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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063665
UUCD1 version UUC-MuM-01075
Ensembl Protein ID ENSMUSP00000028841.7
UniProt Accession Q80U87; A2AI53; Q80YP2; Q8R0D3; Q9EQU1; Q9WVP5; UBP8_MOUSE
Genbank Protein ID BAB18534.1; AAD38869.1; BAC65477.1; CAM14544.1; AAH27052.1; AAH50947.1; AAH61465.1; AAH66126.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; Ubiquitin isopeptidase Y; Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8
Genbank Nucleotide ID AB045709; AF057146; AK122195; AL732330; BC027052; BC050947; BC061465; BC066126
Gene Name Usp8; Kiaa0055; Ubpy
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027363.15 ENSMUST00000028841.13 ENSMUSP00000028841.7
ENSMUSG00000027363.15 ENSMUST00000110416.2 ENSMUSP00000106046.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 9628861
Classification
Family E-value Score Start End
DUB/USP 1.90e-108 363.8 739 1069
Active Site
Position(s) Description Evidence
748 Nucleophile
1029 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 739  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAG 825
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkk...eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           ++qqD+qE+l fl+d+l+e+l+k   +k+++ e+ e+ d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 826  SSQQDSQELLLFLMDGLHEDLNKadnRKRHKEENNEHLDDLQAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCRRRSRTFEAFM 912
           *********************8844333333333333445566666***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 913  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 994
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v +   s aY+lfY+
   Q: 995  EnLDLSQYVIGPKNS---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVRS---SAAYILFYT 1069
           ***********9987...69*************************88888*******************...********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1 (By similarity).
 Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1 (By similarity).
Protein Sequence
(Fasta)
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK TSTKNYIHSA QKIFKTAEEC RLDRDEERAY 60
VLYMKYVAVY NLIKKRPDFK QQQDYYLSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063665|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGACGTTTC GAGACGCGAC CCGTCGCCAC GCAATGCGAA TCGGGAAGAG GGGATGAGCT 60
GCGCTGCCGT GCGTCTGAGA GCGAAGGCTC GTTCTCCTTC TGGTGGTGGG CGATGGGCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063665|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0729--SH3-binding
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer
SMART

SM00450--RHOD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0005622--C:intracellular
GO:0030496--C:midbody
GO:0005634--C:nucleus
GO:0045296--F:cadherin binding
GO:0017124--F:SH3 domain binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:84092
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001661 Ailuropoda melanoleuca 81.52 0.00e+00 1655.00
IUUC-Apl-003226 Anas platyrhynchos 69.29 0.00e+00 1418.00
IUUC-Aca-004936 Anolis carolinensis 64.45 0.00e+00 1244.00
IUUC-Ago-007959 Ashbya gossypii 35.62 3.00e-55 210.00
IUUC-Acl-008102 Aspergillus clavatus 31.59 1.00e-51 199.00
IUUC-Afl-008604 Aspergillus flavus 30.77 8.00e-51 195.00
IUUC-Afu-009001 Aspergillus fumigatus 31.94 5.00e-51 196.00
IUUC-Ani-009291 Aspergillus nidulans 31.45 9.00e-51 195.00
IUUC-Ang-009844 Aspergillus niger 32.73 6.00e-50 192.00
IUUC-Aor-010098 Aspergillus oryzae 31.32 4.00e-50 193.00
IUUC-Ate-010585 Aspergillus terreus 31.94 5.00e-50 193.00
IUUC-Ame-010960 Astyanax mexicanus 75.00 6.00e-84 302.00
IUUC-Bta-013008 Bos taurus 83.27 0.00e+00 1649.00
IUUC-Bol-015281 Brassica oleracea 37.91 1.00e-46 181.00
IUUC-Bra-017228 Brassica rapa 39.10 1.00e-48 187.00
IUUC-Cel-018482 Caenorhabditis elegans 31.21 1.00e-51 198.00
IUUC-Cja-019173 Callithrix jacchus 81.31 0.00e+00 1676.00
IUUC-Cfa-021243 Canis familiaris 81.47 0.00e+00 1649.00
IUUC-Cpo-021522 Cavia porcellus 81.34 0.00e+00 1636.00
IUUC-Cre-022582 Chlamydomonas reinhardtii 44.35 7.00e-81 293.00
IUUC-Csa-023616 Chlorocebus sabaeus 81.41 0.00e+00 1397.00
IUUC-Cho-024381 Choloepus hoffmanni 70.02 0.00e+00 1368.00
