PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mes-4 CG10323 14605208 biogrid,i2d,mint,intact exp G NetB Mes-4 25294943 intact exp Ten-m Mes-4 25294943 intact exp G sgg Mes-4 25294943 intact exp BEAF-32A Mes-4 24916307 intact exp G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8MT36 Q9V4B8 - 14605208 - X 2 Q8MT36 Q9V4B8 two hybrid 14605208 direct interaction X 2 Q8MT36 Q9V4B8 two hybrid 14605208 physical association X 2 Q8MT36 Q9V4B8 two hybrid 14605208 physical association X 2 Q8MT36 Q7JN06 two hybrid 24916307 physical association X 2 Q8MT36 anti bait coimmunoprecipitation 24916307 association C 3 Q8MT36 anti bait coimmunoprecipitation 24916307 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Mes-4 CG10323 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_21297|MINT_13184|BIOGRID_44434|UniProt_27016 -|prey|prey|prey -|bait|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8MT36 Q7JN06 MES-4 BEAF-32 0.454 24916307 Q8MT36 O61307 MES-4 TEN-M 0.126 25294943 Q9V4B8 Q8MT36 CG10323 MES-4 0.21 14605208 Q8MT36 P18431 MES-4 SGG 0.126 25294943 Q8MT36 Q24568 MES-4 NETB 0.126 25294943