PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Skp2, isoform A, Skp2, isoform E CG1091, isoform B, RE16970p 14605208 biogrid,i2d,mint,intact exp G G G G MTA1-like Skp2, isoform A, Skp2, isoform E 25294943 intact exp G G G G Skp2, isoform A, Skp2, isoform E JIL-1 25294943 intact exp G Skp2, isoform A, Skp2, isoform E Non-specific serine/threonine protein kinase 15575970 biogrid,i2d,mint,intact exp G G G G Skp2, isoform A, Skp2, isoform E Usp10 25294943 intact exp G G G G ctp Skp2, isoform A, Skp2, isoform E 14605208 biogrid,i2d,mint,intact exp G G G G dap-RA Skp2, isoform A, Skp2, isoform E 23552694 biogrid exp G G G G Cks30A Skp2, isoform A, Skp2, isoform E 21827746,15575970,14605208 biogrid,i2d,mint,intact exp, ortho G cdc2 Skp2, isoform A, Skp2, isoform E 21827746 biogrid exp, ortho G SkpA Skp2, isoform A, Skp2, isoform E 21827746,15575970,23552694,14605208 biogrid,i2d,mint,intact exp, ortho G G G G cdc2c Skp2, isoform A, Skp2, isoform E 21827746 biogrid exp, ortho G Hsp83 Skp2, isoform A, Skp2, isoform E ortho G G G G Pen Skp2, isoform A, Skp2, isoform E ortho G Skp2, isoform A, Skp2, isoform E PPP5 ortho G G G G Skp2, isoform A, Skp2, isoform E Skp2, isoform A, Skp2, isoform E ortho G G G G slmb Skp2, isoform A, Skp2, isoform E ortho G G G G Cyclin D, isoform D, Cyclin D, isoform E, Cyclin D, isoform F Skp2, isoform A, Skp2, isoform E ortho G G G G Rbf Skp2, isoform A, Skp2, isoform E ortho G G G Src64B Skp2, isoform A, Skp2, isoform E ortho G G G Cyclin-dependent kinase 9, GH21935p, Positive transcription elongation factor b small subunit Skp2, isoform A, Skp2, isoform E ortho G G G G Skp2, isoform A, Skp2, isoform E 26S proteasome non-ATPase regulatory subunit 9 ortho G G G G Skp2, isoform A, Skp2, isoform E CG10802, isoform A, LD13611p ortho G G G G Hsc70-1 Skp2, isoform A, Skp2, isoform E ortho G G Skp2, isoform A, Skp2, isoform E CSN6 ortho G G G G Skp2, isoform A, Skp2, isoform E CG3000-PA, isoform A, GH07620p, RE20929p, Retina aberrant in pattern, isoform B ortho G G G G lin19 Skp2, isoform A, Skp2, isoform E ortho G G G G Skp2, isoform A, Skp2, isoform E CG3226-PA, LD13807p ortho G G G G Skp2, isoform A, Skp2, isoform E Nedd8 ortho G G G G Skp2, isoform A, Skp2, isoform E CG2720-PA, LD03220p ortho G G G G Skp2, isoform A, Skp2, isoform E CG5203-PA, Carboxy terminus of Hsp70-interacting protein, RE01069p ortho G G G G Skp2, isoform A, Skp2, isoform E CG11982, LD47007p ortho G G G G Skp2, isoform A, Skp2, isoform E Cullin 5, FI20194p1 ortho G G G G Skp2, isoform A, Skp2, isoform E Sirt4 ortho G G G G Skp2, isoform A, Skp2, isoform E rad50 ortho G G G G Skp2, isoform A, Skp2, isoform E CG16928-PA, Endo/exonuclease Mre11 ortho G G G G Skp2, isoform A, Skp2, isoform E CSN5 ortho G G G G Skp2, isoform A, Skp2, isoform E Cullin 2, isoform A, Cullin 2, isoform B, LD36177p ortho G G G G Mef2 Skp2, isoform A, Skp2, isoform E ortho G G G Skp2, isoform A, Skp2, isoform E l.2.35Df ortho G G G G l(2)37Cc Skp2, isoform A, Skp2, isoform E ortho G G G G Skp2, isoform A, Skp2, isoform E CSN1b ortho G G G G fzy-RA Skp2, isoform A, Skp2, isoform E ortho G Ras85D Skp2, isoform A, Skp2, isoform E ortho G G G G Medea Skp2, isoform A, Skp2, isoform E ortho G G G G CycB Skp2, isoform A, Skp2, isoform E ortho G CycA Skp2, isoform A, Skp2, isoform E ortho G Roc2-RA Skp2, isoform A, Skp2, isoform E ortho G G G G Skp2, isoform A, Skp2, isoform E sbr ortho G G G G Ets97D Skp2, isoform A, Skp2, isoform E ortho G G G RnrS Skp2, isoform A, Skp2, isoform E ortho G G G G Skp2, isoform A, Skp2, isoform E Sirt6 ortho G Skp2, isoform A, Skp2, isoform E CG13900-RA ortho G G G G Skp2, isoform A, Skp2, isoform E CG17441 ortho G G G Skp2, isoform A, Skp2, isoform E Ufd1-like ortho G G G G Skp2, isoform A, Skp2, isoform E Roc1a ortho G G G G Skp2, isoform A, Skp2, isoform E CG31251, RE67940p ortho G wee Skp2, isoform A, Skp2, isoform E ortho G G G Skp2, isoform A, Skp2, isoform E CG9617-RA ortho G G G G Skp2, isoform A, Skp2, isoform E pic ortho G G G G CycE Skp2, isoform A, Skp2, isoform E ortho G Elongin C, isoform A, Elongin C, isoform B, RE05591p, RH71704p Skp2, isoform A, Skp2, isoform E ortho G G G G Skp2, isoform A, Skp2, isoform E CG5001-RA ortho G G G Skp2, isoform A, Skp2, isoform E Probable prefoldin subunit 5 ortho G G G G IP16020p, Phosphatase PTEN, Pten, isoform B, Pten, isoform