• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063532
Ensembl Protein ID ENSMUSP00000002436.9
UniProt Accession Q91VH2; SNX9_MOUSE
Genbank Protein ID AAH14814.1
Protein Name Sorting nexin-9
Genbank Nucleotide ID BC014814
Gene Name Snx9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000002365.9 ENSMUST00000002436.9 ENSMUSP00000002436.9
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 4.90e-11 43.5 4 60
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaq.nddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           k +v+yd+ a+  ++eLt ++G++++v  + +  +gWl+g k+ +g +Gl+P ++ve l
   Q: 4    KARVMYDFAAEpGNNELTVTEGEIITVT-NPNVGGGWLEG-KNNKGEQGLVPTDYVEIL 60
           6789******95689************8.9**********.6**************865 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity).
 Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity).
Protein Sequence
(Fasta)
MATKARVMYD FAAEPGNNEL TVTEGEIITV TNPNVGGGWL EGKNNKGEQG LVPTDYVEIL 60
PNDGKDPFSC GNSVADQAFL DSLTASTAQT NSSSANSNNQ VGGGNDPWTA WNAPKPGNWD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063532|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGACTTTCA GGAACTGCAG GCGCGGGCGG CGGCGGGAGT CGCCGAGCCG CGGGGGCCGG 60
AGCGCCGAGA GCAGGACTGA GGCGGAGCCG CCGCGCCGGG CCGCAGCCAC CGAACCGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063532|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0333--Golgi apparatus
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR027267--AH/BAR-dom
IPR001683--Phox
IPR001452--SH3_domain
IPR028644--SNX9
IPR014536--Snx9_subfam
IPR019497--Sorting_nexin_WASP-bd-dom
PROSITE

