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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Hsa-046916
Ensembl Protein ID ENSP00000287820.6
UniProt Accession P37231; A8K3G6; B5BUA1; O00684; O00710; O14515; Q0QJH8; Q15178; Q15179; Q15180; Q15832; Q86U60; Q96J12; PPARG_HUMAN
Genbank Protein ID AAC51248.1; AAB04028.1; BAA18949.1; AAA80314.2; BAA23354.1; CAA62152.1; CAA62153.1; ABC97372.1; AAP35945.1; BAF83270.1; BAG70151.1; BAG70300.1; AAN38992.2; EAW64124.1; AAH06811.1
Protein Name Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3
Genbank Nucleotide ID U79012; U63415; D83233; L40904; AB005526; X90563; X90563; DQ356894; BT007281; AK290581; AB451337; AB451486; AY157024; AC090947; BC006811
Gene Name PPARG; NR1C3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000132170.19 ENST00000397026.6 ENSP00000380221.2
ENSG00000132170.19 ENST00000397000.5 ENSP00000380196.1
ENSG00000132170.19 ENST00000287820.10 ENSP00000287820.6
ENSG00000132170.19 ENST00000397023.5 ENSP00000380218.1
ENSG00000132170.19 ENST00000396999.2 ENSP00000380195.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteJASPARcircBase
circRNADbCircNetmiRTarBasemicroRNA
TRANSFACmiRWalkTargetScanmiRecords
RepTarmiRNAMapSomamiRmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTDGRACPDTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
BioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 23250430; 24292674
Organism Homo sapiens
Functional Description
(View)

Functional Description



     (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.
(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.
Protein Sequence
(Fasta)
MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF 60
DIKPFTTVDF SSISTPHYED IPFTRTDPVV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046916|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACTTACAAA CGCAAGGAAC TCTGAAAGTG TGCAGCACCA CCGATCAGAA GAGAAAACCA 60
AGGGACCCGA AATATGCTTT AATTAAATTT TCTTTTAAAA TGTCACTGGA AAGAACATCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046916|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0219--Diabetes mellitus
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0550--Obesity
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003077--1Cnucl_rcpt_G
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR022590--PPARgamma_N
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF12577--PPARgamma_N
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01291--PROXISOMPAGR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0033613--F:activating transcription factor binding
GO:0051393--F:alpha-actinin binding
GO:0050544--F:arachidonic acid binding
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004955--F:prostaglandin receptor activity
GO:0046965--F:retinoid X receptor binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0031100--P:animal organ regeneration
GO:0045165--P:cell fate commitment
GO:0048469--P:cell maturation
GO:0071455--P:cellular response to hyperoxia
GO:0032869--P:cellular response to insulin stimulus
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071306--P:cellular response to vitamin E
GO:0030855--P:epithelial cell differentiation
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0007507--P:heart development
GO:0045087--P:innate immune response
GO:0055088--P:lipid homeostasis
GO:0006629--P:lipid metabolic process
GO:0042953--P:lipoprotein transport
GO:0015909--P:long-chain fatty acid transport
GO:0045713--P:low-density lipoprotein particle receptor biosynthetic process
GO:0010742--P:macrophage derived foam cell differentiation
GO:0030224--P:monocyte differentiation
GO:0002674--P:negative regulation of acute inflammatory response
GO:0030308--P:negative regulation of cell growth
GO:0010887--P:negative regulation of cholesterol storage
GO:0032966--P:negative regulation of collagen biosynthetic process
GO:0060336--P:negative regulation of interferon-gamma-mediated signaling pathway
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:2000230--P:negative regulation of pancreatic stellate cell proliferation
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0051974--P:negative regulation of telomerase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0035357--P:peroxisome proliferator activated receptor signaling pathway
GO:0001890--P:placenta development
GO:0045600--P:positive regulation of fat cell differentiation
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0060100--P:positive regulation of phagocytosis, engulfment
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0008217--P:regulation of blood pressure
GO:0060694--P:regulation of cholesterol transporter activity
GO:0042752--P:regulation of circadian rhythm
GO:0060850--P:regulation of transcription involved in cell fate commitment
GO:0031000--P:response to caffeine
GO:0009409--P:response to cold
GO:0042493--P:response to drug
GO:0043627--P:response to estrogen
GO:0035902--P:response to immobilization stress
GO:0033993--P:response to lipid
GO:0055098--P:response to low-density lipoprotein particle
GO:0009612--P:response to mechanical stimulus
GO:1901558--P:response to metformin
GO:0007584--P:response to nutrient
GO:0032526--P:response to retinoic acid
GO:0042594--P:response to starvation
GO:0033189--P:response to vitamin A
GO:0048511--P:rhythmic process
GO:0007165--P:signal transduction
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0050872--P:white fat cell differentiation

