PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus AT23078p flr i2d exp Ald flr 25294943 intact exp G G G G G G G G CG17337, isoform A, RE11562p flr 22036573 biogrid exp G G G G G G G G G CG8204-RA flr 14605208 biogrid,intact exp G G G G G G G G G CG2852-RA flr 19079254 intact exp BG:DS07473.2 flr 22036573 biogrid exp G G G G G G G G G Inos flr 22036573 biogrid exp G G G G G G G G G Moe flr 22036573 biogrid exp, ortho G G G G G G G G G Crc flr 22036573 biogrid exp, ortho G G G G G G G G G Hsc70Cb, isoform G, Hsc70Cb, isoform H flr 22036573 biogrid exp, ortho G G G G G G G G G flr Tal 22036573 biogrid exp, ortho G G G G G G G G G flr Nedd4 ortho G G G G G G G G G BcDNA.LD18761, Nucleoporin 107kD flr ortho G G G G G G G G G flr Gale ortho G G G G G G G G G Myo61F flr ortho G G G G G Beta-lactamase-like protein 2 homolog flr ortho G G G G G G G G G ILK flr ortho G G G G G G G G G flr Rbp6 ortho G G G flr CG3909 ortho G G G G G G G G G drk flr ortho G G G G G G G G G Eno flr ortho G G G G G G G G G CkIIbeta flr ortho G G G G G G G G G CG3542, LD24714p flr ortho G G G G G G Pgi flr ortho G G G G G G G G G FI11917p, KEAP1, Keap1, isoform B flr ortho G G G G G G G G Iap2 flr ortho G G G G G G G G G Cyp1 flr ortho G G G G G G G G G UbcD4 flr ortho G G G G G G G G G Protein phosphatase methylesterase 1, PME-1 flr ortho G G G G G G G G flr Probable 6-phosphogluconolactonase, 6PGL ortho G G G G G G G G G sbr flr ortho G G G G G G G G G RuvB-like helicase 2 flr ortho G G G G G G G G G CG3083-PA flr ortho G G G G G G G G G ImpL3 flr ortho G G G G G CG41378, isoform B flr ortho Pcd flr ortho G G G G G G G G G Act5C flr ortho G G G G G G G G G LD23303p, Twister, isoform A, Twister, isoform B flr ortho Eip55E, isoform A, Eip55E, isoform B, LD22255p flr ortho G G G G G G G G G 14-3-3zeta flr ortho G G G G G G G flr CG8239, isoform A, CG8239, isoform B, LD10857p ortho G G cher flr ortho G G G G G G G Trx-2 flr ortho G G G G G G G G G flr Usp7 ortho G G G G G G G G G Myosin heavy chain-like, isoform B flr ortho G G G G Dis3, isoform A, Dis3, isoform B flr ortho flw flr ortho G G G G G G G G G flr Succinyl-CoA:3-ketoacid-coenzyme A transferase ortho G G G G G G G G G Smt3 flr ortho G G G G G G G G G Hyrax, Hyrax, isoform A, Hyrax, isoform B, LD47989p flr ortho G G G G G G G G G Adenylyl cyclase-associated protein flr ortho G G G G G G G G G Ubi-p63E flr ortho G G G G G G G G G clot flr ortho G G G G G G G G G flr CG7033, SD02216p ortho G G G G G G G G G Mannose-1-phosphate guanyltransferase beta flr ortho G G G G G G G G G LD30634p, Vacuolar H[+] ATPase M8.9 accessory subunit flr ortho G G G G G G G G G Glutamate oxaloacetate transaminase 1, isoform B flr ortho G G G G G G G G G Cullin 3, isoform F, FI19425p1 flr ortho G G G G G G G G G Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase flr ortho G G G G G G G G G 14-3-3epsilon flr ortho G G G G G G G G G SRPK flr ortho G G G G G G G G G cdc2c flr ortho G G G RuvB-like helicase 1 flr ortho G G G G G G G G G Rpn11 flr ortho G G G G G G G G G Pixie, isoform A, Pixie, isoform B, RE71924p flr ortho G G G G G G G G G flr BcDNA:LD24639 ortho G G G G G G G G G pAbp flr ortho G G G G G G G G G CG6218, isoform A, CG6218, isoform B, GH07590p flr ortho G G G G G G G Ts flr ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O97477 Q9VU68 affinity chromatography technology 22036573 physical association X 2 A1ZA28 Q9VU68 two hybrid 14605208 direct interaction X 2 Q9VU68 C7LAH9 affinity chromatography technology 22036573 physical association X 2 Q9VU68 Q9VYR1 affinity chromatography technology 22036573 physical association X 2 Q8MT58 Q9VU68 affinity chromatography technology 22036573 physical association X 2 P29413 Q9VU68 affinity chromatography technology 22036573 physical association X 2 Q9VU68 affinity chromatography technology 22036573 physical association X 2 Q9VU68 M9MSL3 affinity chromatography technology 22036573 physical association X 2 A1ZA28 Q9VU68 two hybrid 14605208 physical association X 2 E4NKJ7 Q9VU68 two hybrid array 19079254 physical association X 2 A1ZA28 Q9VU68 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Crc flr MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74685 bait prey CG17337 flr MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74268 bait prey flr CG8204 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip) BIOGRID_35373|UniProt_53586|DIP_7513 bait|prey|- prey|bait|- Moe flr MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67083 bait prey EndoGI flr MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_73327 bait prey Inos flr MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_72200 bait prey flr CG2852-RA MI:0397(two hybrid array) 19079254 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_43470 prey bait Q9V7D9 flr MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_22854 bait prey flr regucalcin MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74502 prey bait flr Hsc70Cb MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_72981 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VU68 O97477 FLR INOS 0.126 22036573 Q9VU68 P07764 FLR ALD 0.126 25294943 Q9VU68 A1ZA28 FLR CG8204-RA 0.21 14605208 Q9VU68 P29413 FLR CRC 0.126 22036573 Q9VU68 P46150 FLR MOE 0.126 22036573 Q9VU68 E4NKJ7 FLR CG2852-RA 0.126 19079254