PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus dlk-1 rpm-1 i2d exp rpm-1 npp-17 22357847 intact exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q17551 - 15208641 - C 4 Q17551 Q3SWS8 anti tag coimmunoprecipitation 22357847 physical association X 2 Q17551 Q3SWS8 anti tag coimmunoprecipitation 22357847 physical association X 2 Q93454 Q17551 confocal microscopy 22357847 colocalization X 2 Q93454 Q17551 anti tag coimmunoprecipitation 22357847 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B rpm-1 npp-17 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22357847 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_184462|UniProt_21653|UniProt_21648 prey|neutral component|prey bait|neutral component|bait rpm-1 Rae1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22357847 taxid:6239(Caenorhabditis elegans) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_21651|UniProt_184463|UniProt_184465|UniProt_120550|UniProt_21649 prey|unspecified role|prey|prey|unspecified role bait|unspecified role|bait|bait|unspecified role