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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045666
Ensembl Protein ID ENSP00000362372.4
UniProt Accession Q6RI45; C9IZ39; C9J3F3; Q2T9J6; Q5JRN1; Q6RI37; Q6RI42; Q6RI44; Q8N916; BRWD3_HUMAN
Genbank Protein ID AAS45471.1; AAS45472.1; AAS45473.1; AAS45474.1; AAS45475.1; AAS45476.1; AAS45477.1; AAS45478.1; AAS45479.1; AAS45480.1; AAS45481.1; AAS45482.1; AAS45483.1; AAS45484.1; AAS45485.1; CAI39936.2; CAI39936.2; CAI39936.2; CAI95143.1; CAI95143.1; CAI95143.1; CAI95405.1; CAI95405.1; CAI95405.1; AAI11491.1; BAC04641.1
Protein Name Bromodomain and WD repeat-containing protein 3
Genbank Nucleotide ID AY497046; AY497047; AY497048; AY497049; AY497050; AY497051; AY497052; AY497053; AY497054; AY497055; AY497056; AY497057; AY497058; AY497059; AY497060; AL590031; AL512504; AL669934; AL512504; AL590031; AL669934; AL669934; AL512504; AL590031; BC111490; AK095887
Gene Name BRWD3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000165288.10 ENST00000373275.4 ENSP00000362372.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Variation
ClinVarGWAS CentralOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.70e-30 104.3 178 215
UBD/Beta-Prp 6.00e-52 178.3 280 539
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+af  s++++ +GsdD+ +k+W +++g+ll
   Q: 178  GHLSSVYCVAFdrSGRRIFTGSDDCLVKIWATDDGRLL 215
           8**********96669******************9987 PP
   

   UBD/Beta-Prp
   S: 22   ksllatgsrdgtikvwdvttgkl........lrslsgheae..vtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlsls 101
           +++l+++++dgti  w+++ +++        + + s    +  +++ +fs+ g ++ tgs+D++i+++    + ++ +  l+ h+d+v++++
   Q: 280  NRYLTSTGADGTICFWQWHVKTMkfrdrpvkFTERSRP--GvqISCSSFSSGGMFITTGSTDHVIRIYylGSEVPEKIAELESHTDKVVAVQ 369
           689*************9998777667776433333333..35599***********************877789****************** PP
   S: 102  fspsg..dklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl 175
           f+ +g   ++vsGs+d t+r+w+ +++++ +                  +++++  v++v+++  +  ++++ ++  +++W++ tg+ll+tl
   Q: 370  FCNNGdsLRFVSGSRDGTARIWQYQQQEWKSIvldmatkmtgnnlpsgEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTL 461
           ***8832468*******************999************998888888889************************************ PP
   S: 176  tgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiri 248
           +g h+d v  l+   fd+  + ++s+++dg + +wdl +g+ +r + +         v + +fsp++++++++ s+g + +
   Q: 462  SG-HDDEVFVLEahpFDQ--RIILSAGHDGNIFIWDLDRGTKIRNYFNMIegqghGAVFDCKFSPDGNHFACTDSHGHLLL 539
           *9.*********555555..99********************98887755455567788899999***9999999988766 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Protein Sequence
(Fasta)
MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG KEHRRSFEDL 60
VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV GRQSLLRDAK DCKSTLWNGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045666|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTCCTTCC TCCTCCGCCT CCTCAGCTCT TGGGCTAGAA TATCTATGGG TCGAAACGTG 60
ATGCGATGAA TTCGAGAGAG AGCGAAACTA GGACGAGGAG TGCGGCGGAA GCGGCGGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045666|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR001487--Bromodomain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00439--Bromodomain
PF00400--WD40
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00320--WD40
Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
KEGG hsa:254065
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001881 Ailuropoda melanoleuca 97.06 0.00e+00 3148.00
IUUC-Apl-004016 Anas platyrhynchos 80.04 0.00e+00 2264.00
IUUC-Aca-004722 Anolis carolinensis 78.31 0.00e+00 2211.00
IUUC-Ame-010602 Astyanax mexicanus 76.39 0.00e+00 1137.00
IUUC-Bta-013198 Bos taurus 95.78 0.00e+00 2868.00
IUUC-Cfa-020963 Canis familiaris 96.73 0.00e+00 3115.00
IUUC-Cpo-022448 Cavia porcellus 89.12 0.00e+00 2843.00
IUUC-Csa-023166 Chlorocebus sabaeus 99.40 0.00e+00 3063.00
IUUC-Cin-025553 Ciona intestinalis 38.35 1.00e-111 397.00
IUUC-Csv-025813 Ciona savignyi 43.49 0.00e+00 638.00
IUUC-Dre-028508 Danio rerio 65.83 0.00e+00 1886.00
IUUC-Dno-030070 Dasypus novemcinctus 93.51 0.00e+00 3013.00
IUUC-Dor-031052 Dipodomys ordii 79.71 0.00e+00 1434.00
IUUC-Ete-032650 Echinops telfairi 86.29 0.00e+00 1838.00
IUUC-Eca-033953 Equus caballus 97.12 0.00e+00 2809.00
IUUC-Eeu-034871 Erinaceus europaeus 82.86 0.00e+00 1345.00
IUUC-Fca-036099 Felis catus 96.56 0.00e+00 3150.00
IUUC-Fal-037246 Ficedula albicollis 81.01 0.00e+00 2438.00
IUUC-Gga-041097 Gallus gallus 82.46 0.00e+00 2528.00
IUUC-Gac-042435 Gasterosteus aculeatus 65.25 0.00e+00 1848.00
IUUC-Loc-051802 Lepisosteus oculatus 69.54 0.00e+00 2063.00
IUUC-Laf-053942 Loxodonta africana 96.08 0.00e+00 3014.00
IUUC-Mcc-054645 Macaca mulatta 99.52 0.00e+00 3069.00
IUUC-Meu-056321 Macropus eugenii 76.27 0.00e+00 1113.00
IUUC-Mga-060063 Meleagris gallopavo 83.11 0.00e+00 2477.00
IUUC-Mmr-061262 Microcebus murinus 96.33 0.00e+00 2997.00
IUUC-Mdo-062320 Monodelphis domestica 75.78 0.00e+00 2305.00
IUUC-Mmu-063163 Mus musculus 94.62 0.00e+00 3036.00
IUUC-Mpu-066628 Mustela putorius furo 96.61 0.00e+00 3155.00
IUUC-Mlu-068082 Myotis lucifugus 96.63 0.00e+00 2964.00
IUUC-Nle-069609 Nomascus leucogenys 99.40 0.00e+00 3079.00
IUUC-Ont-071589 Oreochromis niloticus 66.21 0.00e+00 1816.00
IUUC-Ocu-074122 Oryctolagus cuniculus 94.83 0.00e+00 2132.00
IUUC-Ola-086580 Oryzias latipes 66.20 0.00e+00 1883.00
IUUC-Oga-089053 Otolemur garnettii 95.45 0.00e+00 3092.00
IUUC-Oar-090042 Ovis aries 96.45 0.00e+00 3150.00
IUUC-Ptr-091268 Pan troglodytes 98.61 0.00e+00 3016.00
IUUC-Pan-092376 Papio anubis 99.46 0.00e+00 3068.00
IUUC-Psi-093408 Pelodiscus sinensis 81.32 0.00e+00 2531.00
IUUC-Pfo-096515 Poecilia formosa 66.33 0.00e+00 1787.00
IUUC-Pab-097672 Pongo abelii 97.41 0.00e+00 3019.00
IUUC-Pva-102512 Pteropus vampyrus 97.75 0.00e+00 2357.00
IUUC-Rno-105797 Rattus norvegicus 94.21 0.00e+00 2922.00
IUUC-Sha-107061 Sarcophilus harrisii 76.72 0.00e+00 2311.00
IUUC-Sit-110017 Setaria italica 29.00 2.00e-56 215.00
IUUC-Sar-113004 Sorex araneus 84.22 0.00e+00 1662.00
IUUC-Tgu-117254 Taeniopygia guttata 81.94 0.00e+00 2434.00
IUUC-Tru-118186 Takifugu rubripes 65.47 0.00e+00 1837.00
IUUC-Tsy-119003 Tarsius syrichta 90.34 0.00e+00 2723.00
IUUC-Tni-120110 Tetraodon nigroviridis 65.24 0.00e+00 1805.00
IUUC-Tbe-127813 Tupaia belangeri 78.35 0.00e+00 932.00
IUUC-Ttr-129265 Tursiops truncatus 93.01 0.00e+00 2849.00
IUUC-Vpa-130736 Vicugna pacos 90.29 0.00e+00 1498.00
Created Date 25-Jun-2017

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