PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ten-m Bre1 25294943 intact exp G G G G G G G Ino80 Bre1 25294943 intact exp G G G G G G G G Fur2 Bre1 14605208 biogrid,i2d,mint,intact exp G G G G G G G G Bre1 CG9040-PA 14605208 biogrid,i2d,mint,intact exp sgg Bre1 25294943 intact exp G G G hk Bre1 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Ecdysone-induced protein 63E, isoform N Bre1 25294943 intact exp G G G G G G G G G CG5059-PA, isoform A, RE48077p Bre1 25294943 intact exp G G G G G G G G G CG2813-PA, Coiled, isoform B, LD16147p Bre1 25294943 intact exp G G G G G G G G G PAPLA1 Bre1 25294943 intact exp G G G G G G G G G Bre1 sec10 15710747 biogrid,i2d,intact exp G G G G G G G G G CG12360, isoform A, CG12360, isoform B, RE12073p Bre1 ortho G G G G G G G G G CG3018-PA, isoform A, Dorsal interacting protein 4, GM08377p, Lesswright, isoform A, Lesswright, isoform C, Lesswright, isoform D, RE25737p, Ubiquitin-conjugating enzyme, Ubiquitin-conjugating enzyme 9, Ubiquitin-conjugating enzyme 9 homolog Bre1 ortho G G G G G G G G G Bre1 Synaptosomal-associated protein ortho G G G G G G G G G Bre1 Bre1 ortho G G G G G G G G G Bre1 CG3909 ortho G G G G G G G G G CG7220-RB Bre1 ortho G G G G G G G G G Cyclin-dependent kinase 9, GH21935p, Positive transcription elongation factor b small subunit Bre1 ortho G G G G G G G G G CIAPIN1 Bre1 ortho G G G G G G G G G Bre1 Tal ortho G G G G G G G G G CG12320 Bre1 ortho G G G Sep1 Bre1 ortho G G G G G G G G G Syx1A Bre1 ortho G G G G G G G Bre1 Ubiquitin-conjugating enzyme E2 S ortho G G G eff Bre1 ortho G G G G G G G G G Hsp83 Bre1 ortho G G G G G G G G G Bre1 Spt6 ortho G G G G G G G G G Wnt5 Bre1 ortho G Bre1 Phosphoinositide phospholipase C ortho G G G G G G G G G sbr Bre1 ortho G G G G G G G G G Hsc70-3 Bre1 ortho G G G G G G G G G Hyrax, Hyrax, isoform A, Hyrax, isoform B, LD47989p Bre1 ortho G G G G G G G G G CG2774-RA Bre1 ortho G G G G G G G G G Bre1 LD24756p, Pretaporter, isoform A, Pretaporter, isoform B, Pretaporter, isoform C ortho G G G G G G G G G Cbp80 Bre1 ortho G G G G G G G G G Sirt6 Bre1 ortho G Tfb5-RB Bre1 ortho 14-3-3epsilon Bre1 ortho G G G G G G G G G Antimeros, isoform A, Antimeros, isoform B, LD37523p Bre1 ortho G G G G G G G N Bre1 ortho G G G G Aminopeptidase P, Aminopeptidase P, isoform A, Aminopeptidase P, isoform B, LD20901p Bre1 ortho G G G G G G G G G Dynamin associated protein 160, isoform D Bre1 ortho G G G G G G G G G Bre1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VRP9 Q9XTM1 - 15710747 - X 2 Q9VRP9 Q9VUB1 - 14605208 - X 2 Q9VRP9 Q24185 - 14605208 - X 2 P30432 Q9VRP9 - 14605208 - X 2 Q9VRP9 Q24185 two hybrid 14605208 direct interaction X 2 Q9VRP9 E1JJL5 two hybrid 14605208 direct interaction X 2 Q9VRP9 Q9VUB1 two hybrid 14605208 direct interaction X 2 Q9VRP9 Q9XTM1 two hybrid 15710747 direct interaction X 2 Q9VRP9 Q24185 two hybrid 14605208 physical association X 2 Q9VRP9 P30432-2 two hybrid 14605208 physical association X 2 Q9VRP9 Q9VUB1 two hybrid 14605208 physical association X 2 Q9VRP9 Q9XTM1 two hybrid 15710747 physical association X 2 Q9VRP9 Q24185 two hybrid 14605208 physical association X 2 Q9VRP9 Q9VUB1 two hybrid 14605208 physical association X 2 Q9VRP9 Q9XTM1 two hybrid fragment pooling approach 15710747 physical association X 2 P30432 Q9VRP9 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B hk Bre1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact)|MI:0471(mint) DIP_6989|BIOGRID_34997|UniProt_59060|MINT_22343 -|prey|prey|prey -|bait|bait|bait Bre1 sec10 MI:0018(two hybrid)|MI:0399(two hybrid fragment pooling approach)|MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip) BIOGRID_62608|UniProt_42512|DIP_27536 prey|prey|- bait|bait|- Bre1 CG9040 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_34999|DIP_6991|UniProt_59062|MINT_22345 bait|-|prey|prey prey|-|bait|bait Fur2 Bre1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_34998|DIP_6990|UniProt_59061|MINT_22344 prey|-|prey|prey bait|-|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VRP9 Q8IPU8 BRE1 Q8IPU8 0.126 25294943 Q9VRP9 O61307 BRE1 TEN-M 0.126 25294943 Q9XTM1 Q9VRP9 SEC10 BRE1 0.309 15710747 Q9VRP9 Q9VPR7 BRE1 COLD 0.236 25294943 Q9VRP9 P30432 BRE1 FUR2 0.332 14605208 Q9VRP9 Q9VDY1 BRE1 INO80 0.126 25294943 Q9VRP9 Q9VLS7 BRE1 Q9VLS7 0.126 25294943 Q9VRP9 Q24185 BRE1 HK 0.332 14605208 Q9VUB1 Q9VRP9 Q9VUB1 BRE1 0.183 14605208 Q9VRP9 P18431 BRE1 SGG 0.126 25294943 Q9VRP9 M9PE01 BRE1 M9PE01 0.126 25294943