PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus spd-2 F40F12.5a 14704431 biogrid,i2d exp G F29D10.4 F40F12.5a 23549480 intact exp G Non-specific protein-tyrosine kinase F40F12.5a 23549480 intact exp G F40F12.5a Y111B2A.24 19123269 intact exp F17A2.13 F40F12.5a 19123269 intact exp klp-6 F40F12.5a 14704431 biogrid exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P91870 Q7JMS4 two hybrid 14704431 direct interaction X 2 Q7JMS4 Q8MQ04 two hybrid 14704431 direct interaction X 2 Q19901 Q7JMS4 two hybrid 23549480 physical association X 2 O45539 Q7JMS4 two hybrid 23549480 physical association X 2 Q9BHL0 Q7JMS4 two hybrid pooling approach 19123269 physical association X 2 Q9BHL0 Q7JMS4 two hybrid array 19123269 physical association X 2 Q19510 Q7JMS4 two hybrid pooling approach 19123269 physical association X 2 Q19510 Q7JMS4 two hybrid array 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B cyld-1 Y111B2A.24 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18915|UniProt_20828 prey|prey bait|bait src-2 cyld-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24191 bait prey hum-1 cyld-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24143 bait prey CELE_F17A2.13 cyld-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_20632|UniProt_18715 bait|bait prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7JMS4 Q19901 CYLD-1 HUM-1 0.183 23549480 Q7JMS4 O45539 CYLD-1 SRC-2 0.183 23549480 Q7JMS4 Q19510 CYLD-1 Q19510 0.236 19123269 Q9BHL0 Q7JMS4 Q9BHL0 CYLD-1 0.236 19123269