PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Caspar, isoform A, Caspar, isoform B, LD03368p PAB-dependent poly(A)-specific ribonuclease subunit PAN3 25294943 intact exp G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p CG2246-RA 14605208 biogrid,intact exp G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p CG8206, isoform A, CG8206, isoform B, GH04557p 14605208 biogrid,intact exp G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p LD42296p 14605208 intact exp Caspar, isoform A, Caspar, isoform B, LD03368p CG9083 14605208 biogrid exp Caspar, isoform A, Caspar, isoform B, LD03368p UBR1 ortho G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p ILK ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p pUf68 ortho G G G G G G G G G G His4, His4r, His4:CG31611, His4:CG33869, His4:CG33871, His4:CG33873, His4:CG33875, His4:CG33877, His4:CG33879, His4:CG33881, His4:CG33883, His4:CG33885, His4:CG33887, His4:CG33889, His4:CG33891, His4:CG33893, His4:CG33895, His4:CG33897, His4:CG33899, His4:CG33901, His4:CG33903, His4:CG33905, His4:CG33907, His4:CG33909 Caspar, isoform A, Caspar, isoform B, LD03368p ortho Caspar, isoform A, Caspar, isoform B, LD03368p LD18774p, Oligosaccharide transferase delta subunit, isoform A ortho G G G G G G G G G G CkIIalpha Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Rep ortho G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p TER94 ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Ufd1-like ortho G G G G G G G G G G Hsc70Cb, isoform G, Hsc70Cb, isoform H Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Protein purity of essence ortho G G G G G G G G G G scu Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Set Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Zinc finger CCCH domain-containing protein 15 homolog, DRG family regulatory protein 1 homolog ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Sirt6 ortho G Caspar, isoform A, Caspar, isoform B, LD03368p CG1812, LD33804p ortho G G G G G G G crm Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p WD repeat-containing protein 26 homolog ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Hyrax, Hyrax, isoform A, Hyrax, isoform B, LD47989p ortho G G G G G G G G G G ade3 Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G CkIIbeta Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Ranbp16 ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G EcR Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Pngl ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Phospholipase A2 activator protein, isoform A, Phospholipase A2 activator protein, isoform B, Phospholipase A2 activator protein, isoform C, SD05646p ortho G G G G G G G G G G Hsc70-1 Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G Caspar, isoform A, Caspar, isoform B, LD03368p Rae1 ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Probable protein phosphatase CG10417 ortho G G G G G G G G G G Sec23 Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G slmb Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G CG3689, isoform C Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G lin19 Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G SkpA Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p AnxB11 ortho G G G G G G G G G G Ubi-p63E Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Aph-4 Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G Rcc1 Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p CG5014-PB, isoform B, LD30122p, VAMP-associated protein of 33kDa ortholog A, isoform C, VAMP-associated protein of 33kDa ortholog A, isoform E ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Art4 ortho G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p CG4164, LD30318p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p ortho G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Golgi to ER traffic protein 4 homolog ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Cullin 3, isoform F, FI19425p1 ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Npl4 ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Aats-cys ortho G G G G G G G G G G R Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Updo ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Arginine methyltransferase 3, isoform A, LD34544p ortho G G G arm Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Cullin 2, isoform A, Cullin 2, isoform B, LD36177p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p ATPase ASNA1 homolog ortho G G G G G G G G G G Ost48 Caspar, isoform A, Caspar, isoform B, LD03368p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p RpL24 ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Fas-associated factor, isoform A, Fas-associated factor, isoform B, GH16914p ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Probable phenylalanine--tRNA ligase beta subunit ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7JUP3 Q9VXQ7 - 14605208 - X 2 Q7JUP3 Q8SX59 - 14605208 - X 2 Q7JUP3 Q7KRU0 - 14605208 - X 2 Q7JUP3 Q9VXQ7 two hybrid 14605208 direct interaction X 2 Q7JUP3 two hybrid 14605208 direct interaction X 2 Q7JUP3 two hybrid 14605208 direct interaction X 2 Q7JUP3 Q9VXQ7 two hybrid 14605208 physical association X 2 Q7JUP3 Q8IMI0 two hybrid 14605208 physical association X 2 Q7JUP3 two hybrid 14605208 physical association X 2 Q7JUP3 Q9VXQ7 two hybrid 14605208 physical association X 2 Q7JUP3 Q8SX59 two hybrid 14605208 physical association X 2 Q7JUP3 Q9VA53 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B casp CG9083 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_47684|DIP_25917 bait|- prey|- casp CG2246-RA MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25443 prey bait casp CG8206 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|(biogrid) UniProt_53084|DIP_25835|BIOGRID_33846 prey|-|prey bait|-|bait casp CG2246 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_43383|DIP_19735 prey|- bait|- casp CG9083 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_53171 prey bait