PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus cdc-48.1 ufd-2 21317884 biogrid exp ubxn-4 cdc-48.1 20977550 biogrid exp G cdc-48.1 F45E4.2 19123269 intact exp G cdc-48.1 ufd-1 20977550 biogrid exp G F48A11.5a cdc-48.1 20977550 biogrid exp G cdc-48.1 H06H21.6 20977550 biogrid exp G atx-3 cdc-48.1 21317884,19123269 biogrid,intact exp cdc-48.1 cdc-48.1 18692475,unassigned701,24055316 biogrid,mint,intact,dip exp G cdc-48.1 B0024.10 19123269 intact exp G cdc-48.1 F23C8.4 20977550,19123269,14704431 biogrid,i2d,mint,intact,dip exp G cdc-48.1 dvc-1 19123269 intact exp cdc-48.1 Y94H6A.9a 20977550 biogrid exp G cdc-48.1 cdc-48.2 18692475,unassigned701,19123269 biogrid,mint,intact exp G hpr-1 cdc-48.1 14704431 biogrid,intact exp cdc-48.1 T01E8.9 20977550 biogrid exp cdc-48.1 ima-1 18692475,unassigned701 biogrid,mint,intact exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants G5EC44 P54811 - 14704431 - X 2 P54811 Q9TXH9 - 14704431 - X 2 P54811 Q6A589 affinity chromatography technology 20977550 physical association X 2 P54811 affinity chromatography technology 20977550 physical association X 2 P54811 Q9U3I6 affinity chromatography technology 20977550 physical association X 2 P54811 Q6A589 affinity chromatography technology 20977550 physical association X 2 P54811 Q6A589 two hybrid 20977550 direct interaction X 2 P54811 two hybrid 20977550 direct interaction X 2 P54811 Q9U3I6 two hybrid 20977550 direct interaction X 2 P54811 P54811 two hybrid 18692475 direct interaction X 2 P54811 P54811 x-ray crystallography 24055316 association X 2 P54811 O17850 two hybrid 21317884 direct interaction X 2 P54811 O17850 pull down 21317884 direct interaction X 2 P54811 Q6BEV4 pull down 21317884 direct interaction X 2 P54811 Q6BEV4 pull down 21317884 direct interaction X 2 P54811 O17850 pull down 21317884 direct interaction X 2 Q86DD7 P54811 affinity chromatography technology 20977550 physical association X 2 Q86DD7 P54811 two hybrid 20977550 direct interaction X 2 G5EC44 P54811 two hybrid 14704431 direct interaction X 2 Q22560 P54811 two hybrid 18692475 direct interaction X 2 P34631 P54811 affinity chromatography technology 20977550 physical association X 2 P54811 Q9TXH9 affinity chromatography technology 20977550 physical association X 2 P54811 Q9TXH9 two hybrid 20977550 direct interaction X 2 P54811 two hybrid 20977550 direct interaction X 2 P54811 Q9TXH9 two hybrid 14704431 direct interaction X 2 P54812 P54811 two hybrid 18692475 direct interaction X 2 P54812 P54811 two hybrid 18692475 direct interaction X 2 G5EC44 P54811 two hybrid 14704431 physical association X 2 P54811 P54811 atomic force microscopy 24055316 direct interaction Y 1 P54811 Q9TXH9 two hybrid 14704431 physical association X 2 P54811 O17850 two hybrid pooling approach 19123269 physical association X 2 P54811 O17850 two hybrid array 19123269 physical association X 2 P54811 P54811 two hybrid - physical association X 2 Q22557 P54811 two hybrid pooling approach 19123269 physical association X 2 Q22557 P54811 two hybrid array 19123269 physical association X 2 G5EC44 P54811 two hybrid pooling approach 14704431 physical association X 2 Q22560 P54811 two hybrid - physical association X 2 P54811 Q9TXH9 two hybrid pooling approach 14704431 physical association X 2 P54811 Q17425 two hybrid pooling approach 19123269 physical association X 2 P54811 Q9TXH9 two hybrid pooling approach 19123269 physical association X 2 P54811 Q94230 two hybrid pooling approach 19123269 physical association X 2 P54811 Q17425 two hybrid array 19123269 physical association X 2 P54811 Q9TXH9 two hybrid array 19123269 physical association X 2 P54811 Q94230 two hybrid array 19123269 physical association X 2 P54812 P54811 two hybrid pooling