PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus F46A9.4, SKR-2 C27D9.1 18692475,unassigned701 biogrid,intact exp F46A9.4, SKR-2 T10E9.1 19123269 intact exp F46A9.4, SKR-2 F54D5.9 12445390,14704431,19123269 biogrid,intact exp F46A9.4, SKR-2 Uncharacterized F-box protein C27F2.7 18692475,unassigned701 biogrid,intact exp F46A9.4, SKR-2 let-756 16672054 biogrid,intact exp G F46A9.4, SKR-2 Y113G7B.5b 19123269 intact exp F46A9.4, SKR-2 cgh-1 14704431 biogrid,intact exp G F46A9.4, SKR-2 T05H4.2 19123269 intact exp F46A9.4, SKR-2 F02D10.6 12445390,14704431 biogrid,intact exp F46A9.4, SKR-2 C08E3.7 19123269 intact exp F46A9.4, SKR-2 F08A8.7 18692475,unassigned701,19123269 biogrid,intact exp F46A9.4, SKR-2 C14B1.3 18692475,unassigned701 biogrid,intact exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q19116 G5EDD8 - 12445390 - X 2 G5EDD8 Q20775 - 12445390 - X 2 Q95YF3 G5EDD8 - 14704431 - X 2 G5EDD8 Q17962 two hybrid 18692475 direct interaction X 2 Q19116 G5EDD8 two hybrid 12445390 direct interaction X 2 Q19116 G5EDD8 two hybrid 14704431 direct interaction X 2 G5EDD8 two hybrid 18692475 direct interaction X 2 G5EDD8 two hybrid 18692475 direct interaction X 2 Q11184 G5EDD8 two hybrid 16672054 direct interaction X 2 Q11184 G5EDD8 affinity chromatography technology 16672054 physical association X 2 G5EDD8 Q20775 two hybrid 12445390 direct interaction X 2 G5EDD8 Q20775 two hybrid 12445390 direct interaction X 2 G5EDD8 Q20775 two hybrid 14704431 direct interaction X 2 G5EDX9 G5EDD8 two hybrid 18692475 direct interaction X 2 Q18262 G5EDD8 two hybrid 18692475 direct interaction X 2 Q95YF3 G5EDD8 two hybrid 14704431 direct interaction X 2 Q95YF3 G5EDD8 two hybrid 14704431 physical association X 2 O16525 G5EDD8 two hybrid pooling approach 19123269 physical association X 2 O16525 G5EDD8 two hybrid array 19123269 physical association X 2 G5EDD8 Q17962 two hybrid - physical association X 2 Q19116 G5EDD8 two hybrid 12445390 physical association X 2 Q18255 G5EDD8 two hybrid - physical association X 2 Q18255 G5EDD8 two hybrid - physical association X 2 O01606 G5EDD8 two hybrid pooling approach 19123269 physical association X 2 O01606 G5EDD8 two hybrid array 19123269 physical association X 2 Q11184 G5EDD8 anti tag coimmunoprecipitation 16672054 physical association X 2 Q11184 G5EDD8 two hybrid 16672054 physical association X 2 Q11184 G5EDD8 two hybrid 16672054 physical association X 2 G5EDD8 Q20775 two hybrid 12445390 physical association X 2 G5EDD8 Q20775 two hybrid 12445390 physical association X 2 G5EDD8 Q20775 two hybrid pooling approach 19123269 physical association X 2 G5EDD8 Q2YS43 two hybrid pooling approach 19123269 physical association X 2 G5EDD8 Q2YS43 two hybrid pooling approach 19123269 physical association X 2 G5EDD8 Q20775 two hybrid array 19123269 physical association X 2 G5EDD8 Q2YS43 two hybrid array 19123269 physical association X 2 G5EDD8 Q2YS43 two hybrid array 19123269 physical association X 2 G5EDX9 G5EDD8 two hybrid pooling approach 19123269 physical association X 2 G5EDX9 G5EDD8 two hybrid pooling approach 19123269 physical association X 2 G5EDX9 G5EDD8 two hybrid array 19123269 physical association X 2 G5EDX9 G5EDD8 two hybrid array 19123269 physical association X 2 G5EDX9 G5EDD8 two hybrid - physical association X 2 Q18262 G5EDD8 two hybrid - physical association X 2 O17198 G5EDD8 two hybrid pooling approach 19123269 physical association X 2 O17198 G5EDD8 two hybrid array 19123269 physical association X 2 Q95YF3 G5EDD8 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B C27F2.7 skr-2 MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_24537|BIOGRID_29175 prey|prey bait|bait C27D9.1 skr-2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_24720|BIOGRID_29174|BIOGRID_28976|UniProt_24705 prey|prey|bait|bait bait|bait|prey|prey fog-2 skr-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_18989|UniProt_18986|UniProt_20899|UniProt_20900 prey|bait|prey|bait bait|prey|bait|prey F54D5.9 skr-2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 12445390,14704431,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(intact) BIOGRID_25809|UniProt_415|BIOGRID_22888|BIOGRID_25777|UniProt_20895|UniProt_18985|UniProt_410 bait|bait|prey|prey|prey|prey|prey prey|prey|bait|bait|bait|bait|bait CELE_T10E9.1 skr-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_20901|UniProt_18987 prey|prey bait|bait C14B1.3 skr-2 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24833 prey bait fbxa-164 skr-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18113|UniProt_20028 bait|bait prey|prey let-756 skr-2 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 16672054 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_941|UniProt_917|UniProt_84422|UniProt_946|BIOGRID_25667|BIOGRID_25652 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey skr-2 fbxa-101 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_18616|UniProt_18619|UniProt_20530|UniProt_20533|UniProt_24850 bait|prey|bait|prey|bait prey|bait|prey|bait|prey fbxa-196 skr-2 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18988|UniProt_20898 bait|bait prey|prey cgh-1 skr-2 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_21481|UniProt_29648 bait|bait prey|prey F02D10.6 skr-2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12445390,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_411|BIOGRID_22887|BIOGRID_25801 prey|prey|prey bait|bait|bait