PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus cul-1 Y37D8A.16 14704431 biogrid,i2d exp G asna-1 cul-1 14704431 biogrid,i2d exp G F15C11.2a cul-1 14704431 biogrid exp G asp-3 cul-1 14704431 biogrid,i2d exp G cul-1 zer-1 17304241 biogrid exp G F46A9.5 cul-1 18718460 biogrid exp G cul-1 R05F9.10 14704431 biogrid,i2d exp, ortho G cul-1 dre-1 ortho G cul-1 ATP synthase subunit alpha, mitochondrial ortho G Serine/threonine-protein phosphatase cul-1 ortho G hsp-60 cul-1 ortho G cul-1 cul-5 ortho cul-1 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase F56D2.6 ortho G cul-1 snr-4 ortho G lin-23 cul-1 ortho G cul-1 uba-3 ortho G rps-5 cul-1 ortho G cul-1 F01G4.2a ortho G rpl-35 cul-1 ortho G cul-1 D2096.8 ortho G cct-4 cul-1 ortho G cul-1 C04F12.4 ortho G hsp-6 cul-1 ortho G tbb-4 cul-1 ortho G cul-1 snr-7 ortho G cul-1 T22D1.10 ortho G cul-1 tag-72 ortho G hmp-2 cul-1 ortho G cul-1 C26F1.4 ortho G eef-1G cul-1 ortho G tpi-1 cul-1 ortho G R11H6.5 cul-1 ortho G cul-1 Y37E3.8a ortho G B0205.3 cul-1 ortho G cul-1 T08B2.9a ortho G cul-1 rpl-43 ortho G WW domain-containing protein ZK1098.1 cul-1 ortho G cul-1 T12A2.7 ortho G cul-1 cri-3 ortho G cul-1 F48E3.3 ortho G cul-1 rrt-1 ortho G cul-1 Y54H5A.1 ortho G cul-1 cks-1 ortho G ncbp-1 cul-1 ortho G cul-1 ned-8 ortho G rpl-38 cul-1 ortho G cul-1 F58E10.3a ortho G Putative DEAD-box RNA helicase, Y71H2AM.19b cul-1 ortho G cul-1 JC8.2 ortho G rpl-4 cul-1 ortho G mceIA cul-1 ortho G cul-1 dcaf-1 ortho G cul-1 prdx-3 ortho G cul-1 Y46E12BL.2a ortho G cul-1 K08D10.4 ortho G cul-1 brap-2 ortho G uaf-1 cul-1 ortho G cul-1 rpl-10a ortho G cul-1 K08E3.4 ortho G rps-17 cul-1 ortho G cul-1 rbx-1 ortho G Putative pyridoxal kinase cul-1 ortho G cul-1 rps-6 ortho G cul-1 C44B7.2a ortho cul-1 T02C12.3 ortho G C24H12.4a cul-1 ortho G ZK1307.6 cul-1 ortho cul-1 rpl-8 ortho G cul-1 rps-27 ortho G B0511.6 cul-1 ortho G cul-1 wdr-5.1 ortho G pas-6 cul-1 ortho G rpl-12 cul-1 ortho G ers-1 cul-1 ortho G rpl-19 cul-1 ortho G cul-1 K08D10.3a ortho G cul-1 cul-1 ortho G cul-1 rps-23 ortho G cct-2 cul-1 ortho G cul-1 Uncharacterized protein T27F2.1 ortho G cul-1 pas-4 ortho G rps-1 cul-1 ortho G Lon protease homolog, mitochondrial cul-1 ortho G cul-1 F29D10.4 ortho G cul-1 Y53F4B.22a ortho G W09D10.3 cul-1 ortho G K11C4.3c cul-1 ortho G cul-1 F10G7.8 ortho G rps-8 cul-1 ortho G pcn-1 cul-1 ortho sdhb-1 cul-1 ortho G cul-1 T24B8.1a ortho G cul-1 chk-1 ortho G cul-1 Y48G8AL.5a ortho trs-1 cul-1 ortho G let-70 cul-1 ortho G cul-1 pcm-1 ortho G chc-1 cul-1 ortho G rpl-24.1 cul-1 ortho G cyn-1 cul-1 ortho G cul-1 T24H10.3 ortho G cul-1 pkd-2 ortho cul-1 F40F11.1 ortho G CTP synthase cul-1 ortho rpl-33 cul-1 ortho G cul-1 nlk ortho G cul-1 xrn-2 ortho G cul-1 enol-1 ortho cul-1 Y38C1AA.11 ortho G R10A10.2 cul-1 ortho G cul-1 C29F9.7 ortho G cul-1 eef-1B.2 ortho G cul-1 jmjd-2 ortho cul-1 W02D3.11a ortho G cul-1 K10B3.10b ortho G cul-1 Y113G7A.3 ortho G cul-1 rps-9 ortho G F53A3.3a cul-1 ortho G drs-1 cul-1 ortho G cul-1 T24F1.3a ortho G rps-14 cul-1 ortho G cul-1 Y56A3A.32a ortho G cul-1 rpl-31 ortho G rpl-5 cul-1 ortho G rps-0 cul-1 ortho G rps-12 cul-1 ortho G cul-1 pas-2 ortho G rpl-13 cul-1 ortho G cul-1 mlc-5 ortho G F48E8.7a cul-1 ortho rpl-27 cul-1 ortho G cul-1 rpa-0 ortho G cul-1 F52B10.1 ortho G DNA polymerase delta catalytic subunit cul-1 ortho G rps-21 cul-1 ortho G cul-1 rps-28 ortho G cul-1 pbs-3 ortho G mfb-1 cul-1 ortho G cul-1 T03F6.1 ortho G rps-2 cul-1 ortho G nath-10 cul-1 ortho G snr-3 cul-1 ortho G Uncharacterized F-box/LRR-repeat protein C02F5.7 cul-1 ortho G cul-1 fsn-1 ortho G rpl-23 cul-1 ortho G csn-2 cul-1 ortho cul-1 pas-3 ortho