PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ebi MED30 22036573 biogrid exp G G G G G G G G ebi MED18 22036573 biogrid exp G G G G G G G G G ebi MED23 22036573 biogrid exp ebi CG2017, isoform A, SD03629p 22036573 biogrid exp G G G G G G G G G ebi Cleavage and polyadenylation specificity factor subunit CG7185 22036573 biogrid exp G G G G G G G G G ebi CG34159, LD45253p 22036573 biogrid exp G G G G G G G G G ebi La-related protein CG11505 22036573 biogrid exp G ebi MED14 22036573 biogrid exp G G G G G G G G G ebi MED10 22036573 biogrid exp G G G G G G G G G MED6 ebi 22036573 biogrid exp G G G G G G G G P-element somatic inhibitor, isoform C ebi 22036573 biogrid exp G G G G G G G G ebi Ptip 22036573 biogrid exp G boca ebi 22036573 biogrid exp G G G G G G G G G ebi MED16 22036573 biogrid exp ebi Cdk8 22036573 biogrid exp G G G G ebi RE32936p, SET and MYND domain protein 4 18714374 biogrid exp ebi Brahma associated protein 155 kDa, LD22973p, Moira, isoform A 22036573 biogrid exp G G G G G G G G G enc ebi 22036573 biogrid exp G G G G G G G G G CtBP ebi 18309295 intact exp G G G G G G G G G CG17002, isoform B, LD41464p ebi 22036573 biogrid exp G G G G G G G G phyl ebi 11032805 biogrid,intact exp G G G MED8 ebi 22036573 biogrid exp G G G G G G G G G ttk ebi 11032805 biogrid,intact exp G G G G G G G G G Ssdp ebi 22036573 biogrid exp G G G G G G G G G skd ebi 22036573 biogrid exp G sinah ebi 17561381 biogrid exp MED20 ebi 22036573 biogrid exp G G G G G ebi MED15 22036573 biogrid exp G G G G G G G G G brm ebi 22036573 biogrid exp G G G G G G G G G ebi CG3008, RE33807p 22036573 biogrid exp G G G G G G G G G ebi MED4 22036573 biogrid exp G G G HDAC4 ebi 21565616 intact exp ebi MED17 22036573 biogrid exp G G G G G G G ebi PTIP associated 1, RE09126p, RH21749p 22036573 biogrid exp G G G G G G G G G ebi MED25 22036573 biogrid exp G G G G G G G ebi MED11 22036573 biogrid exp G G G G G G G G G dsh ebi 22036573 biogrid exp G G G G G G G sec24 ebi 22036573 biogrid exp G G G G G G G G G ebi MED27 22036573 biogrid exp G G ix ebi 22036573 biogrid exp G G G G G sna ebi 18309295 mint,intact exp ebi MED7 22036573 biogrid exp G G G G G G G G G ebi Usp10 22036573 biogrid exp G G G G G G G G G sina ebi 17561381,11032805 biogrid,intact exp, ortho G G G G G G G G G ebi Bap60 22036573 biogrid exp, ortho G G G G G G G G G HDAC3 ebi 18309295 mint,intact exp, ortho G G G G G G G G G GH08712p, SNR1, Snf5-related 1 ebi 22036573 biogrid exp, ortho G G G G G G G G G His4, His4r, His4:CG31611, His4:CG33869, His4:CG33871, His4:CG33873, His4:CG33875, His4:CG33877, His4:CG33879, His4:CG33881, His4:CG33883, His4:CG33885, His4:CG33887, His4:CG33889, His4:CG33891, His4:CG33893, His4:CG33895, His4:CG33897, His4:CG33899, His4:CG33901, His4:CG33903, His4:CG33905, His4:CG33907, His4:CG33909 ebi ortho His3, His3:CG31613, His3:CG33803, His3:CG33806, His3:CG33809, His3:CG33812, His3:CG33815, His3:CG33818, His3:CG33821, His3:CG33824, His3:CG33827, His3:CG33830, His3:CG33833, His3:CG33836, His3:CG33839, His3:CG33842, His3:CG33845, His3:CG33848, His3:CG33851, His3:CG33854, His3:CG33857, His3:CG33860, His3:CG33863, His3:CG33866 ebi ortho ebi shu ortho G G ebi CG6617-PA, LD25271p ortho G G G G G G G G G arm ebi ortho G G G G G G G G G DnaJ-1 ebi ortho G G G G G G G G G ebi CG3436, isoform A, CG3436, isoform C, GM13767p ortho G G G G G G G G G ebi CG3226-PA, LD13807p ortho G G G G G G G G G Sin3A ebi ortho G G G G G G G G G ebi emb ortho G G G G G G G G G SkpA ebi ortho G G G G G G G G G ebi ebi ortho G G G G G G G G G ebi CG8184, isoform H ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VNG0 