PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ubc-1 Y54G2A.31 11778048,14704431 biogrid,i2d,mint,intact exp G asp-6 ubc-1 11778048,14704431 biogrid,i2d,mint,intact exp G ubc-1 Y38F1A.2 i2d exp G ubc-1 T01D1.6 14704431 biogrid,i2d,mint,intact exp G C50F4.11, MDF-1 ubc-1 11778048,14704431 biogrid,intact exp G ubc-1 ZK742.3 14704431 biogrid,i2d,mint,intact exp G crt-1 ubc-1 11778048,14704431 biogrid,i2d,mint,intact exp G gpd-2 ubc-1 11778048 i2d,mint,intact exp G ubc-1 F29D10.2 14704431 biogrid,mint,intact exp G ubc-1 Uncharacterized RING finger protein T02C1.1 i2d exp gpd-3 ubc-1 14704431 biogrid,i2d exp G ubc-1 hum-6 11778048,14704431 biogrid,i2d,mint,intact exp G rfp-1 ubc-1 11778048,14732404,19123269,14704431 biogrid,i2d,mint,intact exp, ortho G ubc-1 ubr-1 14732404 biogrid,i2d,intact exp, ortho G pbs-6 ubc-1 ortho G Zinc finger protein ZPR1 homolog ubc-1 ortho G pcn-1 ubc-1 ortho ubc-1 cdk-9 ortho G ubc-1 Y110A7A.4 ortho ubc-1 pbs-4 ortho G ubc-1 Y110A2AL.13 ortho G ubc-1 xrn-2 ortho G C44E4.1a ubc-1 ortho cdk-1 ubc-1 ortho ubc-1 ubc-1 ortho G ubq-2 ubc-1 ortho G ubc-1 F23C8.4 ortho G F39B2.2 ubc-1 ortho G ubc-1 mdt-31 ortho G SerRS ubc-1 ortho G klp-6 ubc-1 ortho G ubc-1 ctr-9 ortho G ubc-1 C08H9.2a ortho G ubc-1 cdc-73 ortho G ubc-1 ttll-12 ortho G ubc-1 M03C11.4 ortho ubc-1 C47E12.5a ortho G ubc-1 F38E9.5 ortho G F15C11.2a ubc-1 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P27798 P52478 - 12679813 - X 2 P27798 P52478 - 11778048 - X 2 P52478 Q95XX0 - 12679813 - X 2 P52478 Q95XX0 - 11778048 - X 2 P52478 G5EFM0 - 11778048 - X 2 P52478 G5EFM0 - 12679813 - X 2 P52478 O01530 - 11778048 - X 2 P52478 O01530 - 12679813 - X 2 Q9XWM0 P52478 - 15530417 - X 2 P91443 P52478 - 12679813 - X 2 P91443 P52478 - 11778048 - X 2 Q23090 P52478 - 14704431 - X 2 P52478 P17330 - 12679813 - X 2 P52478 - 14704431 - X 2 P52478 P34537-2 - 15530417 - X 2 P52478 P34537-2 - 11778048 - X 2 P52478 P34537-2 - 12679813 - X 2 P52478 P34537-2 - 14704431 - X 2 P52478 P91419 - 14704431 - X 2 P27798 P52478 two hybrid 14704431 direct interaction X 2 P52478 G5EFM0 two hybrid 14704431 direct interaction X 2 P52478 O01530 two hybrid 14704431 direct interaction X 2 P52478 Q95XX0 two hybrid 14704431 direct interaction X 2 P52478 P91133 two hybrid 14732404 direct interaction X 2 P91443 P52478 two hybrid 14704431 direct interaction X 2 Q23090 P52478 two hybrid 14704431 direct interaction X 2 P52478 two hybrid 14704431 direct interaction X 2 P52478 P17330 two hybrid 14704431 direct interaction X 2 P52478 P34537-2 two hybrid 14704431 direct interaction X 2 P52478 P91419 two hybrid 14704431 direct interaction X 2 P52478 P34537-2 two hybrid 14732404 direct interaction X 2 P52478 P34537-2 pull down 14732404 direct interaction X 2 Q23090 P52478 two hybrid 14704431 physical association X 2 P52478 two hybrid 14704431 physical association X 2 P52478 P34537 two hybrid 14704431 physical association X 2 P52478 P91419 two hybrid 14704431 physical association X 2 Q19899 P52478 two hybrid pooling approach 14704431 physical association X 2 P17329 P52478 two hybrid pooling approach 11778048 physical association X 2 P27798 P52478 two hybrid pooling approach 11778048 physical association X 2 P52478 G5EFM0 two hybrid pooling approach 11778048 physical association X 2 P52478 O01530 two hybrid pooling approach 11778048 physical association X 2 P52478 Q95XX0 two hybrid pooling approach 11778048 physical association X 2 P52478 P91133 two hybrid 14732404 physical association X 2 P91443 P52478 two hybrid pooling approach 11778048 physical association X 2 Q23090 P52478 two hybrid pooling approach 14704431 physical association X 2 P52478 