G C44E4.4 cul-1 ortho G cul-1 cdk-9 ortho G tRNA-splicing ligase RtcB homolog cul-1 ortho G trr-1 cul-1 ortho G rps-13 cul-1 ortho G cul-1 cct-8 ortho G Probable rRNA-processing protein EBP2 homolog cul-1 ortho G cul-1 C47E12.5a ortho G gsp-2 cul-1 ortho G cul-1 daf-21 ortho G tag-320 cul-1 ortho G rpl-10 cul-1 ortho G eef-2 cul-1 ortho G cul-1 C14A4.14 ortho G cand-1 cul-1 ortho G rps-3 cul-1 ortho G cul-1 mdt-6 ortho cul-1 rps-16 ortho G rpl-21 cul-1 ortho G cul-1 rha-1 ortho G cul-1 rpl-16 ortho G cul-1 cul-3 ortho G F09E5.15b cul-1 ortho G mlc-4 cul-1 ortho G DNA-binding protein LAG-1, K08B4.1a, Lag-1 protein cul-1 ortho G Uncharacterized protein C30C11.4 cul-1 ortho G cul-1 Proteasome subunit beta type ortho G Uncharacterized cyclin-like protein ZK353.1 cul-1 ortho G cul-1 rpl-9 ortho G cul-1 cul-2 ortho G T08A11.2 cul-1 ortho G C02F4.1, CED-5 cul-1 ortho G D1081.8 cul-1 ortho G cul-1 rps-4 ortho G cul-1 csn-6 ortho G cul-1 T07A9.11 ortho G eef-1B.1 cul-1 ortho G cul-1 pas-5 ortho G SerRS cul-1 ortho G top-1 cul-1 ortho G cul-1 D2089.4a ortho G Y57G11C.16 cul-1 ortho G cul-1 C07H6.4 ortho G cul-1 Y55F3BR.1 ortho G cul-1 K08E3.5b ortho G mrpl-11 cul-1 ortho G cul-1 rack-1 ortho G panl-3 cul-1 ortho G cul-1 pdl-1 ortho G cul-1 M04F3.4a, M04F3.4b ortho G rpl-22 cul-1 ortho G cul-1 gsy-1 ortho G cul-1 krs-1 ortho G R06A4.8 cul-1 ortho G ahcy-1 cul-1 ortho G rpl-6 cul-1 ortho G cul-1 Y73B6BL.33a ortho G cul-1 F23C8.4 ortho G cul-1 Y105E8A.16 ortho G rpl-3 cul-1 ortho G hsp-1 cul-1 ortho G cul-1 atad-3 ortho G cul-1 C17E4.5 ortho G cul-1 mrpl-19 ortho G cul-1 Y47H9C.5a ortho cul-1 dcn-1 ortho cul-1 K08E3.7a ortho G cul-1 npp-17 ortho G cul-1 enpl-1 ortho G cul-1 Y106G6H.3a ortho G cul-1 rps-7 ortho G cul-1 rsp-3 ortho G csn-5 cul-1 ortho G pas-7 cul-1 ortho G cul-1 T01E8.4 ortho G cul-1 ubc-12 ortho G rpl-18 cul-1 ortho G cul-1 mtr-4 ortho G rps-25 cul-1 ortho G cul-1 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial ortho G snr-1 cul-1 ortho G K02F2.3 cul-1 ortho G pas-1 cul-1 ortho G ubq-2 cul-1 ortho G eif-6 cul-1 ortho G ndx-2 cul-1 ortho D2030.2a cul-1 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q17389 G5EFF7 - 14704431 - X 2 Q17389 - 15208641 - C 4 P30632 Q17389 - 14704431 - X 2 Q17389 Q21746 - 14704431 - X 2 Q17389 Q9XWV6 - 14704431 - X 2 Q17389 - 14704431 - X 2 P55956 Q17389 two hybrid 14704431 direct interaction X 2 Q17389 Q2WF59 affinity chromatography technology 17304241 physical association X 2 Q17389 G5EFF7 two hybrid 14704431 direct interaction X 2 G5ECU1 Q17389 two hybrid 18718460 direct interaction X 2 P30632 Q17389 two hybrid 14704431 direct interaction X 2 Q17389 Q21746 two hybrid 14704431 direct interaction X 2 Q17389 Q9XWV6 two hybrid 14704431 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B asna-1 cul-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_22142 prey bait cul-1 Y37D8A.16 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_22141 bait prey cul-1 sgt-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_22140 bait prey asp-3 cul-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_22139 prey bait cul-1 skr-1 MI:0018(two hybrid) 18718460 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28477 bait prey cul-1 zer-1 MI:0004(affinity chromatography technology) 17304241 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_28519 bait prey cul-1 ubql-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_22138 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q2WF59 Q17389 ZER-1 CUL-1 0.21 17304241 Q17389 G5ECU1 CUL-1 SKR-1 0.309 18718460 Q17389 P55956 CUL-1 ASP-3 0.183 14704431 Q17389 P30632 CUL-1 ASNA-1 0.183 14704431