iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064340

UUCD1 version

UUC-MuM-00098

Ensembl Protein ID

ENSMUSP00000140049.1

UniProt Accession

Q62210; A6H6S7; O08864; BIRC2_MOUSE

Genbank Protein ID

AAC42078.1; AAC53532.1; AAI45986.1

Protein Name

Baculoviral IAP repeat-containing protein 2; Cellular inhibitor of apoptosis 1; Inhibitor of apoptosis protein 2; RING-type E3 ubiquitin transferase BIRC2

Genbank Nucleotide ID

L49433; U88909; BC145985

Gene Name

Birc2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000057367.12	ENSMUST00000190341.6	ENSMUSP00000140049.1
ENSMUSG00000057367.12	ENSMUST00000054878.5	ENSMUSP00000062610.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	30.92	2.00e-49	194.00	IUUC-Dme-031819
E3 activity/RING/RING	83.23	0.00e+00	1006.00	IUUC-Hsa-045769

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Protein Sequence
(Fasta)

MDKTVSQRLG QGTLHQKLKR IMEKSTILSN WTKESEEKMK FDFSCELYRM STYSAFPRGV 60
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKQGDSPV EKHRQFYPSC SFVQTLLSAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGGCTTT TGGGAAGGCT GCGGATCAAC AATCAGGCGC CTCTGCTTCC AGGGCGCCGG 60
GGGCCTGACT CGGTGGTGAG TGCGGCTGCC TTCGTCAGGA CGGGCGAGCG TGGCTCTCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR028795--C-IAP1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS50209--CARD
PS50089--ZF_RING_2

Pfam

PF00653--BIR
PF00619--CARD

SMART

SM00238--BIR
SM00114--CARD
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0001741--C:XY body
GO:0051087--F:chaperone binding
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0098770--F:FBXO family protein binding
GO:0047485--F:protein N-terminus binding
GO:0003713--F:transcription coactivator activity
GO:0016740--F:transferase activity
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071356--P:cellular response to tumor necrosis factor
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070266--P:necroptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0060546--P:negative regulation of necroptotic process
GO:1902443--P:negative regulation of ripoptosome assembly involved in necroptotic process
GO:0001890--P:placenta development
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902524--P:positive regulation of protein K48-linked ubiquitination
GO:1902523--P:positive regulation of protein K63-linked ubiquitination
GO:1902527--P:positive regulation of protein monoubiquitination
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051291--P:protein heterooligomerization
GO:0000209--P:protein polyubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051726--P:regulation of cell cycle
GO:0045595--P:regulation of cell differentiation
GO:0050727--P:regulation of inflammatory response
GO:0060544--P:regulation of necroptotic process
GO:1901222--P:regulation of NIK/NF-kappaB signaling
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0051591--P:response to cAMP
GO:0045471--P:response to ethanol
GO:0001666--P:response to hypoxia
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:11797

