PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ACT1 RTC1 25073740 intact exp VPS1 RTC1 25073740 intact exp NAB2 RTC1 19840948 biogrid exp HSP12 RTC1 19536198 intact exp HSP78 RTC1 19536198 intact exp SSE1 RTC1 19536198 intact exp GPM1 RTC1 25073740 intact exp NSR1 RTC1 25073740 intact exp FBA1 RTC1 25073740 intact exp RTC1 NOP56 25073740 intact exp TOR1 RTC1 25073740 intact exp PMA1 RTC1 25073740 intact exp RTC1 YRA1 25073740 intact exp KOG1 RTC1 25073740 intact exp RTC1 NOP58 25073740 intact exp IMD3 RTC1 25073740 intact exp LST8 RTC1 25073740 intact exp SSA1 RTC1 19536198 intact exp MSS116 RTC1 25073740 intact exp SSA2 RTC1 19536198 intact exp HRR25 RTC1 25073740 intact exp SSC1 RTC1 19536198,25073740 intact exp RTC1 SRL2 18467557 biogrid,i2d,mint,intact exp RRP5 RTC1 25073740 intact exp RVB1 RTC1 25073740 intact exp RFA1 RTC1 25073740 intact exp RIM1 RTC1 25073740 intact exp SIS1 RTC1 19536198 intact exp SWA2 RTC1 19536198 intact exp HSP82 RTC1 25073740 intact exp RTC1 RVB2 25073740 intact exp MGM101 RTC1 25073740 intact exp SSB1 RTC1 19536198 intact exp IML1 RTC1 21454883,25073740 biogrid,intact exp FPR4 RTC1 25073740 intact exp NOP1 RTC1 25073740 intact exp NPR3 RTC1 21454883,25073740 biogrid,intact exp NPR2 RTC1 21454883,25073740 biogrid,intact exp MIS1 RTC1 i2d exp DED1 RTC1 25073740 intact exp SEA4 RTC1 21454883,25073740 biogrid,intact exp RAD52 RTC1 25073740 intact exp PSA1 RTC1 i2d exp PRP43 RTC1 25073740 intact exp SPL2 RTC1 18467557, 23023127 biogrid,i2d,mint,intact exp, pred SEC13 RTC1 21454883,25073740, 23023127 biogrid,intact exp, pred MTC5 RTC1 21454883,25073740, 23023127 biogrid,intact exp, pred RTC1 BSC1 18467557, 23023127 biogrid,i2d,mint,intact exp, pred RTC1 SUS1 18467557, 23023127 biogrid,i2d,mint,intact exp, pred KIN2 RTC1 20489023, 23023127 biogrid,mint,intact exp, pred SEH1 RTC1 21454883,25073740,18046405, 23023127 biogrid,intact exp, pred RBS1 RTC1 18467557, 23023127 biogrid,i2d,mint,intact exp, pred MCK1 RTC1 20489023, 23023127 biogrid,mint,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG63 Q08281 biochemical 23583075 association X 2 Q08281 Q05672 protein complementation assay 18467557 direct interaction X 2 Q08281 Q12020 protein complementation assay 18467557 direct interaction X 2 Q08281 P13186 affinity chromatography technology 20489023 physical association X 2 Q08281 P53011 affinity chromatography technology 21454883 physical association X 2 Q08281 P47170 affinity chromatography technology 21454883 physical association X 2 Q08281 P47170 affinity chromatography technology 21454883 physical association X 2 Q08281 Q03897 affinity chromatography technology 21454883 physical association X 2 Q08281 P38164 affinity chromatography technology 21454883 physical association X 2 Q08281 P39923 affinity chromatography technology 21454883 physical association X 2 Q08281 P53011 affinity chromatography technology 21454883 physical association X 2 Q08281 Q03897 affinity chromatography technology 21454883 physical association X 2 Q08281 P38164 affinity chromatography technology 21454883 physical association X 2 Q08281 P53011 affinity