PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG15071 Ubc7 14605208 biogrid,intact exp G Ubiquitin thioesterase otubain-like Ubc7 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G CG5482, isoform A, CG5482, isoform B, CG5482, isoform C, CG5482, isoform D, LD36412p Ubc7 14605208 biogrid,intact exp G G G G G G G G G G Ubc7 Rae1 22036573 biogrid exp G G G G G G G G G G LD45836p, Vacuolar protein sorting 37B, isoform A, Vacuolar protein sorting 37B, isoform B, Vacuolar protein sorting 37B, isoform C Ubc7 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G CG1227, isoform A, CG1227, isoform B, LD17053p Ubc7 ortho G G G G G G G G G CathD, Cathepsin D, SD07085p Ubc7 ortho G G G G G G G G G G Hsc70-5 Ubc7 ortho G G G G G G G G G G r Ubc7 ortho G G Solute carrier family 35 member E1 homolog Ubc7 ortho G G G G G G G G G EG:152A3.5 protein (Fbgn0003116, GH15456p, PRUNE protein, Prune Ubc7 ortho G G G G G G G G G CG11089-RA Ubc7 ortho Psa-RC Ubc7 ortho G G G G G G G G G G SdhB Ubc7 ortho G G G G G G G G G G CG5313-PA, Replication factor C subunit 3, SD11293p Ubc7 ortho G G CG6766-RA Ubc7 ortho G G G G G G G G G G E3 ubiquitin-protein ligase parkin Ubc7 ortho G G G G G G G G G Nuclear GTP binding protein, Nucleostemin ortholog 2, SD10213p Ubc7 ortho G G CG33158 Ubc7 ortho G G G Ubc7 sec10 ortho G G G G G G G G G G CG9515, isoform B, CG9515-PA, isoform A Ubc7 ortho dod Ubc7 ortho G G G G Ubc7 pex10 ortho G G G G G G G G G G Eukaryotic initiation factor 4A-III, eIF-4A-III, eIF4A-III Ubc7 ortho G G G G G G G G G G Coprox Ubc7 ortho G G G G G G G G G G vps24 Ubc7 ortho G G G G G G G G G G spel1 Ubc7 ortho G G G G Trim9, isoform B Ubc7 ortho G G G FI02023p, Qless, isoform A, Qless, isoform B Ubc7 ortho G G G G G G G G Immune response deficient 1, isoform A Ubc7 ortho G G G G G G G G G Adaptor protein complex 1, mu subunit, Clathrin-associated adaptor complex AP-1 medium chain, Clathrin-associated protein, LD31377p Ubc7 ortho G G G G G G G G G G mgr Ubc7 ortho G G G G G G G G G G Elp1 Ubc7 ortho G G G G G G G G CG6745, GH24787p Ubc7 ortho G CG4433-RB Ubc7 ortho G G G G G G G G G Pka-R2 Ubc7 ortho G G G G G G G G CG7656-RA Ubc7 ortho G G G G G G G G G G Xeroderma pigmentosum D ortholog Ubc7 ortho G G G wol Ubc7 ortho G G G G G G G G G G Jafrac1 Ubc7 ortho G G G G G G G G G G Ubc7 LD37736p, Zpr1 ortho G G G G G G G G G G Trc8 Ubc7 ortho G G G G G G G G G G Rab1-RA Ubc7 ortho G G G G G G G G G G RpA-70 Ubc7 ortho G G G G G G G G G G D-Importin 7/RanBP7, FI03666p, Moleskin Ubc7 ortho G G G G G G G G G G hoip Ubc7 ortho RE58623p, Serine palmitoyltransferase subunit I, isoform A, Serine palmitoyltransferase subunit I, isoform B, Serine palmitoyltransferase subunit I, isoform C Ubc7 ortho G G G G G G G G G G LD29171p, Sec71 ortholog Ubc7 ortho G G G G G G G G G G NAA20 ortholog, isoform B Ubc7 ortho G G G G G G G