D, Pten, isoform G, Pten, isoform H Skp2, isoform A, Skp2, isoform E ortho G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7YZ95 Q24152 affinity chromatography technology 21827746 physical association X 2 Q7YZ95 O77430 affinity chromatography technology 21827746 physical association X 2 Q7YZ95 Q7JNL9 affinity chromatography technology 23552694 physical association X 2 Q7YZ95 O77430 affinity chromatography technology 23552694 physical association X 2 Q7YZ95 O77430 affinity chromatography technology 23552694 physical association X 2 Q7YZ95 Q7JNL9 affinity chromatography technology 23552694 physical association X 2 Q7YZ95 Q86BP3 two hybrid 14605208 direct interaction X 2 Q7YZ95 O77430 two hybrid 15575970 direct interaction X 2 Q7YZ95 O77430 two hybrid 14605208 direct interaction X 2 M9NDP1 Q7YZ95 two hybrid 14605208 direct interaction X 2 Q7YZ95 C0MJ66 affinity chromatography technology 21827746 physical association X 2 Q7YZ95 E1JIR3 affinity chromatography technology 21827746 physical association X 2 Q7YZ95 two hybrid 15575970 direct interaction X 2 Q9VHN1 Q7YZ95 affinity chromatography technology 21827746 physical association X 2 Q9VHN1 Q7YZ95 two hybrid 14605208 direct interaction X 2 Q9VHN1 Q7YZ95 two hybrid 15575970 direct interaction X 2 Q9VI58 Q7YZ95 two hybrid 14605208 physical association X 2 Q7YZ95 O77430 two hybrid 14605208 physical association X 2 Q7YZ95 O77430 two hybrid 15575970 physical association X 2 Q7YZ95 Q24190 two hybrid 15575970 physical association X 2 M9NDP1 Q7YZ95 two hybrid 14605208 physical association X 2 Q9VHN1 Q7YZ95 two hybrid 14605208 physical association X 2 Q9VHN1 Q7YZ95 two hybrid 15575970 physical association X 2 Q9VHN1 Q7YZ95 two hybrid 15575970 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B dap Skp2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23552694 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0796(suppressive genetic interaction defined by inequality) (biogrid)|(biogrid)|(biogrid) BIOGRID_75595|BIOGRID_75599|BIOGRID_75600 prey|bait|bait bait|prey|prey ctp Skp2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0471(mint)|(intact) DIP_25298|BIOGRID_47229|MINT_16958|UniProt_63208 -|bait|prey|prey -|prey|bait|bait cdc2c Skp2 MI:0004(affinity chromatography technology) 21827746 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75385 prey bait Pak Skp2 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_20781|UniProt_40702 bait|bait prey|prey CycE Skp2 MI:0004(affinity chromatography technology) 23552694 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_75601 bait prey Skp2 CG1091 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint) BIOGRID_35530|UniProt_53836|MINT_23100 prey|bait|bait bait|prey|prey Skp2 Pak MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59316 prey bait Skp2 Cks85A MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208,15575970,21827746 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint)|(intact)|MI:0465(dip)|(intact)|(biogrid)|MI:0471(mint)|(biogrid) MINT_17800|UniProt_41055|BIOGRID_75381|MINT_20055|UniProt_53421|DIP_26149|UniProt_39926|BIOGRID_58568|MINT_21655|BIOGRID_33924 prey|prey|prey|prey|prey|-|prey|prey|prey|bait bait|bait|bait|bait|bait|-|bait|bait|bait|prey Skp2 CG5363 MI:0004(affinity chromatography technology) 21827746 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75384 bait prey Cks30A Skp2 MI:0004(affinity chromatography technology) 21827746 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75379 bait prey skpA Skp2 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 14605208,15575970,21827746,23552694 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0471(mint)|(intact)|(biogrid)|(intact)|(biogrid)|MI:0471(mint)|MI:0465(dip)|(biogrid) BIOGRID_32162|BIOGRID_75386|MINT_20054|UniProt_61242|BIOGRID_75596|UniProt_39924|BIOGRID_58567|MINT_9552|DIP_17285|BIOGRID_75597 bait|prey|bait|bait|prey|bait|bait|bait|-|bait prey|bait|prey|prey|bait|prey|prey|prey|-|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7YZ95 O77430 SKP2 SKPA 0.354 15575970,14605208 Q7YZ95 Q24190 SKP2 PAK 0.183 15575970 Q9VHN1 Q7YZ95 CKS85A SKP2 0.354 15575970,14605208 Q9V3I5 Q7YZ95 JIL-1 SKP2 0.126 25294943 Q9VI58 Q7YZ95 Q9VI58 SKP2 0.183 14605208 Q9VNF6 Q7YZ95 MTA1-LIKE SKP2 0.126 25294943 Q9W0L7 Q7YZ95 CG13903 SKP2 0.126 25294943 Q7YZ95 Q24117 SKP2 CTP 0.21 14605208