PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZC239.15 lgg-2 19123269 intact exp Major sperm protein lgg-2 19123269 intact exp G lgg-2 ZK121.2 19123269 intact exp G ELMO domain-containing protein C56G7.3 lgg-2 19123269 intact exp lgg-2 Y65B4BR.4a 19123269 intact exp G Uncharacterized protein C06E1.1 lgg-2 19123269 intact exp F18A1.3b, LIR-1A protein lgg-2 19123269 intact exp G ZK1055.7 lgg-2 19123269 intact exp G lgg-2 Y87G2A.3a 19123269,14704431 biogrid,i2d,mint,intact,dip exp, ortho G apl-1 lgg-2 ortho G lgg-2 Y56A3A.21 ortho G rps-17 lgg-2 ortho G lgg-2 ATP synthase subunit alpha, mitochondrial ortho G rps-3 lgg-2 ortho G prdx-3 lgg-2 ortho G pcn-1 lgg-2 ortho pkc-3 lgg-2 ortho G F40F4.5 lgg-2 ortho G lgg-2 pad-2 ortho snr-3 lgg-2 ortho G F39B1.1 lgg-2 ortho G tbb-4 lgg-2 ortho G lgg-2 Y113G7A.3 ortho G cct-2 lgg-2 ortho G rpl-21 lgg-2 ortho G F16D3.1 lgg-2 ortho lgg-2 Y73B6BL.33a ortho G lgg-2 lgg-2 ortho G lgg-2 C53D5.6 ortho G lgg-2 Serrate RNA effector molecule homolog ortho G lgg-2 M04F3.4a, M04F3.4b ortho G F32H2.5 lgg-2 ortho G K02F2.3 lgg-2 ortho G ZC518.2 lgg-2 ortho G K10B3.10b lgg-2 ortho G B0205.3 lgg-2 ortho G F38B6.4 lgg-2 ortho G Protein LTV1 homolog lgg-2 ortho G lgg-2 pcm-1 ortho G F25B4.5 lgg-2 ortho G rpl-3 lgg-2 ortho G rpl-38 lgg-2 ortho G T24F1.3a lgg-2 ortho G rps-13 lgg-2 ortho G hsp-1 lgg-2 ortho G lgg-2 art-1 ortho G D2085.1 lgg-2 ortho G lgg-2 Y38C1AA.11 ortho G dcaf-1 lgg-2 ortho G kin-3 lgg-2 ortho G lin-23 lgg-2 ortho G alx-1 lgg-2 ortho G atg-7 lgg-2 ortho G Ribosomal RNA processing protein 1 homolog lgg-2 ortho G lgg-2 rps-4 ortho G snr-1 lgg-2 ortho G D2089.4a lgg-2 ortho G WW domain-containing protein ZK1098.1 lgg-2 ortho G cct-5 lgg-2 ortho G ZK328.2 lgg-2 ortho G dhc-1 lgg-2 ortho G lgg-2 Y54H5A.1 ortho G adr-2 lgg-2 ortho G lgg-2 Y105E8A.16 ortho G K11C4.3c lgg-2 ortho G lgg-2 C44B7.2a ortho T11G6.8a lgg-2 ortho G S-methyl-5'-thioadenosine phosphorylase lgg-2 ortho G K07E3.4a, K07E3.4b lgg-2 ortho G chc-1 lgg-2 ortho G lgg-2 Y54E10A.6 ortho lgg-2 Y57G11C.10b ortho G gmps-1 lgg-2 ortho G R11H6.5 lgg-2 ortho G lgg-2 C04F12.4 ortho G lgg-2 C14A4.14 ortho G Y45F10A.6a lgg-2 ortho Elongation factor Tu homologue, Y71H2AM.23 lgg-2 ortho G cyn-1 lgg-2 ortho G Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, MCCase subunit beta lgg-2 ortho G lgg-2 Proteasome subunit beta type ortho G F46H5.4 lgg-2 ortho G Putative DEAD-box RNA helicase, Y71H2AM.19b lgg-2 ortho G rpl-4 lgg-2 ortho G lgg-2 W02D3.11a ortho G Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial lgg-2 ortho G lgg-2 Y69A2AR.7a ortho G Uncharacterized protein C30C11.4 lgg-2 ortho G lgg-1 lgg-2 ortho G lgg-2 rpl-17 ortho G Putative pyridoxal kinase lgg-2 ortho G R06B10.5 lgg-2 ortho mog-5 lgg-2 ortho G Ceprp21 lgg-2 ortho G lgg-2 rpl-31 ortho G lgg-2 R151.7a ortho G pink-1 lgg-2 ortho lgg-2 Y47G6A.20b ortho G rps-14 lgg-2 ortho G cct-6 lgg-2 ortho G C31C9.2 lgg-2 ortho G rpl-18 lgg-2 ortho G lgg-2 Y73B6BL.3 ortho G daf-21 lgg-2 ortho G C27H6.2 lgg-2 ortho G F35H12.2b lgg-2 ortho G CTP synthase lgg-2 ortho ahcy-1 lgg-2 ortho G rha-1 lgg-2 ortho G lgg-2 Autophagy protein 5 ortho G dld-1 lgg-2 ortho G Putative pre-mRNA-splicing factor ATP-dependent RNA helicase F56D2.6 lgg-2 ortho G cct-1 lgg-2 ortho G rps-9 lgg-2 ortho G lgg-2 Autophagy-related protein 3 ortho G lgg-2 F58E10.3a ortho G eef-2 lgg-2 ortho G rps-16 lgg-2 ortho G rpl-6 lgg-2 ortho G rab-33 lgg-2 ortho G Calumenin-like protein, M03F4.7a lgg-2 ortho G lgg-2 Y47G6A.11 ortho F09E5.15b lgg-2 ortho G sem-5 lgg-2 ortho G lgg-2 rpa-0 ortho G F49E10.1 lgg-2 ortho G lgg-2 Coatomer subunit beta ortho G lgg-2 Y55F3BR.1 ortho G lgg-2 F25H2.1 ortho cri-3 lgg-2 ortho G lgg-2 T10B5.5a ortho G spr-2 lgg-2 ortho G lgg-2 Y47H9C.5a ortho atp-2 lgg-2 ortho G tag-320 lgg-2 ortho G cct-4 lgg-2 ortho G Probable ornithine