G G G CG31739, isoform A, CG31739, isoform B, CG31739, isoform C, SD02215p Ubc7 ortho G G G G G G G G G G Chondrocyte-derived ezrin-like domain containing protein ortholog, isoform E, SD10794p Ubc7 ortho G G G G G G G G G G Cpsf73 Ubc7 ortho G G G G G G G G Gos28 Ubc7 ortho G G G G G G G G G G bai Ubc7 ortho G G G G G G G G G G 26S proteasome non-ATPase regulatory subunit 9 Ubc7 ortho G G G G G G G G G G SD21818p, Seryl-tRNA synthetase, isoform A, Seryl-tRNA synthetase, isoform B Ubc7 ortho G G G G G G G G G CG11306, isoform A, CG11306, isoform B, HL02815p, RE27026p Ubc7 ortho G G G G G G G G G G Probable DNA-directed RNA polymerase III subunit RPC6, DNA-directed RNA polymerase III subunit F, RNA polymerase III subunit C6 Ubc7 ortho G G G G G G CG18048, RE67941p Ubc7 ortho G G G LD31102p, MAPK phosphatase 4, isoform B, MAPK phosphatase 4, isoform C Ubc7 ortho G G G G G G G G Rpd3 Ubc7 ortho G G G G G G G G G RpS13 Ubc7 ortho G G G G G G G G G G Ubc7 l(1)G0022 ortho G G G G G G G G G G Proteasome-associated protein ECM29 homolog Ubc7 ortho G G G G G G G G G G Hsp60 Ubc7 ortho G G G G G G G G G G GH24511p, Ubiquitin activating enzyme 1, isoform A Ubc7 ortho G G G G G G G G G G AT19154p, Synthesis of cytochrome c oxidase Ubc7 ortho G G G G G G G G G G l(2)tid Ubc7 ortho G G G G G G G G G G Ubc7 EG:33C11.2 ortho G Ubc7 CG1375 ortho G G G G G G G G G Ubc7 Coq5 ortho G G G G G G G G G Ubc7 CG2253-PA, RE04053p ortho G Probable ATP-dependent RNA helicase CG8611 Ubc7 ortho G RpII215 Ubc7 ortho G G G G G G G G G G Ubc7 HBS1-RA ortho G G G G G G G G G G Ubc7 CG2875-RB ortho G G G G G G Aats-val Ubc7 ortho G G G G G G G G G Walrus, isoform A, Walrus, isoform B Ubc7 ortho G G G G G G G G G G CG11851, LD40966p Ubc7 ortho G G G G G G G G G G Bem46, Bem46-like protein Ubc7 ortho G G G G G G G G G G Pis Ubc7 ortho G G G G G G G G G G viaf Ubc7 ortho G G G G G G G G G G ATPsyn-gamma Ubc7 ortho G G G G G G G G G G Nedd4 Ubc7 ortho G G G G G G G G G RpI1 Ubc7 ortho G G G G G G G G G G SkpA Ubc7 ortho G G G G G G G G G G Kdm2 Ubc7 ortho G G G G G G G G G CG4957 Ubc7 ortho G G G G G G G G G G CG8549, isoform B, CG8549-PA Ubc7 ortho G G G G G G G G G G Nop56-RA Ubc7 ortho G G G G G G G G G G DNApol-alpha180 Ubc7 ortho G CG15100 Ubc7 ortho G G G G G G G G G G Ubc7 Roc1a ortho G G G G G G G G G Fdxh Ubc7 ortho G G G G G G G G G G CG1645 Ubc7 ortho G G Npl4 Ubc7 ortho G G G G G G G G G G Sply Ubc7 ortho G G G G G G G G G G Cpr Ubc7 ortho G G G G G G G G G G Aminopeptidase P, Aminopeptidase P, isoform A, Aminopeptidase P, isoform B, LD20901p Ubc7 ortho G G G G G G G G G G UbcE2H Ubc7 ortho G G G G G G G G G G CG5823, isoform A, CG5823, isoform B, HL05730p, RE16955p Ubc7 ortho G G G G G G G G G G Coq3 Ubc7 ortho G G G G G G G G G G D-tyrosyl-tRNA(Tyr) deacylase Ubc7 ortho G G G G G G G G CG14544, SD21096p Ubc7 ortho G RpS27A Ubc7 