KEGG hsa:5468
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001214 Ailuropoda melanoleuca 95.25 0.00e+00 962.00
IUUC-Aca-005129 Anolis carolinensis 88.75 0.00e+00 876.00
IUUC-Ame-010818 Astyanax mexicanus 65.78 0.00e+00 644.00
IUUC-Bta-013226 Bos taurus 95.84 0.00e+00 977.00
IUUC-Cja-019236 Callithrix jacchus 99.01 0.00e+00 1008.00
IUUC-Cfa-020281 Canis familiaris 98.22 0.00e+00 1001.00
IUUC-Cpo-021587 Cavia porcellus 96.23 0.00e+00 930.00
IUUC-Csa-023400 Chlorocebus sabaeus 99.16 0.00e+00 951.00
IUUC-Cho-024593 Choloepus hoffmanni 85.94 0.00e+00 851.00
IUUC-Dre-028176 Danio rerio 61.28 1.00e-154 539.00
IUUC-Dno-029063 Dasypus novemcinctus 93.47 0.00e+00 945.00
IUUC-Ete-032520 Echinops telfairi 94.26 0.00e+00 949.00
IUUC-Fca-035935 Felis catus 97.82 0.00e+00 997.00
IUUC-Fal-037524 Ficedula albicollis 92.21 0.00e+00 883.00
IUUC-Gga-041223 Gallus gallus 92.84 0.00e+00 888.00
IUUC-Gac-042156 Gasterosteus aculeatus 62.45 0.00e+00 638.00
IUUC-Ggo-045265 Gorilla gorilla 99.60 0.00e+00 1015.00
IUUC-Lch-049759 Latimeria chalumnae 80.56 0.00e+00 680.00
IUUC-Loc-051870 Lepisosteus oculatus 74.17 0.00e+00 748.00
IUUC-Laf-054483 Loxodonta africana 96.04 0.00e+00 974.00
IUUC-Meu-056587 Macropus eugenii 94.60 0.00e+00 921.00
IUUC-Mga-059530 Meleagris gallopavo 92.84 0.00e+00 888.00
IUUC-Mmr-060576 Microcebus murinus 96.24 0.00e+00 984.00
IUUC-Mdo-061854 Monodelphis domestica 98.11 0.00e+00 937.00
IUUC-Mmu-063724 Mus musculus 96.24 0.00e+00 986.00
IUUC-Mpu-066888 Mustela putorius furo 98.74 0.00e+00 980.00
IUUC-Mlu-067978 Myotis lucifugus 97.03 0.00e+00 1022.00
IUUC-Nle-070069 Nomascus leucogenys 99.60 0.00e+00 1014.00
IUUC-Opr-070630 Ochotona princeps 93.85 0.00e+00 797.00
IUUC-Ont-071399 Oreochromis niloticus 60.41 5.00e-180 624.00
IUUC-Ocu-074862 Oryctolagus cuniculus 97.27 0.00e+00 939.00
IUUC-Ola-087266 Oryzias latipes 56.42 2.00e-159 555.00
IUUC-Oga-089143 Otolemur garnettii 96.63 0.00e+00 991.00
IUUC-Oar-089725 Ovis aries 95.64 0.00e+00 974.00
IUUC-Ptr-091580 Pan troglodytes 99.80 0.00e+00 1016.00
IUUC-Psi-093041 Pelodiscus sinensis 91.40 0.00e+00 872.00
IUUC-Pfo-097438 Poecilia formosa 58.74 2.00e-177 615.00
IUUC-Pab-098333 Pongo abelii 98.74 0.00e+00 944.00
IUUC-Pca-100861 Procavia capensis 97.48 0.00e+00 937.00
IUUC-Pva-102186 Pteropus vampyrus 87.52 0.00e+00 869.00
IUUC-Rno-105583 Rattus norvegicus 95.84 0.00e+00 982.00
IUUC-Sha-107484 Sarcophilus harrisii 96.12 0.00e+00 942.00
IUUC-Sar-112996 Sorex araneus 85.54 0.00e+00 650.00
IUUC-Ssc-115945 Sus scrofa 97.82 0.00e+00 991.00
IUUC-Tsy-119098 Tarsius syrichta 88.71 0.00e+00 874.00
IUUC-Tni-120902 Tetraodon nigroviridis 61.30 2.00e-173 602.00
IUUC-Tbe-127225 Tupaia belangeri 75.64 0.00e+00 715.00
IUUC-Ttr-129292 Tursiops truncatus 97.62 0.00e+00 993.00
IUUC-Vpa-130378 Vicugna pacos 91.10 0.00e+00 786.00
Created Date 25-Jun-2017

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