PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus nhr-12 sel-10 14704431 biogrid,i2d,mint,intact exp G sel-10 R10D12.13b 14704431 biogrid,i2d exp G fem-2 sel-10 15306688 intact exp sel-10 zyg-1 22623721 biogrid exp nhr-22 sel-10 10615043,14704431 biogrid,i2d,mint,intact exp ttm-4 sel-10 10615043,14704431 biogrid,i2d,mint,intact exp G sel-10 sel-10 18718460,14704431 biogrid,intact exp G Y41C4A.12b sel-10 14704431 biogrid,i2d,mint,intact exp G lin-12 sel-10 9389650,10615043,14704431 biogrid,i2d,mint,intact exp G R10D12.14c sel-10 10615043 intact exp G F46A9.5 sel-10 11731503,18718460,10615043,19123269,14704431 biogrid,intact exp G fem-3 sel-10 15306688 intact exp fem-1 sel-10 15306688 intact exp G htz-1 sel-10 ortho G rho-1 sel-10 ortho G sel-10 Y71H2B.3 ortho G sel-10 Y39B6A.2a ortho G sel-10 rpl-7A ortho G rpa-0 sel-10 ortho G B0365.3 sel-10 ortho G Y55F3AL.1a sel-10 ortho G rps-2 sel-10 ortho G M05D6.2 sel-10 ortho G rps-3 sel-10 ortho G rskn-1 sel-10 ortho G rps-5 sel-10 ortho G Enhancer of rudimentary homolog sel-10 ortho G Probable electron transfer flavoprotein subunit alpha, mitochondrial, Alpha-ETF sel-10 ortho G ten-1 sel-10 ortho G wdr-5.1 sel-10 ortho G ubq-2 sel-10 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants G5ECU1 Q93794 - 10615043 - X 2 G5ECU1 Q93794 - 14704431 - X 2 G5ECU1 Q93794 - 12679813 - X 2 G5ECU1 Q93794 - 11731503 - X 2 Q9U2I3 Q93794 - 14704431 - X 2 Q93794 Q21701 - 14704431 - X 2 Q20330 Q93794 - 12679813 - X 2 Q20330 Q93794 - 10615043 - X 2 Q93794 - 14704431 - X 2 Q09587 Q93794 - 14704431 - X 2 Q09587 Q93794 - 12679813 - X 2 Q09587 Q93794 - 10615043 - X 2 Q93794 P14585 - 10615043 - X 2 Q93794 - 10615043 - X 2 Q93794 - 12679813 - X 2 G5ECU1 Q93794 two hybrid 14704431 physical association X 2 Q9U2I3 Q93794 two hybrid 14704431 physical association X 2 Q93794 Q21701 two hybrid 14704431 physical association X 2 Q93794 two hybrid 14704431 physical association X 2 Q09587 Q93794 two hybrid 14704431 physical association X 2 G5ECU1 Q93794 two hybrid pooling approach 10615043 physical association X 2 G5ECU1 Q93794 two hybrid 11731503 physical association X 2 G5ECU1 Q93794 two hybrid pooling approach 14704431 physical association X 2 G5ECU1 Q93794 two hybrid pooling approach 19123269 physical association X 2 G5ECU1 Q93794 two hybrid array 19123269 physical association X 2 Q93794 Q21701 two hybrid pooling approach 14704431 physical association X 2 Q20330 Q93794 two hybrid pooling approach 10615043 physical association X 2 P31695 Q93794 anti bait coimmunoprecipitation 9389650 physical association X 2 P31695 Q93794 anti tag coimmunoprecipitation 9389650 physical association X 2 P49594 Q93794 anti tag coimmunoprecipitation 15306688 physical association X 2 P49594 Q93794 anti tag coimmunoprecipitation 15306688 physical association X 2 P34691 Q93794 anti tag coimmunoprecipitation 15306688 physical association X 2 P34691 Q93794 anti tag coimmunoprecipitation 15306688 physical association X 2 Q09587 Q93794 two hybrid pooling approach 10615043 physical association X 2 Q09587 Q93794 two hybrid pooling approach 14704431 physical association X 2 Q93794 C6KRN1 two hybrid pooling approach 10615043 physical association X 2 Q93794 P14585 two hybrid array 10615043 physical association X 2 Q93794 Q8I4D6 two hybrid pooling approach 14704431 physical association X 2 Q93794 P17221 anti tag coimmunoprecipitation 15306688 physical association X 2 Q93794 P17221 anti tag coimmunoprecipitation 15306688 physical association X 2 Q93794 P14585 anti tag coimmunoprecipitation 9389650 physical association X 2 Q93794 P14585 anti tag coimmunoprecipitation 9389650 