PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus klp-6 siah-1 14704431 biogrid,i2d,mint,intact,dip exp G rpy-1 siah-1 14704431 biogrid,i2d,mint,intact,dip exp G ZK849.2a siah-1 14704431 mint,intact,dip exp G tir-1 siah-1 14704431,15048112 biogrid,i2d,mint,intact,dip exp G ZK849.1 siah-1 14704431 biogrid,i2d exp mrpl-18 siah-1 14704431 biogrid,i2d,mint,intact,dip exp G siah-1 VW02B12L.3 14704431 biogrid,i2d,mint,intact,dip exp G nhr-19 siah-1 14704431 biogrid,i2d,mint,intact exp G Y119C1B.8a siah-1 14704431 biogrid,i2d,mint,intact,dip exp G siah-1 Y48G1C.1 14704431 biogrid,i2d,mint,intact,dip exp Inhibitor of apoptosis homolog, T27F2.3 siah-1 14704431 biogrid,intact exp G F31C3.2b siah-1 14704431 biogrid,intact exp G F58B6.3b siah-1 unassigned1274 intact exp let-413 siah-1 14704431 biogrid,i2d,mint,intact,dip exp G F25H2.1 siah-1 ortho csn-5 siah-1 ortho G siah-1 Y37E3.8a ortho G siah-1 eef-1B.2 ortho G Putative hydroxypyruvate isomerase siah-1 ortho G hmp-2 siah-1 ortho G Protein N-terminal glutamine amidohydrolase siah-1 ortho F32B6.8b siah-1 ortho siah-1 pfk-1 ortho G let-70 siah-1 ortho G siah-1 Y110A7A.8 ortho G H24G06.1a siah-1 ortho G Y54G2A.31 siah-1 ortho G Beta-lactamase-like protein 2 homolog siah-1 ortho siah-1 H27M09.1 ortho G mab-21 siah-1 ortho G sft-4 siah-1 ortho G T19B4.7, Unc-40 protein siah-1 ortho G F16D3.1 siah-1 ortho arc-1 siah-1 ortho G Phosphoinositide phospholipase C siah-1 ortho G arx-6 siah-1 ortho F28C6.8b siah-1 ortho G rpt-4 siah-1 ortho G ZK783.2 siah-1 ortho G F40F4.5 siah-1 ortho G siah-1 siah-1 ortho G jnk-1 siah-1 ortho G C45G3.3 siah-1 ortho dld-1 siah-1 ortho G unc-116 siah-1 ortho G siah-1 Y47G6A.20b ortho G Ubiquitin carboxyl-terminal hydrolase siah-1 ortho G rpl-9 siah-1 ortho G F32E10.1 siah-1 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q965X6 - 14704431 - X 2 Q965X6 Q9XXA2 - 14704431 - X 2 Q965X6 G5EFA2 - 14704431 - X 2 Q965X6 O18301 - 14704431 - X 2 Q965X6 Q9XU12 - 14704431 - X 2 Q965X6 P34378 - 14704431 - X 2 Q86DA5-2 Q965X6 - 14704431 - X 2 Q965X6 Q09485 - 14704431 - X 2 Q965X6 G5EFM8 - 14704431 - X 2 Q965X6 O61967-2 - 14704431 - X 2 Q965X6 Q09528 - 14704431 - X 2 Q965X6 - 14704431 - X 2 Q965X6 P34378 two hybrid 14704431 direct interaction X 2 Q965X6 G5EFR3 two hybrid 14704431 direct interaction X 2 Q965X6 G5ED75 two hybrid 14704431 direct interaction X 2 Q965X6 G5EFA2 two hybrid 14704431 direct interaction X 2 Q965X6 Q9XXA2 two hybrid 14704431 direct interaction X 2 Q965X6 Q95Y80 two hybrid 14704431 direct interaction X 2 Q965X6 Q9N3P1 two hybrid 14704431 direct interaction X 2 Q965X6 O18301 two hybrid 14704431 direct interaction X 2 Q965X6 Q09485 two hybrid 14704431 direct interaction X 2 Q965X6 Q09528 two hybrid 14704431 direct interaction X 2 Q965X6 Q86DA5-5 two hybrid 14704431 direct interaction X 2 Q965X6 O61967 two hybrid 14704431 direct interaction X 2 Q965X6 P34378 two hybrid 14704431 physical association X 2 Q965X6 Q86DA5 two hybrid 14704431 physical association X 2 Q965X6 Q9XU12 two hybrid 14704431 physical association X 2 Q965X6 G5EFA2 two hybrid 14704431 physical association X 2 Q965X6 Q9XXA2 two hybrid 14704431 physical association X 2 Q965X6 Q95Y80 two hybrid 14704431 physical association X 2 Q965X6 Q95Y80 affinity chromatography technology 14704431 physical association X 2 Q965X6 Q9N3P1 two hybrid 14704431 physical association X 2 Q965X6 two hybrid 14704431 physical association X 2 Q965X6 Q09485 two hybrid 14704431 physical association X 2 Q965X6 Q09528 two hybrid 14704431 physical association X 2 Q965X6 O61967 two hybrid 14704431 physical association X 2 Q965X6 G5EFM8 two hybrid 14704431 physical association X 2 Q965X6 Q95Y80 anti tag coimmunoprecipitation 14704431 physical association X 2 Q965X6 P34378 two hybrid pooling approach 14704431 physical association X 2 Q965X6 Q86DA5 two hybrid pooling approach 14704431 physical association X 2 Q965X6 Q9XU12 two hybrid