iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046941

UUCD1 version

UUC-HoS-00397

Ensembl Protein ID

ENSP00000404602.2

UniProt Accession

Q9NWF9; Q6Y691; Q75ML7; Q7Z2H7; Q7Z7C1; Q8NHW7; Q9NYT1; RN216_HUMAN

Genbank Protein ID

AAL38043.1; AAP47174.1; AAP47175.1; AAO60361.1; AAO60362.1; AAO60363.1; CAD97648.1; AAS07532.1; AAH00787.2; AAH63825.1; BAA91422.1; AAF36723.1

Protein Name

E3 ubiquitin-protein ligase RNF216; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 1; Zinc finger protein inhibiting NF-kappa-B

Genbank Nucleotide ID

AY062174; AF513717; AF513718; AY177396; AY177397; AY177398; BX537406; AC008167; BC000787; BC063825; AK000916; AF228527

Gene Name

RNF216; TRIAD3; UBCE7IP1; ZIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000011275.18	ENST00000425013.6	ENSP00000404602.2
ENSG00000011275.18	ENST00000389902.7	ENSP00000374552.3
ENSG00000011275.18	ENST00000389900.8	ENSP00000374550.4
ENSG00000011275.18	ENST00000411812.1	ENSP00000409837.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RBR	RBR	20414355

Classification

Family	E-value	Score	Start	End
E3 activity/RBR	5.10e-41	141.4	515	703

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleC..ehtfCkeClkqy.lelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaa 87
           C++C+ e+++eelt   +C  +h fCkeCl +y +e+ + +g+  e+sc++ +c++++++se++++l+++ lyk+ye+ ++ee+v+a++a
   Q: 515  CRCCYGEFPFEELT---QCadAHLFCKECLIRYaQEAVFGSGK-LELSCMEGSCTCSFPTSELEKVLPQTILYKYYER-KAEEEVAAAYA 599
           **********9888...77779***********4455555555.*********************************9.99********* PP
   S: 88   lkwcpapdCslvvllekeaeklevecekcgkefCveCkeew..HeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekne 175
            +++++p+Cs+++ll+++++++++++++c+ke+C++C+  w  H+gl+C+el+ek++ ++   +++ ++++++a+++kC+kC + ++k+e
   Q: 600  DELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWkeHNGLTCEELAEKDDIKY---RTSIEEKMTAARIRKCHKCGTGLIKSE 686
           *******************************************************99999...899************************ PP
   S: 176  gCnhmtCakCkaefCwlC 193
           gCn+m+C +C+a++C+lC
   Q: 687  GCNRMSC-RCGAQMCYLC 703
           *******.9********* PP

Organism

Homo sapiens

Functional Description
(View)

Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.

Protein Sequence
(Fasta)

MEEGNNNEEV IHLNNFHCHR GQEWINLRDG PITISDSSDE ERIPMLVTPA PQQHEEEDLD 60
DDVILTEDDS EDDYGEFLDL GPPGISEFTK PSGQTEREPK PGPSHNQAAN DIVNPRSEQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTACCCGGA GTGCCTCTAT GGTTCTTCCT GTCCTTAGTC GGGAGGGGGC GCTGTGCGCA 60
GGCGCGAGGT GACGCCGCGG CAGGGCCGGA AGGAGTGCAG CGGCTGCCAC GGAGCTCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-1016--Hypogonadotropic hypogonadism
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR002867--IBR_dom

SMART

SM00647--IBR

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0006915--P:apoptotic process
GO:0032480--P:negative regulation of type I interferon production
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0050691--P:regulation of defense response to virus by host
GO:0032648--P:regulation of interferon-beta production
GO:0016032--P:viral process

KEGG

hsa:54476

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008315	Aspergillus clavatus	33.60	3.00e-30	127.00
IUUC-Afl-008385	Aspergillus flavus	35.75	3.00e-30	127.00
IUUC-Ani-009166	Aspergillus nidulans	36.92	7.00e-29	122.00
IUUC-Ang-009679	Aspergillus niger	34.39	6.00e-28	119.00
IUUC-Aor-010208	Aspergillus oryzae	36.27	1.00e-23	104.00
IUUC-Ame-011379	Astyanax mexicanus	65.09	2.00e-173	603.00
IUUC-Bta-013550	Bos taurus	88.63	0.00e+00	1397.00
IUUC-Csa-024269	Chlorocebus sabaeus	97.69	0.00e+00	1556.00
IUUC-Cgl-026651	Colletotrichum gloeosporioides	27.68	1.00e-33	138.00
IUUC-Cne-027073	Cryptococcus neoformans	39.58	1.00e-36	147.00
IUUC-Dre-027806	Danio rerio	45.41	1.00e-174	607.00
IUUC-Dse-031551	Dothistroma septosporum	34.58	8.00e-28	118.00
IUUC-Eca-034282	Equus caballus	91.89	0.00e+00	1457.00
IUUC-Fox-037923	Fusarium oxysporum	34.02	9.00e-27	115.00
IUUC-Fso-038201	Fusarium solani	36.05	9.00e-25	108.00
IUUC-Gmo-039065	Gadus morhua	67.58	2.00e-67	249.00
IUUC-Ggr-039902	Gaeumannomyces graminis	35.85	3.00e-26	114.00
IUUC-Gac-041625	Gasterosteus aculeatus	55.26	4.00e-88	318.00
IUUC-Ggo-044824	Gorilla gorilla	100.00	2.00e-11	60.10
IUUC-Mcc-055112	Macaca mulatta	97.69	0.00e+00	1552.00
IUUC-Mor-057161	Magnaporthe oryzae	34.73	3.00e-25	110.00
IUUC-Mla-059062	Melampsora laricipopulina	36.97	1.00e-33	137.00
IUUC-Mvi-060218	Microbotryum violaceum	35.04	3.00e-30	127.00
IUUC-Mmu-064401	Mus musculus	86.95	0.00e+00	1320.00
IUUC-Ncr-068705	Neurospora crassa	30.57	2.00e-23	103.00
IUUC-Oan-073478	Ornithorhynchus anatinus	75.95	0.00e+00	1189.00
IUUC-Ola-086823	Oryzias latipes	68.12	2.00e-122	432.00
IUUC-Pno-094885	Phaeosphaeria nodorum	32.58	3.00e-24	107.00
IUUC-Ppa-095391	Physcomitrella patens	40.23	4.00e-41	162.00
IUUC-Pab-098076	Pongo abelii	99.54	0.00e+00	1587.00
IUUC-Pca-100450	Procavia capensis	84.20	1.00e-159	557.00
IUUC-Pte-104212	Pyrenophora teres	42.74	1.00e-21	98.20
IUUC-Pyt-104636	Pyrenophora triticirepentis	29.71	9.00e-12	65.50
IUUC-Smo-109322	Selaginella moellendorffii	46.12	1.00e-48	187.00
IUUC-Ssc-115410	Sus scrofa	96.78	0.00e+00	754.00
IUUC-Tre-121991	Trichoderma reesei	39.52	5.00e-23	103.00
IUUC-Tvi-122601	Trichoderma virens	36.49	8.00e-28	117.00
IUUC-Tme-126901	Tuber melanosporum	41.78	7.00e-43	169.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence