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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046291
UUCD1 version UUC-HoS-00242
Ensembl Protein ID ENSP00000323879.4
UniProt Accession Q8NHG8; ZNRF2_HUMAN
Genbank Protein ID AAQ08115.1; AAM88868.1
Protein Name E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; RING-type E3 ubiquitin transferase ZNRF2; Zinc/RING finger protein 2
Genbank Nucleotide ID AF513707; AF527533
Gene Name ZNRF2; RNF202
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000180233.10 ENST00000323037.4 ENSP00000323879.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19648646
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00045 22.3 199 237
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCP 43
           CaiCle++++g     lpC  ++h+ C+  w         + +CP
   Q: 199  CAICLEELQQGdtIARLPCLCIYHKGCIDEW------FEVNRSCP 237
           ********44443666***************......66666677 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
 May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MGAKQSGPAA ANGRTRAYSG SDLPSSSSGG ANGTAGGGGG ARAAAAGRFP AQVPSAHQPS 60
ASGGAAAAAA APAAPAAPRS RSLGGAVGSV ASGARAAQSP FSIPNSSSGP YGSQDSVHSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046291|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGGCCACG TGCGGGAGGA GGGGCCGCCT TCTGGTTGGC GCCCGGTGTC CGTTCCTCCT 60
ATCGGCGTAG GCCCCGCGAG GAAGACAAGG GCGCGCCCTG GCTGGGAGGG CGTGGCCAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046291|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:223082
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002006 Ailuropoda melanoleuca 99.05 9.00e-62 227.00
IUUC-Apl-003883 Anas platyrhynchos 96.63 1.00e-49 187.00
IUUC-Aca-004497 Anolis carolinensis 71.37 5.00e-69 253.00
IUUC-Acl-008261 Aspergillus clavatus 46.30 3.00e-10 60.10
IUUC-Afl-008724 Aspergillus flavus 51.85 1.00e-11 64.70
IUUC-Afu-008835 Aspergillus fumigatus 47.17 3.00e-10 60.50
IUUC-Ang-009666 Aspergillus niger 48.15 2.00e-11 64.30
IUUC-Ate-010331 Aspergillus terreus 29.86 1.00e-10 61.20
IUUC-Ame-011041 Astyanax mexicanus 86.79 2.00e-55 208.00
IUUC-Bgr-012049 Blumeria graminis 45.95 4.00e-07 50.10
IUUC-Bta-013206 Bos taurus 87.30 7.00e-93 333.00
IUUC-Cel-018347 Caenorhabditis elegans 55.56 9.00e-35 139.00
IUUC-Cja-019912 Callithrix jacchus 98.51 2.00e-61 228.00
IUUC-Cpo-021391 Cavia porcellus 97.73 4.00e-49 185.00
IUUC-Csa-023094 Chlorocebus sabaeus 90.08 4.00e-69 254.00
IUUC-Cin-025162 Ciona intestinalis 47.59 2.00e-35 142.00
IUUC-Csv-026373 Ciona savignyi 53.39 6.00e-36 144.00
IUUC-Dre-027399 Danio rerio 60.71 5.00e-47 180.00
IUUC-Dno-029420 Dasypus novemcinctus 88.66 9.00e-67 246.00
IUUC-Dme-031584 Drosophila melanogaster 73.47 8.00e-41 160.00
IUUC-Eca-034068 Equus caballus 98.84 3.00e-50 189.00
IUUC-Fca-035770 Felis catus 96.59 8.00e-51 191.00
IUUC-Gmo-039148 Gadus morhua 73.20 8.00e-65 239.00
IUUC-Gga-041010 Gallus gallus 89.44 3.00e-63 234.00
IUUC-Gac-041711 Gasterosteus aculeatus 87.60 3.00e-59 221.00
IUUC-Lch-049870 Latimeria chalumnae 93.02 3.00e-45 174.00
IUUC-Loc-052877 Lepisosteus oculatus 91.43 2.00e-56 211.00
IUUC-Laf-054451 Loxodonta africana 89.24 5.00e-65 240.00
IUUC-Mcc-055078 Macaca mulatta 86.01 8.00e-71 259.00
IUUC-Mmr-061658 Microcebus murinus 97.73 4.00e-49 185.00
IUUC-Mdo-062052 Monodelphis domestica 82.55 2.00e-65 242.00
IUUC-Mmu-063964 Mus musculus 88.36 3.00e-63 234.00
IUUC-Mlu-067009 Myotis lucifugus 92.66 8.00e-58 214.00
IUUC-Nfi-068593 Neosartorya fischeri 47.17 2.00e-10 60.80
IUUC-Ncr-068662 Neurospora crassa 48.98 6.00e-09 56.20
IUUC-Nle-069306 Nomascus leucogenys 88.57 4.00e-69 254.00
IUUC-Oga-088009 Otolemur garnettii 93.39 1.00e-75 276.00
IUUC-Ptr-091609 Pan troglodytes 94.21 1.00e-72 266.00
IUUC-Pan-092598 Papio anubis 86.01 8.00e-71 259.00
IUUC-Psi-093749 Pelodiscus sinensis 98.82 3.00e-50 189.00
IUUC-Pma-094361 Petromyzon marinus 77.01 6.00e-40 154.00
IUUC-Pfo-096340 Poecilia formosa 91.43 2.00e-57 214.00
IUUC-Pab-097603 Pongo abelii 85.19 2.00e-67 248.00
IUUC-Pva-102216 Pteropus vampyrus 98.82 5.00e-48 184.00
IUUC-Pyt-104423 Pyrenophora triticirepentis 37.70 2.00e-08 54.30
IUUC-Rno-104829 Rattus norvegicus 93.13 1.00e-60 226.00
IUUC-Ssl-108602 Sclerotinia sclerotiorum 46.00 6.00e-08 52.40
IUUC-Ssc-116023 Sus scrofa 96.59 8.00e-49 184.00
IUUC-Tru-117571 Takifugu rubripes 75.86 4.00e-61 227.00
IUUC-Tni-120337 Tetraodon nigroviridis 87.50 2.00e-54 205.00
IUUC-Tbe-127983 Tupaia belangeri 97.01 5.00e-64 237.00
IUUC-Ttr-129090 Tursiops truncatus 84.77 4.00e-72 264.00
Created Date 25-Jun-2017

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