iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.70e-12	46.3	121	172

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           v   + ++++ + +L +++G+ ++++   +++++W+++ +++ g  Gl+P+n+v+
   Q: 121  VVGTFKFTGERETDLPFEQGERLEIL--SKTNQDWWEA-RNALGTTGLVPANYVQ 172
           566799********************..778889****.5999**********96 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis (PubMed:10707082, PubMed:6857247, PubMed:1936965, PubMed:11449278, PubMed:15744306, PubMed:19402756, PubMed:20226672). Has a role in the migration of the 2 gonadal distal tip cells (DTCs) (PubMed:10707082).

Protein Sequence
(Fasta)

MTTNGFDPFE WRSFYFPGMS REEAHKLLGE PQVSIGTFLM RDSSRPGEYS LTVREADEGN 60
AVCHYLIERG EPKEDGTAAA GVKIANQSFP DIPALLNHFK MRVLTEASLL AAYKKPIIEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAATGACG ACAAACGGGT TCGATCCATT CGAGTGGCGT TCATTCTACT TCCCAGGAAT 60
GAGCCGTGAA GAGGCTCACA AGTTGCTCGG CGAGCCACAA GTATCGATCG GCACCTTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0581--Phagocytosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005886--C:plasma membrane
GO:0032403--F:protein complex binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0031532--P:actin cytoskeleton reorganization
GO:0006915--P:apoptotic process
GO:0016477--P:cell migration
GO:0043652--P:engulfment of apoptotic cell
GO:1903356--P:positive regulation of distal tip cell migration
GO:1901076--P:positive regulation of engulfment of apoptotic cell
GO:0012501--P:programmed cell death
GO:0007165--P:signal transduction

