PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RPS31 CUE5 i2d exp GIS2 CUE5 21232131 biogrid exp ATG8 CUE5 25042851 biogrid,intact exp SSN3 CUE5 16319894 biogrid,i2d exp FPR1 CUE5 25042851 biogrid,intact exp RPL40A CUE5 i2d exp UBI4 CUE5 12628920,25042851,16554755 biogrid,i2d,mint,intact exp CLB1 CUE5 16554755 intact exp HSP82 CUE5 19536198,26217697 biogrid,intact exp TMA19 CUE5 25042851 biogrid,intact exp SSA1 CUE5 26217697,23217712 biogrid,intact exp RPN11 CUE5 20170199 biogrid exp BNI1 CUE5 24133141 biogrid exp SBP1 CUE5 23222640 biogrid exp CLB2 CUE5 15200949 biogrid exp RPL40B CUE5 16554755 biogrid,i2d exp SWE1 CUE5 i2d exp NSE3 CUE5 14690591 intact exp HUA1 CUE5 18719252, 23023127 biogrid,intact exp, pred CUE5 CUE5 18467557, 23023127 biogrid,i2d,mint,intact exp, pred RVS167 CUE5 19841731,14737190, 23023127 i2d,mint,intact exp, pred LSB3 CUE5 19841731,22615397,18467557,16554755,18719252,11805837,11743162,14737190, 23023127 biogrid,i2d,mint,intact,dip exp, pred TRM732 CUE5 16554755, 23023127 biogrid,i2d,mint,intact exp, pred DSK2 CUE5 16554755, 23023127 biogrid,i2d,mint,intact exp, pred YCK1 CUE5 16319894, 23023127 biogrid exp, pred GCD7 CUE5 18719252, 23023127 biogrid,intact exp, pred NAB2 CUE5 19840948, 23023127 biogrid exp, pred LSB1 CUE5 19841731, 23023127 mint,intact exp, pred PIN3 CUE5 11743162,19841731, 23023127 mint,intact exp, pred RSP5 CUE5 17551511,25042851, 23023127 biogrid,intact exp, pred CUE5 LAS17 21035341, 23023127 biogrid exp, pred SSE2 CUE5 19536198, 23023127 intact exp, pred YSC84 CUE5 11743162,19841731,18467557,14737190, 23023127 biogrid,i2d,mint,intact exp, pred PDX1 CUE5 23023127 pred SWA2 CUE5 23023127 pred UBX7 CUE5 23023127 pred UBP14 CUE5 23023127 pred UBI4 CUE5 23023127 pred CUE5 MEX67 23023127 pred CUE5 RUP1 23023127 pred MYO3 CUE5 23023127 pred CUE2 CUE5 23023127 pred SMI1 CUE5 23023127 pred UBX4 CUE5 23023127 pred PAB1 CUE5 23023127 pred STP22 CUE5 23023127 pred EDE1 CUE5 23023127 pred SHP1 CUE5 23023127 pred CUE3 CUE5 23023127 pred CUE5 MDY2 23023127 pred EGD2 CUE5 23023127 pred RAD23 CUE5 23023127 pred CUE1 CUE5 23023127 pred UBX5 CUE5 23023127 pred UBX6 CUE5 23023127 pred PAN1 CUE5 23023127 pred TUP1 CUE5 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08412 - 14737190 - X 2 Q08412 - 14737190 - X 2 Q08412 - 14737190 - X 2 Q08412 P32793 - 14737190 - X 2 Q08412 P32793 - 14737190 - X 2 Q08412 - 11805837 - C 9 Q08412 - 15200949 - C 11 Q08412 P39743 - 14737190 - X 2 Q12446 Q08412 affinity chromatography technology 21035341 physical association X 2 P20081 Q08412 affinity chromatography technology 25042851 physical association X 2 P38182 Q08412 affinity chromatography technology 25042851 physical association X 2 P38182 Q08412 affinity chromatography technology 25042851 physical association X 2 P38182 Q08412 affinity chromatography technology 25042851 physical association X 2 Q08412 P32793 protein complementation assay 18467557 direct interaction X 2 Q08412 P32793 two hybrid 19841731 direct interaction X 2 P48510 Q08412 affinity chromatography technology 16554755 physical association X 2 P39940 Q08412 affinity chromatography technology 25042851 physical association X 2 P39940 Q08412 enzymatic study 17551511 direct interaction X 2 P24869 Q08412 affinity chromatography technology 15200949 physical association X 2 P0CH08 Q08412 affinity chromatography technology 16554755 physical association X 2 P0CG63 Q08412 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q08412 biochemical 23583075 association X 2 P0CG63 Q08412 pull down 12628920 direct interaction X 2 P0CG63 Q08412 pull down 25042851 direct interaction X 2 P0CG63 Q08412 affinity