ortho G G G G G G G G G G Hel25E Ubc7 ortho G G G G G G G G G G Atg18 Ubc7 ortho G G G G G G G G G G CG33230-RA Ubc7 ortho G G G G G G G G G G Probable trans-2-enoyl-CoA reductase, mitochondrial Ubc7 ortho G G G G G G G G G G WD repeat-containing protein 59 homolog Ubc7 ortho G G G G G G G G G Ubc7 CG1291-PA, RE67594p ortho G G G G G G G G G CG3409-RA Ubc7 ortho G G G G G G G G G S-adenosylmethionine mitochondrial carrier protein homolog Ubc7 ortho G G G G G G G G G G As Ubc7 ortho G G G G G G G G G G Ubc7 SMC3 ortho G G Uncharacterized protein CG9548 Ubc7 ortho G G G G G G G G G G Ubc7 Ubc7 ortho G G G G G G G G G G Act5C Ubc7 ortho G G G G G G G G G G Ubc7 Cas ortho G G G G G G G G G G CG5205 Ubc7 ortho G G G G G G G G G G CG10483, GH26628p Ubc7 ortho G G G G LD22577p, Smt3 activating enzyme 2 Ubc7 ortho G G G G G G G G G G Ubc7 Arfrp1 ortho G G G G G G G G G G CG5828, isoform A, CG5828, isoform B Ubc7 ortho G G G G G G G G G G Ubi-p63E Ubc7 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A1ZBC3 Q9VXE8 - 14605208 - X 2 Q9VXE8 Q9VN88 - 14605208 - X 2 Q9VXE8 Q9VL00 - 14605208 - X 2 Q9VXE8 Q7K3D4 - 14605208 - X 2 A1ZBC3 Q9VXE8 two hybrid 14605208 direct interaction X 2 Q9VXE8 Q9VN88 two hybrid 14605208 direct interaction X 2 Q9VXE8 Q9VL00 two hybrid 14605208 direct interaction X 2 Q9VXE8 Q7K3D4 two hybrid 14605208 direct interaction X 2 Q9W2E7 Q9VXE8 affinity chromatography technology 22036573 physical association X 2 A1ZBC3 Q9VXE8 two hybrid 14605208 physical association X 2 Q9VXE8 Q9VN88 two hybrid 14605208 physical association X 2 Q9VXE8 Q9VL00 two hybrid 14605208 physical association X 2 Q9VXE8 Q7K3D4 two hybrid 14605208 physical association X 2 A1ZBC3 Q9VXE8 two hybrid 14605208 physical association X 2 Q9VXE8 Q9VN88 two hybrid 14605208 physical association X 2 Q9VXE8 Q9VL00 two hybrid 14605208 physical association X 2 Q9VXE8 Q7K3D4 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CG4968 crl MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|(biogrid) MINT_15179|UniProt_50608|BIOGRID_33265 bait|bait|prey prey|prey|bait crl CG15071 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_59629|BIOGRID_31816 bait|prey prey|bait Q9V8K4 crl MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_15180 prey bait Q9V8L1 crl MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_8000 prey bait CG5482 crl MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_50609|BIOGRID_33266 prey|prey bait|bait Rae1 crl MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71929 prey bait CG1115 crl MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_54397|MINT_23592|BIOGRID_30265 bait|bait|bait prey|prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VXE8 Q7K3D4 CRL Q7K3D4 0.183 14605208 Q9VXE8 Q9VL00 CRL Q9VL00 0.183 14605208 Q9VXE8 Q9VN88 CRL VPS37B 0.183 14605208 Q9VXE8 A1ZBC3 CRL A1ZBC3 0.183 14605208