PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus air-2 lin-10 21110867 intact exp Inhibitor of apoptosis homolog, T27F2.3 air-2 12707312 biogrid exp air-2 LIN-7 21110867 intact exp air-2 F02E8.1 14704431 biogrid,i2d,mint,intact,dip exp air-2 wrn-1 11778048,14704431 biogrid,i2d,mint,intact exp air-2 W03F11.6a 21110867 intact exp air-2 Uncharacterized serine carboxypeptidase F41C3.5 14704431 biogrid,i2d,mint,intact,dip exp air-2 C14F11.6 14704431 biogrid,i2d,mint,intact,dip exp Incenp-like protein ICP-1, Y39G10AR.13a air-2 18692475,unassigned701,11050385,12707312,15916946,14704431 biogrid,intact exp K01A6.2a air-2 21110867 intact exp air-2 T25C8.2 14704431 biogrid exp air-2 csc-1 12707312 biogrid exp air-2 air-2 15916946 i2d,intact exp, ortho air-2 tlk-1 15916946 intact exp, ortho air-2 pas-5 ortho air-2 arx-4 ortho air-2 rpl-12 ortho air-2 rpl-38 ortho air-2 cks-1 ortho air-2 M04F3.4a, M04F3.4b ortho air-2 ess-2 ortho air-2 rps-1 ortho CTP synthase air-2 ortho air-2 pas-6 ortho fbp air-2 ortho air-2 hmp-2 ortho air-2 F53C11.7 ortho air-2 F41E6.9 ortho klp-6 air-2 ortho air-2 W07G4.3 ortho air-2 rpl-22 ortho air-2 gsp-2 ortho air-2 C44C8.6 ortho air-2 C13F10.4 ortho air-2 T04A8.11 ortho air-2 hsp-60 ortho air-2 rps-16 ortho air-2 Probable trans-2-enoyl-CoA reductase 1, mitochondrial ortho air-2 C26E6.3 ortho air-2 mrpl-24 ortho air-2 daf-21 ortho air-2 B0286.4a ortho air-2 rpa-0 ortho air-2 hsp-1 ortho air-2 rpl-23 ortho air-2 Y54G2A.31 ortho air-2 trs-1 ortho air-2 cdk-8 ortho air-2 T24F1.3a ortho air-2 pfk-1 ortho air-2 pcm-1 ortho air-2 hda-1 ortho air-2 pas-1 ortho air-2 emo-1 ortho air-2 eef-2 ortho R08C7.10b air-2 ortho air-2 Transcription elongation factor 1 homolog ortho air-2 rha-1 ortho air-2 R11H6.5 ortho air-2 C17G10.2 ortho air-2 pph-6 ortho air-2 rps-6 ortho air-2 rpia-1 ortho air-2 ZK742.1a ortho air-2 T23H2.5 ortho air-2 rps-5 ortho air-2 hsp-6 ortho air-2 Probable DNA topoisomerase 2 ortho air-2 Y110A7A.4 ortho air-2 T25D3.2 ortho air-2 Y39B6A.39a ortho air-2 Proteasome subunit beta type ortho air-2 lin-40 ortho air-2 lig-1 ortho air-2 pcn-1 ortho ZK1307.8 air-2 ortho air-2 rps-14 ortho air-2 irs-1 ortho air-2 C14A4.14 ortho air-2 cdc-37 ortho air-2 vrk-1 ortho air-2 Y106G6H.3a ortho air-2 apl-1 ortho air-2 rps-27 ortho air-2 C47E12.5a ortho air-2 pig-1 ortho air-2 dcr-1 ortho air-2 Uncharacterized protein T27F2.1 ortho air-2 gsk-3 ortho air-2 rsp-3 ortho air-2 rps-3 ortho air-2 rps-4 ortho air-2 kin-3 ortho air-2 mek-2 ortho Calumenin-like protein, M03F4.7a air-2 ortho air-2 hda-6 ortho air-2 cdk-1 ortho air-2 tbb-4 ortho air-2 gsp-1 ortho air-2 K07G5.2 ortho air-2 M03A8.2 ortho air-2 crn-1 ortho air-2 DNA helicase ortho air-2 F40F11.1 ortho air-2 rpl-27 ortho air-2 ccf-1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O01427 G5EE37 - 15916946 - X 2 O01427 Q19126 - 14704431 - X 2 O01427 G5EE37 - 15916946 - X 2 O01427 G5EE37 - 14704431 - X 2 O01427 O01427 - 15916946 - X 2 Q17993 O01427 - 14704431 - X 2 O01427 Q19546 - 11778048 - X 2 O01427 Q19546 - 12679813 - X 2 O01427 P52717 - 14704431 - X 2 O01427 G5EE37 two hybrid 18692475 direct interaction X 2 O01427 Q19126 two hybrid 14704431 direct interaction X 2 O01427 G5EE37 two hybrid 14704431 direct interaction X 2 O01427 G5EE37 pull down 12707312 direct interaction X 2 O01427 O45952 pull down 12707312 direct interaction X 2 O01427 G5EE37 pull down 12707312 direct interaction X 2 O01427 G5EE37 pull down 11050385 direct interaction X 2 Q17993 O01427 two hybrid 14704431 direct interaction X 2 O01427 P52717 two hybrid 14704431 direct interaction X 2 O01427 Q19546 two hybrid 14704431 direct interaction X 2 O01427 O45815 two hybrid 14704431 direct interaction X 2 G5EFA2 O01427 pull down 12707312 direct interaction X 2 O01427 Q19126 two hybrid 14704431 physical association X 2 O01427 G5EE37 two hybrid 14704431 physical association X 2 Q17993 O01427 two hybrid 14704431 physical association X 2 O01427 P52717 two hybrid 14704431 physical association X 2 O01427 protein kinase assay 15916946 phosphorylation reaction C 3 O01427 G5EE37 two hybrid pooling approach 14704431 physical association X 2 O01427 