PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus sqv-4 ZK470.5a 23549480 intact exp G F46H5.6 ZK470.5a 23549480 intact exp alx-1 ZK470.5a 23549480 intact exp G Uncharacterized protein C34C12.4 ZK470.5a 23549480 intact exp G F35G12.3a, SEL-5A serine/threonine kinase ZK470.5a 23549480 intact exp G Uncharacterized protein F10E9.3 ZK470.5a 23549480 intact exp nd4 ZK470.5a 23549480 intact exp G Non-specific protein-tyrosine kinase ZK470.5a 23549480 intact exp G csn-5 ZK470.5a 23549480 intact exp G fln-1 ZK470.5a 23549480 intact exp G F22E12.1 ZK470.5a 23549480 intact exp DNA topoisomerase ZK470.5a 23549480 intact exp par-3 ZK470.5a 23549480 intact exp G sec-16 ZK470.5a 23549480 intact exp G mig-15 ZK470.5a 23549480 intact exp G JC8.10b, Synaptojanin UNC-26A ZK470.5a 23549480 intact exp ZK470.5a ani-3 23549480 intact exp sap-49 ZK470.5a 23549480 intact exp cdh-4 ZK470.5a 23549480 intact exp G C06G1.5b ZK470.5a 23549480 intact exp ttm-4 ZK470.5a 23549480 intact exp G T22A3.3a ZK470.5a 23549480 intact exp C07G1.4b ZK470.5a 23549480 intact exp G Uncharacterized protein C09G1.4 ZK470.5a 23549480 intact exp G F29G6.3b ZK470.5a 23549480 intact exp G Uncharacterized protein B0303.7 ZK470.5a 23549480 intact exp G R06A4.4a ZK470.5a 23549480 intact exp bcl-11 ZK470.5a 23549480 intact exp G ZK470.5a F41B4.1 23549480 intact exp G F31D5.3b ZK470.5a 23549480 intact exp pak-1 ZK470.5a 23549480 intact exp, ortho G dyn-1 ZK470.5a 23549480 intact exp, ortho G ZK470.5a C29F9.7 ortho G F46F6.2b ZK470.5a ortho gex-2 ZK470.5a ortho G ZK470.5a C30F8.4a ortho G eef-1G ZK470.5a ortho G spr-2 ZK470.5a ortho G ZK470.5a ZK470.5a ortho G let-413 ZK470.5a ortho G C02F4.1, CED-5 ZK470.5a ortho G unc-97 ZK470.5a ortho G T07A9.11 ZK470.5a ortho G gex-3 ZK470.5a ortho G F40G9.17 ZK470.5a ortho ZK470.5a Y116A8C.12 ortho G ZK470.5a W03F11.6a ortho K11E4.4a ZK470.5a ortho ZK470.5a Y47D3A.4 ortho eif-3.H ZK470.5a ortho G F40F4.5 ZK470.5a ortho G ZK470.5a T28F12.3 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9XWN6 Q95PW9 two hybrid 23549480 physical association X 2 P91820 Q95PW9 two hybrid 23549480 physical association X 2 Q17850 Q95PW9 two hybrid 23549480 physical association X 2 Q95PW9 P24892 two hybrid 23549480 physical association X 2 Q95PW9 Q17795 two hybrid 23549480 physical association X 2 Q95PW9 G5ECQ3 two hybrid 23549480 physical association X 2 Q95PW9 Q8IAA6 two hybrid 23549480 physical association X 2 Q95PW9 Q19319 two hybrid 23549480 physical association X 2 Q95PW9 P39055 two hybrid 23549480 physical association X 2 Q95PW9 P34643 two hybrid 23549480 physical association X 2 Q95PW9 Q17795 two hybrid 23549480 physical association X 2 Q95PW9 Q966J6 two hybrid 23549480 physical association X 2 Q95PW9 O62332 two hybrid 23549480 physical association X 2 Q95PW9 Q09269 two hybrid 23549480 physical association X 2 Q3Y407 Q95PW9 two hybrid 23549480 physical association X 2 G5ED57 Q95PW9 two hybrid 23549480 physical association X 2 Q20330 Q95PW9 two hybrid 23549480 physical association X 2 D0IMZ5 Q95PW9 two hybrid 23549480 physical association X 2 Q23356 Q95PW9 two hybrid 23549480 physical association X 2 B3CJ53 Q95PW9 two hybrid 23549480 physical association X 2 Q95PW9 P91001 two hybrid 23549480 physical association X 2 Q95PW9 Q09442 two hybrid 23549480 physical association X 2 Q95PW9 Q17865 two hybrid 23549480 physical association X 2 Q95PW9 Q19905 two hybrid 23549480 physical association X 2 Q95PW9 E3W743 two hybrid 23549480 physical association X 2 Q95PW9 P34397 two hybrid 23549480 physical association X 2 Q95PW9 P34552 two hybrid 23549480 physical association X 2 Q95PW9 P34258 two hybrid 23549480 physical association X 2 Q95PW9 Q7JPE2 two hybrid 23549480 physical association X 2 Q95PW9 Q17353 two hybrid 23549480 physical association X 2 Q95PW9 P34552 two hybrid 23549480 physical association X 2 Q95PW9 Q17744 two hybrid 23549480 physical association X 2 Q95PW9 P34258 two hybrid 23549480 physical association X 2 Q95PW9 H1UBJ9 two hybrid 23549480 physical association X 2 A9D4E4 Q95PW9 two hybrid 23549480 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CELE_Y47G6A.5 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23965 prey bait nck-1 CELE_F41B4.