PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus C07G1.5 csn-4 18692475,unassigned701 biogrid,intact exp F14F3.1a, Variable abnormal-3 C07G1.5 14704431 biogrid,intact exp G C07G1.5 F12F6.6 18692475,unassigned701 biogrid,intact exp G wee-1.3 C07G1.5 18692475 mint exp C07G1.5 Y116A8C.36a 23818590 biogrid exp G C07G1.5 Y54E10A.9c 18692475,unassigned701 biogrid,mint,intact exp G ubq-1 C07G1.5 21193406 biogrid exp G C07G1.5 ZK1248.5 18692475 mint exp C07G1.5 EHS-1, ZK1248.3a 23818590 biogrid exp G C07G1.5 T20B5.1 23818590 biogrid exp G F49E2.2c C07G1.5 23549480 intact exp G C07G1.5 cogc-4 18692475 mint exp G dpy-23 C07G1.5 23818590 biogrid exp G C07G1.5 Y54E5A.4 18692475,unassigned701 biogrid,intact exp G wrm-1 C07G1.5 unassigned1274 intact exp R06A4.4a C07G1.5 18692475,unassigned701 biogrid,mint,intact exp T05B11.3 C07G1.5 23818590 biogrid exp G C07G1.5 AP complex subunit beta 23818590 biogrid exp G stam-1 C07G1.5 21193406,11731503,23818590,17581863,23549480 biogrid,intact exp, ortho G lin-2 C07G1.5 unassigned1274 intact exp, ortho G C07G1.5 C07G1.5 23818590 biogrid exp, ortho G C09G12.9 C07G1.5 18692475,unassigned701,23818590 biogrid,mint,intact exp, ortho chc-1 C07G1.5 23818590 biogrid exp, ortho G dnc-2 C07G1.5 ortho G C07G1.5 Annexin ortho G K11C4.3c C07G1.5 ortho G C34C12.5 C07G1.5 ortho G Y48E1C.3 C07G1.5 ortho C07G1.5 F59G1.3 ortho G hsp-1 C07G1.5 ortho G unc-64 C07G1.5 ortho G F55C7.7a, Guanine nucleotide exchange factor UNC-73A C07G1.5 ortho G F53G12.1 C07G1.5 ortho G C17G10.2 C07G1.5 ortho C07G1.5 Y54G2A.31 ortho G C07G1.5 let-49 ortho C07G1.5 F12B6.1a ortho C07G1.5 toe-1 ortho G F39B2.2 C07G1.5 ortho G C07G1.5 ned-8 ortho G C07G1.5 K02A11.1b ortho G arr-1 C07G1.5 ortho G ttc-7 C07G1.5 ortho G C07G1.5 pfk-1 ortho G rps-1 C07G1.5 ortho G ubq-2 C07G1.5 ortho G F36F2.4 C07G1.5 ortho G C07G1.5 dre-1 ortho G Uncharacterized protein F54C8.7 C07G1.5 ortho G Probable phospholipase D F09G2.8 C07G1.5 ortho G Y92H12A.2a C07G1.5 ortho G C07G1.5 W04D2.1a ortho G C01G6.4 C07G1.5 ortho G smo-1 C07G1.5 ortho G sem-5 C07G1.5 ortho G K02F2.3 C07G1.5 ortho G C07G1.5 Y105E8B.2a ortho G C07G1.5 W06D4.5 ortho G C07G1.5 C05D9.1 ortho G C07G1.5 sqv-4 ortho G C26C6.1a C07G1.5 ortho G C07G1.5 jnk-1 ortho G C07G1.5 R151.7a ortho G F33A8.6 C07G1.5 ortho ZK1151.1c C07G1.5 ortho G C07G1.5 Ectopic P granules protein 3 ortho ufd-2 C07G1.5 ortho C07G1.5 T12A2.7 ortho G C07G1.5 C47E12.5a ortho G C07G1.5 C30F8.2 ortho G stip-1 C07G1.5 ortho G apl-1 C07G1.5 ortho G Phosphoinositide 3-kinase adapter subunit, Y110A7A.10 C07G1.5 ortho G F26H9.6 C07G1.5 ortho G C07G1.5 fln-1 ortho G C07G1.5 D1014.3 ortho G F36D4.3b, Hum-2 C07G1.5 ortho G C07G1.5 Probable Golgi transport protein 1 ortho G C07G1.5 pak-1 ortho G unc-18 C07G1.5 ortho G C07G1.5 T13H5.4 ortho G C07G1.5 Y113G7A.3 ortho G sds-22 C07G1.5 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q17796 - 14704431 - X 2 P90961 Q17796 affinity chromatography technology 23818590 physical association X 2 Q17796 Q9XWK3 two hybrid 18692475 direct interaction X 2 Q17796 O76258 two hybrid 18692475 direct interaction X 2 Q17796 O01498 biochemical 23818590 association X 2 Q17796 D9N122 affinity chromatography technology 23818590 physical association X 2 Q17796 O01498 affinity chromatography technology 23818590 physical association X 2 Q17796 O01498 affinity chromatography technology 23818590 physical association X 2 Q17796 D9N122 affinity chromatography technology 23818590 physical association X 2 Q17796 O01498 affinity chromatography technology 23818590 physical association X 2 Q17796 D9N122 affinity chromatography technology 23818590 physical association X 2 Q17796 Q7YZG9 affinity chromatography technology 23818590 physical association X 2 Q17796 O76258 affinity chromatography technology 23818590 physical association X 2 Q17796 O01498 affinity chromatography technology 21193406 physical association X 2 Q17796 O01498 affinity chromatography technology 21193406 physical association X 2 Q17796 O01498 biochemical 21193406 association X 2 P0CG71 Q17796 pull down 21193406 direct interaction X 2 Q17796 Q9N3F4 two hybrid 18692475 direct interaction X 2 Q17796 Q9N359 two hybrid 18692475 direct interaction X 2 Q17796 Q19371 two hybrid 18692475 direct interaction X 2 Q17796 O62333 two hybrid 18692475 direct interaction X 2 Q17796 Q17796 affinity chromatography technology 23818590 physical association X 2 Q17796 Q17796 affinity chromatography technology 23818590 physical association X 2 Q17796 P34574 affinity chromatography technology 23818590 physical