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000162	Aegilops tauschii	40.74	1.00e-08	54.70
IUUC-Aml-002369	Ailuropoda melanoleuca	81.96	0.00e+00	986.00
IUUC-Apl-003549	Anas platyrhynchos	68.36	0.00e+00	791.00
IUUC-Aca-004515	Anolis carolinensis	66.04	0.00e+00	737.00
IUUC-Acl-008330	Aspergillus clavatus	31.25	9.00e-16	79.30
IUUC-Afl-008648	Aspergillus flavus	32.56	2.00e-16	81.60
IUUC-Afu-008813	Aspergillus fumigatus	32.74	3.00e-15	77.40
IUUC-Ani-009424	Aspergillus nidulans	33.14	2.00e-15	77.80
IUUC-Ang-009667	Aspergillus niger	32.30	8.00e-14	72.80
IUUC-Ame-011877	Astyanax mexicanus	52.77	6.00e-178	617.00
IUUC-Bta-012450	Bos taurus	80.72	0.00e+00	872.00
IUUC-Bci-013905	Botrytis cinerea	35.00	4.00e-17	83.20
IUUC-Bol-015478	Brassica oleracea	32.76	5.00e-10	62.80
IUUC-Bra-017001	Brassica rapa	33.62	2.00e-10	63.90
IUUC-Cel-018418	Caenorhabditis elegans	41.67	5.00e-09	55.50
IUUC-Cja-018895	Callithrix jacchus	82.26	0.00e+00	982.00
IUUC-Cfa-020419	Canis familiaris	82.42	0.00e+00	988.00
IUUC-Cpo-022048	Cavia porcellus	82.26	0.00e+00	982.00
IUUC-Csa-024159	Chlorocebus sabaeus	76.82	0.00e+00	887.00
IUUC-Cho-024277	Choloepus hoffmanni	77.94	0.00e+00	907.00
IUUC-Cin-025521	Ciona intestinalis	29.64	2.00e-74	273.00
IUUC-Csv-026182	Ciona savignyi	30.34	5.00e-67	248.00
IUUC-Dre-028647	Danio rerio	53.18	2.00e-174	605.00
IUUC-Dno-029509	Dasypus novemcinctus	77.15	0.00e+00	892.00
IUUC-Dor-030796	Dipodomys ordii	71.88	2.00e-91	330.00
IUUC-Dme-031819	Drosophila melanogaster	30.07	2.00e-67	250.00
IUUC-Eca-033393	Equus caballus	84.86	0.00e+00	981.00
IUUC-Eeu-035114	Erinaceus europaeus	78.06	0.00e+00	927.00
IUUC-Fca-036034	Felis catus	79.55	0.00e+00	948.00
IUUC-Fal-037656	Ficedula albicollis	67.54	0.00e+00	785.00
IUUC-Fox-037889	Fusarium oxysporum	32.18	8.00e-16	79.30
IUUC-Fso-038452	Fusarium solani	32.61	2.00e-14	74.70
IUUC-Gmo-038477	Gadus morhua	54.31	3.00e-168	585.00
IUUC-Gga-040601	Gallus gallus	69.72	0.00e+00	815.00
IUUC-Gac-041467	Gasterosteus aculeatus	54.61	2.00e-169	588.00
IUUC-Ggo-044857	Gorilla gorilla	82.42	0.00e+00	988.00
IUUC-Hsa-045769	Homo sapiens	82.74	0.00e+00	991.00
IUUC-Itr-048441	Ictidomys tridecemlineatus	84.58	0.00e+00	1010.00
IUUC-Lch-050259	Latimeria chalumnae	59.64	0.00e+00	682.00
IUUC-Lpe-051271	Leersia perrieri	38.30	3.00e-07	53.10
IUUC-Loc-052169	Lepisosteus oculatus	53.08	9.00e-164	570.00
IUUC-Lma-052958	Leptosphaeria maculans	33.55	3.00e-11	63.90
IUUC-Laf-053449	Loxodonta africana	81.57	0.00e+00	964.00
IUUC-Mcc-055282	Macaca mulatta	75.86	0.00e+00	886.00
IUUC-Meu-056241	Macropus eugenii	62.52	0.00e+00	642.00
IUUC-Mga-059947	Meleagris gallopavo	68.67	0.00e+00	812.00
IUUC-Mdo-062352	Monodelphis domestica	71.98	0.00e+00	865.00
IUUC-Mac-065489	Musa acuminata	27.18	8.00e-10	57.40
IUUC-Mpu-065890	Mustela putorius furo	82.34	0.00e+00	898.00
IUUC-Mlu-068077	Myotis lucifugus	83.47	0.00e+00	987.00
IUUC-Nfi-068591	Neosartorya fischeri	32.56	3.00e-15	77.40
IUUC-Ncr-068787	Neurospora crassa	32.28	1.00e-13	72.00
IUUC-Nle-070081	Nomascus leucogenys	81.77	0.00e+00	989.00
IUUC-Opr-070561	Ochotona princeps	77.74	0.00e+00	919.00
IUUC-Ont-071776	Oreochromis niloticus	53.85	3.00e-173	602.00
IUUC-Oan-073604	Ornithorhynchus anatinus	72.98	0.00e+00	847.00
IUUC-Ocu-073963	Oryctolagus cuniculus	83.31	0.00e+00	967.00
IUUC-Oba-075143	Oryza barthii	40.43	2.00e-07	53.90
IUUC-Ogu-078452	Oryza glumaepatula	45.45	5.00e-07	48.90
IUUC-Ome-081435	Oryza meridionalis	43.48	2.00e-06	47.00
IUUC-Oni-082044	Oryza nivara	43.64	1.00e-09	57.80
IUUC-Opu-084085	Oryza punctata	39.58	2.00e-06	46.60
IUUC-Oru-085060	Oryza rufipogon	44.19	1.00e-06	47.80
IUUC-Osa-085816	Oryza sativa	40.43	4.00e-08	52.00
IUUC-Ola-086446	Oryzias latipes	51.45	3.00e-163	568.00
IUUC-Oga-087976	Otolemur garnettii	84.19	0.00e+00	998.00
IUUC-Oar-090097	Ovis aries	80.35	0.00e+00	974.00
IUUC-Ptr-091137	Pan troglodytes	82.58	0.00e+00	991.00
IUUC-Pan-092673	Papio anubis	83.39	0.00e+00	998.00
IUUC-Psi-092992	Pelodiscus sinensis	67.76	0.00e+00	792.00
IUUC-Ppa-095167	Physcomitrella patens	42.86	2.00e-11	63.20
IUUC-Pfo-096790	Poecilia formosa	51.74	7.00e-165	574.00
IUUC-Pab-098734	Pongo abelii	84.14	0.00e+00	976.00
IUUC-Pop-098944	Populus trichocarpa	42.59	8.00e-10	57.80
IUUC-Pca-100708	Procavia capensis	71.56	3.00e-165	574.00
IUUC-Pva-102788	Pteropus vampyrus	82.29	0.00e+00	977.00
IUUC-Rno-105026	Rattus norvegicus	90.36	0.00e+00	1063.00
IUUC-Sha-107229	Sarcophilus harrisii	67.93	0.00e+00	799.00
IUUC-Sja-107720	Schizosaccharomyces japonicus	33.56	3.00e-16	80.90
IUUC-Spo-108317	Schizosaccharomyces pombe	31.15	1.00e-18	89.00
IUUC-Smo-109461	Selaginella moellendorffii	42.59	7.00e-11	60.80
IUUC-Ssc-115804	Sus scrofa	80.45	0.00e+00	951.00
IUUC-Tgu-116931	Taeniopygia guttata	67.76	0.00e+00	796.00
IUUC-Tru-117620	Takifugu rubripes	51.89	3.00e-170	591.00
IUUC-Tni-119683	Tetraodon nigroviridis	52.10	5.00e-169	587.00
IUUC-Tre-121884	Trichoderma reesei	32.50	4.00e-12	67.00
IUUC-Tvi-122552	Trichoderma virens	31.88	3.00e-12	67.80
IUUC-Tbe-127523	Tupaia belangeri	82.90	0.00e+00	1002.00
IUUC-Ttr-128954	Tursiops truncatus	79.26	0.00e+00	942.00
IUUC-Vpa-130441	Vicugna pacos	81.58	0.00e+00	980.00
IUUC-Xtr-132031	Xenopus tropicalis	56.48	0.00e+00	632.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence