PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O45539 P29355 - 12679813 - X 2 O45539 P29355 - 10615043 - X 2 O45539 P46941 - 14704431 - X 2 O45539 P29355 two hybrid 14704431 direct interaction X 2 O45539 P46941 two hybrid 14704431 direct interaction X 2 O45539 P46941 two hybrid 14704431 physical association X 2 Q8MPW4 O45539 two hybrid 23549480 physical association X 2 O61701 O45539 two hybrid 23549480 physical association X 2 P91820 O45539 two hybrid 23549480 physical association X 2 Q93203 O45539 two hybrid 23549480 physical association X 2 Q93203 O45539 two hybrid 23549480 physical association X 2 Q65ZB4 O45539 two hybrid 23549480 physical association X 2 F5GUF0 O45539 two hybrid 23549480 physical association X 2 Q21648 O45539 two hybrid 23549480 physical association X 2 O45539 P29355 two hybrid pooling approach 10615043 physical association X 2 O45539 G5EDS1 two hybrid pooling approach 19123269 physical association X 2 O45539 G5EDS1 two hybrid array 19123269 physical association X 2 O45539 P39055 two hybrid 23549480 physical association X 2 O45539 Q11181 two hybrid 23549480 physical association X 2 O45539 Q17744 two hybrid 23549480 physical association X 2 O45539 Q09442 two hybrid 23549480 physical association X 2 O45539 Q17865 two hybrid 23549480 physical association X 2 O45539 Q95QQ9 two hybrid 23549480 physical association X 2 O45539 Q19849 two hybrid 23549480 physical association X 2 O45539 Q7JMS4 two hybrid 23549480 physical association X 2 O45539 Q22002 two hybrid 23549480 physical association X 2 O45539 Q22387 two hybrid 23549480 physical association X 2 O45539 P39055 two hybrid 23549480 physical association X 2 O45539 Q09442 two hybrid 23549480 physical association X 2 O45539 G4RTG4 two hybrid 23549480 physical association X 2 O45539 E3W743 two hybrid 23549480 physical association X 2 O45539 E7EM33 two hybrid 23549480 physical association X 2 O45539 Q965Y4 two hybrid 23549480 physical association X 2 A5PEX6 O45539 two hybrid 23549480 physical association X 2 G5EGI2 O45539 two hybrid 23549480 physical association X 2 C1P629 O45539 two hybrid 23549480 physical association X 2 Q1XFY2 O45539 two hybrid 23549480 physical association X 2 Q19019 O45539 two hybrid 23549480 physical association X 2 G5ECW9 O45539 two hybrid 23549480 physical association X 2 Q09294 O45539 two hybrid 23549480 physical association X 2 Q21301 O45539 two hybrid 23549480 physical association X 2 Q18225 O45539 two hybrid 23549480 physical association X 2 P91563 O45539 two hybrid pooling approach 19123269 physical association X 2 P91563 O45539 two hybrid array 19123269 physical association X 2 G5ED33 O45539 two hybrid 23549480 physical association X 2 G5ED33 O45539 two hybrid 23549480 physical association X 2 O45539 P46941 two hybrid pooling approach 14704431 physical association X 2 O45539 Q966J6 two hybrid 23549480 physical association X 2 O45539 Q03601 two hybrid 23549480 physical association X 2 O45539 O01900 two hybrid 23549480 physical association X 2 O45539 Q9U290 two hybrid 23549480 physical association X 2 O45539 Q965S4 two hybrid 23549480 physical association X 2 O45539 O01900 two hybrid 23549480 physical association X 2 O45539 Q09345 two hybrid 23549480 physical association X 2 O45539 O45812 two hybrid 23549480 physical association X 2 O45539 Q9U290 two hybrid 23549480 physical association X 2 G5ED57 O45539 two hybrid 23549480 physical association X 2 G5EC72 O45539 two hybrid 23549480 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B src-2 T11B7.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24200 bait prey src-2 CELE_F41B4.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24192 bait prey src-2 CELE_Y110A2AM.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23658 bait prey src-2 unc-43 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23653 bait prey src-2 rga-4 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24206 bait prey src-2 CELE_Y48C3A.12 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23657|UniProt_24204 bait|bait prey|prey src-2 CELE_T23G11.7 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23656 bait prey src-2 crml-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23651 bait prey src-2 C49H3.6 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24186 bait prey src-2 mab-10 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24199 bait prey src-2 flh-2 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24185 bait prey src-2 cfim-2 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24187 bait prey src-2 cyld-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24191 bait prey src-2 sem-5 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 