PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Npl4 Cdc14, isoform A, Cdc14, isoform D 15575970 biogrid,i2d,mint,intact exp G G G G G G Npl4 CG11286, isoform A 15575970 biogrid,i2d,mint,intact exp G CG14744, isoform C Npl4 15575970 biogrid exp G Npl4 CG11030-RA 25294943 intact exp G G G G G Npl4 PGAP5 15575970 biogrid,i2d,mint,intact exp G G G G G G G G G G Npl4 LD22957p i2d exp Mad Npl4 15575970 biogrid,i2d,mint,intact exp G G G G G G G G G G dap Npl4 15575970 i2d,mint,intact exp ci Npl4 23747190 biogrid exp G G G G G G G G AT11889p, CG7196, isoform A, CG7196, isoform C Npl4 14605208 biogrid,i2d,mint,intact exp G Cyclin D, isoform D, Cyclin D, isoform E, Cyclin D, isoform F Npl4 15575970 biogrid exp G G G G G G Cyclin H Npl4 15575970 mint,intact exp Npl4 CG9273 protein, CG9273-PA, GM04951p, Replication protein A2, isoform A, Replication protein A2, isoform B 15575970 biogrid,i2d,mint,intact exp G G G Tsc1 Npl4 i2d exp dap-RA Npl4 15575970 biogrid exp G G G G G G G G G G LD33277p Npl4 15575970 mint,intact exp CycD Npl4 15575970 mint,intact exp Nejire, isoform C Npl4 15575970 biogrid,i2d exp G G G G G G G G G SD10969p Npl4 16603075 intact exp ptc Npl4 15575970 biogrid,i2d,mint,intact exp Npl4 CG13599, RE56765p 16603075 intact exp G G shep Npl4 25294943 intact exp G G G G G G G G G G Cdk5 Npl4 15575970 biogrid,i2d,mint,intact exp G G G G G G G G G Npl4 LD23779p, Tsc1 14605208 biogrid,mint,intact exp G G G G G G G G G G CG15218-PA, isoform A, Cyclin K, isoform B, Cyclin K, isoform C, LD21709p Npl4 15575970 biogrid,i2d,mint,intact exp G G G G G G G G G G Cyclin H, Cyclin H homolog Npl4 15575970 biogrid,i2d exp G G G G G G G G G G hth Npl4 25294943 intact exp G G G Cyclin G, isoform A, Cyclin G, isoform B, Cyclin G, isoform C, Cyclin G, isoform D, Cyclin G, isoform F, LD46284p Npl4 15575970 biogrid,intact exp G G G G G G G G G G Npl4 CG15800 15575970 biogrid,i2d,mint,intact exp G TER94 Npl4 23747190 biogrid exp, ortho G G G G G G G G G G Npl4 Npl4 15575970 intact exp, ortho G G G G G G G G G G Npl4 Ufd1-like 14605208,22036573 biogrid,i2d,mint,intact exp, ortho G G G G G G G G G G Npl4 CG9018, isoform A ortho G G G G G G G G Npl4 NC2beta ortho G G G G G G G G G tRNA (guanine-N(7)-)-methyltransferase Npl4 ortho G G G G G G G G G Npl4 Fas-associated factor, isoform A, Fas-associated factor, isoform B, GH16914p ortho G G G G G G G G G G Npl4 Ubiquitin thioesterase OTU1 ortho G G G G G G G G G G slmb Npl4 ortho G G G G G G G G G GH24511p, Ubiquitin activating enzyme 1, isoform A Npl4 ortho G G G G G G G G G G Npl4 As ortho G G G G G G G G G G Npl4 Eukaryotic initiation factor 4A-III, eIF-4A-III, eIF4A-III ortho G G G G G G G G G G E(z) Npl4 ortho G G G G G G G RnrS Npl4 ortho G G G G G G G Gl Npl4 ortho G G G G G G G G G G La Npl4 ortho G G G G G G G G G G Npl4 CG9934, isoform A, CG9934, isoform B, LD24832p ortho G G G G G G G G G G sbr Npl4 ortho G G G G G G G G G G CG31759, isoform C, CG31759, isoform D Npl4 ortho G G G Npl4 Aats-gly-RB ortho G G G G G G G G G G Vha55 Npl4 ortho G G G G G G G G G G LD22577p, Smt3 activating enzyme 2 Npl4 ortho G G G G G G G G G G cact Npl4 ortho G G G G G G G G G G Npl4 Phospholipase A2 activator protein, isoform A, Phospholipase A2 activator protein, isoform B, Phospholipase A2 activator protein, isoform C, SD05646p ortho G G G G G G G G G G PyK Npl4 ortho G G G G G G G G