PS50195--PX
PS50002--SH3
Pfam

PF10456--BAR_3_WASP_bdg
PF00787--PX
PF00018--SH3_1
SMART

SM00312--PX
SM00326--SH3
Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0030136--C:clathrin-coated vesicle
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005802--C:trans-Golgi network
GO:0005545--F:1-phosphatidylinositol binding
GO:0071933--F:Arp2/3 complex binding
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0035091--F:phosphatidylinositol binding
GO:0042803--F:protein homodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0036089--P:cleavage furrow formation
GO:0006897--P:endocytosis
GO:0016197--P:endosomal transport
GO:0006886--P:intracellular protein transport
GO:0060988--P:lipid tube assembly
GO:0000281--P:mitotic cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0097320--P:plasma membrane tubulation
GO:0043547--P:positive regulation of GTPase activity
GO:0051044--P:positive regulation of membrane protein ectodomain proteolysis
GO:0045860--P:positive regulation of protein kinase activity
GO:0032461--P:positive regulation of protein oligomerization
GO:0006898--P:receptor-mediated endocytosis
KEGG mmu:66616
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001493 Ailuropoda melanoleuca 92.72 0.00e+00 1091.00
IUUC-Apl-003889 Anas platyrhynchos 83.42 0.00e+00 989.00
IUUC-Ang-009589 Aspergillus niger 44.26 6.00e-06 45.40
IUUC-Aor-009976 Aspergillus oryzae 42.62 1.00e-05 45.10
IUUC-Ate-010396 Aspergillus terreus 37.36 5.00e-06 45.80
IUUC-Ame-011163 Astyanax mexicanus 62.40 0.00e+00 753.00
IUUC-Bta-013027 Bos taurus 90.89 0.00e+00 1076.00
IUUC-Cel-018605 Caenorhabditis elegans 32.93 8.00e-63 234.00
IUUC-Cja-019428 Callithrix jacchus 91.11 0.00e+00 1093.00
IUUC-Cfa-021208 Canis familiaris 92.74 0.00e+00 1092.00
IUUC-Cpo-021353 Cavia porcellus 93.78 0.00e+00 1110.00
IUUC-Cho-025020 Choloepus hoffmanni 97.72 1.00e-156 546.00
IUUC-Cin-025695 Ciona intestinalis 38.97 2.00e-83 303.00
IUUC-Csv-025870 Ciona savignyi 34.22 1.00e-90 327.00
IUUC-Cgl-026608 Colletotrichum gloeosporioides 44.26 6.00e-05 42.00
IUUC-Dre-027983 Danio rerio 62.26 0.00e+00 756.00
IUUC-Dme-031845 Drosophila melanogaster 37.85 9.00e-70 258.00
IUUC-Fca-036506 Felis catus 91.61 0.00e+00 1072.00
IUUC-Fal-037443 Ficedula albicollis 77.88 0.00e+00 949.00
IUUC-Gmo-039464 Gadus morhua 58.52 0.00e+00 645.00
IUUC-Gac-041835 Gasterosteus aculeatus 58.03 0.00e+00 663.00
IUUC-Ggo-045438 Gorilla gorilla 86.82 0.00e+00 1021.00
IUUC-Hsa-046762 Homo sapiens 90.60 0.00e+00 1086.00
IUUC-Itr-048294 Ictidomys tridecemlineatus 92.72 0.00e+00 1095.00
IUUC-Lch-049906 Latimeria chalumnae 67.97 2.00e-167 581.00
IUUC-Loc-052748 Lepisosteus oculatus 66.56 0.00e+00 769.00
IUUC-Lma-053062 Leptosphaeria maculans 45.90 6.00e-07 49.30
IUUC-Laf-053373 Loxodonta africana 91.93 0.00e+00 1096.00
IUUC-Mcc-054953 Macaca mulatta 90.77 0.00e+00 1060.00
IUUC-Mga-059536 Meleagris gallopavo 80.57 0.00e+00 993.00
IUUC-Mmr-061000 Microcebus murinus 91.61 0.00e+00 1090.00
IUUC-Mdo-061885 Monodelphis domestica 87.10 0.00e+00 1048.00
IUUC-Mlu-067143 Myotis lucifugus 89.63 0.00e+00 1067.00
IUUC-Ont-072028 Oreochromis niloticus 65.20 0.00e+00 775.00
IUUC-Oan-073741 Ornithorhynchus anatinus 70.70 1.00e-55 208.00
IUUC-Ola-086919 Oryzias latipes 64.18 0.00e+00 772.00
IUUC-Oga-088465 Otolemur garnettii 91.43 0.00e+00 1053.00
IUUC-Oar-089562 Ovis aries 90.73 0.00e+00 1076.00
IUUC-Ptr-090632 Pan troglodytes 90.60 0.00e+00 1086.00
IUUC-Pan-092192 Papio anubis 90.77 0.00e+00 1057.00
IUUC-Psi-093346 Pelodiscus sinensis 83.39 0.00e+00 1006.00
IUUC-Pma-094619 Petromyzon marinus 38.65 2.00e-77 283.00
IUUC-Pno-094868 Phaeosphaeria nodorum 45.90 4.00e-07 49.30
IUUC-Pfo-096634 Poecilia formosa 64.19 0.00e+00 765.00
IUUC-Pab-097866 Pongo abelii 90.71 0.00e+00 1080.00
IUUC-Pva-102273 Pteropus vampyrus 91.03 0.00e+00 1053.00
IUUC-Pte-104168 Pyrenophora teres 45.90 5.00e-07 49.30
IUUC-Pyt-104443 Pyrenophora triticirepentis 45.90 5.00e-07 49.30
IUUC-Rno-105513 Rattus norvegicus 91.92 0.00e+00 1082.00
IUUC-Ssc-116184 Sus scrofa 91.54 0.00e+00 1089.00
IUUC-Tgu-117370 Taeniopygia guttata 84.00 0.00e+00 1025.00
IUUC-Tru-117764 Takifugu rubripes 60.38 0.00e+00 734.00
IUUC-Tni-119947 Tetraodon nigroviridis 66.00 0.00e+00 774.00
IUUC-Ttr-128700 Tursiops truncatus 87.23 0.00e+00 1031.00
IUUC-Xtr-132466 Xenopus tropicalis 68.39 0.00e+00 789.00
IUUC-Xma-134033 Xiphophorus maculatus 63.24 0.00e+00 748.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved