PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Probable multifunctional protein ADE2, AIRC ced-2 23549480 intact exp G F52C6.3 ced-2 23549480 intact exp clik-1 ced-2 23549480 intact exp G chc-1 ced-2 23549480 intact exp G Adenomatous polyposis coli protein-related protein 1, APC-related protein 1 ced-2 20126385 biogrid,dip exp G C02F4.1, CED-5 ced-2 21616056 biogrid exp, ortho G ced-12 ced-2 11703940 intact exp, ortho G Non-specific protein-tyrosine kinase ced-2 ortho G rps-3 ced-2 ortho G rpl-33 ced-2 ortho G NMDA-type ionotropic glutamate receptor NMR-2, T01C3.10a ced-2 ortho G rha-1 ced-2 ortho G cct-5 ced-2 ortho G spr-2 ced-2 ortho G daf-21 ced-2 ortho G ced-2 ced-2 ortho G Y50E8A.4a ced-2 ortho T07F12.1 ced-2 ortho gsp-2 ced-2 ortho G H27M09.1 ced-2 ortho G daf-2 ced-2 ortho G rps-5 ced-2 ortho G cor-1 ced-2 ortho rpt-4 ced-2 ortho G F40F4.5 ced-2 ortho G PX domain-containing protein F17H10.3 ced-2 ortho G C44E4.4 ced-2 ortho G rpl-23 ced-2 ortho G R12E2.1 ced-2 ortho ZK742.1a ced-2 ortho G hsp-6 ced-2 ortho G C30F8.4a ced-2 ortho G F16D3.1 ced-2 ortho Enhancer of rudimentary homolog ced-2 ortho G jnk-1 ced-2 ortho G rpt-3 ced-2 ortho G sem-5 ced-2 ortho G F22G12.4a ced-2 ortho rps-13 ced-2 ortho G Y110A7A.8 ced-2 ortho G C04F1.3, CeLIM-7 ced-2 ortho G Phosphoinositide 3-kinase adapter subunit, Y110A7A.10 ced-2 ortho G C27A7.4 ced-2 ortho G fln-1 ced-2 ortho G T22D1.9 ced-2 ortho G tbb-4 ced-2 ortho G T08G11.3 ced-2 ortho G T28F12.3 ced-2 ortho G Putative DEAD-box RNA helicase, Y71H2AM.19b ced-2 ortho G ced-2 T10B5.5a ortho G T07A9.11 ced-2 ortho G vms-1 ced-2 ortho G rpt-2 ced-2 ortho G age-1 ced-2 ortho G gta-1 ced-2 ortho G Y46G5A.19b ced-2 ortho G cgh-1 ced-2 ortho G hsp-1 ced-2 ortho G C55F2.1b ced-2 ortho G top-3 ced-2 ortho cel-1 ced-2 ortho G Y48G10A.1 ced-2 ortho G F33G12.2 ced-2 ortho G K04G2.6 ced-2 ortho rps-25 ced-2 ortho G LIM and SH3 domain protein F42H10.3 ced-2 ortho G tRNA-splicing ligase RtcB homolog ced-2 ortho G Y71H2AM.11 ced-2 ortho G sta-1 ced-2 ortho G Y39G10AR.8 ced-2 ortho G Y41G9A.4b ced-2 ortho G eef-1G ced-2 ortho G dpy-23 ced-2 ortho G C16A3.8 ced-2 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q21227-2 Q9NHC3 two hybrid 20126385 direct interaction X 2 G5EEN3 Q9NHC3 pull down 21616056 direct interaction X 2 G5EEN3 Q9NHC3 pull down 21616056 direct interaction X 2 Q21227-2 Q9NHC3 two hybrid 20126385 direct interaction X 2 Q21227-2 Q9NHC3 two hybrid 20126385 direct interaction X 2 Q9NHC3 three hybrid 11703940 physical association C 3 Q10457 Q9NHC3 two hybrid 23549480 physical association X 2 Q23050 Q9NHC3 two hybrid 23549480 physical association X 2 Q9NHC3 P34574 two hybrid 23549480 physical association X 2 O44820 Q9NHC3 two hybrid 23549480 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NHC3 Q10457 CED-2 Q10457 0.183 23549480 Q9NHC3 O44820 CED-2 O44820 0.183 23549480 Q9NHC3 Q23050 CED-2 Q23050 0.183 23549480 Q9NHC3 Q8STE5 CED-2 CED-12 0.21 11703940 Q9NHC3 P34574 CED-2 CHC-1 0.183 23549480 Q9NHC3 Q21227 CED-2 APR-1 0.523 20126385