G G rad23 Npl4 ortho G G G G G G G G G G Npl4 CG12795, LD41381p ortho G G G G G G G G G Eno Npl4 ortho G G G G G G G G G G Npl4 Ubc7 ortho G G G G G G G G G G Caspar, isoform A, Caspar, isoform B, LD03368p Npl4 ortho G G G G G G G G G G sm Npl4 ortho G G G G G G G G Npl4 mRpL19 ortho G G G G G G G G G G Ubi-p63E Npl4 ortho G G G G G G G G G G Npl4 CG3744, isoform D, CG3744, isoform G ortho G G G G G G G G Octbeta2R Npl4 ortho Npl4 Coq6 ortho G G G G G G G G G G Npl4 CG8209, GM09977p ortho G G G G G G G G G G Npl4 Adenylyl cyclase-associated protein ortho G G G G G G G G G G GH01724p, p47 Npl4 ortho G G G G G G G G G G Ubiquitin-fold modifier 1 Npl4 ortho Flo-1 Npl4 ortho G G G G G G G G G G Itp-r83A Npl4 ortho G G G G G G G G G Mitochondrial ribosomal protein S9, RH44312p Npl4 ortho G G G G G G G G G G Aos1, CG12276 protein, CG12276-PA, LD33652p Npl4 ortho G G G G G G G G G G Npl4 CG3590-RA ortho G G G G G G G CG42306-RA Npl4 ortho Npl4 ND-30 ortho G G G G G G G G G G Npl4 lap ortho G G G G Dynein assembly factor 5, axonemal Npl4 ortho G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VBP9 Q9VCC9 two hybrid 14605208 physical association X 2 Q9VBP9 Q8T3J9 two hybrid 14605208 physical association X 2 Q9VBP9 Q9VTF9 two hybrid 14605208 physical association X 2 Q9GTQ8 Q9VBP9 two hybrid 15575970 physical association X 2 Q9VBP9 Q9VCC9 two hybrid 14605208 physical association X 2 Q9VBP9 Q8T3J9 two hybrid 14605208 physical association X 2 Q9VBP9 Q95TJ9 two hybrid 15575970 physical association X 2 Q9VBP9 Q9VIH1 two hybrid 15575970 physical association X 2 Q9VBP9 Q9VLR9 two hybrid 15575970 physical association X 2 Q9VBP9 Q961D1 two hybrid 15575970 physical association X 2 Q9VBP9 Q95TP4 two hybrid 15575970 physical association X 2 Q9VBP9 Q9VCG0 two hybrid 16603075 physical association X 2 Q9VLW7 Q9VBP9 two hybrid 15575970 physical association X 2 Q9VBP9 Q9VTF9 two hybrid 14605208 physical association X 2 Q9VBP9 P42003 two hybrid 15575970 physical association X 2 Q9VBP9 P48609 two hybrid 15575970 physical association X 2 Q9VBP9 Q9VI02 two hybrid 15575970 physical association X 2 Q9VBP9 O17144 two hybrid 15575970 physical association X 2 Q9VBP9 Q8IGE8 two hybrid 15575970 physical association X 2 Q9VBP9 Q9W1J7 two hybrid 15575970 physical association X 2 Q9VBP9 P91668 two hybrid 15575970 physical association X 2 Q9VBP9 Q95R37 two hybrid 16603075 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CycG CG4673 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_58702|UniProt_40064 bait|bait prey|prey CycD CG4673 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59431 bait prey CycD CG4673 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_20372|UniProt_40830 bait|bait prey|prey TER94 CG4673 MI:0004(affinity chromatography technology) 23747190 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75641 prey bait CG7196 CG4673 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0465(dip) UniProt_50772|MINT_15337|DIP_23571 bait|bait|- prey|prey|- ptc CG4673 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_20377|UniProt_40836 bait|bait prey|prey nej CG4673 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_20380|UniProt_40840 bait|bait prey|prey Q9V9W0 CG4673 MI:0018(two hybrid) 15575970 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_20270 bait prey CG12393 CG4673 MI:0018(two hybrid) 16603075 