pooling approach 14704431 physical association X 2 Q965X6 G5EFA2 two hybrid pooling approach 14704431 physical association X 2 Q965X6 Q9XXA2 two hybrid pooling approach 14704431 physical association X 2 Q965X6 Q95Y80 two hybrid pooling approach 14704431 physical association X 2 Q965X6 Q9N3P1 two hybrid pooling approach 14704431 physical association X 2 Q965X6 O18302 two hybrid pooling approach 14704431 physical association X 2 Q965X6 Q09528 two hybrid pooling approach 14704431 physical association X 2 Q965X6 O61967 two hybrid pooling approach 14704431 physical association X 2 Q965X6 G5EFM8 two hybrid pooling approach 14704431 physical association X 2 Q965X6 Q09485 two hybrid pooling approach 14704431 physical association X 2 Q965X6 Q86DA5-3 two hybrid 15048112 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B siah-1 F31C3.2 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_22499 prey bait siah-1 F31C3.2 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_30526 prey bait siah-1 bir-1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_24356|UniProt_28237 prey|prey bait|bait siah-1 klp-7 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_23404 prey bait siah-1 klp-7 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip)|(intact) MINT_1373|DIP_2928|UniProt_31314 prey|-|prey bait|-|bait D2007.4 siah-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0465(dip)|(intact)|(biogrid) MINT_41|DIP_1789|UniProt_30172|BIOGRID_22119 bait|-|bait|bait prey|-|prey|prey let-413 siah-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|MI:0465(dip) BIOGRID_22452|MINT_390|UniProt_30478|DIP_2094 bait|bait|bait|- prey|prey|prey|- siah-1 ebp-2 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0465(dip)|(biogrid)|MI:0471(mint) UniProt_28282|DIP_3894|BIOGRID_24404|MINT_2394 prey|-|prey|prey bait|-|bait|bait tir-1 siah-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431,15048112 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|(intact)|MI:0471(mint)|(biogrid) DIP_1944|UniProt_297|UniProt_30329|MINT_209|BIOGRID_22280 -|null|bait|bait|bait -|prey|prey|prey|prey rpy-1 siah-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0465(dip) MINT_6981|UniProt_29799|DIP_1416 bait|bait|- prey|prey|- CELE_ZK849.1 siah-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_25533 bait prey nhr-19 siah-1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|MI:0471(mint)|(biogrid) DIP_1825|UniProt_30209|MINT_78|BIOGRID_22155 -|bait|bait|bait -|prey|prey|prey siah-1 bet-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0465(dip) MINT_6433|UniProt_28699|UniProt_996|MINT_2823|DIP_4310 prey|prey|prey|prey|- bait|bait|bait|bait|- siah-1 Y48G1C.1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint)|MI:0465(dip) BIOGRID_25052|UniProt_28912|MINT_3066|DIP_4520 prey|prey|prey|- bait|bait|bait|- O62195 siah-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip) MINT_442|DIP_2141 bait|- prey|- gopc-1 siah-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0465(dip) MINT_3574|UniProt_29358|DIP_4965 bait|bait|- prey|prey|- Q22837 siah-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip) MINT_2344|DIP_3848 bait|- prey|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q965X6 Q22837 SIAH-1 Q22837 0.033 14704431 Q965X6 O17801 SIAH-1 TIR-1 0.033 14704431 Q965X6 O61967 SIAH-1 LET-413 0.309 14704431 Q965X6 Q86DA5 SIAH-1 TIR-1 0.507 15048112,14704431 Q965X6 Q95Y80 SIAH-1 BET-1 0.416 14704431 Q9N3P1 Q965X6 Q9N3P1 SIAH-1 0.155 14704431 Q965X6 G5EFM8 SIAH-1 G5EFM8 0.126 14704431 Q965X6 O18302 SIAH-1 GOPC-1 0.155 14704431 Q965X6 O62195 SIAH-1 O62195 0.033 14704431 Q965X6 Q09485 SIAH-1 RPY-1 0.309 14704431 Q965X6 Q09528 SIAH-1 NHR-19 0.309 14704431 Q965X6 Q965F9 SIAH-1 Q965F9 0.183 26780296 Q9XU12 Q965X6 KLP-7 SIAH-1 0.155 14704431 Q9XXA2 Q965X6 EBP-2 SIAH-1 0.155 14704431 Q965X6 P34378 SIAH-1 MRPL-18 0.309 14704431 Q965X6 G5EFA2 SIAH-1 BIR-1 0.126 14704431