IUUC-Cin-025287 Ciona intestinalis 49.12 9.00e-96 345.00
IUUC-Csv-026253 Ciona savignyi 47.16 2.00e-86 314.00
IUUC-Cne-026821 Cryptococcus neoformans 39.89 8.00e-75 276.00
IUUC-Dre-028440 Danio rerio 67.63 0.00e+00 731.00
IUUC-Dno-029039 Dasypus novemcinctus 80.46 0.00e+00 1679.00
IUUC-Dor-031043 Dipodomys ordii 94.40 5.00e-130 459.00
IUUC-Dse-031463 Dothistroma septosporum 28.86 1.00e-42 169.00
IUUC-Dme-032089 Drosophila melanogaster 45.18 8.00e-83 301.00
IUUC-Ete-033040 Echinops telfairi 74.80 0.00e+00 1363.00
IUUC-Eca-033449 Equus caballus 81.20 0.00e+00 1649.00
IUUC-Eeu-034693 Erinaceus europaeus 95.26 1.00e-130 461.00
IUUC-Fca-035794 Felis catus 95.37 0.00e+00 906.00
IUUC-Fal-037322 Ficedula albicollis 77.28 0.00e+00 860.00
IUUC-Gmo-038584 Gadus morhua 61.47 0.00e+00 658.00
IUUC-Gga-041188 Gallus gallus 80.67 0.00e+00 882.00
IUUC-Gac-041850 Gasterosteus aculeatus 73.40 0.00e+00 737.00
IUUC-Ggo-045565 Gorilla gorilla 81.75 0.00e+00 1689.00
IUUC-Hsa-046438 Homo sapiens 81.66 0.00e+00 1685.00
IUUC-Itr-048883 Ictidomys tridecemlineatus 84.57 0.00e+00 1680.00
IUUC-Kpa-049321 Komagataella pastoris 32.97 1.00e-49 191.00
IUUC-Lch-050485 Latimeria chalumnae 80.39 0.00e+00 852.00
IUUC-Lma-053021 Leptosphaeria maculans 32.53 8.00e-54 206.00
IUUC-Laf-053432 Loxodonta africana 78.20 0.00e+00 1601.00
IUUC-Mcc-055823 Macaca mulatta 81.66 0.00e+00 1687.00
IUUC-Meu-056099 Macropus eugenii 95.17 1.00e-160 560.00
IUUC-Mla-059089 Melampsora laricipopulina 40.80 8.00e-73 269.00
IUUC-Mga-059739 Meleagris gallopavo 88.96 0.00e+00 875.00
IUUC-Mvi-060559 Microbotryum violaceum 39.83 5.00e-77 283.00
IUUC-Mmr-061158 Microcebus murinus 80.81 0.00e+00 1637.00
IUUC-Mdo-061801 Monodelphis domestica 85.54 0.00e+00 938.00
IUUC-Mpu-066738 Mustela putorius furo 80.75 0.00e+00 1629.00
IUUC-Mlu-067307 Myotis lucifugus 77.86 0.00e+00 1632.00
IUUC-Nfi-068410 Neosartorya fischeri 32.22 3.00e-51 197.00
IUUC-Nle-069314 Nomascus leucogenys 81.48 0.00e+00 1679.00
IUUC-Opr-070378 Ochotona princeps 72.12 0.00e+00 1073.00
IUUC-Ont-071545 Oreochromis niloticus 75.66 0.00e+00 754.00
IUUC-Oan-073537 Ornithorhynchus anatinus 71.78 0.00e+00 1427.00
IUUC-Ocu-074193 Oryctolagus cuniculus 83.10 0.00e+00 1690.00
IUUC-Ola-086622 Oryzias latipes 57.29 0.00e+00 1063.00
IUUC-Oga-088271 Otolemur garnettii 80.34 0.00e+00 1633.00
IUUC-Oar-090431 Ovis aries 82.78 0.00e+00 1638.00
IUUC-Ptr-091339 Pan troglodytes 81.66 0.00e+00 1724.00
IUUC-Pan-091783 Papio anubis 71.01 0.00e+00 775.00
IUUC-Psi-093187 Pelodiscus sinensis 63.41 9.00e-150 524.00
IUUC-Pma-094626 Petromyzon marinus 58.43 6.00e-142 497.00
IUUC-Pfo-096463 Poecilia formosa 74.04 0.00e+00 741.00
IUUC-Pab-097645 Pongo abelii 81.40 0.00e+00 1682.00
IUUC-Pva-103222 Pteropus vampyrus 92.23 0.00e+00 739.00
IUUC-Pgr-103408 Puccinia graminis 35.92 1.00e-54 208.00
IUUC-Ptt-103699 Puccinia triticina 46.50 7.00e-69 256.00
IUUC-Pte-104348 Pyrenophora teres 29.13 5.00e-40 160.00
IUUC-Pyt-104711 Pyrenophora triticirepentis 31.39 2.00e-51 197.00
IUUC-Rno-105510 Rattus norvegicus 93.62 0.00e+00 1907.00
IUUC-Sce-106166 Saccharomyces cerevisiae 34.71 9.00e-52 198.00
IUUC-Sha-106879 Sarcophilus harrisii 83.39 0.00e+00 918.00
IUUC-Sja-107836 Schizosaccharomyces japonicus 37.14 6.00e-50 192.00
IUUC-Sar-113019 Sorex araneus 74.64 0.00e+00 1566.00
IUUC-Sre-115031 Sporisorium reilianum 36.49 4.00e-68 253.00
IUUC-Ssc-116334 Sus scrofa 83.23 0.00e+00 1678.00
IUUC-Tgu-117062 Taeniopygia guttata 82.16 0.00e+00 863.00
IUUC-Tru-117908 Takifugu rubripes 58.45 0.00e+00 1138.00
IUUC-Tsy-118867 Tarsius syrichta 77.25 0.00e+00 947.00
IUUC-Tni-120206 Tetraodon nigroviridis 55.71 0.00e+00 1045.00
IUUC-Tme-127144 Tuber melanosporum 40.56 3.00e-79 290.00
IUUC-Tbe-127877 Tupaia belangeri 97.39 2.00e-83 304.00
IUUC-Ttr-128580 Tursiops truncatus 78.96 0.00e+00 1570.00
IUUC-Uma-129340 Ustilago maydis 37.63 6.00e-70 259.00
IUUC-Vpa-130541 Vicugna pacos 80.75 0.00e+00 1639.00
IUUC-Xtr-132161 Xenopus tropicalis 75.30 0.00e+00 781.00
IUUC-Xma-134271 Xiphophorus maculatus 74.24 0.00e+00 742.00
IUUC-Yli-134561 Yarrowia lipolytica 36.19 2.00e-60 227.00
Created Date 25-Jun-2017

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