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24455 bait prey nck-1 CELE_F13H6.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23961 bait prey sap-49 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23950 prey bait pak-1 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24454 prey bait dyn-1 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24450 prey bait nck-1 F22E12.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23967 bait prey nck-1 sel-5 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23962 bait prey csn-5 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23949 prey bait nck-1 fln-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23957 bait prey nck-1 hpo-34 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23953 bait prey par-3 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23971 prey bait nck-1 ani-3 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24457 bait prey nck-1 unc-26 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23963 bait prey imb-2 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24456 prey bait cdh-4 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23968 prey bait grd-7 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23970 prey bait ttm-4 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23954 prey bait C09G1.4 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23951 prey bait nd4 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23955 prey bait nck-1 CELE_Y48C3A.14 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24460 bait prey alx-1 nck-1 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23972|UniProt_23964 prey|prey bait|bait mig-15 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23958 prey bait C06G1.5 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24452 prey bait wsp-1 nck-1 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23959|UniProt_24453 prey|prey bait|bait ZK512.5 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24451 prey bait F10E9.3 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23960 prey bait sqv-4 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23952 prey bait lst-1 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23956 prey bait B0303.7 nck-1 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_23966|UniProt_24458 prey|prey bait|bait C34C12.4 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24459 prey bait cpna-1 nck-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23969 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q95PW9 Q09442 NCK-1 SAP-49 0.183 23549480 Q95PW9 Q19905 NCK-1 SQV-4 0.183 23549480 Q95PW9 P24892 NCK-1 ND4 0.183 23549480 Q95PW9 Q8IAA6 NCK-1 Q8IAA6 0.183 23549480 Q95PW9 E3W743 NCK-1 HPO-34 0.183 23549480 Q95PW9 G5ECQ3 NCK-1 SEL-5 0.183 23549480 Q95PW9 G5ED57 NCK-1 G5ED57 0.183 23549480 Q95PW9 H2KYS8 NCK-1 CPNA-1 0.183 23549480 Q95PW9 O62332 NCK-1 IMB-2 0.183 23549480 Q95PW9 P34397 NCK-1 P34397 0.183 23549480 Q95PW9 P34643 NCK-1 SEC-16 0.183 23549480 Q95PW9 Q17795 NCK-1 WSP-1 0.332 23549480 Q95PW9 Q17865 NCK-1 Q17865 0.183 23549480 Q95PW9 Q19319 NCK-1 CDH-4 0.183 23549480 Q95PW9 Q20330 NCK-1 IFO-1 0.183 23549480 Q95PW9 Q3Y407 NCK-1 GRD-7 0.183 23549480 Q966J6 Q95PW9 Q966J6 NCK-1 0.183 23549480 Q9XWN6 Q95PW9 ANI-3 NCK-1 0.183 23549480 Q95PW9 P39055 NCK-1 DYN-1 0.183 23549480 Q95PW9 P34258 NCK-1 P34258 0.183 23549480 Q95PW9 P34552 NCK-1 ALX-1 0.183 23549480 Q95PW9 D0IMZ5 NCK-1 FLN-1 0.183 23549480 Q95PW9 P91001 NCK-1 CSN-5 0.183 23549480 Q95PW9 P91820 NCK-1 LST-1 0.183 23549480 Q95PW9 G5ECL2 NCK-1 UNC-26 {ECO:0000312|WORMBASE:JC8.10B} 0.183 23549480 Q95PW9 H1UBJ9 NCK-1 H1UBJ9 0.183 23549480 Q95PW9 Q23356 NCK-1 MIG-15 0.183 23549480 Q95PW9 A9D4E4 NCK-1 A9D4E4 0.183 23549480 Q95PW9 Q17353 NCK-1 PAR-3 0.183 23549480 Q95PW9 Q17744 NCK-1 Q17744 0.183 23549480 Q95PW9 Q17850 NCK-1 PAK-1 0.183 23549480 Q95PW9 Q09269 NCK-1 Q09269 0.183 23549480