association X 2 Q17796 Q9U2T9 affinity chromatography technology 23818590 physical association X 2 Q17796 Q22601 affinity chromatography technology 23818590 physical association X 2 Q17796 P35603 affinity chromatography technology 23818590 physical association X 2 Q17796 Q9U2T9 affinity chromatography technology 23818590 physical association X 2 Q17796 G5EE71 two hybrid 14704431 direct interaction X 2 Q17796 O01498 two hybrid 11731503 physical association X 2 Q17796 O01498 confocal microscopy 17581863 colocalization X 2 Q17796 O01498 two hybrid 23549480 physical association X 2 Q17796 A6ZJ46 two hybrid 23549480 physical association X 2 Q17796 O76258 two hybrid - physical association X 2 Q17796 Q9XWK3 two hybrid - physical association X 2 Q17796 G5EDS1 two hybrid pooling approach 14704431 physical association X 2 Q17796 Q19371 two hybrid - physical association X 2 Q17796 O62333 two hybrid - physical association X 2 Q17796 Q65XX1 two hybrid - physical association X 2 Q17796 Q9N359 two hybrid - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B hgrs-1 CELE_F49E2.2 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23663 prey bait imb-2 hgrs-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint) MINT_5292|MINT_5291|MINT_5290|UniProt_24787|MINT_5316|MINT_5293 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey stam-1 hgrs-1 MI:0018(two hybrid)|MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0018(two hybrid)|MI:0401(biochemical)|MI:0018(two hybrid) 11731503,17581863,21193406,23549480,23818590 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0403(colocalization) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact) UniProt_838|BIOGRID_29565|BIOGRID_28368|BIOGRID_29553|BIOGRID_28366|BIOGRID_28367|BIOGRID_29552|UniProt_23533|BIOGRID_29548|UniProt_219 prey|prey|prey|prey|prey|bait|bait|bait|prey|null bait|bait|bait|bait|bait|prey|prey|prey|bait|bait hgrs-1 vab-3 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_30354|BIOGRID_22306 prey|prey bait|bait hgrs-1 npp-4 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_24847|BIOGRID_28784 prey|prey bait|bait hgrs-1 vbh-1 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24846 prey bait ubq-1 hgrs-1 MI:0004(affinity chromatography technology) 21193406 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28369 prey bait wee-1.3 hgrs-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_6063|MINT_6064|MINT_6062 bait|bait|bait prey|prey|prey hgrs-1 sec-24.1 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_29071|UniProt_24732 prey|prey bait|bait tsg-101 hgrs-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint) MINT_4031|MINT_4032|UniProt_24845|MINT_4033 bait|bait|bait|bait prey|prey|prey|prey hgrs-1 cogc-4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_6028|MINT_6027|MINT_6026 prey|prey|prey null|null|null hgrs-1 vbh-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_6087|MINT_6088|MINT_6086 prey|prey|prey bait|bait|bait clic-1 hgrs-1 MI:0401(biochemical) 23818590 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_29568 prey bait hgrs-1 csn-4 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_28795|UniProt_24922 prey|prey bait|bait hgrs-1 ZK1248.5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_6325|MINT_6327|MINT_6329|MINT_6326|MINT_6328 prey|prey|prey|prey|prey bait|bait|bait|bait|bait dpy-23 hgrs-1 MI:0401(biochemical) 23818590 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_29573 prey bait Q17359 hgrs-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint) DIP_1970|MINT_235 -|bait -|prey hgrs-1 apa-2 MI:0401(biochemical) 23818590 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_29571 bait prey chc-1 hgrs-1 MI:0401(biochemical) 23818590 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_29567 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q19371 Q17796 SEC-24.1 HGRS-1 0.183 unassigned701 Q17796 Q10953 HGRS-1 WRM-1 0.183 26780296 Q9N359 Q17796 CSN-4 HGRS-1 0.183 unassigned701 Q9XWK3 Q17796 NPP-4 HGRS-1 0.183 unassigned701 Q17796 O62333 HGRS-1 IMB-2 0.332 unassigned701,18692475 Q17796 O76258 HGRS-1 TSG-101 0.332 unassigned701,18692475 Q65XX1 Q17796 VBH-1 HGRS-1 0.332 unassigned701,18692475 Q95XZ0 Q17796 COGC-4 HGRS-1 0.183 18692475 Q17796 O01498 HGRS-1 STAM-1 0.507 17581863,23549480,11731503 Q17796 P54936 HGRS-1 LIN-2 0.332 26780296 Q17796 A6ZJ46 HGRS-1 A6ZJ46 0.183 23549480 Q17796 Q17359 HGRS-1 Q17359 0.033 14704431 Q17796 G5EDS1 HGRS-1 VAB-3 0.126 14704431 Q17796 O18209 HGRS-1 WEE-1.3 0.183 18692475 Q23414 Q17796 Q23414 HGRS-1 0.183 18692475