PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ik2-RB PPP5 25294943 intact exp G G ik2-RB CG11656, GH08448p 14605208 biogrid,i2d,mint,intact exp CG8213, isoform C ik2-RB 25294943 intact exp ik2-RB CG34404-RC 14605208 biogrid,i2d,mint,intact exp spn-F ik2-RB 14605208 biogrid,i2d,mint,intact exp G G NetB ik2-RB 25294943 intact exp th ik2-RB 16887178 biogrid exp G G Pka-R2 ik2-RB 25294943 intact exp G G ik2-RB 4E-binding protein THOR, CG8846-PA, HL08053p, Thor, isoform B 25294943 intact exp G G ik2-RB Early girl, isoform A, Early girl, isoform B, LD41235p ortho G G Cctgamma ik2-RB ortho G G PpV ik2-RB ortho G G csw ik2-RB ortho G G ik2-RB HERC2 ortho G G Src64B ik2-RB ortho G G ik2-RB LD11955p, Mind bomb 2, isoform A, Mind bomb 2, isoform B, Mind bomb 2, isoform C ortho G G Cdc37 ik2-RB ortho G G ik2-RB sec5 ortho G G 14-3-3epsilon ik2-RB ortho G G slmb ik2-RB ortho G G ik2-RB l(1)G0022 ortho G G CG8258, LD24495p ik2-RB ortho G G ik2-RB Tom70-RA ortho G G ik2-RB T-complex protein 1 subunit delta ortho G G RpL11 ik2-RB ortho G G ik2-RB bel ortho G G ik2-RB GH01161p, TNF-receptor-associated factor 6 ortho G G RpL7 ik2-RB ortho G G abs ik2-RB ortho G G RpS8 ik2-RB ortho G G Hsp83 ik2-RB ortho G G Cep135, isoform B ik2-RB ortho G RuvB-like helicase 2 ik2-RB ortho G G ik2-RB CG5886, GH01188p ortho G G ik2-RB MED4 ortho G ik2-RB Dreadlocks, isoform B, Dreadlocks, isoform C, Dreadlocks, isoform D, LD42588p ortho G G betaTub60D ik2-RB ortho G G SkpA ik2-RB ortho G G GM12270p, T-complex chaperonin 5, isoform A ik2-RB ortho G G Hsc70-1 ik2-RB ortho ik2-RB Retinoblastoma-binding protein 5 homolog ortho G Fmr1 ik2-RB ortho G G ik2-RB ik2-RB ortho G G T-cp1 ik2-RB ortho G G CG5603-PD, isoform D, Cylindromatosis ortholog, isoform E, FI01020p ik2-RB ortho G G blw ik2-RB ortho G G Hsc70-3 ik2-RB ortho G G emb ik2-RB ortho G G ik2-RB mib1 ortho G G lin19 ik2-RB ortho G G cact ik2-RB ortho G G ik2-RB RuvB-like helicase 1 ortho G G Hsc70-5 ik2-RB ortho G G ik2-RB CG7033, SD02216p ortho G G AGO1-RC ik2-RB ortho G G RpS18 ik2-RB ortho G G RpL13 ik2-RB ortho G G ik2-RB sec8 ortho G G ik2-RB Cell surface receptor TOLLO, LD33590p, Toll-8, Tollo ortho G G fs(1)N ik2-RB ortho G G PyK ik2-RB ortho G G ik2-RB CG3008, RE33807p ortho G G ik2-RB LD47396p, Tcp-1eta ortho G G CG32850-PA, RE41137p ik2-RB ortho G Ubi-p63E ik2-RB ortho G G RpS5a ik2-RB ortho G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9V3Y8 Q9V9Y9 - 14605208 - X 2 Q9V3Y8 Q9VG03 - 14605208 - X 2 Q7KSI6 Q9V3Y8 - 14605208 - X 2 Q9V3Y8 Q9VG03 two hybrid 14605208 direct interaction X 2 Q9V3Y8 Q9V9Y9 two hybrid 14605208 direct interaction X 2 Q9V3Y8 M9PI74 affinity chromatography technology 16887178 physical association X 2 Q9V3Y8 M9PI74 affinity chromatography technology 16887178 physical association X 2 Q9V3Y8 M9PI74 enzymatic study 16887178 direct interaction X 2 Q9V3Y8 Q9VF74 two hybrid 14605208 direct interaction X 2 Q9V3Y8 Q9VG03 two hybrid 14605208 physical association X 2 Q9V3Y8 Q9V9Y9 two hybrid 14605208 physical association X 2 Q9V3Y8 Q9VF74 two hybrid 14605208 physical association X 2 Q9V3Y8 pull down 25294943 association C 11 Q9V3Y8 Q9V9Y9 two hybrid 14605208 physical association X 2 Q9V3Y8 Q9VG03 two hybrid 14605208 physical association X 2 Q9V3Y8 pull down 25294943 association C 6 Q9V3Y8 Q9VF74 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ik2 CG34404 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_25554|MINT_18685 prey|prey bait|null ik2 CG34404-RC MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_19843 - - ik2 CG11656 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_63932|MINT_25046 prey|prey bait|bait ik2 spn-F MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(intact)|MI:0471(mint) DIP_10667|UniProt_64686|MINT_25755 -|prey|prey -|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9XZ56 Q9V3Y8 THOR IK2 0.126 25294943 Q9V3Y8 Q24568 IK2 NETB 0.236 25294943 Q9V9Y9 Q9V3Y8 SPN-F IK2 0.183 14605208 Q9VF74 Q9V3Y8 Q9VF74 IK2 0.183 14605208 Q9VG03 Q9V3Y8 Q9VG03 IK2 0.183 14605208 Q9VH81 Q9V3Y8 Q9VH81 IK2 0.126 25294943 Q9V3Y8 B7YZU2 IK2 B7YZU2 0.126 25294943 Q9V3Y8 P81900 IK2 PKA-R2 0.126 25294943