PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ENT1 Maf-like protein YOR111W 11283351 biogrid,i2d,mint,intact,dip exp SSB2 ENT1 19536198 intact exp SSA2 ENT1 16429126 intact exp NIS1 ENT1 16537494 dip exp SSE1 ENT1 16429126,19536198 intact exp RGA2 ENT1 16537494 biogrid,dip exp UBI4 ENT1 11988742,12529323 biogrid exp SSB1 ENT1 16429126,19536198 intact exp BEM3 ENT1 16537494 biogrid,dip exp IVY1 ENT1 i2d exp FIR1 ENT1 16537494 dip exp HSC82 ENT1 19536198 intact exp HSP78 ENT1 19536198 intact exp PRK1 ENT1 20489023, 23023127 biogrid,mint,intact exp, pred SLA2 ENT1 22927393, 23023127 biogrid,dip exp, pred RGA1 ENT1 16537494, 23023127 biogrid,dip exp, pred YSC84 ENT1 19841731, 23023127 biogrid,mint,intact exp, pred EDE1 ENT1 12529323, 23023127 biogrid exp, pred MSL5 ENT1 9207794, 23023127 biogrid,i2d,dip exp, pred ENT1 ENT1 11805826, 23023127 mint,intact exp, pred LAS17 ENT1 11743162, 23023127 biogrid,i2d,mint,intact,dip exp, pred ENT2 ENT1 23023127 i2d exp, pred PAN1 ENT1 12529323,9531549, 23023127 biogrid,i2d,intact,dip exp, pred CHC1 ENT1 10449404,12529323,14704157,15992543, 23023127 biogrid,i2d exp, pred HSE1 ENT1 23023127 pred ENT3 ENT1 23023127 pred TLG2 ENT1 23023127 pred ARC15 ENT1 23023127 pred YAP1802 ENT1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12446 Q12518 - 11743162 - X 2 P32521 Q12518 - 9531549 - X 2 Q99210 Q12518 - 11283351 - X 2 P22137 Q12518 - 10449404 - X 2 Q12186 Q12518 - 9207794 - X 2 Q12446 Q12518 two hybrid 11743162 direct interaction X 2 P0CG63 Q12518 pull down 12529323 direct interaction X 2 P0CG63 Q12518 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q12518 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q12518 unspecified method 11988742 direct interaction X 2 P0CG63 Q12518 pull down 11988742 direct interaction X 2 P0CG63 Q12518 affinity chromatography technology 21427232 physical association X 2 P0CG63 Q12518 affinity chromatography technology 22106047 physical association X 2 P0CG63 Q12518 affinity chromatography technology 22081111 physical association X 2 P40494 Q12518 affinity chromatography technology 20489023 physical association X 2 P32521 Q12518 two hybrid 12529323 direct interaction X 2 P32521 Q12518 two hybrid 9531549 direct interaction X 2 Q99210 Q12518 two hybrid 11283351 direct interaction X 2 Q06407 Q12518 two hybrid 16537494 direct interaction X 2 Q06407 Q12518 affinity chromatography technology 16537494 physical association X 2 P22137 Q12518 affinity chromatography technology 14704157 physical association X 2 P22137 Q12518 affinity chromatography technology 10449404 physical association X 2 P22137 Q12518 imaging technique 15992543 colocalization X 2 P22137 Q12518 pull down 12529323 direct interaction X 2 P32793 Q12518 two hybrid 19841731 direct interaction X 2 P32873 Q12518 two hybrid 16537494 direct interaction X 2 Q12518 P34216 two hybrid 12529323 direct interaction X 2 Q12518 P34216 pull down 12529323 direct interaction X 2 Q12518 P39083 two hybrid 16537494 direct interaction X 2 Q12518 P39083 affinity chromatography technology 16537494 physical association X 2 P33338 Q12518 affinity chromatography technology 22927393 physical association X 2 Q12186 Q12518 two hybrid 9207794 direct interaction X 2 Q12446 Q12518 two hybrid 11743162 physical association X 2 P32521 Q12518 two hybrid 9531549 physical association X 2 Q99210 Q12518 two hybrid pooling approach 11283351 physical association X 2 Q06407 Q12518 pull down 16537494 direct interaction X 2 Q06407 Q12518 two hybrid 16537494 direct interaction X 2 Q06407 Q12518 pull down 16537494 direct interaction X 2 Q06407 Q12518 two hybrid 16537494 direct interaction X 2 Q06407 Q12518 isothermal titration calorimetry 16537494 direct interaction X 2 Q06407 Q12518 pull down 16537494 direct interaction X 2 Q12518 two hybrid 16537494 physical association X 2 P53939 Q12518 two hybrid 16537494 physical association X 2 P32873 Q12518 two hybrid 16537494 physical association X 2 P32873 Q12518 two hybrid 16537494 physical association X 2 Q12518 pull down 22927393 direct interaction X 2 Q12518 pull down 22927393 direct interaction X 2 Q12518 P39083 two hybrid 16537494 direct interaction X 2 Q12518 P39083 two hybrid 16537494 direct interaction X 2 Q12518 P39083 pull down 16537494 direct interaction X 2 Q12186 Q12518 two hybrid 9207794 physical association X 2 P32589 Q12518 tandem affinity purification 19536198 association X 2 Q12446 Q12518 two hybrid 11743162 physical association X 2 P15108 Q12518 tandem affinity purification 19536198 association X 2 P32521 Q12518 two hybrid 9531549 physical association X 2 Q99210 Q12518 two hybrid fragment pooling approach 11283351 physical association X 2 Q12518 Q12518 tandem affinity purification 11805826 physical association X 2 Q12518 P33416 tandem affinity purification 19536198 association X 2 Q12518 tandem affinity purification 16429126 association C 4 Q12518 anti tag coimmunoprecipitation 20489023 association C 17 P11484 Q12518 tandem affinity purification 19536198 association X 2 P32793 Q12518 two hybrid pooling approach 19841731 physical association X 2 P0CG48 Q12518 pull down 11988742 direct interaction X 2 P0CG48 Q12518 pull down 11988742 physical association X 2 P0CG48 Q12518 pull down 11988742 physical association X 2 P40150 Q12518 tandem affinity purification 19536198 association X 2 Q12446 Q12518 two hybrid 11743162 - X 2 P32521 Q12518 two hybrid 9531549 - X 2 Q99210 Q12518 two hybrid 11283351 - X 2 Q12518 Q05785 interaction detection method 10449404 - X 2 Q12186 Q12518 two hybrid 9207794 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PAN1 ENT1 9531549,12529323 0018,0018 LC YSC84 ENT1 19841731,19841731 0398,0018 HT BEM3 ENT1 16537494 0018 LC SLA2 ENT1 25898165 0114 LC EDE1 ENT1 12529323,12529323 0018,0096 LC RGA1 ENT1 16537494,16537494,16537494 0096,0018,0004 LC FIR1 ENT1 16537494 0018 LC NIS1 ENT1 16537494 0018 LC RGA2 ENT1 16537494,16537494,16537494,16537494 0096,0018,0065,0004 LC MSL5 ENT1 9207794 0018 HT LAS17 ENT1 11743162,11743162 0397,0018 HT ENT1 Q99210 11283351,11283351,11283351 0018,0399,0398 HT UBI4 ENT1 11988742,12529323,11988742,22106047,22081111 0004,0096,0096,0004,0004 LC SSA2 ENT1 16429126 0676 HT SSB1 ENT1 19536198,16429126 0676,0676 HT HSC82 ENT1 19536198 0676 HT CHC1 ENT1 15992543,14704157,12529323,10449404 0428,0004,0096,0004 LC SSE1 ENT1 19536198,16429126 0676,0676 HT SLA2 ENT1 22927393,22927393 0096,0004 LC HSP78 ENT1 19536198 0676 HT EDE1 ENT1 12529323,12529323 0018,0096 LC RGA1 ENT1 16537494,16537494,16537494 0096,0018,0004 LC SSB2 ENT1 19536198 0676 HT PRK1 ENT1 20489023,20489023 0007,0004 HT RGA2 ENT1 16537494,16537494,16537494,16537494 0096,0018,0065,0004 LC ENT1 ENT1 11805826,11805826 0676,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12518 Q12221 ENT1 PUF2 0.126 26668354 Q12518 P0CG48 ENT1 UBC 0.569 11988742 Q12518 P0CG63 ENT1 UBI4 0.671 11988742,12529323 Q12518 P34216 ENT1 EDE1 0.523 12529323 Q12518 P22137 ENT1 CHC1 0.569 14704157,12529323,10449404 Q12518 P32521 ENT1 PAN1 0.523 9531549,12529323 Q99210 Q12518 Q99210 ENT1 0.236 11283351 Q12518 P32589 ENT1 SSE1 0.236 16429126,19536198 Q12518 P39083 ENT1 RGA1 0.454 16537494 Q12518 P32793 ENT1 YSC84 0.286 19841731 Q12518 P33338 ENT1 SLA2 0.21 22927393 Q12518 P40150 ENT1 SSB2 0.126 19536198 Q12518 P40494 ENT1 PRK1 0.286 20489023 Q12518 P11484 ENT1 SSB1 0.236 16429126,19536198 Q12518 P10592 ENT1 SSA2 0.126 16429126 Q12518 P32873 ENT1 BEM3 0.309 16537494 Q12518 P33416 ENT1 HSP78 0.126 19536198 Q12518 Q12446 ENT1 LAS17 0.21 11743162 Q12518 Q06407 ENT1 RGA2 0.454 16537494 Q12518 Q12186 ENT1 MSL5 0.21 9207794 Q12518 Q12518 ENT1 ENT1 0.155 11805826 Q12518 P15108 ENT1 HSC82 0.126 19536198