chromatography technology 25042851 physical association X 2 P0CG63 Q08412 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q08412 affinity chromatography technology 12872131 physical association X 2 P0CG63 Q08412 affinity chromatography technology 21427232 physical association X 2 P0CG63 Q08412 affinity chromatography technology 14557538 physical association X 2 P0CG63 Q08412 affinity chromatography technology 22106047 physical association X 2 Q08412 P35691 affinity chromatography technology 25042851 physical association X 2 Q08412 P43603 affinity chromatography technology 16554755 physical association X 2 Q08412 Q03496 affinity chromatography technology 16554755 physical association X 2 Q08412 P39073 enzymatic study 16319894 direct interaction X 2 Q08412 P23291 enzymatic study 16319894 direct interaction X 2 Q08412 P43603 protein complementation assay 18467557 direct interaction X 2 Q08412 Q08412 protein complementation assay 18467557 direct interaction X 2 Q08412 P43603 two hybrid 18719252 direct interaction X 2 Q08412 P40325 two hybrid 18719252 direct interaction X 2 Q08412 P32502 two hybrid 18719252 direct interaction X 2 Q08412 P43603 two hybrid 19841731 direct interaction X 2 Q08412 P43588 affinity chromatography technology 20170199 physical association X 2 Q08412 P43603 affinity chromatography technology 11805837 physical association X 2 Q08412 P43603 protein complementation assay 22615397 direct interaction X 2 Q08412 anti tag coimmunoprecipitation 11805837 - C 9 Q08412 P43603 anti tag coimmunoprecipitation 11805837 physical association X 2 Q08412 pull down 23217712 association C 317 Q08412 anti tag coimmunoprecipitation 25042851 association C 4 Q08412 anti tag coimmunoprecipitation 11805837 association C 9 Q08412 anti tag coimmunoprecipitation 25042851 association C 3 Q08412 anti tag coimmunoprecipitation 25042851 association C 3 P42858 Q08412 anti tag coimmunoprecipitation 25042851 physical association X 2 P38182 Q08412 anti tag coimmunoprecipitation 25042851 physical association X 2 P38182 Q08412 pull down 25042851 direct interaction X 2 P38182 Q08412 anti tag coimmunoprecipitation 25042851 physical association X 2 Q08412 P32793 peptide array 14737190 direct interaction X 2 Q08412 P32793 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08412 P32793 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08412 P32793 inferred by author 19841731 direct interaction X 2 Q08412 P32793 peptide array 19841731 direct interaction X 2 Q08412 P32793 peptide array 19841731 direct interaction X 2 Q08412 P32793 two hybrid array 19841731 physical association X 2 Q08412 P32793 two hybrid pooling approach 19841731 physical association X 2 P32590 Q08412 tandem affinity purification 19536198 association X 2 P53281 Q08412 inferred by author 19841731 direct interaction X 2 P48510 Q08412 tandem affinity purification 16554755 physical association X 2 P39940 Q08412 anti tag coimmunoprecipitation 25042851 physical association X 2 Q08412 pull down 14690591 association C 35 Q08412 inferred by author 16554755 association C 7 Q06449 Q08412 inferred by author 19841731 direct interaction X 2 P0CG63 Q08412 tandem affinity purification 16554755 physical association X 2 P02829 Q08412 tandem affinity purification 19536198 association X 2 Q08412 P39743 peptide array 14737190 direct interaction X 2 Q08412 P43603 peptide array 14737190 direct interaction X 2 Q08412 Q03496 tandem affinity purification 16554755 physical association X 2 Q08412 P43603 tandem affinity purification 16554755 physical association X 2 Q08412 P43603 tandem affinity purification 16554755 physical association X 2 Q08412 Q03496 