iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046912

Ensembl Protein ID

ENSP00000432000.1

UniProt Accession

Q8IWQ3; B3KVE9; E9PLM7; O60843; O95099; Q5J5B4; Q6ZMQ4; Q8TB60; BRSK2_HUMAN

Genbank Protein ID

AAS86443.1; AAP97723.1; AAP97724.1; AAP97725.1; AAP97726.1; AAP97727.1; AAN87839.1; BAG53761.1; BAD18671.1; CAA07196.1; AAH24291.1; AAD09654.1

Protein Name

Serine/threonine-protein kinase BRSK2; Brain-selective kinase 2; Brain-specific serine/threonine-protein kinase 2; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A

Genbank Nucleotide ID

AY505125; AF533876; AF533877; AF533878; AF533879; AF533880; AY166857; AK122851; AK131534; AC091196; BC024291; AF020089

Gene Name

BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000174672.15	ENST00000308219.13	ENSP00000310697.9
ENSG00000174672.15	ENST00000529433.5	ENSP00000433684.1
ENSG00000174672.15	ENST00000528841.5	ENSP00000432000.1
ENSG00000174672.15	ENST00000526678.5	ENSP00000433370.1
ENSG00000174672.15	ENST00000382179.5	ENSP00000371614.1
ENSG00000174672.15	ENST00000529951.5	ENSP00000432252.1
ENSG00000174672.15	ENST00000533606.2	ENSP00000436474.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	22609399; 23029325

Organism

Homo sapiens

Functional Description
(View)

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.

Protein Sequence
(Fasta)

MTSTGKDGGA QHAQYVGPYR LEKTLGKGQT GLVKLGVHCV TCQKVAIKIV NREKLSESVL 60
MKVEREIAIL KLIEHPHVLK LHDVYENKKY LYLVLEHVSG GELFDYLVKK GRLTPKEARK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGTTCGGC TCAGCTGCAC GGCTCGGCTC GGCTCGGCTC GGCTCGGCTG CGCGGCCGCT 60
GACGGGCGTG CGCTGGGGGC GCGGGGCGCG GGGCGCGGGC CTCGGCGGCG GCGGCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0256--Endoplasmic reticulum
KW-0268--Exocytosis
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0051117--F:ATPase binding
GO:0060590--F:ATPase regulator activity
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0031532--P:actin cytoskeleton reorganization
GO:0007409--P:axonogenesis
GO:0051301--P:cell division
GO:0036503--P:ERAD pathway
GO:0030010--P:establishment of cell polarity
GO:0006887--P:exocytosis
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0007067--P:mitotic nuclear division
GO:0030182--P:neuron differentiation
GO:0018105--P:peptidyl-serine phosphorylation
GO:0006468--P:protein phosphorylation
GO:0043462--P:regulation of ATPase activity
GO:0061178--P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:1904152--P:regulation of retrograde protein transport, ER to cytosol

KEGG

hsa:9024

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003374	Anas platyrhynchos	92.39	0.00e+00	1214.00
IUUC-Bta-012608	Bos taurus	97.45	0.00e+00	1274.00
IUUC-Cel-018416	Caenorhabditis elegans	67.22	2.00e-156	546.00
IUUC-Cja-019882	Callithrix jacchus	97.76	0.00e+00	1295.00
IUUC-Cpo-021604	Cavia porcellus	96.44	0.00e+00	1294.00
IUUC-Csv-025996	Ciona savignyi	54.76	0.00e+00	659.00
IUUC-Dre-028706	Danio rerio	85.10	0.00e+00	1088.00
IUUC-Dme-031685	Drosophila melanogaster	76.42	5.00e-165	575.00
IUUC-Eca-033483	Equus caballus	97.19	0.00e+00	1221.00
IUUC-Fal-037499	Ficedula albicollis	92.94	0.00e+00	1208.00
IUUC-Gmo-039305	Gadus morhua	85.07	0.00e+00	702.00
IUUC-Gac-042120	Gasterosteus aculeatus	85.74	0.00e+00	955.00
IUUC-Itr-048825	Ictidomys tridecemlineatus	96.75	0.00e+00	1290.00
IUUC-Mcc-055306	Macaca mulatta	96.73	0.00e+00	1316.00
IUUC-Mor-057261	Magnaporthe oryzae	41.19	9.00e-82	298.00
IUUC-Mga-059357	Meleagris gallopavo	93.05	0.00e+00	1209.00
IUUC-Mmr-061711	Microcebus murinus	83.51	0.00e+00	1047.00
IUUC-Mdo-062356	Monodelphis domestica	82.46	0.00e+00	968.00
IUUC-Mmu-063511	Mus musculus	97.83	0.00e+00	1389.00
IUUC-Mlu-068102	Myotis lucifugus	97.14	0.00e+00	919.00
IUUC-Ont-072425	Oreochromis niloticus	92.58	0.00e+00	1130.00
IUUC-Ola-086969	Oryzias latipes	87.82	0.00e+00	1124.00
IUUC-Pan-092910	Papio anubis	99.73	0.00e+00	1379.00
IUUC-Psi-093857	Pelodiscus sinensis	88.33	0.00e+00	980.00
IUUC-Pfo-097195	Poecilia formosa	92.12	0.00e+00	1127.00
IUUC-Rno-105039	Rattus norvegicus	83.83	0.00e+00	1107.00
IUUC-Sha-107449	Sarcophilus harrisii	89.74	0.00e+00	684.00
IUUC-Tgu-117372	Taeniopygia guttata	90.83	0.00e+00	1216.00
IUUC-Tru-118645	Takifugu rubripes	90.83	0.00e+00	1155.00
IUUC-Tni-120483	Tetraodon nigroviridis	77.04	0.00e+00	1015.00
IUUC-Tme-126887	Tuber melanosporum	48.77	3.00e-83	302.00
IUUC-Xtr-132457	Xenopus tropicalis	88.73	0.00e+00	1175.00
IUUC-Xma-134021	Xiphophorus maculatus	85.73	0.00e+00	1120.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence