PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus C17H11.6d par-6 21110867 intact exp G B0001.1a par-6 21110867 intact exp G W10D9.4 par-6 21110867 intact exp G F07A11.2a par-6 21110867 intact exp Y39B6A.46 par-6 21110867 intact exp F48E3.8a par-6 21110867 intact exp par-6 par-6 21110867 intact exp G par-6 Y11D7A.14 21110867 intact exp G fem-2 par-6 18502413 biogrid exp H06I04.1a par-6 21110867,14704431 biogrid,i2d,mint,intact,dip exp G F53B3.1 par-6 21110867,14704431 biogrid,i2d,mint,intact,dip exp ZK849.2a par-6 14704431 i2d,mint,intact,dip exp G T09E8.1c par-6 18692475,21110867,unassigned701 biogrid,intact exp Proteasomal ubiquitin receptor ADRM1 homolog par-6 21110867 intact exp G pac-1 par-6 21110867,unassigned1274 intact exp G Uncharacterized protein R06F6.12 par-6 21110867 intact exp G fem-1 par-6 18502413 biogrid exp G par-6 Y69H2.3b 21110867 intact exp G pkc-2 par-6 14704431 biogrid,i2d,mint,intact,dip exp G nhr-111 par-6 21110867 intact exp fem-3 par-6 18502413 biogrid exp mig-6 par-6 21110867 intact exp G par-6 Y105E8A.6 21110867 intact exp par-3 par-6 16996049 intact exp G dnc-2 par-6 18692475,21110867,unassigned701,unassigned1274 biogrid,intact exp G Y77E11A.7a par-6 21110867 intact exp F30H5.3 par-6 21110867 intact exp Y73B6BL.33a par-6 21110867 intact exp G ZK849.1 par-6 14704431 biogrid,i2d exp cdc-42 par-6 16996049,11412997 intact exp, ortho G pkc-3 par-6 21857670,18502617,unassigned1274,16996049,14704431 biogrid,i2d,mint,intact,dip exp, ortho G Uncharacterized protein C30C11.4 par-6 ortho G F33G12.2 par-6 ortho G F32A6.4b par-6 ortho G Nephrocystin-4-like protein, R13H4.1 par-6 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NAN2 P90980-2 - 14704431 - X 2 Q9NAN2 Q9N5N7 - 14704431 - X 2 Q9NAN2 Q20709 - 14704431 - X 2 Q9NAN2 Q19266 - 14704431 - X 2 Q9NAN2 O18301 - 14704431 - X 2 Q9NAN2 Q20709 two hybrid 14704431 physical association X 2 Q9NAN2 Q9N5N7 two hybrid 14704431 physical association X 2 Q9NAN2 two hybrid 14704431 physical association X 2 Q9NAN2 P90980 two hybrid 14704431 physical association X 2 Q9NAN2 Q19266 two hybrid 14704431 physical association X 2 Q9NAN2 Q20709 two hybrid pooling approach 14704431 physical association X 2 Q9NAN2 Q9N5N7 two hybrid pooling approach 14704431 physical association X 2 Q9NAN2 Q20709 two hybrid array 21110867 physical association X 2 Q9NAN2 Q8MXV3 two hybrid array 21110867 physical association X 2 Q9NAN2 O45521 two hybrid array 21110867 physical association X 2 Q9NAN2 Q20709 anti tag coimmunoprecipitation 21110867 physical association X 2 Q9NAN2 Q9NEZ5 anti tag coimmunoprecipitation 21110867 physical association X 2 Q9NAN2 Q9NEZ5 anti tag coimmunoprecipitation 21110867 physical association X 2 Q9NAN2 Q20709 anti tag coimmunoprecipitation 21110867 physical association X 2 Q9NAN2 Q8MXV3 anti tag coimmunoprecipitation 21110867 physical association X 2 Q9NAN2 G5EBP7 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q20709 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q6BEV5 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q9NEZ5 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q19130 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 O17286 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q17410 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 H2L041 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 O76840 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q8MXR2 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 G5EEK3 two hybrid - physical association X 2 Q05062 Q9NAN2 two hybrid 11412997 physical association X 2 Q05062 Q9NAN2 two hybrid 16996049 physical association X 2 Q05062 Q9NAN2 fluorescence microscopy 16996049 colocalization X 2 B1Q249 Q9NAN2 anti tag coimmunoprecipitation 21110867 physical association X 2 P34288 Q9NAN2 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 P90980 two hybrid pooling approach 14704431 physical association X 2 Q9NAN2 Q19266 two hybrid pooling approach 14704431 physical association X 2 Q9NAN2 Q19266 two hybrid 16996049 physical association X 2 Q9NAN2 Q17353 two hybrid 16996049 physical association X 2 Q9NAN2 H2L0E1 two hybrid array 21110867 physical association X 2 Q9NAN2 Q8MYM0 two hybrid array 21110867 physical association X 2 Q9NAN2 A8WI97 two hybrid array 21110867 physical association X 2 Q9NAN2 H2L0E1 anti tag coimmunoprecipitation 21110867 physical association X 2 Q9NAN2 H2L0E1 anti tag coimmunoprecipitation 21110867 physical association X 2 Q9NAN2 Q09289 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 H2L0E1 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q09248 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q09983 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q9XWR0 two hybrid pooling approach 21110867 physical association X 2 Q9NAN2 Q09248 two hybrid - physical association X 2 O18302 Q9NAN2 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B par-6 F48E3.8 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22084 bait prey C56G2.7 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22072 prey bait par-3 