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 P21461 pull down 17561381 direct interaction X 2 Q95RJ9 P21461 pull down 17561381 direct interaction X 2 Q95RJ9 P21461 affinity chromatography technology 17561381 physical association X 2 Q95RJ9 P21461 pull down 11032805 direct interaction X 2 Q95RJ9 Q9VEC1 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 P51140 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 E1JIH5 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9VVS4 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q8T9B6 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9W278 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q960F7 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9W1X7 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9W0L7 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9Y149 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9W0P3 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 M9PFS6 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9VT57 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9VYZ8 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 A1ZAK7 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9I7T7-2 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9VDR1 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q24090 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9VTX2 pull down 18714374 direct interaction X 2 Q95RJ9 Q8T3Y0 pull down 17561381 direct interaction X 2 Q95RJ9 Q8T3Y0 pull down 17561381 direct interaction X 2 Q95RJ9 Q8T3Y0 affinity chromatography technology 17561381 physical association X 2 Q95RJ9 P42282 pull down 11032805 direct interaction X 2 Q95RJ9 Q27934 pull down 11032805 direct interaction X 2 Q95RJ9 Q27934 affinity chromatography technology 11032805 physical association X 2 Q95RJ9 Q27934 pull down 11032805 direct interaction X 2 Q95RJ9 Q27934 affinity chromatography technology 11032805 physical association X 2 Q95RJ9 Q9XZT1 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 A1ZBT5 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9GYV9 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9VL29 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9VYG2 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9GYU7 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 P91641 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 M9PE05 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 A8JNW4 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 Q9VEB9 affinity chromatography technology 22036573 physical association X 2 Q7KBL8 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 A1Z813 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q9VSH4 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q9VS38 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q9VF03 Q95RJ9 affinity chromatography technology 22036573 physical association X 2 Q95RJ9 P21461 pull down 11032805 physical association X 2 Q95RJ9 P21461 pull down 11032805 physical association X 2 Q95RJ9 pull down 11032805 association C 4 Q95RJ9 anti tag coimmunoprecipitation 21565616 association C 4 Q95RJ9 pull down 11032805 association C 3 Q95RJ9 pull down 18309295 association C 3 Q95RJ9 P42282 pull down 11032805 physical association X 2 Q95RJ9 Q27934 pull down 11032805 physical association X 2 Q95RJ9 Q27934 pull down 11032805 physical association X 2 Q95RJ9 P08044 pull down 18309295 physical association X 2 Q95RJ9 P08044 pull down 18309295 physical association X 2 Q95RJ9 Q9VNC2 anti bait coimmunoprecipitation 18309295 physical association