tandem affinity purification 16554755 physical association X 2 Q08412 Q03496 tandem affinity purification 16554755 physical association X 2 Q08412 P43603 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08412 P43603 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08412 Q08412 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08412 P40325 two hybrid 18719252 physical association X 2 Q08412 P32502 two hybrid 18719252 physical association X 2 Q08412 P43603 two hybrid 18719252 physical association X 2 Q08412 P39743 inferred by author 19841731 direct interaction X 2 Q08412 P43603 peptide array 19841731 direct interaction X 2 Q08412 P43603 peptide array 19841731 direct interaction X 2 Q08412 P43603 two hybrid array 19841731 physical association X 2 Q08412 mass spectrometry studies of complexes 11805837 - C 10

PPI - HINT Gene A Gene B PMID Method Quality YCK1 CUE5 16319894 0415 LC GCD7 CUE5 18719252 0018 HT YSC84 CUE5 19841731,19841731,19841731,18467557,18467557,19841731,14737190,19841731,14737190 0081,0018,0363,0111,0090,0397,0081,0398,0045 HT SSN3 CUE5 16319894 0415 LC RVS167 CUE5 14737190,14737190 0081,0045 HT RSP5 CUE5 17551511 0415 LC HUA1 CUE5 18719252 0018 HT LSB3 CUE5 18719252,19841731,18467557,18467557,19841731,14737190,19841731,22615397,14737190 0018,0018,0111,0090,0397,0081,0081,0090,0045 HT,LC CUE5 CUE5 18467557,18467557 0111,0090 HT HSP82 CUE5 19536198,26217697 0676,0004 HT,LC UBI4 CUE5 25042851,16554755,25042851,12628920,14557538,22106047 0096,0676,0004,0096,0004,0004 LC,HT RPL40A CUE5 16554755 0004 HT RPL40B CUE5 16554755 0004 HT SSA1 CUE5 23217712,26217697 0096,0004 LC FPR1 CUE5 25042851,25042851 0004,0007 LC CLB1 CUE5 16554755 0363 HT CLB2 CUE5 15200949 0004 LC NAB2 CUE5 19840948 0004 LC SSE2 CUE5 19536198 0676 HT YSC84 CUE5 19841731,19841731,19841731,19841731,19841731 0081,0018,0363,0397,0398 LC TMA19 CUE5 25042851,25042851 0004,0007 LC ATG8 CUE5 25042851,25042851,25042851 0004,0096,0007 LC RVS167 CUE5 19841731 0363 LC RSP5 CUE5 25042851,25042851 0004,0007 LC BNI1 CUE5 24133141 0096 LC RPN11 CUE5 20170199 0004 LC LSB3 CUE5 11805837,16554755,16554755,11805837 0004,0676,0004,0007 HT DSK2 CUE5 16554755,16554755 0676,0004 HT LSB1 CUE5 19841731 0363 LC TRM732 CUE5 16554755,16554755 0676,0004 HT PIN3 CUE5 19841731 0363 LC CUE5 LAS17 21035341 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q08412 P24868 CUE5 CLB1 0.126 16554755 Q12446 Q08412 LAS17 CUE5 0.126 21035341 Q08412 P0CH08 CUE5 RPL40A 0.126 16554755 Q08412 P0CH09 CUE5 RPL40B 0.126 16554755 Q08412 P10080 CUE5 SBP1 0.126 23222640 Q08412 P10591 CUE5 SSA1 0.126 23217712 Q08412 P0CG63 CUE5 UBI4 0.396 16554755,12628920 Q08412 P38182 CUE5 ATG8 0.659 25042851 Q08412 P43603 CUE5 LSB3 0.888 22615397,19841731,18467557,18719252,14737190,16554755,11805837 Q08412 P32502 CUE5 GCD7 0.332 18719252 Q08412 P02829 CUE5 HSP82 0.332 19536198,26217697,26804907 Q08412 P32505 CUE5 NAB2 0.126 19840948 Q08412 P39073 CUE5 SSN3 0.183 16319894 Q08412 P39743 CUE5 RVS167 0.454 14737190,19841731 Q08412 P39940 CUE5 RSP5 0.376 25042851 Q08412 P40325 CUE5 HUA1 0.332 18719252 Q08412 P43588 CUE5 RPN11 0.126 20170199 Q08412 P48510 CUE5 DSK2 0.236 16554755 Q08412 P41832 CUE5 BNI1 0.183 24133141 Q08412 P42858 CUE5 HTT 0.21 25042851 Q08412 Q06449 CUE5 PIN3 0.332 19841731 Q08412 Q05541 CUE5 NSE3 0.126 14690591 Q08412 P53849 CUE5 GIS2 0.126 21232131 Q08412 P20081 CUE5 FPR1 0.21 25042851 Q08412 P32590 CUE5 SSE2 0.126 19536198 Q08412 P32793 CUE5 YSC84 0.801 19841731,18467557,14737190 Q08412 P35691 CUE5 TMA19 0.21 25042851 Q08412 P53281 CUE5 LSB1 0.332 19841731 Q08412 Q03496 CUE5 TRM732 0.332 16554755 Q08412 Q08412 CUE5 CUE5 0.155 18467557