chromatography technology 18046405 physical association X 2 Q08281 Q6WNK7 protein complementation assay 18467557 direct interaction X 2 Q08281 Q12140 protein complementation assay 18467557 direct interaction X 2 Q08281 P38839 protein complementation assay 18467557 direct interaction X 2 Q08281 P21965 affinity chromatography technology 20489023 physical association X 2 Q08281 P38742 affinity chromatography technology 21454883 physical association X 2 Q08281 Q04491 affinity chromatography technology 21454883 physical association X 2 Q08281 anti tag coimmunoprecipitation 20489023 association C 35 Q08281 affinity chromatography technology 25073740 association C 36 Q08281 Q05672 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08281 Q12020 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08281 Q06677 tandem affinity purification 19536198 association X 2 Q08281 P25294 tandem affinity purification 19536198 association X 2 Q08281 P10592 tandem affinity purification 19536198 association X 2 Q08281 P22943 tandem affinity purification 19536198 association X 2 P10591 Q08281 tandem affinity purification 19536198 association X 2 Q08281 anti tag coimmunoprecipitation 20489023 association C 8 Q08281 affinity chromatography technology 25073740 association C 5 Q08281 anti tag coimmunoprecipitation 20489023 association C 35 Q08281 affinity chromatography technology 25073740 association C 32 Q08281 affinity chromatography technology 25073740 association C 10 Q08281 affinity chromatography technology 25073740 association C 18 Q08281 affinity chromatography technology 25073740 association C 8 Q08281 affinity chromatography technology 25073740 association C 8 Q08281 cross-linking study 25073740 physical association C 8 Q08281 affinity chromatography technology 25073740 association C 8 Q08281 cosedimentation through density gradient 25073740 physical association C 8 P32589 Q08281 tandem affinity purification 19536198 association X 2 Q08281 P38839 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08281 Q12140 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08281 Q6WNK7 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08281 P0CS90 tandem affinity purification 19536198 association X 2 Q08281 P11484 tandem affinity purification 19536198 association X 2 Q08281 P33416 tandem affinity purification 19536198 association X 2

PPI - HINT Gene A Gene B PMID Method Quality SPL2 RTC1 18467557,18467557 0111,0090 HT IML1 RTC1 25073740,25073740,25073740 0004,0029,0030 LC RBS1 RTC1 18467557,18467557 0111,0090 HT RTC1 SRL2 18467557,18467557 0111,0090 HT RTC1 BSC1 18467557,18467557 0111,0090 HT RTC1 SUS1 18467557,18467557 0111,0090 HT GPM1 RTC1 25073740 0004 LC HSP82 RTC1 25073740 0004 LC PMA1 RTC1 25073740 0004 LC DED1 RTC1 25073740 0004 LC RAD52 RTC1 25073740 0004 LC SSC1 RTC1 25073740,19536198 0004,0676 LC,HT SSA1 RTC1 19536198 0676 HT SSA2 RTC1 19536198 0676 HT SSB1 RTC1 19536198 0676 HT KIN2 RTC1 20489023,20489023 0007,0004 HT FBA1 RTC1 25073740 0004 LC MSS116 RTC1 25073740 0004 LC NOP1 RTC1 25073740 0004 LC VPS1 RTC1 25073740 0004 LC MCK1 RTC1 20489023,20489023 0007,0004 HT RFA1 RTC1 25073740 0004 LC HSP12 RTC1 19536198 0676 HT SIS1 RTC1 19536198 0676 HT NSR1 RTC1 25073740 0004 LC HRR25 RTC1 25073740 0004 LC RIM1 RTC1 25073740 0004 LC NAB2 RTC1 19840948 0004 LC SSE1 RTC1 19536198 0676 HT MGM101 RTC1 25073740 0004 LC HSP78 RTC1 19536198 0676 HT TOR1 RTC1 25073740 0004 LC SEA4 RTC1 25073740,21454883 0004,0004 LC NPR3 RTC1 25073740,21454883 0004,0004 LC KOG1 RTC1 25073740 0004 LC NPR2 RTC1 25073740,21454883 0004,0004 LC LST8 RTC1 25073740 0004 LC IML1 RTC1 25073740,25073740,21454883,25073740 0004,0029,0004,0030 LC IMD3 RTC1 25073740 0004 LC SEH1 RTC1 25073740,21454883,18046405 0004,0004,0004 LC PRP43 RTC1 25073740 0004 LC ACT1 RTC1 25073740 0004 LC MTC5 RTC1 25073740,21454883 0004,0004 LC RVB1 RTC1 25073740 0004 LC SEC13 RTC1 25073740,21454883 0004,0004 LC RRP5 RTC1 25073740 0004 LC FPR4 RTC1 25073740 0004 LC SWA2 RTC1 19536198 0676 HT RTC1 YRA1 25073740 0004 LC RTC1 NOP56 25073740 0004 LC RTC1 RVB2 25073740 0004 LC RTC1 NOP58 25073740 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q08281 P22943 RTC1 HSP12 0.126 19536198 Q08281 P11484 RTC1 SSB1 0.126 19536198 Q08281 Q03897 RTC1 MTC5 0.523 25073740,21454883 Q08281 P38164 RTC1 SEA4 0.523 25073740,21454883 Q08281 P47170 RTC1 IML1 0.636 25073740,21454883 Q08281 P39923 RTC1 NPR2 0.309 25073740,21454883 Q08281 Q04491 RTC1 SEC13 0.309 25073740,21454883 Q08281 P53011 RTC1 SEH1 0.523 25073740,21454883,18046405 Q12020 Q08281 SRL2 RTC1 0.286 18467557 Q12140 Q08281 BSC1 RTC1 0.286 18467557 Q6WNK7 Q08281 SUS1 RTC1 0.286 18467557 Q08281 P38839 RTC1 SPL2 0.286 18467557 Q08281 P38742 RTC1 NPR3 0.396 25073740,21454883 Q08281 P32505 RTC1 NAB2 0.126 19840948 Q08281 P32589 RTC1 SSE1 0.126 19536198 Q08281 P33416 RTC1 HSP78 0.126 19536198 Q08281 P00950 RTC1 GPM1 0.126 25073740 Q08281 P02829 RTC1 HSP82 0.126 25073740 Q08281 P05030 RTC1 PMA1 0.126 25073740 Q08281 P06634 RTC1 DED1 0.126 25073740 Q08281 P06778 RTC1 RAD52 0.126 25073740 Q08281 P0CS90 RTC1 SSC1 0.236 19536198,25073740 Q08281 P10591 RTC1 SSA1 0.126 19536198 Q08281 P10592 RTC1 SSA2 0.126 19536198 Q08281 P13186 RTC1 KIN2 0.332 20489023 Q08281 P14540 RTC1 FBA1 0.126 25073740 Q08281 P15424 RTC1 MSS116 0.126 25073740 Q08281 P15646 RTC1 NOP1 0.126 25073740 Q08281 P21576 RTC1 VPS1 0.126 25073740 Q08281 P22336 RTC1 RFA1 0.126 25073740 Q08281 P25294 RTC1 SIS1 0.126 19536198 Q08281 P27476 RTC1 NSR1 0.126 25073740 Q08281 P29295 RTC1 HRR25 0.126 25073740 Q08281 P32445 RTC1 RIM1 0.126 25073740 Q08281 P32787 RTC1 MGM101 0.126 25073740 Q08281 P35169 RTC1 TOR1 0.126 25073740 Q08281 P38873 RTC1 KOG1 0.126 25073740 Q08281 P41318 RTC1 LST8 0.126 25073740 Q08281 P50095 RTC1 IMD3 0.126 25073740 Q08281 P53131 RTC1 PRP43 0.126 25073740 Q08281 P60010 RTC1 ACT1 0.126 25073740 Q08281 Q03940 RTC1 RVB1 0.126 25073740 Q08281 Q05022 RTC1 RRP5 0.126 25073740 Q08281 Q05672 RTC1 RBS1 0.286 18467557 Q08281 Q06205 RTC1 FPR4 0.126 25073740 Q08281 Q06677 RTC1 SWA2 0.126 19536198 Q12159 Q08281 YRA1 RTC1 0.126 25073740 Q12460 Q08281 NOP56 RTC1 0.126 25073740 Q12464 Q08281 RVB2 RTC1 0.126 25073740 Q12499 Q08281 NOP58 RTC1 0.126 25073740 Q08281 P21965 RTC1 MCK1 0.286 20489023