10615043,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint)|(intact) BIOGRID_21574|UniProt_1061|MINT_6899|3063 prey|prey|prey|prey bait|bait|bait|bait src-2 hpo-34 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23648 bait prey src-2 nhl-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24194 bait prey src-2 C09G1.4 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24183 bait prey src-2 C06G1.5 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24181 bait prey src-2 C05D10.4 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24180 bait prey src-2 wve-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24198 bait prey src-2 egl-44 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24190 bait prey src-2 pat-12 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24202 bait prey src-2 pqn-87 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23660 bait prey src-2 EEED8.3 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24188 bait prey src-2 pcf-11 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23655 bait prey src-2 snn-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24203 bait prey src-2 tag-343 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24193 bait prey src-2 rme-4 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23650 bait prey src-2 eps-8 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_24205|UniProt_23659 bait|bait prey|prey src-2 F22E12.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23646 bait prey F59E12.9 src-2 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23652|UniProt_24195 prey|prey bait|bait src-2 sli-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24196 bait prey src-2 vab-3 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_20602|UniProt_18688 prey|prey bait|bait src-2 CELE_F54D5.15 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23649 bait prey src-2 tag-325 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|MI:0471(mint)|(biogrid) UniProt_29926|DIP_1543|MINT_7142|BIOGRID_21830 prey|-|prey|prey bait|-|bait|bait src-2 sap-49 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23643|UniProt_24182 bait|bait prey|prey src-2 lst-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23654 bait prey src-2 R02F2.5 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24197 bait prey src-2 C11E4.6 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23645|UniProt_24184 bait|bait prey|prey src-2 alp-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24201 bait prey src-2 dyn-1 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_24179|UniProt_23644 bait|bait prey|prey src-2 ajm-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23647 bait prey src-2 ZC239.15 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19034|UniProt_20945 bait|bait prey|prey src-2 cyk-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24189 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q21648 O45539 Q21648 SRC-2 0.183 23549480 Q19019 O45539 SLI-1 SRC-2 0.183 23549480 O45539 A5PEX6 SRC-2 PQN-87 0.183 23549480 O45539 C1P629 SRC-2 CFIM-2 0.183 23549480 O45539 E3W743 SRC-2 HPO-34 0.183 23549480 O45539 G5EC72 SRC-2 ALP-1 0.183 23549480 O45539 G5ECW9 SRC-2 RME-4 0.183 23549480 O45539 G5ED57 SRC-2 G5ED57 0.183 23549480 O45539 G5EGI2 SRC-2 SNN-1 0.183 23549480 O45539 O01900 SRC-2 O01900 0.183 23549480 P39055 O45539 DYN-1 SRC-2 0.183 23549480 P46941 O45539 TAG-325 SRC-2 0.309 14704431 P91820 O45539 LST-1 SRC-2 0.183 23549480 Q09294 O45539 Q09294 SRC-2 0.183 23549480 Q09345 O45539 PCF-11 SRC-2 0.183 23549480 Q09442 O45539 SAP-49 SRC-2 0.183 23549480 Q11181 O45539 Q11181 SRC-2 0.183 23549480 Q18225 O45539 FLH-2 SRC-2 0.183 23549480 Q19849 O45539 EGL-44 SRC-2 0.183 23549480 Q1XFY2 O45539 TAG-343 SRC-2 0.183 23549480 Q22002 O45539 MAB-10 SRC-2 0.183 23549480 Q22387 O45539 Q22387 SRC-2 0.183 23549480 Q7JMS4 O45539 CYLD-1 SRC-2 0.183 23549480 Q965Y4 O45539 Q965Y4 SRC-2 0.183 23549480 Q9U290 O45539 Q9U290 SRC-2 0.183 23549480 O45812 O45539 O45812 SRC-2 0.183 23549480 O61701 O45539 CYK-1 SRC-2 0.183 23549480 Q65ZB4 O45539 Q65ZB4 SRC-2 0.183 23549480 P91563 O45539 P91563 SRC-2 0.236 19123269 O45539 G5EDS1 SRC-2 VAB-3 0.236 19123269 P29355 O45539 SEM-5 SRC-2 0.286 10615043,14704431 Q93203 O45539 Q93203 SRC-2 0.332 23549480 Q95QA6 O45539 PAT-12 SRC-2 0.183 23549480 Q95QQ9 O45539 Q95QQ9 SRC-2 0.183 23549480 Q965S4 O45539 RGA-4 SRC-2 0.183 23549480 Q966J6 O45539 Q966J6 SRC-2 0.183 23549480 O45539 E7EM33 SRC-2 UNC-43 0.183 23549480 O45539 F5GUF0 SRC-2 WVE-1 0.183 23549480 O45539 G4RTG4 SRC-2 AJM-1 0.183 23549480 O45539 G5ED33 SRC-2 EPS-8 0.332 23549480 Q03601 O45539 NHL-1 SRC-2 0.183 23549480 Q21301 O45539 CRML-1 SRC-2 0.183 23549480 Q17744 O45539 Q17744 SRC-2 0.183 23549480 Q17865 O45539 Q17865 SRC-2 0.183 23549480