aminotransferase, mitochondrial lgg-2 ortho G lgg-2 Y56A3A.32a ortho G ZK1248.10 lgg-2 ortho G mdh-2 lgg-2 ortho G hsp-6 lgg-2 ortho G let-268 lgg-2 ortho tRNA-splicing ligase RtcB homolog lgg-2 ortho G lgg-2 rsp-3 ortho G rpl-5 lgg-2 ortho G rps-8 lgg-2 ortho G eef-1G lgg-2 ortho G lgg-2 snr-7 ortho G pyp-1 lgg-2 ortho G lgg-2 rbg-1 ortho G lgg-2 T22D1.10 ortho G Enhancer of rudimentary homolog lgg-2 ortho G C14A4.2 lgg-2 ortho G drs-1 lgg-2 ortho G lgg-2 Putative U5 small nuclear ribonucleoprotein 200 kDa helicase ortho G lgg-2 rpl-8 ortho G lgg-2 cct-8 ortho G rpl-13 lgg-2 ortho G rps-2 lgg-2 ortho G lgg-2 Y59A8B.6 ortho G C26H9A.2c lgg-2 ortho G lgg-2 xrn-2 ortho G Uncharacterized protein B0303.3 lgg-2 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q23536 - 14704431 - X 2 Q9NA30 Q23536 two hybrid 14704431 direct interaction X 2 Q9NA30 Q23536 two hybrid 14704431 physical association X 2 Q23536 Q9N2Z7 two hybrid pooling approach 19123269 physical association X 2 Q23536 P91563 two hybrid pooling approach 19123269 physical association X 2 Q23536 Q9N2Z7 two hybrid array 19123269 physical association X 2 Q23536 P91563 two hybrid array 19123269 physical association X 2 Q09292 Q23536 two hybrid pooling approach 19123269 physical association X 2 Q09292 Q23536 two hybrid array 19123269 physical association X 2 Q9N4P3 Q23536 two hybrid pooling approach 19123269 physical association X 2 Q9N4P3 Q23536 two hybrid array 19123269 physical association X 2 Q9NA30 Q23536 two hybrid pooling approach 14704431 physical association X 2 Q9NA30 Q23536 two hybrid pooling approach 19123269 physical association X 2 Q9NA30 Q23536 two hybrid array 19123269 physical association X 2 Q23536 G5EBR0 two hybrid pooling approach 19123269 physical association X 2 Q23536 Q9NAM2 two hybrid pooling approach 19123269 physical association X 2 Q23536 O76449 two hybrid pooling approach 19123269 physical association X 2 Q23536 P34296 two hybrid pooling approach 19123269 physical association X 2 Q23536 G5EBR0 two hybrid array 19123269 physical association X 2 Q23536 Q9NAM2 two hybrid array 19123269 physical association X 2 Q23536 O76449 two hybrid array 19123269 physical association X 2 Q23536 P34296 two hybrid array 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B C06E1.1 lgg-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19983|UniProt_18069 prey|prey bait|bait ZK1055.7 lgg-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_21626|UniProt_19714 prey|prey bait|bait lgg-2 atg-4.1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 14704431,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact)|(intact)|(intact)|MI:0471(mint) DIP_4791|BIOGRID_25319|UniProt_21618|UniProt_29183|UniProt_19706|MINT_3348 -|prey|bait|prey|bait|prey -|bait|prey|bait|prey|bait lgg-2 Y105C5B.19 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_21519|UniProt_19602 bait|bait prey|prey lgg-2 wwp-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_21612|UniProt_19698 bait|bait prey|prey lgg-2 ZK121.2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_21632|UniProt_19715 bait|bait prey|prey C56G7.3 lgg-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18519|UniProt_20436 prey|prey bait|bait lgg-2 lir-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18724|UniProt_20641 bait|bait prey|prey ZC239.15 lgg-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19712|UniProt_21622 prey|prey bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NA30 Q23536 ATG-4.1 LGG-2 0.354 19123269,14704431 Q9N2Z7 Q23536 WWP-1 LGG-2 0.236 19123269 Q23536 P91563 LGG-2 P91563 0.236 19123269 Q9NAM2 Q23536 Q9NAM2 LGG-2 0.236 19123269 Q9N4P3 Q23536 Q9N4P3 LGG-2 0.236 19123269 Q23536 G5EBR0 LGG-2 LIR-1 0.236 19123269 Q23536 O76449 LGG-2 O76449 0.236 19123269 Q23536 Q09292 LGG-2 Q09292 0.236 19123269 Q23536 P34296 LGG-2 P34296 0.236 19123269