_54267 prey|bait bait|prey Q9V859 CG16947-RA MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_9489 prey bait CG16947-RA brk MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0465(dip)|(biogrid) MINT_9492|UniProt_61181|DIP_17225|BIOGRID_32150 bait|bait|-|bait prey|prey|-|prey Spn28D CG16947-RA MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|MI:0465(dip) MINT_9491|BIOGRID_32149|UniProt_61180|DIP_17224 prey|prey|prey|- bait|bait|bait|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VMD4 Q8INW0 CG16947-RA HAKAI 0.033 14605208 Q9XTN4 Q9VMD4 BRK CG16947-RA 0.183 14605208 Q9VMD4 Q7JWN2 CG16947-RA Q7JWN2 0.183 14605208 Q9VMD4 Q9V771 CG16947-RA CYP6A23 0.21 14605208 Q9VMD4 Q9V9R4 CG16947-RA Q9V9R4 0.183 14605208 Q9VMD4 Q9VFH2 CG16947-RA HEXIM 0.183 14605208 Q9VMD4 Q9VIT1 CG16947-RA HAKAI 0.183 14605208 Q9VMD4 Q9VLU4 CG16947-RA SPN28DC 0.183 14605208 Q9VMD4 O16797 CG16947-RA RPL3 0.21 14605208 Q9VMD4 P27398 CG16947-RA SOL 0.183 14605208 Q9VQ36 Q9VMD4 FRTZ CG16947-RA 0.183 14605208 Q9VSG8 Q9VMD4 Q9VSG8 CG16947-RA 0.183 14605208 Q9VWH4 Q9VMD4 L(1)G0156 CG16947-RA 0.183 14605208 Q9VMD4 A1Z6W9 CG16947-RA PWN 0.183 14605208 Q9VMD4 Q27333 CG16947-RA L(2)NOT 0.183 14605208 Q9VMD4 A1ZAX1 CG16947-RA EIF3-S8 0.183 14605208