approach 19123269 physical association X 2 P54812 P54811 two hybrid pooling approach 19123269 physical association X 2 P54812 P54811 two hybrid array 19123269 physical association X 2 P54812 P54811 two hybrid array 19123269 physical association X 2 P54812 P54811 two hybrid - physical association X 2 P54812 P54811 two hybrid - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B cdc-48.1 rbcL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20977550 taxid:6239(Caenorhabditis elegans) taxid:173407() MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_28450|BIOGRID_28459|BIOGRID_28462 prey|bait|prey bait|prey|bait ubxn-4 cdc-48.1 MI:0004(affinity chromatography technology) 20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_28451 bait prey cdc-48.1 ubxn-5 MI:0004(affinity chromatography technology) 20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_28463 prey bait cdc-48.1 psaB MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20977550 taxid:6239(Caenorhabditis elegans) taxid:177057() MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_28449|BIOGRID_28461 prey|prey bait|bait cdc-48.1 B0024.10 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_17847|UniProt_19761 prey|prey bait|bait cdc-48.1 mrt-2 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_24959|UniProt_28826 prey|prey bait|bait cdc-48.1 ufd-1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_28458|BIOGRID_28465 bait|prey prey|bait atx-3 cdc-48.1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18020|UniProt_19937 bait|bait prey|prey cdc-48.1 cdc-48.2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 18692475,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(biogrid)|MI:0471(mint)|(intact)|(intact)|(intact) MINT_4309|MINT_3993|MINT_4305|BIOGRID_28913|MINT_3990|MINT_4306|MINT_3989|UniProt_18018|UniProt_25041|UniProt_25220|BIOGRID_29018|MINT_3985|UniProt_18017|UniProt_19932|UniProt_19933 prey|bait|prey|bait|bait|prey|bait|bait|prey|bait|prey|bait|prey|bait|prey bait|prey|bait|prey|prey|bait|prey|prey|bait|prey|bait|prey|bait|prey|bait cdc-48.1 ubxn-6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_28452|BIOGRID_28464 prey|prey bait|bait cdc-48.1 ima-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_24762|MINT_3994|BIOGRID_28914 bait|bait|bait prey|prey|prey cdc-48.1 T19B10.6 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18022|UniProt_19935 prey|prey bait|bait cdc-48.1 Q9U2I2 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint) DIP_4436|MINT_2959 -|prey -|bait cdc-48.1 plp-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18019|UniProt_19936 prey|prey bait|bait cdc-48.1 ubxn-1 MI:0398(two hybrid pooling approach)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,19123269,20977550 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(intact)|(intact)|MI:0465(dip) UniProt_18021|BIOGRID_28460|BIOGRID_22402|MINT_340|BIOGRID_28448|UniProt_30438|UniProt_19934|DIP_2054 prey|prey|prey|prey|prey|prey|prey|- bait|bait|bait|bait|bait|bait|bait|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q17425 P54811 Q17425 CDC-48.1 0.236 19123269 Q22557 P54811 DVC-1 CDC-48.1 0.236 19123269 P54811 O17850 CDC-48.1 ATX-3 0.748 19123269,21317884 Q94230 P54811 PLP-1 CDC-48.1 0.236 19123269 P54811 P54811 CDC-48.1 CDC-48.1 0.671 18692475,24055316,unassigned701 P54812 P54811 CDC-48.2 CDC-48.1 0.787 19123269,unassigned701,18692475 Q9TXH9 P54811 UBXN-1 CDC-48.1 0.354 19123269,14704431 Q9U2I2 P54811 Q9U2I2 CDC-48.1 0.033 14704431 P54811 P34631 CDC-48.1 UBXN-4 0.21 20977550 P54811 G5EC44 CDC-48.1 MRT-2 0.126 14704431 Q09349 P54811 UFD-2 CDC-48.1 0.523 21317884 Q19584 P54811 UFD-1 CDC-48.1 0.454 20977550 Q22560 P54811 IMA-1 CDC-48.1 0.454 unassigned701,18692475