PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG15126-RA Fem-1 14605208 biogrid exp Fem-1 nos 14605208 biogrid exp G Fem-1 GH09868p, RH39704p, TAR DNA-binding protein-43 homolog, isoform B, TAR DNA-binding protein-43 homolog, isoform C, TAR DNA-binding protein-43 homolog, isoform D, TAR DNA-binding protein-43 homolog, isoform E, TAR DNA-binding protein-43 homolog, isoform F 14605208 biogrid exp G G G G G G G G G G Fem-1 CG10365-RD 14605208 biogrid exp G G G G G G G G G G Fem-1 CG9312, GH09754p 14605208 biogrid exp G G Fem-1 CG43373, isoform C 14605208 biogrid exp Fem-1 baf 14605208 biogrid exp G G G G G G G G G G Fem-1 Probable peroxisomal acyl-coenzyme A oxidase 1 14605208 biogrid exp G G G G G G G G G G Fem-1 Homeobrain, IP01393p 14605208 biogrid exp G G Fem-1 nAChRalpha6 14605208 biogrid exp G G Fem-1 CG32810-RB 14605208 biogrid exp G G G G G G G G G Glycogenin Fem-1 14605208 biogrid exp G G G G G G Fem-1 CG18081, isoform B, CG18081, isoform C, CG18081-PA, RE63284p 14605208 biogrid exp G G G G G G G G G G Fem-1 Slob 14605208 biogrid exp G G G Fem-1 hfw 14605208 biogrid exp G G G G G G G G G G Patronin Fem-1 14605208 biogrid exp G G G G G G G G Fem-1 CG6567, GH11067p 14605208 biogrid exp G G G G G G G G G G Fem-1 Atg5 14605208 biogrid exp G G G G G G G G G Fem-1 RE63021p, Ras-associated protein 2-like, isoform A, Ras-related protein 2-like protein 14605208 biogrid exp G G G G G G G G G G Fem-1 Bap60 14605208 biogrid exp G G G G G G G G G G Fem-1 KATNA1 14605208 biogrid exp G G G G Fem-1 Sos 14605208 biogrid exp G G G G G G G G G G Fem-1 CG4582 14605208 biogrid exp Fem-1 Rack1 ortho G G G G G G G G G G Fem-1 Cullin 5, FI20194p1 ortho G G G G G G G G G G Fem-1 CSN3 ortho G G G G G G G G G G Fem-1 DCN1-like protein ortho G G G G G G G G G G Fem-1 DNA repair protein Rad9, LD10092p, Rad9, isoform A, Rad9-like protein ortho Fem-1 Cullin 2, isoform A, Cullin 2, isoform B, LD36177p ortho G G G G G G G G G G Fem-1 Nedd8 ortho G G G G G G G G G G Fem-1 CSN4 ortho G G G G G G G G G G Fem-1 Fem-1 ortho G G G G G G G G G G Fem-1 grp ortho G G G G G G G G G G Fem-1 CSN6 ortho G G G G G G G G G G Fem-1 CG7565-RA ortho G G G G Fem-1 Auxillin, isoform A, Auxillin, isoform B, SD05837p ortho G G G G G G G G G G Fem-1 Elongin C, isoform A, Elongin C, isoform B, RE05591p, RH71704p ortho G G G G G G G G G G Fem-1 CG10376, SD03870p ortho G G G G G G G G G Fem-1 CG10947-RB ortho G Fem-1 Roc1a ortho G G G G G G G G G Fem-1 CSN5 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VFR4 A1ZBY1 two hybrid 14605208 direct interaction X 2 A1ZBY1 O96692 two hybrid 14605208 direct interaction X 2 A1ZBY1 two hybrid 14605208 direct interaction X 2 A1ZBY1 Q7KML2 two hybrid 14605208 direct interaction X 2 A1ZBY1 Q9VGV9 two hybrid 14605208 direct interaction X 2 A1ZBY1 Q9VLU0 two hybrid 14605208 direct interaction X 2 A1ZBY1 Q7KTF8 two hybrid 14605208 direct interaction X 2 A1ZBY1 two hybrid 14605208 direct interaction X 2 P26675 A1ZBY1 two hybrid 14605208 direct interaction X 2 Q9VYG2 A1ZBY1 two hybrid 14605208 direct interaction X 2 Q9VCI9 A1ZBY1 two hybrid 14605208 direct interaction X 2 Q9W2P8 A1ZBY1 two hybrid 14605208 direct interaction X 2 Q9W3R7 A1ZBY1 two hybrid 14605208 direct interaction X 2 Q9W579 A1ZBY1 two hybrid 14605208 direct interaction X 2 A1ZBY1 