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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063845
UUCD1 version UUC-MuM-00009
Ensembl Protein ID ENSMUSP00000018681.7
UniProt Accession P23798; PCGF2_MOUSE
Genbank Protein ID BAA14122.1; AAL90776.1; AAL90777.1; AAH16419.1
Protein Name Polycomb group RING finger protein 2; DNA-binding protein Mel-18; Melanoma nuclear protein 18; RING finger protein 110; Zinc finger protein 144
Genbank Nucleotide ID D90085; AF483502; AF483503; BC016419
Gene Name Pcgf2; Mel-18; Mel18; Rnf110; Zfp144; Znf144
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000018537.16 ENSMUST00000018681.13 ENSMUSP00000018681.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20087442
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.30e-06 28.3 18 56
ULD/UDP/UFD/RAWUL 5.60e-28 98.4 148 228
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
    Ca+C f d + ++ C H f+++C+ ++ ++ +CP C
   Q: 18 CALCGGYFIDATTIVECLHSFCKTCIVRY------LETNKYCPMC 56
    ********999999***************......********** PP
   


   ULD/UDP/UFD/RAWUL

   S: 18   k............lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkegpLvLqYr 86
    k + ++lrc+a++tV+hl kfl++k++++s+y+v++l+ede+L++++tL++i+yi+ w+++gpL+L+Yr
   Q: 148 KnltengdgdkekTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYR 228
    44455555555559******************************************************************9 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex.
Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex.
Protein Sequence
(Fasta)
MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV 60
HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063845|E3,RING;ULD,RAWUL|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGAGGGAGG CGCACCGGCG GCGAAAAGGC GCGCGTCCTC TCTCGACTCC TCGCTTCCTA 60
TTGCGTCGGG GCCTCTCGAA TTCGGCTAGT TATTGTGTCT CTGGCTCGGC GCCCGAGTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063845|E3,RING;ULD,RAWUL|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0016604--C:nuclear body
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0070301--P:cellular response to hydrogen peroxide
GO:0048706--P:embryonic skeletal system development
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0016573--P:histone acetylation
GO:0001701--P:in utero embryonic development
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG mmu:22658
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002051 Ailuropoda melanoleuca 93.27 4.00e-153 534.00
IUUC-Aca-004230 Anolis carolinensis 75.00 1.00e-139 489.00
IUUC-Aly-005613 Arabidopsis lyrata 40.96 3.00e-12 66.20
IUUC-Bta-013298 Bos taurus 95.61 9.00e-161 559.00
IUUC-Bol-015090 Brassica oleracea 36.73 4.00e-13 69.30
IUUC-Cja-019674 Callithrix jacchus 95.91 3.00e-160 557.00
IUUC-Cfa-020865 Canis familiaris 89.31 6.00e-144 503.00
IUUC-Cpo-022149 Cavia porcellus 93.27 1.00e-157 548.00
IUUC-Csa-024153 Chlorocebus sabaeus 96.49 8.00e-161 559.00
IUUC-Dno-029941 Dasypus novemcinctus 93.57 9.00e-154 536.00
IUUC-Dor-030557 Dipodomys ordii 95.91 2.00e-160 558.00
IUUC-Eca-033878 Equus caballus 96.86 5.00e-151 526.00
IUUC-Eeu-035039 Erinaceus europaeus 90.64 4.00e-147 514.00
IUUC-Fca-036531 Felis catus 89.21 2.00e-139 488.00
IUUC-Gga-040960 Gallus gallus 83.71 2.00e-128 452.00
IUUC-Ggo-045132 Gorilla gorilla 96.20 8.00e-161 559.00
IUUC-Hsa-045703 Homo sapiens 95.91 2.00e-160 558.00
IUUC-Itr-048008 Ictidomys tridecemlineatus 97.08 5.00e-162 563.00
IUUC-Lch-050240 Latimeria chalumnae 73.47 2.00e-126 445.00
IUUC-Laf-053589 Loxodonta africana 96.21 1.00e-159 555.00
IUUC-Mcc-055228 Macaca mulatta 96.20 2.00e-159 554.00
IUUC-Meu-056268 Macropus eugenii 81.58 1.00e-131 462.00
IUUC-Mga-059555 Meleagris gallopavo 76.77 2.00e-82 298.00
IUUC-Mmr-060605 Microcebus murinus 96.20 1.00e-160 558.00
IUUC-Mdo-061947 Monodelphis domestica 82.08 1.00e-151 528.00
IUUC-Mpu-066061 Mustela putorius furo 95.32 4.00e-160 557.00
IUUC-Mlu-067426 Myotis lucifugus 90.41 5.00e-142 496.00
IUUC-Nle-069772 Nomascus leucogenys 89.40 1.00e-153 535.00
IUUC-Ocu-074159 Oryctolagus cuniculus 81.77 7.00e-141 493.00
IUUC-Oga-088514 Otolemur garnettii 96.20 4.00e-161 560.00
IUUC-Oar-090406 Ovis aries 90.94 2.00e-160 557.00
IUUC-Ptr-091467 Pan troglodytes 95.91 3.00e-160 557.00
IUUC-Psi-093492 Pelodiscus sinensis 82.65 3.00e-149 520.00
IUUC-Pab-098045 Pongo abelii 90.14 5.00e-139 487.00
IUUC-Pca-100551 Procavia capensis 95.91 6.00e-161 560.00
IUUC-Pva-102686 Pteropus vampyrus 96.49 3.00e-161 561.00
IUUC-Rno-105679 Rattus norvegicus 99.42 2.00e-165 574.00
IUUC-Sha-107443 Sarcophilus harrisii 73.04 2.00e-132 465.00
IUUC-Ssc-115591 Sus scrofa 77.68 5.00e-136 476.00
Created Date 25-Jun-2017

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