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44446 bait prey CycH CG4673 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59436 bait prey CG7196 CG4673 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_45967 prey bait Cdk5 CG4673 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_20371|BIOGRID_59430|UniProt_40831 bait|bait|bait prey|prey|prey CycH CG4673 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_40837|MINT_20376 bait|bait prey|prey Mad CG4673 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint) UniProt_40063|BIOGRID_58701|MINT_21590 bait|bait|bait prey|prey|prey ci CG4673 MI:0004(affinity chromatography technology) 23747190 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75643 bait prey Q9V4X0 CG4673 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_20374|UniProt_40833 bait|bait prey|prey CycK CG4673 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_20375|BIOGRID_59435|UniProt_40835 bait|bait|bait prey|prey|prey dap CG4673 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59439 bait prey CG4673 Tsc1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_50770|MINT_15335|BIOGRID_45966 prey|prey|bait bait|bait|prey CG4673 CG13599 MI:0018(two hybrid) 16603075 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44317 prey bait CG4673 CG8455 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|(biogrid) MINT_20370|UniProt_40829|BIOGRID_59429 prey|prey|prey bait|bait|bait CG4673 cdc14 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_20373|UniProt_40832 prey|prey bait|bait CG4673 CG11286 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_21615|BIOGRID_59434|UniProt_40834 prey|prey|prey bait|bait|bait CG4673 RPA2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_40828|MINT_20369|BIOGRID_59428 prey|prey|prey bait|bait|bait CG4673 Ufd1-like MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|MI:0471(mint)|MI:0465(dip)|(biogrid) BIOGRID_68411|UniProt_50771|MINT_15336|DIP_23570|BIOGRID_33304 prey|prey|prey|-|bait bait|bait|bait|-|prey dap CG4673 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_40839|MINT_20379 bait|bait prey|prey CG4673 CG15800 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_40838|MINT_20378|BIOGRID_59438 prey|prey|prey bait|bait|bait CG4673 cdc14 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59432 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VBP9 Q8MSV2 NPL4 SHEP 0.126 25294943 Q9VBP9 O46339 NPL4 HTH 0.126 25294943 Q9VTF9 Q9VBP9 UFD1-LIKE NPL4 0.436 14605208,22036573 Q9VBP9 Q95R37 NPL4 Q95R37 0.183 16603075 Q9VBP9 Q95TJ9 NPL4 CYCG 0.332 15575970 Q9VBP9 O17144 NPL4 CYCH 0.183 15575970 Q9VBP9 P42003 NPL4 MAD 0.332 15575970 Q9VBP9 P48609 NPL4 CDK5 0.332 15575970 Q9VBP9 P91668 NPL4 DAP 0.183 15575970 Q9VBP9 Q7KN62 NPL4 TER94 0.21 23747190 Q9VBP9 Q8IGE8 NPL4 PTC 0.183 15575970 Q9VBP9 Q8T3J9 NPL4 Q8T3J9 0.183 14605208 Q9VBP9 Q95TP4 NPL4 NEJ 0.183 15575970 Q9VBP9 Q961D1 NPL4 CYCK 0.183 15575970 Q9VBP9 Q9GTQ8 NPL4 CYCD 0.183 15575970 Q9VCC9 Q9VBP9 TSC1 NPL4 0.183 14605208 Q9VI02 Q9VBP9 Q9VI02 NPL4 0.183 15575970 Q9VIH1 Q9VBP9 RPA2 NPL4 0.183 15575970 Q9VLR9 Q9VBP9 PGAP5 NPL4 0.332 15575970 Q9VLW7 Q9VBP9 CDC14 NPL4 0.183 15575970 Q9W1J7 Q9VBP9 Q9W1J7 NPL4 0.183 15575970 Q9VCG0 Q9VBP9 Q9VCG0 NPL4 0.183 16603075 Q9VMM7 Q9VBP9 CG11030-RA NPL4 0.126 25294943 Q9VBP9 P18502 NPL4 PTC 0.183 15575970 Q9VBP9 P19538 NPL4 CI 0.21 23747190