X 2 Q95RJ9 Q9VNC2 anti bait coimmunoprecipitation 18309295 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B para ebi MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476160 bait prey phyl ebi MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 11032805 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact) UniProt_39034|UniProt_39031|UniProt_39032|UniProt_39029 bait|prey|bait|prey prey|bait|prey|bait sna ebi MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18309295 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|(intact) UniProt_45188|MINT_19874|MINT_19870|UniProt_45184 prey|prey|bait|bait bait|bait|prey|prey RpS5a ebi MI:0004(affinity chromatography technology) 16554755 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_382468 prey bait ttk ebi MI:0096(pull down)|MI:0096(pull down) 11032805 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0914(association) (intact)|(intact) UniProt_39028|UniProt_39029 prey|prey bait|bait pnut ebi MI:0004(affinity chromatography technology) 9755175 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_559248 prey bait ebi Paf-AHalpha MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 10403407,12393914,12684376,12748292,16319894,16847059,17178716,9774644 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_366763|BIOGRID_398700|BIOGRID_358343|BIOGRID_457738|BIOGRID_352913|BIOGRID_436233|BIOGRID_366766|BIOGRID_366762|BIOGRID_403581 prey|prey|prey|prey|bait|bait|prey|prey|prey bait|bait|bait|bait|prey|prey|bait|bait|bait Odc1 ebi MI:0004(affinity chromatography technology) 21987634 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_619055 bait prey sina ebi MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 11032805 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_39032|UniProt_39029|UniProt_39033|UniProt_39030 bait|prey|bait|prey prey|bait|prey|bait ebi Hdac3 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18309295 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|MI:0471(mint) UniProt_45189|MINT_19875|UniProt_45191|MINT_19876 bait|bait|prey|prey prey|prey|bait|bait ebi Rpn11 MI:0018(two hybrid) 19841731 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_476086 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q95RJ9 Q8MSX1 EBI ENC 0.126 22036573 Q95RJ9 O46036 EBI CTBP 0.21 18309295 Q95RJ9 Q8I9J6 EBI HDAC4 0.21 21565616 Q95RJ9 P25439 EBI BRM 0.126 22036573 Q95RJ9 Q8T9B6 EBI BOCA 0.126 22036573 Q95RJ9 Q7KBL8 EBI IX 0.126 22036573 Q95RJ9 Q7KTX8 EBI SKD 0.126 22036573 Q95RJ9 P21461 EBI SINA 0.837 11032805,17561381 Q95RJ9 Q27934 EBI PHYL 0.884 11032805 Q95RJ9 A1ZBT5 EBI MED8 0.126 22036573 Q95RJ9 P08044 EBI SNA 0.376 18309295 Q95RJ9 P17789 EBI TTK 0.309 11032805 Q95RJ9 Q8MSX2 EBI MED6 0.126 22036573 Q95RJ9 Q8T3Y0 EBI SINAH 0.623 17561381 Q9GYU7 Q95RJ9 MED10 EBI 0.126 22036573 Q9GYV9 Q95RJ9 MED7 EBI 0.126 22036573 Q9I7T7 Q95RJ9 Q9I7T7 EBI 0.126 22036573 Q9VDR1 Q95RJ9 MED25 EBI 0.126 22036573 Q9VEC1 Q95RJ9 MED17 EBI 0.126 22036573 Q9VNC2 Q95RJ9 HDAC3 EBI 0.376 18309295 Q9VNG0 Q95RJ9 MED27 EBI 0.126 22036573 Q9VS38 Q95RJ9 MED4 EBI 0.126 22036573 Q9VSH4 Q95RJ9 Q9VSH4 EBI 0.126 22036573 Q9VVS4 Q95RJ9 MED11 EBI 0.126 22036573 Q9VYG2 Q95RJ9 BAP60 EBI 0.126 22036573 Q9W0P3 Q95RJ9 MED30 EBI 0.126 22036573 Q9W0P8 Q95RJ9 MED14 EBI 0.126 22036573 Q9W1X7 Q95RJ9 MED23 EBI 0.126 22036573 Q9W278 Q95RJ9 MED16 EBI 0.126 22036573 Q9XZT1 Q95RJ9 MED18 EBI 0.126 22036573 Q9Y149 Q95RJ9 MED15 EBI 0.126 22036573 Q9VT57 Q95RJ9 CDK8 EBI 0.126 22036573 Q95RJ9 P91641 EBI MED20 0.126 22036573 Q95RJ9 P42282 EBI TTK 0.569 11032805 Q95RJ9 P51140 EBI DSH 0.126 22036573