P34537 two hybrid pooling approach 11778048 physical association X 2 P52478 P34537 two hybrid pooling approach 14704431 physical association X 2 P52478 P91419 two hybrid pooling approach 14704431 physical association X 2 P52478 P34537 two hybrid 14732404 physical association X 2 P52478 P34537 two hybrid 14732404 physical association X 2 P52478 P34537 anti bait coimmunoprecipitation 14732404 physical association X 2 P52478 P34537 two hybrid pooling approach 19123269 physical association X 2 P52478 P34537 two hybrid array 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B rfp-1 ubc-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 11778048,14704431,14732404,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_21786|UniProt_1324|DIP_1518|MINT_7102|MINT_7103|UniProt_20274|UniProt_18362|113586|UniProt_184|UniProt_183|UniProt_182|UniProt_29901 prey|prey|-|prey|prey|prey|prey|prey|bait|bait|prey|prey bait|bait|-|bait|bait|bait|bait|bait|prey|prey|bait|bait crt-1 ubc-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 11778048,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(intact)|(biogrid) UniProt_1325|MINT_7106|113589|BIOGRID_21789 prey|prey|prey|prey bait|bait|bait|bait asp-6 ubc-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 11778048,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid)|(intact) UniProt_1321|MINT_7099|BIOGRID_21783|113577 prey|prey|prey|prey bait|bait|bait|bait ubc-1 CELE_ZK742.3 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip)|(biogrid)|(intact) MINT_7107|DIP_1520|BIOGRID_21790|UniProt_29903 bait|-|bait|bait prey|-|prey|prey ubc-1 mdf-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 11778048,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_1320|BIOGRID_21782|113574 bait|bait|bait prey|prey|prey ubc-1 abu-11 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0465(dip) MINT_7104|UniProt_29902|DIP_1519 bait|bait|- prey|prey|- ubc-1 hum-6 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 11778048,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|(intact) MINT_7105|BIOGRID_21788|UniProt_1323|113583 bait|bait|bait|bait prey|prey|prey|prey ubc-1 Q9NGT4 MI:0398(two hybrid pooling approach) 11778048 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_7098 bait prey gpd-3 ubc-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_21785 prey bait ubc-1 ubr-1 MI:0018(two hybrid) 14732404 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_181 bait prey ubc-1 F29D10.2 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0465(dip)|(biogrid) MINT_7100|UniProt_29900|DIP_1517|BIOGRID_21784 bait|bait|-|bait prey|prey|-|prey gpd-2 ubc-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 11778048 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|(intact) MINT_7101|UniProt_1322|113580 prey|prey|prey bait|bait|bait ubc-1 ubc-13 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 11778048,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|MI:0471(mint) 113955|BIOGRID_25120|UniProt_1447|MINT_3142 prey|prey|prey|prey bait|bait|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P91419 P52478 ABU-11 UBC-1 0.155 14704431 Q23090 P52478 Q23090 UBC-1 0.155 14704431 P91133 P52478 UBR-1 UBC-1 0.523 14732404 P52478 P34537 UBC-1 RFP-1 0.88 14704431,14732404,11778048,19123269 Q95XX0 P52478 UBC-13 UBC-1 0.286 14704431,11778048 P52478 P27798 UBC-1 CRT-1 0.286 14704431,11778048 P91443 P52478 HUM-6 UBC-1 0.286 14704431,11778048 P52478 G5EFM0 UBC-1 MDF-1 0.126 11778048 P52478 O01530 UBC-1 ASP-6 0.286 14704431,11778048 P52478 P17330 UBC-1 GPD-3 0.183 14704431 Q19899 P52478 Q19899 UBC-1 0.155 14704431 P52478 P17329 UBC-1 GPD-2 0.126 11778048