PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG4973 protein, CG4973-PA, LD35003p, Midlife crisis Usp7 22036573 biogrid exp G G G G G G G G G Fer1HCH-RD CG4973 protein, CG4973-PA, LD35003p, Midlife crisis 25294943 intact exp G G G G G G G G G CG4973 protein, CG4973-PA, LD35003p, Midlife crisis l(3)01239 22036573 biogrid exp G G G G G G G G G CkIIalpha CG4973 protein, CG4973-PA, LD35003p, Midlife crisis 22036573 biogrid exp G G G G G G G G G CG4973 protein, CG4973-PA, LD35003p, Midlife crisis CG7995-RA ortho G G G G G G G G G Top2 CG4973 protein, CG4973-PA, LD35003p, Midlife crisis ortho G G G G G G G G G Gyc76C CG4973 protein, CG4973-PA, LD35003p, Midlife crisis ortho G G G G CG4973 protein, CG4973-PA, LD35003p, Midlife crisis CG9890, LD46465p ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A4V2B8 Q9VDP8 affinity chromatography technology 22036573 physical association X 2 Q9VDP8 Q9VTE5 affinity chromatography technology 22036573 physical association X 2 Q9VDP8 Q9VYQ8 affinity chromatography technology 22036573 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CkIIalpha CG4973 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_73412 bait prey CG4973 Usp7 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74989 prey bait CG4973 l(3)01239 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70009 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VDP8 Q9VA83 MDLC {ECO:0000313|FLYBASE:FBGN0038772} FER2LCH 0.126 25294943