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Y41C4A.12 sel-10 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_972|BIOGRID_23013|UniProt_30954 prey|prey|prey bait|bait|bait nhr-12 sel-10 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip)|(biogrid)|(intact) MINT_970|DIP_2569|BIOGRID_23011|UniProt_30955 prey|-|prey|prey bait|-|bait|bait fem-2 sel-10 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15306688 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_975|UniProt_977 prey|bait bait|prey lin-12 sel-10 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 10615043,14704431,9389650 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint) MINT_6411|BIOGRID_23615|3027|UniProt_1049|UniProt_23247|UniProt_23248|MINT_1590 bait|bait|bait|bait|bait|prey|bait prey|prey|prey|prey|prey|bait|prey Q93647 sel-10 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 10615043,14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|MI:0471(mint) DIP_2567|MINT_967|MINT_966 -|prey|prey -|bait|bait sel-10 CC8.1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_23007|DIP_2566|UniProt_30951|MINT_964 bait|-|bait|bait prey|-|prey|prey nhr-22 sel-10 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0397(two hybrid array)|MI:0398(two hybrid pooling approach) 10615043,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint)|(intact)|(intact) DIP_2568|MINT_969|UniProt_30953|BIOGRID_23010|MINT_968|UniProt_1139|3297 -|prey|prey|prey|prey|prey|prey -|bait|bait|bait|bait|bait|bait fem-3 sel-10 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15306688 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_972|UniProt_976 bait|prey prey|bait fem-1 sel-10 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15306688 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_974|UniProt_973 bait|prey prey|bait sel-10 sao-1 MI:0398(two hybrid pooling approach)|MI:0397(two hybrid array) 10615043 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) 3303|UniProt_1141 bait|bait prey|prey ttm-4 sel-10 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0397(two hybrid array)|MI:0398(two hybrid pooling approach) 10615043,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|MI:0471(mint) BIOGRID_23008|3294|UniProt_1138|MINT_965 prey|prey|prey|prey bait|bait|bait|bait sel-10 Q9XVJ6 MI:0398(two hybrid pooling approach) 10615043 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_971 bait prey sel-10 Y41C4A.12 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_2570 - - sel-10 skr-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0397(two hybrid array)|MI:0018(two hybrid) 10615043,11731503,14704431,18718460,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact) UniProt_20904|BIOGRID_23009|3300|BIOGRID_28476|UniProt_18992|UniProt_30952|UniProt_1140|UniProt_851 prey|bait|bait|bait|prey|bait|bait|prey bait|prey|prey|prey|bait|prey|prey|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q93794 Q21701 SEL-10 NHR-12 0.309 14704431 Q93794 Q8I4D6 SEL-10 Q8I4D6 0.126 14704431 Q9GT24 Q93794 ZYG-1 SEL-10 0.21 22623721 Q9N5V2 Q93794 Q9N5V2 SEL-10 0.033 14704431 Q93794 Q09587 SEL-10 NHR-22 0.396 10615043,14704431 Q93794 G5ECU1 SEL-10 SKR-1 0.772 10615043,14704431,18718460,11731503,19123269 Q93794 P14585 SEL-10 LIN-12 0.286 10615043,14704431 Q93794 Q93647 SEL-10 Q93647 0.033 14704431 Q93794 Q93794 SEL-10 SEL-10 0.332 18718460 Q9U2I3 Q93794 Q9U2I3 SEL-10 0.033 14704431 Q93794 P34691 SEL-10 FEM-3 0.21 15306688 Q93794 C6KRN1 SEL-10 SAO-1 0.126 10615043 Q93794 P49594 SEL-10 FEM-2 0.21 15306688 Q93794 P17221 SEL-10 FEM-1 0.21 15306688 Q93794 Q20330 SEL-10 IFO-1 0.126 10615043