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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063758
Ensembl Protein ID ENSMUSP00000116006.1
UniProt Accession Q60611; Q91XB1; SATB1_MOUSE
Genbank Protein ID AAA17372.1; BAC40427.1; BAE34542.1; CAJ18578.1; AAH11132.1; EDL23652.1
Protein Name DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1
Genbank Nucleotide ID U05252; AK088563; AK158518; CT010371; BC011132; CH466559
Gene Name Satb1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000023927.15 ENSMUST00000144331.7 ENSMUSP00000116006.1
ENSMUSG00000023927.15 ENSMUST00000140979.7 ENSMUSP00000118839.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 25124042
Classification
Family E-value Score Start End
ULD/UDP/UBQ/UBQ_Other 9.30e-11 42.6 76 162
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlkvnpsd.tVaeLKeki.....ekk.lgip.peqqrLiykGkiL...eddktLady.glkdgstihllekksg 75
           v+++v++++++ e+++k ++++ +V+++K+++     e++ l+++ +++++ + kG i+   +++++L+++ +++d++++++l+++++
   Q: 76   VFCVVEHYENAiEYDCK-EEHAeFVLVRKDMLfnqliEMAlLSLGySHSSAAQAKGLIQvgkWNPVPLSYVtDAPDATVADMLQDVYH 162
           689**************.77777*******99999998888*********************************************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.
 Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.
Protein Sequence
(Fasta)
MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGG KMQGVPLKHS 60
GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL VRKDMLFNQL IEMALLSLGY 120
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Protein Fasta Sequence


>IUUC-Mmu-063758|ULD,UBQ_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
TCACCTGACT TCCTCCTCCG CTGGCACACA CACACACCAA TGCCCCGCGC TCTGCACCCC 60
CAAAGCCCAG GCAAACAACG ACAAGAGGAA GCGGCGGGCG GCGAGGGTGC GCGGCGGGGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063758|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0371--Homeobox
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR003350--CUT_dom
IPR032355--CUTL
IPR009057--Homeobox-like
IPR001356--Homeobox_dom
IPR010982--Lambda_DNA-bd_dom
IPR032392--ULD
PROSITE

PS51042--CUT
PS50071--HOMEOBOX_2
Pfam

PF02376--CUT
PF16557--CUTL
PF00046--Homeobox
PF16534--ULD
SMART

SM01109--CUT
SM00389--HOX
Gene Ontology

GO:0000785--C:chromatin
GO:0016604--C:nuclear body
GO:0005720--C:nuclear heterochromatin
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0050798--P:activated T cell proliferation
GO:0043367--P:CD4-positive, alpha-beta T cell differentiation
GO:0043374--P:CD8-positive, alpha-beta T cell differentiation
GO:0006325--P:chromatin organization
GO:0006338--P:chromatin remodeling
GO:0008544--P:epidermis development
GO:0016571--P:histone methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0060004--P:reflex
GO:0006355--P:regulation of transcription, DNA-templated
GO:0042110--P:T cell activation
GO:0006351--P:transcription, DNA-templated
KEGG mmu:20230
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001269 Ailuropoda melanoleuca 99.33 0.00e+00 1226.00
IUUC-Apl-003442 Anas platyrhynchos 92.95 0.00e+00 1414.00
IUUC-Aca-004969 Anolis carolinensis 90.28 0.00e+00 1392.00
IUUC-Ame-010811 Astyanax mexicanus 71.01 0.00e+00 1108.00
IUUC-Bta-012461 Bos taurus 90.92 0.00e+00 1361.00
IUUC-Cel-018701 Caenorhabditis elegans 34.00 1.00e-10 61.20
IUUC-Cja-020003 Callithrix jacchus 98.49 0.00e+00 1216.00
IUUC-Cfa-020082 Canis familiaris 99.16 0.00e+00 1222.00
IUUC-Cpo-021601 Cavia porcellus 97.51 0.00e+00 1427.00
IUUC-Csa-023306 Chlorocebus sabaeus 99.49 0.00e+00 1229.00
IUUC-Cho-025063 Choloepus hoffmanni 92.57 0.00e+00 987.00
IUUC-Dre-028396 Danio rerio 66.95 0.00e+00 1042.00
IUUC-Dno-029755 Dasypus novemcinctus 89.45 0.00e+00 1082.00
IUUC-Dor-030766 Dipodomys ordii 99.42 0.00e+00 1077.00
IUUC-Ete-032547 Echinops telfairi 90.40 5.00e-134 472.00
IUUC-Eca-033394 Equus caballus 99.49 0.00e+00 1227.00
IUUC-Eeu-034706 Erinaceus europaeus 98.66 0.00e+00 1076.00
IUUC-Fca-036482 Felis catus 90.60 0.00e+00 1339.00
IUUC-Fal-037384 Ficedula albicollis 94.37 0.00e+00 1444.00
IUUC-Fso-038109 Fusarium solani 44.74 4.10e-02 33.90
IUUC-Gmo-038956 Gadus morhua 75.64 0.00e+00 686.00
IUUC-Ggr-039906 Gaeumannomyces graminis 33.33 8.00e-04 34.70
IUUC-Gga-040653 Gallus gallus 94.37 0.00e+00 1442.00
IUUC-Gac-041928 Gasterosteus aculeatus 72.27 0.00e+00 841.00
IUUC-Ggo-044842 Gorilla gorilla 99.16 0.00e+00 1227.00
IUUC-Hsa-046800 Homo sapiens 99.49 0.00e+00 1230.00
IUUC-Lch-050515 Latimeria chalumnae 89.70 0.00e+00 1109.00
IUUC-Loc-052600 Lepisosteus oculatus 76.10 0.00e+00 1239.00
IUUC-Laf-054011 Loxodonta africana 99.32 0.00e+00 1231.00
IUUC-Mga-059444 Meleagris gallopavo 94.38 0.00e+00 1415.00
IUUC-Mmr-061285 Microcebus murinus 99.49 0.00e+00 1233.00
IUUC-Mdo-062444 Monodelphis domestica 98.31 0.00e+00 1218.00
IUUC-Mpu-066758 Mustela putorius furo 99.32 0.00e+00 1229.00
IUUC-Mlu-067012 Myotis lucifugus 95.69 0.00e+00 1420.00
IUUC-Nle-069511 Nomascus leucogenys 99.49 0.00e+00 1232.00
IUUC-Opr-070880 Ochotona princeps 83.11 0.00e+00 1000.00
IUUC-Ont-072450 Oreochromis niloticus 67.76 0.00e+00 1006.00
IUUC-Oan-073212 Ornithorhynchus anatinus 97.40 3.00e-87 313.00
IUUC-Ocu-074585 Oryctolagus cuniculus 99.49 0.00e+00 1231.00
IUUC-Oba-075370 Oryza barthii 36.96 1.00e-03 36.60
IUUC-Olo-080429 Oryza longistaminata 32.61 1.40e-02 34.30
IUUC-Ome-081450 Oryza meridionalis 34.78 7.00e-03 35.40
IUUC-Oni-082089 Oryza nivara 24.66 3.20e-02 32.00
IUUC-Ola-087463 Oryzias latipes 59.97 0.00e+00 754.00
IUUC-Oga-089020 Otolemur garnettii 99.32 0.00e+00 1230.00
IUUC-Oar-090026 Ovis aries 90.32 0.00e+00 1379.00
IUUC-Ptr-090639 Pan troglodytes 97.38 0.00e+00 1437.00
IUUC-Pan-092418 Papio anubis 99.62 0.00e+00 1075.00
IUUC-Psi-093141 Pelodiscus sinensis 97.43 0.00e+00 1023.00
IUUC-Ppa-095438 Physcomitrella patens 30.77 9.00e-03 34.70
IUUC-Pfo-096325 Poecilia formosa 73.72 0.00e+00 1026.00
IUUC-Pab-098180 Pongo abelii 97.51 0.00e+00 1438.00
IUUC-Pca-100487 Procavia capensis 98.99 0.00e+00 1226.00
IUUC-Pva-102302 Pteropus vampyrus 90.71 0.00e+00 1107.00
IUUC-Rno-105734 Rattus norvegicus 99.61 0.00e+00 1457.00
IUUC-Sha-106963 Sarcophilus harrisii 98.31 0.00e+00 1218.00
IUUC-Stu-112175 Solanum tuberosum 34.21 5.90e-01 28.10
IUUC-Sar-113384 Sorex araneus 99.16 0.00e+00 1225.00
IUUC-Ssc-115971 Sus scrofa 94.13 0.00e+00 1413.00
IUUC-Tgu-117121 Taeniopygia guttata 91.97 0.00e+00 1438.00
IUUC-Tru-118767 Takifugu rubripes 61.21 0.00e+00 766.00
IUUC-Tni-120223 Tetraodon nigroviridis 75.71 0.00e+00 887.00
IUUC-Ttr-128230 Tursiops truncatus 99.32 0.00e+00 1223.00
IUUC-Vpa-130676 Vicugna pacos 90.67 0.00e+00 968.00
IUUC-Xtr-132122 Xenopus tropicalis 85.10 0.00e+00 1273.00
Created Date 25-Jun-2017

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