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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047011
UUCD1 version UUC-HoS-01250
Ensembl Protein ID ENSP00000365682.3
UniProt Accession Q04724; A8K495; Q5T3G4; Q969V9; TLE1_HUMAN
Genbank Protein ID AAA61192.1; BAF83549.1; CAI14977.1; CAI14977.1; CAI12595.1; CAI12595.1; EAW62636.1; AAH10100.1; AAH15747.1
Protein Name Transducin-like enhancer protein 1; E(Sp1) homolog; Enhancer of split groucho-like protein 1
Genbank Nucleotide ID M99435; AK290860; AL365190; AL353682; AL353682; AL365190; CH471089; BC010100; BC015747
Gene Name TLE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000196781.14 ENST00000376499.7 ENSP00000365682.3
ENSG00000196781.14 ENST00000376484.1 ENSP00000365667.1
ENSG00000196781.14 ENST00000418319.5 ENSP00000391347.1
ENSG00000196781.14 ENST00000376463.2 ENSP00000365646.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17041588; 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.60e-21 76.0 614 652
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 614  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 652
           8***********999*********************998 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
 Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Protein Sequence
(Fasta)
MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047011|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTGCCCGCC GGGGAGGGTG GCCGATTGGC GGAGCGCACT CCTGCTGTTT TCCCCACCAT 60
CTCGTGGATG TCGTCCCTCG GGTGGTGAGA GAACTTTGCA GTGGGCTGGA GCGCCCTTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047011|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03920--TLE_N
PF00400--WD40
PRINTS

PR01850--GROUCHOFAMLY
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0009887--P:animal organ morphogenesis
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0007275--P:multicellular organism development
GO:2000811--P:negative regulation of anoikis
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0010628--P:positive regulation of gene expression
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG hsa:7088
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001746 Ailuropoda melanoleuca 95.10 0.00e+00 1268.00
IUUC-Apl-003594 Anas platyrhynchos 94.94 0.00e+00 1251.00
IUUC-Aca-005053 Anolis carolinensis 94.10 0.00e+00 1291.00
IUUC-Bta-013380 Bos taurus 90.92 0.00e+00 1164.00
IUUC-Cja-019135 Callithrix jacchus 99.74 0.00e+00 1320.00
IUUC-Cfa-020611 Canis familiaris 99.44 0.00e+00 1200.00
IUUC-Cpo-022495 Cavia porcellus 98.70 0.00e+00 1312.00
IUUC-Csa-024056 Chlorocebus sabaeus 99.87 0.00e+00 1343.00
IUUC-Csv-026174 Ciona savignyi 57.29 1.00e-161 563.00
IUUC-Dno-029011 Dasypus novemcinctus 98.83 0.00e+00 1312.00
IUUC-Ete-032533 Echinops telfairi 86.88 0.00e+00 1196.00
IUUC-Eca-033351 Equus caballus 99.74 0.00e+00 1320.00
IUUC-Eeu-034666 Erinaceus europaeus 99.48 0.00e+00 1083.00
IUUC-Fal-036696 Ficedula albicollis 97.76 0.00e+00 1263.00
IUUC-Gga-041113 Gallus gallus 98.05 0.00e+00 1362.00
IUUC-Gac-041999 Gasterosteus aculeatus 81.12 0.00e+00 1185.00
IUUC-Ggo-045164 Gorilla gorilla 100.00 0.00e+00 1345.00
IUUC-Lch-050437 Latimeria chalumnae 94.81 0.00e+00 1128.00
IUUC-Loc-052819 Lepisosteus oculatus 91.17 0.00e+00 1240.00
IUUC-Laf-053862 Loxodonta africana 96.15 0.00e+00 1280.00
IUUC-Mcc-055735 Macaca mulatta 95.77 0.00e+00 1326.00
IUUC-Mmr-061207 Microcebus murinus 96.03 0.00e+00 1273.00
IUUC-Mdo-062493 Monodelphis domestica 98.83 0.00e+00 1366.00
IUUC-Mmu-063795 Mus musculus 93.61 0.00e+00 1274.00
IUUC-Mpu-065819 Mustela putorius furo 99.22 0.00e+00 1344.00
IUUC-Mlu-067047 Myotis lucifugus 99.35 0.00e+00 1303.00
IUUC-Nle-069684 Nomascus leucogenys 99.74 0.00e+00 1336.00
IUUC-Opr-071172 Ochotona princeps 98.31 0.00e+00 1295.00
IUUC-Ont-072102 Oreochromis niloticus 81.59 0.00e+00 1196.00
IUUC-Ocu-074592 Oryctolagus cuniculus 96.10 0.00e+00 1324.00
IUUC-Oga-088629 Otolemur garnettii 96.54 0.00e+00 1277.00
IUUC-Oar-089551 Ovis aries 98.31 0.00e+00 1296.00
IUUC-Ptr-091207 Pan troglodytes 99.61 0.00e+00 1338.00
IUUC-Pan-091822 Papio anubis 95.77 0.00e+00 1326.00
IUUC-Psi-093594 Pelodiscus sinensis 95.22 0.00e+00 1284.00
IUUC-Pma-094452 Petromyzon marinus 78.30 0.00e+00 1111.00
IUUC-Pfo-096239 Poecilia formosa 80.65 0.00e+00 1187.00
IUUC-Pab-097687 Pongo abelii 100.00 0.00e+00 1327.00
IUUC-Pca-100675 Procavia capensis 98.78 0.00e+00 1061.00
IUUC-Pva-102355 Pteropus vampyrus 95.38 0.00e+00 1208.00
IUUC-Rno-106027 Rattus norvegicus 96.76 0.00e+00 1330.00
IUUC-Sha-107419 Sarcophilus harrisii 93.85 0.00e+00 1284.00
IUUC-Sar-113585 Sorex araneus 86.75 0.00e+00 717.00
IUUC-Ssc-116151 Sus scrofa 99.22 0.00e+00 1314.00
IUUC-Tgu-117387 Taeniopygia guttata 97.40 0.00e+00 1339.00
IUUC-Tsy-119342 Tarsius syrichta 92.49 0.00e+00 1031.00
IUUC-Tbe-127881 Tupaia belangeri 96.49 0.00e+00 1301.00
IUUC-Vpa-130631 Vicugna pacos 90.04 2.00e-81 296.00
IUUC-Xtr-131792 Xenopus tropicalis 89.30 0.00e+00 1242.00
Created Date 25-Jun-2017

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