KEGG

cel:CELE_Y41D4B.13

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001192	Ailuropoda melanoleuca	29.90	3.00e-25	107.00
IUUC-Apl-004166	Anas platyrhynchos	30.71	8.00e-25	106.00
IUUC-Aca-004695	Anolis carolinensis	29.75	9.00e-25	105.00
IUUC-Ame-011721	Astyanax mexicanus	30.92	3.00e-27	114.00
IUUC-Bta-012320	Bos taurus	30.00	1.00e-25	108.00
IUUC-Cja-019935	Callithrix jacchus	30.33	1.00e-27	115.00
IUUC-Cfa-021221	Canis familiaris	30.00	2.00e-25	108.00
IUUC-Cpo-022079	Cavia porcellus	30.03	3.00e-25	107.00
IUUC-Csa-023877	Chlorocebus sabaeus	30.03	6.00e-25	106.00
IUUC-Cho-024775	Choloepus hoffmanni	30.36	7.00e-26	109.00
IUUC-Cin-025128	Ciona intestinalis	27.33	7.00e-24	102.00
IUUC-Csv-026340	Ciona savignyi	26.28	7.00e-19	86.70
IUUC-Dre-027390	Danio rerio	30.72	3.00e-26	110.00
IUUC-Dno-029847	Dasypus novemcinctus	30.00	1.00e-25	108.00
IUUC-Dor-030297	Dipodomys ordii	29.84	2.00e-26	111.00
IUUC-Dme-031600	Drosophila melanogaster	35.04	6.00e-36	142.00
IUUC-Ete-032604	Echinops telfairi	27.83	4.00e-17	79.70
IUUC-Eca-033233	Equus caballus	30.17	1.00e-27	115.00
IUUC-Eeu-034642	Erinaceus europaeus	28.30	1.00e-19	88.60
IUUC-Fca-036412	Felis catus	30.03	3.00e-25	107.00
IUUC-Fal-037170	Ficedula albicollis	30.14	1.00e-24	105.00
IUUC-Gmo-038849	Gadus morhua	31.88	9.00e-26	109.00
IUUC-Ggr-040073	Gaeumannomyces graminis	46.43	2.00e-08	52.40
IUUC-Gga-040733	Gallus gallus	30.80	2.00e-23	101.00
IUUC-Gac-041569	Gasterosteus aculeatus	30.67	2.00e-27	114.00
IUUC-Ggo-045475	Gorilla gorilla	30.00	1.00e-25	108.00
IUUC-Hsa-046008	Homo sapiens	30.00	1.00e-25	108.00
IUUC-Itr-048092	Ictidomys tridecemlineatus	30.72	1.00e-25	109.00
IUUC-Lch-050385	Latimeria chalumnae	29.51	2.00e-26	111.00
IUUC-Loc-052916	Lepisosteus oculatus	31.48	5.00e-31	126.00
IUUC-Laf-053896	Loxodonta africana	30.69	2.00e-27	115.00
IUUC-Mcc-055280	Macaca mulatta	30.00	1.00e-25	108.00
IUUC-Meu-056783	Macropus eugenii	28.77	3.00e-19	87.00
IUUC-Mpo-057361	Magnaporthe poae	44.64	1.00e-08	50.80
IUUC-Mga-059586	Meleagris gallopavo	30.82	9.00e-24	102.00
IUUC-Mdo-062691	Monodelphis domestica	30.33	1.00e-26	112.00
IUUC-Mmu-063691	Mus musculus	30.00	1.00e-25	108.00
IUUC-Mpu-065737	Mustela putorius furo	30.00	1.00e-25	108.00
IUUC-Mlu-067005	Myotis lucifugus	30.33	1.00e-26	112.00
IUUC-Nle-069118	Nomascus leucogenys	30.03	5.00e-25	106.00
IUUC-Opr-071114	Ochotona princeps	30.67	4.00e-28	117.00
IUUC-Ont-071608	Oreochromis niloticus	29.87	1.00e-28	119.00
IUUC-Oan-072801	Ornithorhynchus anatinus	30.69	7.00e-27	112.00
IUUC-Ocu-073759	Oryctolagus cuniculus	30.38	1.00e-25	108.00
IUUC-Ola-086748	Oryzias latipes	30.07	7.00e-23	99.80
IUUC-Oga-088248	Otolemur garnettii	30.38	2.00e-25	108.00
IUUC-Oar-089221	Ovis aries	30.56	2.00e-24	105.00
IUUC-Ptr-091553	Pan troglodytes	30.03	5.00e-25	106.00
IUUC-Pan-092242	Papio anubis	30.00	1.00e-25	108.00
IUUC-Psi-093287	Pelodiscus sinensis	28.90	2.00e-19	87.40
IUUC-Pma-094340	Petromyzon marinus	31.17	2.00e-29	121.00
IUUC-Pfo-096090	Poecilia formosa	31.79	2.00e-29	121.00
IUUC-Pab-097823	Pongo abelii	32.63	3.00e-19	87.00
IUUC-Pca-101068	Procavia capensis	30.00	1.00e-25	108.00
IUUC-Pva-102346	Pteropus vampyrus	30.14	4.00e-25	107.00
IUUC-Rno-105288	Rattus norvegicus	30.00	1.00e-25	108.00
IUUC-Sha-106511	Sarcophilus harrisii	29.59	9.00e-16	75.10
IUUC-Sar-113583	Sorex araneus	30.03	5.00e-26	110.00
IUUC-Ssc-115339	Sus scrofa	30.03	1.00e-25	108.00
IUUC-Tgu-116926	Taeniopygia guttata	29.61	8.00e-21	92.80
IUUC-Tru-118580	Takifugu rubripes	31.25	3.00e-27	114.00
IUUC-Tsy-119327	Tarsius syrichta	30.27	7.00e-25	106.00
IUUC-Tni-120626	Tetraodon nigroviridis	30.97	2.00e-25	108.00
IUUC-Tbe-127436	Tupaia belangeri	30.17	3.00e-26	110.00
IUUC-Ttr-128248	Tursiops truncatus	30.38	3.00e-25	107.00
IUUC-Vpa-130527	Vicugna pacos	30.00	1.00e-25	108.00
IUUC-Xtr-132626	Xenopus tropicalis	28.85	6.00e-26	109.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence