PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus lin-53 ZK418.4 10615043,14704431 biogrid,i2d,mint,intact exp G C32F10.2, Synthetic multivulva protein LIN-35 Rb lin-53 9875852 biogrid,intact exp G hda-1 lin-53 9875852 biogrid,i2d,intact exp, ortho G lin-53 M03C11.4 18692475,unassigned701,10615043,14704431 biogrid,i2d,mint,intact exp, ortho lin-53 lin-40 18692475,unassigned701,10615043,14704431 biogrid,i2d,mint,intact exp, ortho G klp-6 lin-53 ortho G Histone deacetylase lin-53 ortho G lin-53 rpa-0 ortho G lin-53 C33H5.17 ortho G lin-53 W09B6.2 ortho lin-53 C43H6.3 ortho G Protein disulfide-isomerase lin-53 ortho G kin-3 lin-53 ortho G Thymidine kinase lin-53 ortho lin-53 Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase ortho G psa-4 lin-53 ortho G isw-1 lin-53 ortho G lin-53 set-1 ortho G D1081.8 lin-53 ortho G W01B11.3 lin-53 ortho G lin-53 rbr-2 ortho G lin-53 DNA helicase ortho G lin-53 nhr-69 ortho lin-53 baf-1 ortho lin-9 lin-53 ortho G lin-53 lgg-1 ortho G rpt-3 lin-53 ortho G lin-53 Autophagy protein 5 ortho G B0511.7 lin-53 ortho G lin-53 R07E5.3 ortho G lin-53 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 ortho G lin-53 M01A10.3 ortho G lin-53 pyp-1 ortho G lin-53 Y47D3A.4 ortho lin-53 lin-53 ortho G lin-53 vha-13 ortho G eif-3.C lin-53 ortho G hmp-2 lin-53 ortho G lin-53 hda-6 ortho G lin-53 T06D8.8 ortho G C46A5.9, Host cell factor 1 lin-53 ortho G lin-53 Annexin ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q23482 P90916 - 12679813 - X 2 Q23482 P90916 - 10615043 - X 2 Q23482 P90916 - 12679813 - X 2 P90916 O61907 - 12679813 - X 2 P90916 O61907 - 10615043 - X 2 P90916 - 10615043 - X 2 P90916 - 12679813 - X 2 Q23482 P90916 two hybrid 14704431 direct interaction X 2 P90916 O61907 two hybrid 18692475 direct interaction X 2 P90916 O61907 two hybrid 14704431 direct interaction X 2 O17695 P90916 pull down 9875852 direct interaction X 2 G5EDT1 P90916 pull down 9875852 direct interaction X 2 P90916 two hybrid 18692475 direct interaction X 2 P90916 two hybrid 14704431 direct interaction X 2 Q23482 P90916 two hybrid pooling approach 10615043 physical association X 2 Q23482 P90916 two hybrid array 10615043 physical association X 2 Q21484 P90916 two hybrid pooling approach 10615043 physical association X 2 Q21484 P90916 two hybrid - physical association X 2 P90916 O61907 two hybrid pooling approach 10615043 physical association X 2 P90916 O61907 two hybrid - physical association X 2 Q86S28 P90916 two hybrid - physical association X 2 O17695 P90916 pull down 9875852 physical association X 2 G5EDT1 P90916 pull down 9875852 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B hda-1 lin-53 MI:0096(pull down)|MI:0096(pull down) 9875852 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_28340|UniProt_23246 prey|prey bait|bait lin-53 lin-35 MI:0096(pull down)|MI:0096(pull down) 9875852 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_23244|BIOGRID_28339 bait|bait prey|prey lin-40 lin-53 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 10615043 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|MI:0471(mint) UniProt_1144|UniProt_24557|3312|MINT_1184 prey|prey|prey|prey bait|bait|bait|bait lin-53 hat-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0397(two hybrid array)|MI:0398(two hybrid pooling approach) 10615043,14704431,18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact)|(intact)|MI:0471(mint) UniProt_24528|BIOGRID_29242|BIOGRID_23222|3309|UniProt_1143|MINT_1183 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey lin-53 lin-40 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24605 bait prey lin-53 lin-37 MI:0397(two hybrid array)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0397(two hybrid array)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0397(two hybrid array) 10615043,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact) 3033|3306|MINT_6399|UniProt_1051|MINT_3477|BIOGRID_23224|MINT_1185|UniProt_1142 prey|bait|prey|prey|prey|bait|bait|bait bait|prey|bait|bait|bait|prey|prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86S28 P90916 LIN-40 LIN-53 0.183 unassigned701 P90916 O61907 LIN-53 LIN-40 0.286 10615043,unassigned701 P90916 O17695 LIN-53 HDA-1 0.309 9875852 Q21484 P90916 HAT-1 LIN-53 0.286 10615043,unassigned701 Q23482 P90916 LIN-37 LIN-53 0.236 10615043