PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus par-3 pkc-3 21110867,9716526 intact exp G pkc-3 num-1 11134025,11134024 intact exp G rpn-2 pkc-3 18502617 biogrid exp lin-5 pkc-3 21857670 biogrid exp G pkc-3 par-6 21857670,18502617,unassigned1274,16996049,14704431 biogrid,i2d,mint,intact,dip exp, ortho G pkc-3 pkc-3 ortho G pkc-3 hpd-1 ortho G pkc-3 lgg-2 ortho G apl-1 pkc-3 ortho G F53F10.4 pkc-3 ortho G pak-1 pkc-3 ortho G pkc-3 F11C7.4 ortho cdc-42 pkc-3 ortho G pkc-3 ZK742.1a ortho G Probable mannose-6-phosphate isomerase pkc-3 ortho G pkc-3 Probable trafficking protein particle complex subunit 13 homolog ortho G cdc-37 pkc-3 ortho G C34C6.6a pkc-3 ortho pkc-3 pdk-1 ortho G pkc-3 F25D1.1a ortho G lgg-1 pkc-3 ortho G mek-2 pkc-3 ortho G cdk-7 pkc-3 ortho G C44E4.4 pkc-3 ortho G daf-21 pkc-3 ortho G pkc-3 BE0003N10.2 ortho klp-6 pkc-3 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NAN2 Q19266 - 14704431 - X 2 Q9NAN2-2 Q19266 two hybrid 14704431 direct interaction X 2 Q9NAN2-2 Q19266 biochemical 21857670 colocalization X 2 Q9NAN2-2 Q19266 two hybrid 18502617 direct interaction X 2 P45970 Q19266 enzymatic study 21857670 direct interaction X 2 P45970 Q19266 imaging technique 21857670 colocalization X 2 Q19266 Q18115 two hybrid 18502617 direct interaction X 2 Q19266 Q18115 affinity chromatography technology 18502617 physical association X 2 Q9NAN2 Q19266 two hybrid 14704431 physical association X 2 Q19266 Q9XTY6 coimmunoprecipitation 11134024 physical association X 2 Q19266 Q9XTY6 imaging technique 11134024 colocalization X 2 Q19266 Q9XTY6 coimmunoprecipitation 11134024 physical association X 2 Q19266 Q9XTY6 coimmunoprecipitation 11134024 physical association X 2 Q19266 Q9XTY6 two hybrid 11134024 physical association X 2 Q19266 Q9XTY6 two hybrid 11134024 physical association X 2 Q19266 Q9XTY6 two hybrid 11134025 physical association X 2 Q19266 Q9XTY6 coimmunoprecipitation 11134025 physical association X 2 Q19266 Q9XTY6 coimmunoprecipitation 11134025 physical association X 2 Q19266 Q9XTY6 coimmunoprecipitation 11134025 physical association X 2 Q9NAN2 Q19266 two hybrid pooling approach 14704431 physical association X 2 Q9NAN2 Q19266 two hybrid 16996049 physical association X 2 Q19266 Q17353 anti tag coimmunoprecipitation 9716526 physical association X 2 Q19266 Q17353 anti bait coimmunoprecipitation 9716526 physical association X 2 Q19266 Q17353 fluorescence microscopy 9716526 colocalization X 2 Q17353-3 Q19266 two hybrid pooling approach 21110867 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B pkc-3 par-6 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,16996049 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip)|MI:0471(mint)|(intact) UniProt_30278|BIOGRID_22222|DIP_1894|MINT_147|UniProt_154 bait|bait|-|bait|prey prey|prey|-|prey|bait par-3 pkc-3 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 21110867,9716526 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_23241|UniProt_23242|UniProt_23243|UniProt_21991 bait|prey|neutral component|null prey|bait|neutral component|prey pkc-3 num-1 MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0428(imaging technique) 11134024,11134025 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_1295|UniProt_1294|UniProt_1296|7228|UniProt_1291|UniProt_1293|UniProt_1292|UniProt_509|UniProt_508|UniProt_510|UniProt_511|7246|7225|7235|7240|7231 bait|bait|prey|prey|bait|neutral component|prey|prey|bait|prey|bait|prey|bait|bait|bait|neutral component prey|prey|null|bait|null|neutral component|bait|null|prey|null|null|null|null|prey|prey|neutral component

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q19266 P45970 PKC-3 LIN-5 0.396 21857670 Q19266 Q18115 PKC-3 RPN-2 0.454 18502617 Q9NAN2 Q19266 PAR-6 PKC-3 0.702 21857670,18502617,14704431,26780296 Q9XTY6 Q19266 NUM-1 PKC-3 0.888 11134025,11134024 Q19266 Q17353 PKC-3 PAR-3 0.126 21110867