PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KLHL18, isoform A, KLHL18, isoform C, LD42169p LD25692p, Lethal (2) 37Cb 19624754 biogrid exp G G G G KLHL18, isoform A, KLHL18, isoform C, LD42169p Neto 14605208 biogrid,i2d,mint,intact exp KLHL18, isoform A, KLHL18, isoform C, LD42169p CG5808 19624754 biogrid exp G KLHL18, isoform A, KLHL18, isoform C, LD42169p KLHL18, isoform A, KLHL18, isoform C, LD42169p 19624754 biogrid exp G G G G G G G G G G CG10324-RA KLHL18, isoform A, KLHL18, isoform C, LD42169p 19624754 biogrid exp G G G G G G G G G Cullin 3, isoform F, FI19425p1 KLHL18, isoform A, KLHL18, isoform C, LD42169p 19624754 biogrid exp, ortho G G G G G G G G G G KLHL18, isoform A, KLHL18, isoform C, LD42169p Nedd8 ortho G G G G G G G G G G KLHL18, isoform A, KLHL18, isoform C, LD42169p CG9617-RA ortho G G G G G G G G G G KLHL18, isoform A, KLHL18, isoform C, LD42169p DCN1-like protein ortho G G G G G G G G G G Ef1gamma KLHL18, isoform A, KLHL18, isoform C, LD42169p ortho G G G G G G G G G G CSN4 KLHL18, isoform A, KLHL18, isoform C, LD42169p ortho G G G G G G G G G G Cullin 5, FI20194p1 KLHL18, isoform A, KLHL18, isoform C, LD42169p ortho G G G G G G G G G G Pcmt KLHL18, isoform A, KLHL18, isoform C, LD42169p ortho G G G G G G G G G G CSN6 KLHL18, isoform A, KLHL18, isoform C, LD42169p ortho G G G G G G G G G G KLHL18, isoform A, KLHL18, isoform C, LD42169p CSN5 ortho G G G G G G G G G G CSN3 KLHL18, isoform A, KLHL18, isoform C, LD42169p ortho G G G G G G G G G G CG31251, RE67940p KLHL18, isoform A, KLHL18, isoform C, LD42169p ortho G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VGE5 Q9VES0 affinity chromatography technology 19624754 physical association X 2 Q9VGE5 Q9VIZ3 affinity chromatography technology 19624754 physical association X 2 Q9VGE5 Q9VIZ3 affinity chromatography technology 19624754 physical association X 2 Q9VGE5 Q9VGE5 affinity chromatography technology 19624754 physical association X 2 Q9VGE5 Q9VES0 affinity chromatography technology 19624754 physical association X 2 Q9VYC7 Q9VGE5 two hybrid 14605208 direct interaction X 2 Q9VGE5 Q9XYZ6 affinity chromatography technology 19624754 physical association X 2 Q9VGE5 Q9XYZ6 affinity chromatography technology 19624754 physical association X 2 Q8IP45 Q9VGE5 affinity chromatography technology 19624754 physical association X 2 Q8IP45 Q9VGE5 affinity chromatography technology 19624754 physical association X 2 Q9VYC7 Q9VGE5 two hybrid 14605208 physical association X 2 Q9VYC7 Q9VGE5 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B KLHL18 Neto MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_13648|UniProt_48979 prey|prey bait|bait