par-6 MI:0018(two hybrid) 16996049 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_155 prey bait nfyb-1 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22081 prey bait par-6 unc-95 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_22397|UniProt_22418|UniProt_22076 bait|bait|bait prey|prey|prey pkc-2 par-6 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|MI:0465(dip) BIOGRID_22150|MINT_73|UniProt_30204|DIP_1820 bait|bait|bait|- prey|prey|prey|- lin-24 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22080 prey bait R06F6.12 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22078 prey bait cdc-42 par-6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11412997,16996049 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact)|(intact) UniProt_156|UniProt_33|UniProt_157 prey|bait|neutral component bait|prey|neutral component dnc-2 par-6 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475,21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_22083|BIOGRID_28662|UniProt_24855 prey|prey|prey bait|bait|null par-6 hum-9 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22087 bait prey H06I04.1 par-6 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(intact)|MI:0471(mint) DIP_3831|UniProt_28219|MINT_2325 -|prey|prey -|bait|bait fem-2 par-6 MI:0004(affinity chromatography technology) 18502413 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_28511 prey bait fem-3 par-6 MI:0004(affinity chromatography technology) 18502413 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_28512 prey bait CELE_ZK849.1 par-6 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_24338 prey bait hrpf-2 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22088 prey bait O16257 par-6 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 21110867 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_22085|UniProt_22359 prey|prey bait|bait par-6 C17H11.6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22447 bait prey ztf-20 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22365 prey bait par-6 Y77E11A.7 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_22082|UniProt_22398|UniProt_22362|UniProt_22422 bait|bait|bait|bait prey|prey|prey|prey pkc-3 par-6 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,16996049 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip)|MI:0471(mint)|(intact) UniProt_30278|BIOGRID_22222|DIP_1894|MINT_147|UniProt_154 bait|bait|-|bait|prey prey|prey|-|prey|bait pac-1 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22089 prey bait gopc-1 par-6 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0465(dip)|MI:0471(mint) UniProt_28221|DIP_3832|MINT_2326 prey|-|prey bait|-|bait CELE_F30H5.3 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22086 prey bait par-6 Y69H2.3 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22366 bait prey par-6 noca-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 18692475,21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_28663|UniProt_22075 bait|bait prey|prey mig-6 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22090 prey bait F07A11.2 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22079 prey bait H06I04.1 par-6 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_22423|UniProt_22364|BIOGRID_24337 prey|prey|prey bait|bait|bait par-6 noca-1 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24795 null prey nhr-111 par-6 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_22363 prey bait tra-4 par-6 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact)|(biogrid) UniProt_22077|DIP_3830|UniProt_28220|UniProt_22421|MINT_2324|UniProt_22394|UniProt_22361|BIOGRID_24336 prey|-|prey|prey|prey|prey|prey|prey bait|-|bait|bait|bait|bait|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NAN2 Q8MQ88 PAR-6 PKC-2 0.033 14704431 Q9NAN2 Q8MXR2 PAR-6 HRPF-2 0.126 21110867 Q9NAN2 Q8MXV3 PAR-6 Q8MXV3 0.236 21110867 Q9NAN2 Q8MYM0 PAR-6 ZTF-20 0.126 21110867 Q9NAN2 O45521 PAR-6 NHR-111 0.126 21110867 Q9NAN2 Q9N5N7 PAR-6 Q9N5N7 0.155 14704431 Q9NAN2 H2L041 PAR-6 H2L041 0.126 21110867 Q9NAN2 H2L0E1 PAR-6 H2L0E1 0.416 21110867 Q9NAN2 O17286 PAR-6 NFYB-1 0.126 21110867 Q9NAN2 O76840 PAR-6 MIG-6 0.126 21110867 Q9NAN2 P17221 PAR-6 FEM-1 0.21 18502413 Q9NAN2 P34691 PAR-6 FEM-3 0.21 18502413 Q9NAN2 P49594 PAR-6 FEM-2 0.21 18502413 Q9NAN2 Q09289 PAR-6 Q09289 0.126 21110867 Q9NAN2 Q09983 PAR-6 Q09983 0.126 21110867 Q9NAN2 Q17410 PAR-6 LIN-24 0.126 21110867 Q9NAN2 Q19130 PAR-6 Q19130 0.126 21110867 Q9XWR0 Q9NAN2 HUM-9 PAR-6 0.126 21110867 Q9NAN2 Q6BEV5 PAR-6 Q6BEV5 0.126 21110867 Q9NEZ5 Q9NAN2 UNC-95 PAR-6 0.236 21110867 Q9NAN2 O18302 PAR-6 GOPC-1 0.155 14704431 Q9NAN2 Q20709 PAR-6 TRA-4 0.507 21110867,14704431 Q9NAN2 Q19266 PAR-6 PKC-3 0.702 21857670,18502617,14704431,26780296 Q9NAN2 P34288 PAR-6 PAC-1 0.49 26780296,21110867 Q9NAN2 P90980 PAR-6 PKC-2 0.286 14704431 Q9NAN2 G5EEK3 PAR-6 NOCA-1 0.416 unassigned701,21110867,18692475 Q9NAN2 A8WI97 PAR-6 A8WI97 0.126 21110867 Q9NAN2 B1Q249 PAR-6 B1Q249 0.126 21110867 Q9NAN2 Q09248 PAR-6 DNC-2 0.523 21110867,26780296,unassigned701,18692475