Q19126 two hybrid pooling approach 14704431 physical association X 2 O01427 O01427 protein kinase assay 15916946 phosphorylation reaction X 2 O01427 P34314 anti bait coimmunoprecipitation 15916946 physical association X 2 O01427 P34314 two hybrid 15916946 physical association X 2 O01427 G5EE37 protein kinase assay 15916946 phosphorylation reaction X 2 O01427 G5EE37 two hybrid - physical association X 2 P90976 O01427 anti tag coimmunoprecipitation 21110867 physical association X 2 O17583 O01427 two hybrid pooling approach 21110867 physical association X 2 O17583 O01427 anti tag coimmunoprecipitation 21110867 physical association X 2 Q17993 O01427 two hybrid pooling approach 14704431 physical association X 2 O01427 Q19546 two hybrid pooling approach 11778048 physical association X 2 O01427 P52717 two hybrid pooling approach 14704431 physical association X 2 O01427 Q9BIC1 anti tag coimmunoprecipitation 21110867 physical association X 2 C1P635 O01427 anti tag coimmunoprecipitation 21110867 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B air-2 bir-1 MI:0004(affinity chromatography technology) 12707312 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28273 bait prey air-2 wrn-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 11778048,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(intact)|(biogrid) 113670|MINT_302|UniProt_1352|BIOGRID_22370 prey|prey|prey|prey bait|bait|bait|bait air-2 uniprotkb:(gene name) MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22425 prey bait air-2 asb-2 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0465(dip)|(biogrid)|MI:0471(mint) UniProt_29422|DIP_1035|BIOGRID_21250|MINT_6562 bait|-|bait|bait prey|-|prey|prey air-2 act-5 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_24296 prey bait air-2 air-2 MI:0018(two hybrid) 15916946 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0217(phosphorylation reaction) (intact) UniProt_503 self self air-2 F41C3.5 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|MI:0471(mint)|(biogrid) DIP_1036|UniProt_29420|MINT_6563|BIOGRID_21251 -|bait|bait|bait -|prey|prey|prey air-2 icp-1 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0018(two hybrid) 11050385,12707312,14704431,15916946,18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_29421|BIOGRID_28887|BIOGRID_28274|UniProt_506|UniProt_24738|BIOGRID_28271|BIOGRID_28313|BIOGRID_21252 bait|bait|bait|neutral component|bait|prey|prey|bait prey|prey|prey|neutral component|prey|bait|bait|prey air-2 C14F11.6 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip)|(biogrid)|(intact) MINT_6561|DIP_1034|BIOGRID_21249|UniProt_29419 bait|-|bait|bait prey|-|prey|prey air-2 csc-1 MI:0004(affinity chromatography technology) 12707312 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28272 bait prey air-2 afd-1 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22426 prey bait air-2 magi-1 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22417 prey bait air-2 tlk-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15916946 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_502|UniProt_501|UniProt_507 neutral component|bait|bait neutral component|prey|prey air-2 lin-10 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_21779|UniProt_22401 prey|prey bait|bait air-2 Q9GSQ0 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,18692475 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) DIP_1037|MINT_3910|MINT_3911|MINT_3909|MINT_6564|MINT_3908 -|bait|bait|bait|bait|bait -|prey|prey|prey|prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9GSQ0 O01427 Q9GSQ0 AIR-2 0.21 14704431,18692475 O17583 O01427 LIN-10 AIR-2 0.236 21110867 P34314 O01427 TLK-1 AIR-2 0.472 15916946 O01427 C1P635 AIR-2 MAGI-1 0.126 21110867 O01427 G5EE37 AIR-2 ICP-1 0.309 unassigned701,14704431,15916946 O01427 O01427 AIR-2 AIR-2 0.065 15916946 O45952 O01427 CSC-1 AIR-2 0.309 12707312 P52717 O01427 P52717 AIR-2 0.309 14704431 P90976 O01427 P90976 AIR-2 0.126 21110867 Q17993 O01427 Q17993 AIR-2 0.155 14704431 Q19126 O01427 ASB-2 AIR-2 0.155 14704431 Q19546 O01427 WRN-1 AIR-2 0.286 14704431,11778048 Q9BIC1 O01427 AFD-1 AIR-2 0.126 21110867