two hybrid 14605208 direct interaction X 2 A1ZBY1 Q4QPP5 two hybrid 14605208 direct interaction X 2 A1ZBY1 Q9W1I0 two hybrid 14605208 direct interaction X 2 A1ZBY1 Q9VUU7 two hybrid 14605208 direct interaction X 2 A1ZBY1 A1ZBP6 two hybrid 14605208 direct interaction X 2 A1ZBY1 Q9VV68 two hybrid 14605208 direct interaction X 2 Q9W568 A1ZBY1 two hybrid 14605208 direct interaction X 2 P25724 A1ZBY1 two hybrid 14605208 direct interaction X 2 Q9VBQ2 A1ZBY1 two hybrid 14605208 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B kat-60L1 Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_10411 - - hfw Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_32776|DIP_20630 bait|- prey|- Glycogenin Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_26060 - - CG9312 Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_33904 prey bait ssp4 Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_44911|DIP_22138 bait|- prey|- CG5009 Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_23967|BIOGRID_46282 -|bait -|prey Slob Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_25173|BIOGRID_33694 -|bait -|prey baf Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_25480|BIOGRID_47371 -|bait -|prey Bap60 Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_23298|BIOGRID_45760 -|bait -|prey Fem-1 kat-60L1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_37323 prey bait CG15126-RA Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_15789|BIOGRID_31845 -|bait -|prey Atg5 Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_32074|DIP_16913 bait|- prey|- Rap2l Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_21364 - - inc Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_44825 bait prey CG10365-RD Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_6582|BIOGRID_34719 -|bait -|prey Sos Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_47499|DIP_25656 bait|- prey|- nAcRalpha-30D Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_23095 - - nos Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_46642|DIP_24497 bait|- prey|- Fem-1 CG42513 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_21476|BIOGRID_32929 -|prey -|bait hbn Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_44931 bait prey TBPH Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_6470|BIOGRID_29866 -|bait -|prey nAcRalpha-30D Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_33205 bait prey CG18081 Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_18567|BIOGRID_42641 -|bait -|prey CG4582 Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid) DIP_23487|BIOGRID_45905 -|bait -|prey CG6567 Fem-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_47035|DIP_25052 bait|- prey|- poly Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_26061 - - Glycogenin Fem-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_47802 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IPH9 A1ZBY1 SLOB FEM-1 0.183 14605208 P25724 A1ZBY1 NOS FEM-1 0.21 14605208 P26675 A1ZBY1 SOS FEM-1 0.183 14605208 Q9VLU0 A1ZBY1 BAF FEM-1 0.21 14605208 Q9VYG2 A1ZBY1 BAP60 FEM-1 0.183 14605208 Q9W3R7 A1ZBY1 ATG5 FEM-1 0.21 14605208 Q9W568 A1ZBY1 HFW FEM-1 0.183 14605208 A1ZBY1 A1ZAU8 FEM-1 PATRONIN 0.183 14605208 Q7KML2 A1ZBY1 Q7KML2 FEM-1 0.21 14605208 Q9VJV9 A1ZBY1 SOS FEM-1 0.033 14605208